Article
Reproductive Biology
Laura Diaz-Cueto, Pablo Dominguez-Lopez, Lucero Paniagua, Rebeca Martinez-Quezada, Fabian Arechavaleta-Velasco
Summary: The exposure to Cadmium reduces the invasiveness of trophoblast cells by inhibiting cell adhesion and MMP-9 secretion, as observed through decreased invasion and adhesion of HTR-8/SVneo cells, along with reduced levels and activity of MMP-9 in the culture medium, but increased mRNA expression and intracellular protein levels.
REPRODUCTIVE TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Reyna Penailillo, Stephanie Acuna-Gallardo, Felipe Garcia, Lara J. Monteiro, Gino Nardocci, Mahesh A. Choolani, Matthew W. Kemp, Roberto Romero, Sebastian E. Illanes
Summary: This study investigated the proliferation, migration, and impact on trophoblast invasion capacity of MenSCs under different physiological conditions. The findings suggest a potential role for MenSCs in the implantation process, implying a communication between maternal MenSCs and invading trophoblast cells that could be implicated in the etiology of PE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Beenish Rahat, Abid Hamid, Rashmi Bagga, Jyotdeep Kaur
Summary: The study reveals the association between lower folic acid levels and preeclampsia development. Folic acid supplementation can prevent preeclampsia by regulating the invasive potential of placental trophoblasts through various epigenetic changes.
FRONTIERS IN NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Milosz Caban, Katarzyna Owczarek, Urszula Lewandowska
Summary: Eye diseases are linked to visual impairment and reduced quality of life. Current treatments for these diseases are not satisfactory, highlighting the need for new therapeutic approaches. Matrix metalloproteinases and tissue inhibitors of metalloproteinases play crucial roles in eye diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Jaehoon Bae, Motofumi Kumazoe, Kwan-Woo Lee, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study found that OHBFB inhibits the growth of melanoma cells by activating intracellular signaling pathways, and it also discovered that OHBFB intake can suppress tumor growth.
Review
Medicine, Research & Experimental
Lorena Cayetano-Salazar, Dania A. Nava-Tapia, Kevin D. Astudillo-Justo, Adan Arizmendi-Izazaga, Cesar Sotelo-Leyva, Mayra Herrera-Martinez, Socrates Villegas-Comonfort, Napoleon Navarro-Tito
Summary: Cancer is a leading cause of death globally, with invasion and metastasis being directly responsible. Current therapeutic approaches for cancer suffer from toxicity and chemoresistance, highlighting the need for alternative treatment options. Natural products, particularly flavonoids, have shown promise as they possess antitumor properties in various study models. This review discusses the regulation of tissue inhibitors of metalloproteinases (TIMPs) expression and the role of flavonoids as therapeutic molecules that target TIMPs. Flavonoids exhibit chemopreventive and cytotoxic effects against different types of cancer through various mechanisms and also regulate crucial signaling pathways involved in cancer cell migration, invasion, and metastasis.
Article
Cell Biology
Lanlan Fang, Yibo Gao, Zhen Wang, Yuxi Li, Yang Yan, Ze Wu, Jung-Chien Cheng, Ying-Pu Sun
Summary: This study reveals that downregulation of EGF can lead to poor trophoblast cell invasion by increasing KISS1 expression, which subsequently contributes to the pathogenesis of preeclampsia.
CELL COMMUNICATION AND SIGNALING
(2021)
Review
Biochemistry & Molecular Biology
Christian Behm, Michael Nemec, Fabian Weissinger, Marco Aoqi Rausch, Oleh Andrukhov, Erwin Jonke
Summary: The systematic review revealed that orthodontic forces induce increased expression levels of MMPs and TIMPs in the PDL during orthodontic tooth movement. However, the exact effect may vary depending on intervention and sample parameters as well as subject characteristics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Mei-Tsz Su, Ching-Wei Tsai, Pei-Yin Tsai, Chia-Yih Wang, Hui-Ling Tsai
Summary: This study demonstrates that elevated cellular FN expression in the placenta of preeclamptic patients is associated with the disease, while aspirin inhibits FN expression and reverses FN-mediated trophoblast functions, providing a drug mechanism for disease prevention and a target for preeclampsia intervention.
Article
Medicine, General & Internal
Hiba Abdullah Mohammed, Ali Abbas Abdulkareem, Faraedon Mostafa Zardawi, Sarhang Sarwat Gul
Summary: This study showed that salivary biomarkers have high diagnostic accuracy in diagnosing periodontitis and distinguishing different stages. TIMP-1 can differentiate between S1 and S3 stages.
Article
Biochemistry & Molecular Biology
Anna Helmin-Basa, Izabela Kubiszewska, Malgorzata Wiese-Szadkowska, Edyta Strzyzewska, Aleksandra Skalska-Bugala, Sara Balcerowska, Marta Rasmus, Daria Balcerczyk, Marta Pokrywczynska, Jacek Michalkiewicz, Aneta Krogulska, Adam Glowczewski, Anna Szaflarska-Poplawska
Summary: H. pylori gastritis is associated with upregulation of MMPs in the gastric mucosa. MMP-9 is overexpressed in cases where H. pylori eradication is unsuccessful. MMPs play an important role in stomach remodeling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Developmental Biology
Pingsong Jin, Yijie Zhou, Zheng Liu, Xuehai Chen, Hongbo Qi
Summary: This study investigated the role of Claudin-1 (CLDN1) in trophoblast invasion and endovascular trophoblast (enEVT) differentiation in early-onset preeclampsia (EOPE). The expression and localization of CLDN1 were examined in normal and EOPE placental tissues. Trophoblast invasion and enEVT differentiation were studied using trophoblast cell lines. The results suggest that downregulation of CLDN1 is involved in the pathogenesis of EOPE by regulating trophoblast invasion and enEVT differentiation.
Article
Developmental Biology
Jian Zhao, Haigang Ding, Jinlong Ding, Xiaoliang Shi, Yao He, Hongdan Zhu, Hua Yuan, Tao Zhang, Juan Zhang
Summary: The METTL3-MYLK axis plays an important role in trophoblast invasion.
Article
Endocrinology & Metabolism
Wei Peng, Ying Liu, Hongbo Qi, Qingshu Li
Summary: The study suggests that ACTN4 may play a crucial role in regulating trophoblast proliferation and differentiation in the human placenta during early pregnancy, and dysregulation of this protein may contribute to the pathogenesis of preeclampsia.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Cell Biology
Qian Yang, Yeling Ma, Yanlei Liu, Xuan Shao, Wentong Jia, Xin Yu, Yu-xia Li, Long Yang, Wenwen Gu, Haibin Wang, Jian Wang, Yan-Ling Wang
Summary: The study demonstrated the crucial role of MNSF beta in regulating trophoblast invasion and fetal development. Lack of MNSF beta led to restricted embryonic growth and fetal loss, primarily due to limited trophoblast invasion. Conjugation with IGF2BP2 stabilized the protein and promoted trophoblast invasion.
CELL PROLIFERATION
(2021)