Article
Biotechnology & Applied Microbiology
Zhongchun Xiao, Fang Tang, Liyuan Zhang, Shengting Li, Shufeng Wang, Qiang Huo, Bo Yang, Chao Zhang, Daojie Wang, Qing Li, Lijuan Wei, Tao Guo, Cunmin Qu, Kun Lu, Yanfeng Zhang, Liang Guo, Jiana Li, Nannan Li
Summary: The study on the FAX1-1 gene in rapeseed seeds has the potential to improve seed oil content, oil quality, and biological yield simultaneously, providing new approaches for future molecular breeding.
BIOTECHNOLOGY FOR BIOFUELS
(2021)
Article
Gastroenterology & Hepatology
Christopher L. F. Sun, Darrick K. Li, Ana Cecilia Zenteno, Marjory A. Bravard, Peter Carolan, Bethany Daily, Sami Elamin, Jasmine Ha, Amber Moore, Kyan Safavi, Brian J. Yun, Peter Dunn, Retsef Levi, James M. Richter
Summary: Low-volume bowel preparation (LV-BP) is associated with decreased time to colonoscopy in hospitalized patients, particularly in older patients, patients with chronic kidney disease, and patients hospitalized with gastrointestinal bleeding. Prospective studies are needed to further establish the role of LV-BP for inpatient colonoscopies.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2022)
Article
Plant Sciences
Jutta A. Baldauf, Meiling Liu, Lucia Vedder, Peng Yu, Hans-Peter Piepho, Heiko Schoof, Dan Nettleton, Frank Hochholdinger
Summary: The study found that single-parent expression complementation (SPE) results in approximately 700 additional active genes in genetically diverse maize hybrids. The number of SPE genes is significantly associated with mid-parent heterosis (MPH) for all surveyed phenotypic traits. Maternally and paternally active SPE genes are highly correlated within each SPE type but separated between these two SPE types. SPE_B patterns are associated with growth and development, while SPE_X patterns are enriched in defense and stress response.
Article
Agriculture, Multidisciplinary
Nurten E. Hancioglu, Ahmet Kurunc, Ismail Tontul, Ayhan Topuz
Summary: The study found that oregano plants are slightly sensitive to water stress, but may have developed resistance mechanisms. Yield response factors can reflect the growth and yield situation of oregano plants, and different water stress treatments have an impact on the growth, water use, and yield of oregano plants.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Pharmacology & Pharmacy
Joseph L. Jilek, Kayla L. Frost, Kevyn A. Jacobus, Wenxi He, Erica L. Toth, Michael Goedken, Nathan J. Cherrington
Summary: The study found that NASH-induced changes in transporter expression in the liver and kidneys may affect the metabolism and toxicity of CDDP in rats, leading to reduced nephrotoxicity and increased hepatic accumulation of CDDP. Alterations in renal and hepatic transporter expression in NASH rats may play a role in the clearance and sequestration of CDDP.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Cell Biology
Hao Chen, Jian Ma, Fanfei Kong, Ning Song, Cuicui Wang, Xiaoxin Ma
Summary: The UPF1/LINC00963/miR-508-5p/SOX2 axis has potential value in modulating ECSC maintenance, chemoresistance, and tumorigenesis in EC, highlighting a novel promising target for EC treatment.
CELL DEATH & DISEASE
(2022)
Article
Behavioral Sciences
Marcelo Fernandes Costa, Livia Soledade Rego, Leonardo Dutra Henriques, Carlo Martins Gaddi, Givago Silva Souza
Summary: The increase in ocular light dispersion that occurs with aging negatively affects color perception.
FRONTIERS IN INTEGRATIVE NEUROSCIENCE
(2023)
Article
Neurosciences
Yini Li, Xiaoyang Dou, Jun Liu, Yu Xiao, Zhe Zhang, Lindsey Hayes, Rong Wu, Xiujuan Fu, Yingzhi Ye, Bing Yang, Lyle W. Ostrow, Chuan He, Shuying Sun
Summary: Global reduction of m(6)A leads to mRNA stabilization and repeat RNA decay in C9ORF72-ALS/FTD. Elevating m(6)A reduces repeat RNA and dipeptide repeats, restores mRNA homeostasis, and improves patient neuron survival.
NATURE NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Qi Zhu, Simin Yao, Ziying Ye, Peipei Jiang, Huiyan Wang, Xiwen Zhang, Dan Liu, Haining Lv, Chenrui Cao, Zhenhua Zhou, Zihan Zhou, Weichen Pan, Guangfeng Zhao, Yali Hu
Summary: This study found that there is an increase in ferroptosis load in the endometria of patients with intrauterine adhesions (IUA). Ferroptosis promotes epithelial-mesenchymal transition (EMT) and fibrosis in endometrial epithelial cells, and its inhibition can ameliorate endometrial fibrosis in a murine model of IUA. These findings suggest that ferroptosis may serve as a potential therapeutic target for endometrial fibrosis in IUA.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Multidisciplinary Sciences
Kevin C. Stein, Fabian Morales-Polanco, Joris van der Lienden, T. Kelly Rainbolt, Judith Frydman
Summary: Ageing is accompanied by a decline in cellular proteostasis. Altered translational efficiency during ageing could help drive the collapse of proteostasis, leading to systemic decline.
Article
Biology
Minmin Song, Guangfeng Zhao, Haixiang Sun, Simin Yao, Zhenhua Zhou, Peipei Jiang, Qianwen Wu, Hui Zhu, Huiyan Wang, Chenyan Dai, Jingmei Wang, Ruotian Li, Yun Cao, Haining Lv, Dan Liu, Jianwu Dai, Yan Zhou, Yali Hu
Summary: Emerging evidence suggests a crucial role of circRNAs in regulating pathological processes, with circPTPN12 identified as a factor in endometrial fibrosis pathology. Dysfunction of the circPTPN12 pathway contributes to the pathogenesis of endometrial fibrosis.
Article
Plant Sciences
Xueqian Jiang, Andong Yu, Fan Zhang, Tianhui Yang, Chuan Wang, Ting Gao, Qingchuan Yang, Long-Xi Yu, Zhen Wang, Junmei Kang
Summary: In this study, significant QTLs related to biomass yield and feed quality in alfalfa were identified using linkage mapping. Candidate genes controlling drought tolerance were also identified through RNA-seq analysis. The results of this study are important for improving drought tolerance in alfalfa and further gene research.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Ha An Nguyen, Eric D. Hoffer, Crystal E. Fagan, Tatsuya Maehigashi, Christine M. Dunham
Summary: Rapid and accurate translation is crucial for producing functional proteins. The ribosome monitors the interaction between mRNA codons and tRNA anticodons to ensure fidelity in tRNA selection. The presence of a mismatched tRNA-mRNA pair in the ribosome triggers a reduction in fidelity, facilitating the recognition of sense codons and the degradation of aberrant peptides. Crystal structures of the ribosome reveal the mispositioning of mRNA nucleotides, potentially leading to premature termination.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
William W. Du, Jindong Xu, Weining Yang, Nan Wu, Feiya Li, Le Zhou, Sheng Wang, Xiangmin Li, Alina T. He, Kevin Y. Du, Kaixuan Zeng, Jian Ma, Juanjuan Lyu, Chao Zhang, Chi Zhou, Katarina Maksimovic, Burton B. Yang
Summary: The upregulation of circNlgn in patients with cardiac disease leads to cardiac overload. The novel peptide Nlgn173 binds to nuclear structural proteins and regulators, ultimately contributing to cardiac fibrosis and heart disease. Therapeutic implications may be derived from understanding this dysregulation mechanism.
CIRCULATION RESEARCH
(2021)
Article
Health Care Sciences & Services
Rizwan Qaisar, M. Shahid Iqbal, Asima Karim, Tahir Muhammad, Firdos Ahmad
Summary: The SarQoL questionnaire is a reliable tool for evaluating the quality of life in sarcopenic patients. Increased intestinal permeability is associated with lower scores in SarQoL domains for sarcopenic patients.
QUALITY OF LIFE RESEARCH
(2023)
Article
Pathology
Mark E. Sobel, Jennifer C. Dreyfus, Kelsey Dillehay McKillip, Christi Kolarcik, William A. Muller, Melanie J. Scott, Gene P. Siegal, Kristine Wadosky, Timothy J. O'Leary
AMERICAN JOURNAL OF PATHOLOGY
(2020)
Review
Critical Care Medicine
Yuan-Po Tu, Timothy J. O'Leary
CRITICAL CARE MEDICINE
(2020)
Review
Pathology
Timothy J. O'Leary
Summary: A systematic review comparing saliva and upper airway samples for COVID-19 testing found that nasopharyngeal swabs are slightly more sensitive than saliva samples, especially in early disease diagnosis in ambulatory patients. However, the difference is not significant, and the reduced need for personal protective equipment for saliva sampling may justify the difference.
JOURNAL OF MOLECULAR DIAGNOSTICS
(2021)
Editorial Material
Multidisciplinary Sciences
Kenji Fujiyoshi, Elspeth A. Bruford, Pawel Mroz, Cynthe L. Sims, Timothy J. O'Leary, Anthony W. I. Lo, Neng Chen, Nimesh R. Patel, Keyur Pravinchandra Patel, Barbara Seliger, Mingyang Song, Federico A. Monzon, Alexis B. Carter, Margaret L. Gulley, Susan M. Mockus, Thuy L. Phung, Harriet Feilotter, Heather E. Williams, Shuji Ogino
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Editorial Material
Pathology
Timothy J. O'Leary
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Biology
Yuan-Po Tu, Jameel Iqbal, Timothy O'Leary
Summary: The sensitivity of ID NOW for diagnosing COVID-19 was found to be 84%, with a high correlation to RT-PCR results. ID NOW showed the highest accuracy at viral load levels most likely associated with transmissible infections.
Review
Multidisciplinary Sciences
Yaolin Zhou, Timothy J. O'Leary
Summary: This meta-analysis compared the sensitivity of nasal and nasopharyngeal swabs for diagnosing SARS-CoV-2 infection. Results showed that anterior nares swabs are less sensitive (82% - 88%) than nasopharyngeal swabs (98%). However, all swab types had negative predictive values greater than 98% for populations with 10% specimen positivity.
Meeting Abstract
Clinical Neurology
Philip Harvey, Tim Bigdeli, Yuli Li, Nallakkandi Rajeevan, Bryan Gorman, Saiju Pyarajan, Michael Gaziano, Giulio Genovese, Ayman Fanous, Timothy O'Leary, Theresa Gleason, Ronald Przygodzki, Grant Huang, Sumitra Muralidhar
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2021)
Review
Pathology
Christi L. Kolarcik, Marianna J. Bledsoe, Timothy J. OLeary
Summary: The return of individual research results to vulnerable individuals and populations poses unique challenges and ethical responsibilities. This article discusses the issues and provides recommendations for ensuring ethical research practices.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Psychiatry
Tim B. Bigdeli, Georgios Voloudakis, Peter B. Barr, Bryan R. Gorman, Giulio Genovese, Roseann E. Peterson, David E. Burstein, Vlad Velicu, Yuli Li, Rishab Gupta, Manuel Mattheisen, Simone Tomasi, Nallakkandi Rajeevan, Frederick Sayward, Krishnan Radhakrishnan, Sundar Natarajan, Anil K. Malhotra, Yunling Shi, Hongyu Zhao, Thomas R. Kosten, John Concato, Timothy J. O'Leary, Ronald Przygodzki, Theresa Gleason, Saiju Pyarajan, Mary Brophy, Grant D. Huang, Sumitra Muralidhar, J. Michael Gaziano, Mihaela Aslan, Ayman H. Fanous, Philip D. Harvey, Panos Roussos
Summary: This study aimed to evaluate the penetrance of neuropsychiatric polygenic risk scores (PRSs) in the Veterans Health Administration health care system and their associations with human diseases. The findings showed that PRSs were associated with diagnoses of schizophrenia and bipolar disorder and increased risk for various psychiatric and physical health problems.
Meeting Abstract
Neurosciences
Tim Bigdeli, Yash Joshi, Yuli Li, Nallakkandi Rajeevan, Fred Sayward, Timothy O'Leary, Theresa Gleason, Ronald Przy-Godzki, Grant Huang, Saiju Pyarajan, Sumitra Muralidhar, J. Michael Gaziano, Ayman Fanous, David Braff, Gregory Light, Mihaela Aslan, Philip Harvey
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
David R. Burnaska, Grant D. Huang, Timothy J. O'Leary
Summary: Analysis of scientific and programmatic evaluations of letters of intent (LOIs) received by the Department of Veterans Affairs Cooperative Studies Program revealed that most rejected proposals were declined prior to submission of full proposals due to reasons such as investigator inexperience and perceived lack of scientific impact. Common reasons for negative reviews of LOIs included lack of preliminary data and flawed experimental design, while negative reviews of final proposals often centered around scientific impact and study design issues. Successful projects have been published in high impact clinical journals, suggesting factors that contribute to successful funding support for clinical trials.
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Ralph G. DePalma, Virginia W. Hayes, Timothy J. O'Leary
Summary: This report discusses the dual roles of serum ferritin as an indicator for iron status and inflammation. It highlights the positive associations between serum ferritin levels, inflammatory markers, and mortality rates. Lowering serum ferritin levels within a certain range may be beneficial for reducing cardiovascular mortality.
Meeting Abstract
Neurosciences
Tim Bigdeli, Roseann Peterson, Nikhil Khankari, Nallakkandi Rajeevan, Alan Swann, Frederick Sayward, Jacquelyn Meyers, Yuli Li, David Nielsen, Anna Wilkinson, David Graham, Timothy O'Leary, Hongyu Zhao, Kei-Hoi Cheung, Shrikant Mane, Perry Miller, Mary Brophy, Ronald Przygodszki, Larry Siever, Saiju Pyarajan, Theresa Gleason, Sumitra Muralidhar, J. Michael Gaziano, John Concato, Grant Huang, Ayman Fanous, Mihaela Aslan, Thomas Kosten, Philip Harvey
BIOLOGICAL PSYCHIATRY
(2021)
Article
Psychiatry
Tim B. Bigdeli, Ayman H. Fanous, Yuli Li, Nallakkandi Rajeevan, Frederick Sayward, Giulio Genovese, Rishab Gupta, Krishnan Radhakrishnan, Anil K. Malhotra, Ning Sun, Qiongshi Lu, Yiming Hu, Boyang Li, Quan Chen, Shrikant Mane, Perry Miller, Kei-Hoi Cheung, Raquel E. Gur, Tiffany A. Greenwood, David L. Braff, Eric D. Achtyes, Peter F. Buckley, Michael A. Escamilla, Douglas Lehrer, Dolores P. Malaspina, Steven A. McCarroll, Mark H. Rapaport, Marquis P. Vawter, Michele T. Pato, Carlos N. Pato, Hongyu Zhao, Thomas R. Kosten, Mary Brophy, Saiju Pyarajan, Yunling Shi, Timothy J. O'Leary, Theresa Gleason, Ronald Przygodzki, Sumitra Muralidhar, J. Michael Gaziano, Grant D. Huang, John Concato, Larry J. Siever, Mihaela Aslan, Philip D. Harvey
Summary: Schizophrenia and bipolar disorder are debilitating neuropsychiatric disorders that collectively affect 2% of the world's population. A recent study on US Veterans revealed new susceptibility loci and associations for these disorders, demonstrating the robust generalizability of published findings and providing insights for future research.
SCHIZOPHRENIA BULLETIN
(2021)