Stress-Induced Modulators of Repeat Instability and Genome Evolution

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

(2011) Katharina Schlacher et al.   CELL

Molecular Chaperone Hsp90 Regulates REV1-Mediated Mutagenesis

(2011) F. Mayca Pozo et al.   MOLECULAR AND CELLULAR BIOLOGY

Hsp90 Inhibitor-Mediated Disruption of Chaperone Association of ATR with Hsp90 Sensitizes Cancer Cells to DNA Damage

(2011) K. Ha et al.   MOLECULAR CANCER THERAPEUTICS

PIWI-interacting small RNAs: the vanguard of genome defence

(2011) Mikiko C. Siomi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Impact of a stress-inducible switch to mutagenic repair of DNA breaks on mutation in Escherichia coli

(2011) C. Shee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Variable Tandem Repeats Accelerate Evolution of Coding and Regulatory Sequences

(2010) Rita Gemayel et al.   Annual Review of Genetics

Paternally Induced Transgenerational Environmental Reprogramming of Metabolic Gene Expression in Mammals

(2010) Benjamin R. Carone et al.   CELL

A screen for deubiquitinating enzymes involved in the G2/M checkpoint identifies USP50 as a regulator of HSP90-dependent Wee1 stability

(2010) Bernadette Aressy et al.   CELL CYCLE

Regulation of PIDD auto-proteolysis and activity by the molecular chaperone Hsp90

(2010) A Tinel et al.   CELL DEATH AND DIFFERENTIATION

Stress, genomes, and evolution

(2010) David Mittelman et al.   CELL STRESS & CHAPERONES

Hsp90 modulates CAG repeat instability in human cells

(2010) David Mittelman et al.   CELL STRESS & CHAPERONES

Separate DNA Pol II- and Pol IV-Dependent Pathways of Stress-Induced Mutation during Double-Strand-Break Repair in Escherichia coli Are Controlled by RpoS

(2010) R. L. Frisch et al.   JOURNAL OF BACTERIOLOGY

The Molecular Chaperone Hsp90 Regulates Accumulation of DNA Polymerase η at Replication Stalling Sites in UV-Irradiated Cells

(2010) Takayuki Sekimoto et al.   MOLECULAR CELL

The σE stress response is required for stress-induced mutation and amplification in Escherichia coli

(2010) Janet L. Gibson et al.   MOLECULAR MICROBIOLOGY

Hsp90 prevents phenotypic variation by suppressing the mutagenic activity of transposons

(2010) Valeria Specchia et al.   NATURE

Purified human BRCA2 stimulates RAD51-mediated recombination

(2010) Ryan B. Jensen et al.   NATURE

Drosophila Piwi functions in Hsp90-mediated suppression of phenotypic variation

(2010) Vamsi K Gangaraju et al.   NATURE GENETICS

Repeat instability as the basis for human diseases and as a potential target for therapy

(2010) Arturo López Castel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA

(2010) Jie Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNMT3AMutations in Acute Myeloid Leukemia

(2010) Timothy J. Ley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Competition of Escherichia coli DNA Polymerases I, II and III with DNA Pol IV in Stressed Cells

(2010) P. J. Hastings et al.   PLoS One

Transposon Tn7 Preferentially Inserts into GAA•TTC Triplet Repeats under Conditions Conducive to Y•R•Y Triplex Formation

(2010) Miriam Mancuso et al.   PLoS One

Transcription of AAT•ATT Triplet Repeats in Escherichia coli Is Silenced by H-NS and IS1E Transposition

(2010) Xuefeng Pan et al.   PLoS One

DinB Upregulation Is the Sole Role of the SOS Response in Stress-Induced Mutagenesis in Escherichia coli

(2009) R. S. Galhardo et al.   GENETICS

Enhanced radiosensitization of human glioma cells by combining inhibition of poly(ADP-ribose) polymerase with inhibition of heat shock protein 90

(2009) F. A. Dungey et al.   MOLECULAR CANCER THERAPEUTICS

Mechanisms of change in gene copy number

(2009) P. J. Hastings et al.   NATURE REVIEWS GENETICS

Unstable Tandem Repeats in Promoters Confer Transcriptional Evolvability

(2009) M. D. Vinces et al.   SCIENCE

A Microhomology-Mediated Break-Induced Replication Model for the Origin of Human Copy Number Variation

(2009) P. J. Hastings et al.   PLoS Genetics

A Novel Mechanism of Transposon-Mediated Gene Activation

(2009) Zhongge Zhang et al.   PLoS Genetics

DNA-dependent protein kinase is involved in heat shock protein-mediated accumulation of hypoxia-inducible factor-1α in hypoxic preconditioned HepG2 cells

(2008) Moon Jung Kang et al.   FEBS Journal

Unstable Nucleotide Repeat Minireview Series: A Molecular Biography of Unstable Repeat Disorders

(2008) Harry T. Orr   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA Structure-induced Genomic Instability In Vivo

(2008) Guliang Wang et al.   JNCI-Journal of the National Cancer Institute

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

Hierarchy of nonhomologous end-joining, single-strand annealing and gene conversion at site-directed DNA double-strand breaks

(2008) W. Y. Mansour et al.   NUCLEIC ACIDS RESEARCH

Mutability and Importance of a Hypermutable Cell Subpopulation that Produces Stress-Induced Mutants in Escherichia coli

(2008) Caleb Gonzalez et al.   PLoS Genetics

Starvation Induces Genomic Rearrangements and Starvation-Resilient Phenotypes in Yeast

(2007) S. Coyle et al.   MOLECULAR BIOLOGY AND EVOLUTION

Is evolvability evolvable?

(2007) Massimo Pigliucci   NATURE REVIEWS GENETICS