Article
Marine & Freshwater Biology
So Shinya, Fumiya Nishibe, Yared Beyene Yohannes, Mayumi Ishizuka, Shouta M. Nakayama, Yoshinori Ikenaka
Summary: Pesticide exposure, especially neonicotinoid insecticides (NNIs), is a major factor contributing to the decline of amphibian populations worldwide. However, the metabolism, distribution, and neurotoxicity of NNIs in amphibians remain poorly understood. This study exposed Western clawed frogs to clothianidin (CLT) and found that the highest concentrations of CLT were detected in the skin, indicating high risk of skin absorption. Frogs also showed higher CLT metabolic ability compared to zebrafish. Additionally, NNI residues were detected in wild frogs, soil, and water in agricultural areas of Japan, suggesting the potential toxicity of NNIs to amphibians.
AQUATIC TOXICOLOGY
(2023)
Article
Entomology
Cody Prouty, Lewis J. Bartlett, Vera Krischik, Sonia Altizer
Summary: This study investigates the effects of neonicotinoids on non-target nectar-feeding insects, particularly monarch butterflies. The results show that adult monarch butterflies can tolerate field-relevant doses of neonicotinoids with minimal effects on their survival, reproduction, flight, and behavior. However, higher doses of neonicotinoids can significantly impact monarch butterflies' nectar consumption, survival, flight performance, and reaction time.
ECOLOGICAL ENTOMOLOGY
(2023)
Article
Engineering, Environmental
Kirsten A. Pearsons, Elizabeth K. Rowen, Kyle R. Elkin, Kyle Wickings, Richard G. Smith, John F. Tooker
Summary: The study found that neonicotinoids from insecticidal seed coatings can contaminate soil in treated fields and adjacent areas, but showed little opportunity for winter-planted cover crops to absorb significant residues. Residues persisted in soil at concentrations below 5 ppb, attributed to historic and recent neonicotinoid use. High interplot movement of neonicotinoids was observed, with contamination higher in untreated plots less isolated from treated plots.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Chemistry, Applied
Yudan Wang, Jia 'an Qin, Qian Lu, Jiao Tian, Tongwei Ke, Mengyue Guo, Jiaoyang Luo, Meihua Yang
Summary: In this study, a green analytical method was developed to extract and detect 20 analytes in edible herbs, including 10 neonicotinoid insecticides and their 10 major toxic metabolites. The QuEChERS and LC-MS/MS techniques were used for the analysis of these analytes in five edible herbs. Among the 109 herbal samples tested, 90 samples were found to be positive for the residues of the 20 neonicotinoid insecticides and their metabolites, with the range of total neonicotinoid insecticides residue being 0.26-139.28 μg/kg. Acetamiprid, imidacloprid, and their metabolites were the most frequently detected compounds in herbs. Positive correlations were observed between imidacloprid/acetamiprid and their metabolites in Lycii fructus and Citri reticulatae pericarpium. Therefore, the residue of neonicotinoid insecticides in edible herbs should be given more attention in the future.
Article
Chemistry, Analytical
Changqiu Zhang, Yanqing Li, Ningxia Yang, Minghui You, Jinhua Hao, Jiacheng Wang, Juxiu Li, Min Zhang
Summary: This paper reviewed the electrochemical sensors of neonicotinoid insecticides based on their molecular structure and different strategies. It aims to provide a reference for the effective design of electrochemical sensors for small molecule compounds.
Article
Multidisciplinary Sciences
Victor H. Gonzalez, John M. Hranitz, Mercedes B. McGonigle, Rachel E. Manweiler, Deborah R. Smith, John F. Barthell
Summary: This study investigates the impact of neonicotinoid insecticides on the thermal tolerance of honey bees. Surprisingly, exposure to sublethal doses of these insecticides enhances the heat tolerance and survival rates of bees. This suggests that honey bees have the ability to compensate for elevated temperatures when other stressors are present.
Article
Green & Sustainable Science & Technology
Yuanyuan Zhao, Xixi Li, Qing Li, Hao Yang, Wenjin Zhao, Yu Li
Summary: The study developed a system to design neonic derivatives, simulate microbial degradation of neonic compounds in soil, and formulate dietary control measures for sensitive populations, thereby reducing human health risks associated with pesticide exposure.
JOURNAL OF CLEANER PRODUCTION
(2021)
Article
Environmental Sciences
Yuanyuan Zhao, Xixi Li, Xinao Li, Maosheng Zheng, Yimei Zhang, Yu Li
Summary: The adverse effects of neonicotinoid insecticides on non-target organisms have raised concerns. This study developed a comprehensive system to generate derivatives and mutant receptors with selective-ecotoxicological effects to overcome these effects. Ligand design and receptor modification improved the selective-ecotoxicological effects. Environmental factors, such as alternate fertilizer application, were found to reduce damage to plants caused by pesticide residues.
ENVIRONMENTAL POLLUTION
(2022)
Article
Multidisciplinary Sciences
Travis S. Schmidt, Janet L. Miller, Barbara J. Mahler, Peter C. Van Metre, Lisa H. Nowell, Mark W. Sandstrom, Daren M. Carlisle, Patrick W. Moran, Paul M. Bradley
Summary: Neonicotinoid mixtures are commonly found in streams worldwide, but their ecological impacts are not well understood. This study shows that exposure to neonicotinoids above certain thresholds can lead to a loss in taxa abundance and richness, disrupted adult emergence, and altered trophodynamics. The presence of neonicotinoid mixtures in California streams also poses greater than expected risks to stream health.
Article
Environmental Sciences
Chengyu Pan, Jinxia Yu, Qian Yao, Nan Lin, Zhenping Lu, Yan Zhang, Shasha Zhao, Zixia Wang, Xiaoning Lei, Ying Tian, Yu Gao
Summary: This study investigated the prenatal exposure to neonicotinoid insecticides (NEOs) in pregnant women in China and assessed its association with birth outcomes. The study found that exposure to NEOs may have an impact on the head circumference and ponderal index of newborns, and this association may be mediated by urinary 8-OHdG. These findings are important for understanding the effects of NEOs on human health.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Environmental Sciences
Miaomiao Xu, Zhanpeng Zhang, Zhiyong Li, Shunyan Kan, Zhaoxiang Liu, Desheng Wang, Qihui Liu, Hua Zhang
Summary: This study analyzed NEOs and their metabolites in paired urine and blood samples collected from young adults in China. The results showed widespread detection of NEOs and their metabolites in both urine and blood samples, with gender-related differences in concentrations. Urinary levels were found to be good predictors of human exposure to NEOs and their metabolites.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Yi Yang, Limin Su, Ying Huang, Xiao Zhang, Chao Li, Jia Wang, Lingyun Fan, Shuo Wang, Yuan H. Zhao
Summary: This study systematically investigated the bio-uptake, tissue distribution, and metabolism of neonicotinoids in zebrafish, focusing on clothianidin. The results showed low bioaccumulation potential of CLO in zebrafish, with highest accumulation in intestine and liver, where N-demethylation and nitro-reduction were identified as metabolic pathways. Liver and intestine were found to play a key role in the metabolism and elimination of CLO.
ENVIRONMENTAL POLLUTION
(2022)
Article
Agriculture, Multidisciplinary
Maura J. Hall, Ge Zhang, Matthew E. O'Neal, Steven P. Bradbury, Joel R. Coats
Summary: Adding habitat within agricultural ecosystems is important in supporting pollinators. Pesticide exposure to pollinator habitat near crop fields is necessary for risk assessments. Research found that neonicotinoids detected in milkweed leaves were at concentrations unlikely to negatively impact monarch butterfly larvae.
AGRICULTURE ECOSYSTEMS & ENVIRONMENT
(2022)
Article
Environmental Sciences
So Shinya, Mariko Sashika, Miku Minamikawa, Tetsuji Itoh, Yared Beyene Yohannes, Shouta M. M. Nakayama, Mayumi Ishizuka, Collins Nimako, Yoshinori Ikenaka
Summary: The study evaluated the toxic effects of NNIs on wild raccoons. The results showed that wild raccoons could be frequently exposed to NNIs in the environment, and their cytochrome P450-dependent metabolism of NNIs might be low. These findings contribute to a better understanding of the effects of NNIs on raccoons and provide insights for conservation efforts for wild mammals.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2022)
Article
Marine & Freshwater Biology
D. Riley Rackliffe, Jason T. Hoverman
Summary: Neonicotinoids have global impacts on natural environments, especially on aquatic insects, and can indirectly increase their mortality through predator pressure.
AQUATIC TOXICOLOGY
(2022)
Article
Multidisciplinary Sciences
Megan Keener, Camden Hunt, Timothy G. Carroll, Vladimir Kampel, Roman Dobrovetsky, Trevor W. Hayton, Gabriel Menard
Article
Environmental Sciences
Zachary C. Redman, Cort Anastasio, Ronald S. Tjeerdema
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2020)
Article
Biochemical Research Methods
Zachary C. Redman, Kaylan Brodnax, Jordan Couture, Patrick L. Tomco
Summary: The study identified six distinct rotenoids in CFT Legumine and optimized a sampling procedure for their analysis in surface water, crucial for monitoring rotenoid persistence.
Article
Engineering, Environmental
Zachary C. Redman, Joshua Wesolowski, Patrick L. Tomco
Summary: The research showed that rotenone and deguelin were primarily eliminated from surface waters through photochemical degradation, with limited impact from reactive oxygen species and a potential inhibitory effect from alcohols. The quality of dissolved organic matter (DOM) was identified as the major factor modulating rotenone attenuation, with temperature-dependent mechanisms. Molecular-level characterizations of DOM may help explain the site-specific degradation of these rotenoids in the environment.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Environmental Sciences
Jordan M. Couture, Zachary C. Redman, Jake Bozzini, Robert Massengill, Kristine Dunker, Brandon R. Briggs, Patrick L. Tomco
Summary: In the field, rotenone degraded within <60 days in all lakes, while the primary degradation product, rotenolone, persisted for up to <280 days at two locations. Laboratory simulation indicated that photolysis is the dominant process driving rotenone degradation under Southcentral Alaskan winter conditions.
Article
Chemistry, Multidisciplinary
Fang-Che Hsueh, Luciano Barluzzi, Megan Keener, Thayalan Rajeshkumar, Laurent Maron, Rosario Scopelliti, Marinella Mazzanti
Summary: This study investigates the complex compounds formed by thorium nitrides and azide/nitride thorium complexes. The results show that stable multimetallic azide/nitride thorium complexes can be generated by reducing thorium azide precursors. These complexes are stable in solution, but their synthesis requires careful control of reaction conditions, and different anions result in structural differences. Reactivity studies demonstrate the ability of thorium nitrides to cleave CO in ambient conditions, yielding CN-.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Physical
Yu Rao, Chad T. Palumbo, Amrit Venkatesh, Megan Keener, Gabriele Stevanato, Anne-Sophie Chauvin, Georges Menzildjian, Sergei Kuzin, Maxim Yulikov, Gunnar Jeschke, Anne Lesage, Marinella Mazzanti, Lyndon Emsley
Summary: Nuclear magnetic resonance has low sensitivity, but this can be overcome by dynamic nuclear polarization (DNP). New Gd(III) complexes offer potential for more efficient magic angle spinning DNP.
JOURNAL OF PHYSICAL CHEMISTRY C
(2022)
Article
Chemistry, Multidisciplinary
R. A. Keerthi Shivaraam, Megan Keener, Dieuwertje K. Modder, Thayalan Rajeshkumar, Ivica Zivkovic, Rosario Scopelliti, Laurent MaronMaron, Marinella Mazzanti
Summary: Here, we present the redox reactivity of a multimetallic uranium complex supported by triphenylsiloxide ligands, demonstrating the stabilization of low valent synthons through intramolecular ligand migration. The reduction of the diuranium(IV) complex yields U-II/U-IV and U-I/U-IV complexes via ligand migration and formation of uranium-arene delta-bond interactions. Additionally, the reductive coupling of pyridine is achieved through ligand migration, restoring the original ligand arrangement. This work provides a new method for controlling the redox reactivity of unstable, low-valent metal complexes and can contribute to the development of f-elements redox reactivity.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Megan Keener, R. A. Keerthi Shivaraam, Thayalan Rajeshkumar, Maxime Tricoire, Rosario Scopelliti, Ivica Zivkovic, Anne-Sophie Chauvin, Laurent Maron, Marinella Mazzanti
Summary: The synthesis of molecular uranium complexes in oxidation states lower than +3 remains challenging despite their reactivity and electronic structures. In this study, one- and two-electron reductions of a U(III) complex produced mono-reduced complexes and di-reduced U(I) synthons. EPR, UV/vis/NIR spectroscopy, magnetic, cyclic voltammetry, and computational studies revealed the electronic structures and redox couples of the complexes. The complexes demonstrated the ability to transfer multiple electrons to oxidizing substrates.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Chemistry, Multidisciplinary
Megan Keener, Leonor Maria, Marinella Mazzanti
Summary: Significant advances have been made in the chemistry of actinide-nitrides, particularly with uranium and some breakthroughs with thorium. Synthetic routes to uranium nitrides have been identified, but ligands capable of stabilizing them are still limited. Terminal- and bridging-nitrides are attractive for potential reactivity, especially in the field of uranium complexes for dinitrogen reduction and functionalization. Molecular thorium bridged-nitride complexes have recently been discovered, suggesting the possibility of expanding nitride chemistry to low-valent thorium and transuranic elements.
Article
Engineering, Environmental
Maxwell L. Harsha, Zachary C. Redman, Josh Wesolowski, David C. Podgorski, Patrick L. Tomco
Summary: This study simulated spills in a laboratory setting to generate hydrocarbon oxidation products from crude oil and diesel. The analysis of these products revealed their chemical characteristics and compositional changes, providing a comprehensive approach to monitor oxidation product changes in oil spills.
ENVIRONMENTAL SCIENCE-ADVANCES
(2023)
Article
Environmental Sciences
Elizabeth A. Whisenhant, Phoebe Zito, David C. Podgorski, Amy M. McKenna, Zachary C. Redman, Patrick L. Tomco
Summary: Photo-oxidized petroleum hydrocarbons are a unique class of water-soluble bioavailable compounds that have gained recognition as an urgent research need in high latitudes. Bench-scale spills of refined fuels were irradiated over Alaskan seawater and freshwater, revealing that these fuels produce more photoproducts than crude oil and carry a unique chemical signature. This research highlights the importance of considering marine biota toxicity and suggests the potential of fluorescence spectroscopy for tracking photo-modified water-soluble fractions of petroleum in high latitudes.
Article
Chemistry, Multidisciplinary
Megan Keener, Farzaneh Fadaei-Tirani, Rosario Scopelliti, Ivica Zivkovic, Marinella Mazzanti
Summary: Multimetallic-multielectron cooperativity plays a key role in the metal-mediated cleavage of N-2 to nitrides. This study presents a new approach using dinuclear uranium nitride complexes with diverse ancillary ligands to promote the multielectron transformation of N-2. These complexes provide the first example of N-2 cleavage to nitride by a uranium complex in the absence of reducing alkali metals.
Article
Chemistry, Multidisciplinary
Megan Keener, Maxwell Mattejat, Shao-Liang Zheng, Guang Wu, Trevor W. Hayton, Gabriel Menard
Summary: This study reports the selective electrochemical capture and release of uranyl cation from mixed-metal solutions using the nido-carborane anion. The confirmations of selective capture and release were obtained through analysis of the aqueous and organic phases.
Article
Chemistry, Multidisciplinary
Megan Keener, Rosario Scopelliti, Marinella Mazzanti
Summary: The reactivity of uranium nitrides with protons and ammonia varies depending on the type of ancillary ligands present. While some ligands promote the conversion of nitrogen to ammonia under acidic conditions, others show resistance to protonation and promote the cleavage of N-H bonds in ammonia. These findings have implications for the development of catalytic systems for the conversion of N2 to NH3 under mild conditions.
