Article
Immunology
Zhizhongbin Wu, Yilin Huang, Weiqing Hu, Liyin Ren, Peihua Jiang, Robert F. Margolskee, Hong Wang, Shan Feng
Summary: This study found that a subset of taste bud cells and taste neurons express iNOS proteins after inflammation stimulation, and isolated mouse taste epithelium can release NO in vitro. Furthermore, NO may play an important role in inflammation-associated taste disturbances.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Biochemistry & Molecular Biology
Sheng-Qing Gao, Jia-Jun Shi, Shu-Hao Miao, Tao Li, Chao-Chao Gao, Yan-Ling Han, Jia-Yin Qiu, Yun-Song Zhuang, Meng-Liang Zhou
Summary: This study investigated the contribution of the interaction between endothelial NOX4 and DHFR to eNOS uncoupling after SAH. Inhibiting endothelial NOX4 and increasing endothelial DHFR levels alleviated eNOS uncoupling and improved neurological function after SAH.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Gaynor Aguilar, Francisco Cordova, Tania Koning, Jose Sarmiento, Mauricio P. Boric, Konstantin Birukov, Jorge Cancino, Manuel Varas-Godoy, Andrea Soza, Natascha G. Alves, Patricio E. Mujica, Walter N. Duran, Pamela Ehrenfeld, Fabiola A. Sanchez
Summary: Nitric oxide, produced by eNOS, promotes leukocyte adhesion through the S-nitrosylation pathway, contrary to its known inhibitory role, potentially involving PKCf S-nitrosylation as a key regulatory step.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Agronomy
Pan Shu, Yujing Li, Xinyu Wang, Lan Yao, Jiping Sheng, Lin Shen
Summary: The study demonstrated that treatment with ferulic acid enhanced resistance against Botrytis cinerea in tomato fruit by increasing the activities of defense enzymes and gene expression related to salicylic acid and jasmonic acid signaling pathways.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2021)
Article
Physiology
Stefan Kadach, Ji Won Park, Zdravko Stoyanov, Matthew I. I. Black, Anni Vanhatalo, Mark Burnley, Peter J. J. Walter, Hongyi Cai, Alan N. N. Schechter, Barbora Piknova, Andrew M. M. Jones
Summary: This study investigates the uptake and metabolism of dietary NO3- in skeletal muscles and its effects on exercise performance. The results show that muscle rapidly takes up NO3- after ingestion, and this uptake decreases during exercise. This uptake of NO3- is associated with enhanced torque production during maximal intermittent contractions.
Article
Biochemistry & Molecular Biology
Yin Wu, Ye Ding, Tharmarajan Ramprasath, Ming-Hui Zou
Summary: This review highlights the importance of nitric oxide in maintaining vascular homeostasis and its role in hypertension. Recent studies suggest that BH4 treatment could be a promising therapeutic for hypertension, but abnormalities in BH4 availability can trigger pathological events that affect blood pressure regulation. Continued research in this area is crucial to improve potential therapies for treating hypertension.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Cell Biology
Lina Sakhneny, Laura Mueller, Anat Schonblum, Sivan Azaria, Guzel Burganova, Alona Epshtein, Abigail Isaacson, Heather Wilson, Francesca M. Spagnoli, Limor Landsman
Summary: Glucose homeostasis in the body depends on insulin secretion from mature pancreatic beta cells. This study identifies BMP4 as a critical component in regulating beta cell function, with pericytes as the primary source of BMP4 in the pancreatic microenvironment. The timely production of BMP4 in the islet niche promotes beta cell functional maturation.
DEVELOPMENTAL CELL
(2021)
Article
Cell Biology
Qiuyue Wang, Caihui Zhang, Chen Yang, Yue Sun, Keyang Chen, Yao Lu
Summary: Capsaicin (CAP) may prevent hyperglycemia-induced endothelial dysfunction and diabetic cardiomyopathy through the TRPV1/eNOS pathway.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Immunology
Kangkang Chen, Xinyan Wang, Xiangyi Wei, Jiaqian Chen, Youheng Wei, Haobo Jiang, Zhiqiang Lu, Congjing Feng
Summary: This study investigated the impact of nitric oxide (NO) signaling on antimicrobial peptide (AMP) production using the lepidopteran pest Ostrinia furnacalis and Drosophila S2 cells. The findings suggest that NO-induced AMP production is mediated by the enzyme CanA1 via the IMD pathway.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Wei Chu, Lirong Cao, Gui Daokun, Jiali Zhao
Summary: The study found that iNOS was upregulated in OS tissues and cells, and inhibition of iNOS could reduce the proliferation, migration, and invasion abilities of OS cells while increasing apoptosis. In addition, iNOS inhibition also decreased the levels of MMP2, MMP9, C-MYC, Ki67, and PCNA in OS cells and regulated their expressions through suppressing beta-catenin. Moreover, tumor formation and iNOS/beta-catenin expressions were inhibited in mice transplanted with iNOS knockout OS cells, suggesting that iNOS might be a potential therapeutic target for OS.
JOURNAL OF IMMUNOLOGY RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Weimin Deng, Dalin Sun, Bin Cai, Baofang Jin
Summary: This study aimed to investigate the effect of Yangjing capsule (YC) on oligoasthenozoospermia. The results showed that YC improved the sperm concentration, sperm progressive motility, testicle and epididymis weight, fertility rate, and testis morphology in oligoasthenozoospermia. YC also promoted NO levels through the PLC gamma 1/AKT/eNOS pathway.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Keisuke Nakagawa, Mayuko Itoya, Nao Takemoto, Yuika Matsuura, Masashi Tawa, Yasuo Matsumura, Mamoru Ohkita
Summary: This study showed that IS increases O-2(-) production in vascular tissues, attenuating ACh- and SNP-induced vasorelaxation via potential NO inactivation. Additionally, IS-promoted O-2(-) production in the presence of vascular endothelium is likely through binding to AhR and activation of NADPH oxidase.
Article
Multidisciplinary Sciences
Hwee Hui Lau, Nicole A. J. Krentz, Fernando Abaitua, Marta Perez-Alcantara, Jun-Wei Chan, Jila Ajeian, Soumita Ghosh, Yunkyeong Lee, Jing Yang, Swaraj Thaman, Benoite Champon, Han Sun, Alokkumar Jha, Shawn Hoon, Nguan Soon Tan, Daphne Su-Lyn Gardner, Shih Ling Kao, E. Shyong Tai, Anna L. Gloyn, Adrian Kee Keong Teo
Summary: The coding variant of the PAX4 gene is associated with an altered risk of type 2 diabetes in East Asian populations. This study found that individuals carrying the specific allele of PAX4 exhibited decreased pancreatic beta cell function, and a newly identified allele was found in some diabetes patient pedigrees. Knockdown of the PAX4 gene resulted in impaired insulin secretion and altered hormone gene expression in a human beta cell model. In vitro differentiation experiments also showed that cells carrying specific risk alleles exhibited increased polyhormonal endocrine cell formation and decreased insulin content.
NATURE COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Arbindra Timilsina, Wenxu Dong, Mirza Hasanuzzaman, Binbin Liu, Chunsheng Hu
Summary: Plant survival and adaptation during oxygen deprivation, caused by various biotic and abiotic factors, rely on mechanisms such as fermentation, antioxidant enzymes, and the reduction pathways of nitrate and nitric oxide. Understanding the molecular mechanisms involved in reducing nitric oxide toxicity is important not only for plant physiology, but also for addressing uncertainties in the global nitrous oxide budget.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Chin-Feng Hsuan, Thung-Lip Lee, Wei-Kung Tseng, Chau-Chung Wu, Chi-Chang Chang, Tsui-Ling Ko, Ya-Ling Chen, Jer-Yiing Houng
Summary: The study demonstrated that extracts from Glossogyne tenuifolia (GT) can significantly increase nitric oxide (NO) production in human umbilical vein endothelial cells (HUVECs), with the root methanol extract showing the most potent effect. The root methanol extract increased NO production by increasing eNOS expression and activating eNOS phosphorylation at serine(1177).
Review
Endocrinology & Metabolism
Catherine B. Chan, Naomi Popeski, Mortaza Fatehi Hassanabad, Ronald J. Sigal, Petra O'Connell, Peter Sargious
Summary: Virtual care, particularly telemonitoring, has shown to provide improvements in A1C for patients with diabetes, comparable to or better than usual care, with strongest evidence for type 2 diabetes. Patients generally find virtual care acceptable and express satisfaction with their care, while healthcare providers recognize the benefits but raise concerns regarding technical support, workflow, and compensation.
CANADIAN JOURNAL OF DIABETES
(2021)
Letter
Dermatology
Tze Chiun Lim, Meng Fatt Leong, Hongfang Lu, Chan Du, Andrew C. A. Wan
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Physiology
Carla Sosa Alvarado, Kaiyuan Yang, Hongbo Qiu, Erinn Mills, Janelle M. Fouhse, Tingting Ju, Jean Buteau, Catherine J. Field, Benjamin P. Willing, Catherine B. Chan
Summary: Neonatal antibiotic treatment in piglets led to changes in gut microbiota and alterations in key regulatory genes in pancreatic islets at postnatal days 7 and 14. By postnatal day 49, a reduction in beta-cell area and islet insulin content were observed alongside elevated nonfasted insulin levels, indicating islet stress.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Guangshun Yi, Shujun Gao, Hongfang Lu, Wei Zhi Khoo, Shaoqiong Liu, Shuyun Chng, Yi Yan Yang, Jackie Y. Ying, Yugen Zhang
Summary: Vertically aligned layered double hydroxide (V-LDH) arrays with good topology have been grown on various substrates using a hydrolysis method. The V-LDH surface has enhanced antibacterial properties and biocompatibility, making it potentially useful in a wide range of applications.
ADVANCED MATERIALS INTERFACES
(2022)
Article
Endocrinology & Metabolism
Feiyue Deng, Behnaz Mahmoodi, Catherine B. Chan
Summary: Culturally tailored menu plan combined with nutrition education was found to be feasible and effective in improving diabetes knowledge, diet quality, and clinical outcomes among Chinese immigrants with type 2 diabetes in Canada.
CANADIAN JOURNAL OF DIABETES
(2022)
Article
Chemistry, Multidisciplinary
Yuwei Hu, Shujun Gao, Hongfang Lu, Jackie Y. Ying
Summary: An acid-resistant DNA hydrogel stable at extremely low pH values (as low as 1.2) has been developed. The hydrogel is formed by rational design of adenine (A)-rich and cytosine (C)-rich oligonucleotides, which can cross-link into duplex and quadruplex structures at different pH ranges. Under physiological pH, the hydrogel dissociates into a solution state. This acid-resistant and pH-responsive hydrogel has potential applications in oral drug delivery to acidic environments. Insulin was successfully encapsulated and orally administered using this hydrogel in diabetic rats.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Nutrition & Dietetics
Michelle Capicio, Simran Panesar, Heather Keller, Leah Gramlich, Naomi Popeski, Carlota Basualdo-Hammond, Marlis Atkins, Catherine B. Chan
Summary: This study aimed to examine the effect of a brief education intervention on nutrition risk and use of adaptive strategies among older adults in Canada. The results showed that although the intervention increased awareness of nutrition services and resources, it did not change the participants' utilization of these services.
Article
Biochemistry & Molecular Biology
Stepheny C. de Campos Zani, Myoungjin Son, Khushwant S. Bhullar, Catherine B. Chan, Jianping Wu
Summary: IRW has beneficial effects on body composition and glucose metabolism in HFD mice, improving glucose tolerance, reducing weight gain, and promoting glucose uptake in skeletal muscle through multiple signaling pathways.
Article
Cardiac & Cardiovascular Systems
Emad Yuzbashian, Mohammadreza Pakseresht, Jennifer Vena, Catherine B. Chan
Summary: This study aimed to identify dairy consumption patterns of men and women and assess their associations with incident T2D risk. The results showed that a consumption pattern characterized by higher intake of whole milk, regular cheese, and non-fat milk was associated with a decreased risk of T2D in men, but not in women.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Stepheny C. de Campos C. Zani, Ren Wang, Hellen Veida-Silva, Robin D. D. Clugston, Jessica T. Y. Yue, Marcelo A. A. Mori, Jianping Wu, Catherine B. B. Chan
Summary: Non-alcoholic fatty liver disease (NAFLD) is a global health problem and currently has no approved pharmacological treatment. This study found that a bioactive peptide derived from egg white (Peptide 2) improved insulin sensitivity and decreased hepatic steatosis in high-fat diet-fed mice. This peptide showed better effects than the insulin-sensitizing drug rosiglitazone.
Review
Nutrition & Dietetics
Fatheema B. Subhan, Dineli N. Fernando, Jessica Thorlakson, Catherine B. Chan
Summary: South Asians face a high burden of type 2 diabetes and therefore require nutrition interventions tailored to their needs. The research findings suggest that low-glycemic index and intensive counseling approaches are effective in South Asian countries, while culturally relevant nutrition therapy is needed in Western countries.
CURRENT NUTRITION REPORTS
(2023)
Review
Cardiac & Cardiovascular Systems
Emad Yuzbashian, Dineli N. Fernando, Mohammadreza Pakseresht, Dean T. Eurich, Catherine B. Chan
Summary: This study aimed to investigate the association between regular consumption of dairy products and the risk of developing non-alcoholic fatty liver disease (NAFLD). The findings of the systematic review and meta-analysis revealed a significant association between dairy intake and NAFLD, especially for milk, yogurt, and high-fat dairy products, which were found to be inversely associated with NAFLD risk.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Gerontology
Rebecca Geary, Jessica Mantik, Valerie Moore, Jessica Schuller, Rani Fedoruk, Marlis Atkins, Catherine B. Chan
Summary: This study evaluated the feasibility of routine nutrition risk screening in community-dwelling older adults using a partnership between health care and community-based organizations. The results showed that the partnership was able to provide screening and appropriate referrals for at-risk individuals. However, sustainability requires strengthening of community resources, referral processes, and telephone assessments.
CANADIAN JOURNAL ON AGING-REVUE CANADIENNE DU VIEILLISSEMENT
(2023)
Article
Gerontology
Rani Fedoruk, Heidi Olstad, Lori Watts, Monica Morrison, Jill Ward, Naomi Popeski, Marlis Atkins, Catherine B. Chan
Summary: The objectives of this feasibility study were to measure the prevalence of nutrition risk in community-dwelling older adults and explore their perspectives on the acceptability, value, and effectiveness of nutrition risk screening in primary care and community settings. The study found that moderate and high nutrition risks affected a significant proportion of those screened. Interviewees agreed that screening is acceptable, important, and valuable, but the effectiveness of the screening needs further investigation.
CANADIAN JOURNAL ON AGING-REVUE CANADIENNE DU VIEILLISSEMENT
(2023)
Article
Nanoscience & Nanotechnology
Siti Nurhanna Riduan, Guangshun Yi, Shujun Gao, Jeremy Pang Kern Tan, Yee Lin Tan, Yuan Yuan, Hongfang Lu, Shuyun Chng, Jin Ting Ong, Pei Yun Hon, Mohammad Yazid Abdad, Shawn Vasoo, Brenda S. P. Ang, Yi Yan Yang, Jackie Y. Ying, Yugen Zhang
Summary: The ZnO nanopillar surface shows promise in terms of large-scale synthesis, material durability, and biocompatibility. It maintains stable antimicrobial activity even under highly accelerated lifetime tests, making it effective against clinically isolated pathogens. These findings highlight the potential broad applicability of ZnO nanopillar surfaces in healthcare and consumer industries.
ACS APPLIED BIO MATERIALS
(2021)