Journal
JOURNAL OF MOLECULAR BIOLOGY
Volume 423, Issue 5, Pages 782-788Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2012.08.012
Keywords
adaptation; bacterial chemotaxis; motor switch; feedback control
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Funding
- National Institutes of Health [GM081747, AI016478]
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We analyze a model for motor-level adaptation in Escherichia coli based upon the premise that clockwise (CW) and counter-clockwise (CCW) states have different preferred numbers of FliM subunits. We show that this model provides a simple mechanism for the recently observed motor-level adaptation, and it also explains the long-lasting puzzle on the thresholds observed when tethered cells are used to monitor responses to temporal ramps. We note that the motor-level adaptation has the same negative-feedback network design as the upstream receptor-level adaptation, and the tandem architecture of one control circuit followed by the other mitigates the effects of cell-to-cell variation and broadens the range of stimuli over which cells optimally respond. (C) 2012 Elsevier Ltd. All rights reserved.
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