Article
Multidisciplinary Sciences
Supriya Priyadarsani, Avinash Singh Patel, Abhijit Kar, Sukanta Dash
Summary: This study explored the extraction of lycopene from grapefruit using supercritical carbon dioxide (CO2) extraction technique. The experimental design showed that extraction pressure, extraction time, and their interaction significantly affected the lycopene yield. Optimum conditions for lycopene extraction from grapefruit were identified as 305 bar pressure, 35 g/min CO2 flow rate, 135 min of extraction time, and 70 degrees C temperature.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Physical
Hsuan-Wen Wang, Chieh-Ming Hsieh
Summary: This study proposes combining the PSRK EOS with sublimation pressures estimated from the Lee-Kesler (LK) equation to predict solubility, demonstrating the feasibility of predicting solubility with only input of molecular structure.
JOURNAL OF SUPERCRITICAL FLUIDS
(2022)
Article
Chemistry, Physical
Salal Hasan Khudaida, Yu-Ming Chen, Ya-Fang Zheng, Chieh-Ming Hsieh, Chie-Shaan Su
Summary: This study aimed to improve the dissolution rate of haloperidol by nanonization using the rapid expansion of supercritical solution (RESS) process. The solubility data of haloperidol in supercritical CO2 were measured and correlated, and the effects of operating parameters were compared and discussed. The crystal habit of haloperidol was modified and the mean particle size was reduced to 300 nm. The dissolution rate of haloperidol was enhanced by 74 times after the RESS processing.
JOURNAL OF SUPERCRITICAL FLUIDS
(2023)
Article
Energy & Fuels
Osei Asafu-Adjaye, Brian Via, Bhima Sastri, Sujit Banerjee
Summary: Using supercritical CO2 to treat black liquor can generate a porous liquid/solid structure and achieve dewatering for improving energy efficiency. The deposited lignin from black liquor can be used as biofuel or chemical feedstock.
Article
Multidisciplinary Sciences
Mahboubeh Pishnamazi, Samyar Zabihi, Sahar Jamshidian, Fatemeh Borousan, Ali Zeinolabedini Hezave, Azam Marjani, Saeed Shirazian
Summary: Efficient processes for continuous manufacturing of solid dosage oral formulations are crucial in the pharmaceutical industry to implement the Quality-by-Design paradigm. Supercritical solvent-based manufacturing can be used in pharmaceutical processing due to its operational advantages. Solubility measurements are essential prior to evaluating the possibility of supercritical processing for a specific medicine, as demonstrated in this study on decitabine. The study found that the solubility of decitabine varied with temperature and pressure, with a direct relation to pressure and a temperature-dependence determined by the crossover pressure. Theoretical models were used to correlate the solubility data, with linear models showing the highest accuracy in predicting decitabine solubilities.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Physical
Yuanci Li, Ameer A. Alameri, Zainab A. Farhan, Hafidh l. AI Sadi, Manal E. Alosaimi, Ahmed Ghaleb AbdalSalam, Dheyaa Jumaah Jasim, Salema K. Hadrawi, Muataz Mohammed Al-Taee, Ali H. Lafta, Hakeem A. Othman, Saleh Mousa Alzahrani, Ashraf A. Moniem, Taha Alqadi
Summary: In this study, the preparation of drug nanoparticles using supercritical-based processing as a green technology was investigated and evaluated. Computational works were conducted to analyze the possibility of manufacturing nanomedicine with this novel technology and compared with experimental measurements. Chlorothiazide was used as a model drug, and gradient boosting model showed the best results for modeling the data.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Thermodynamics
Saad M. Alshahrani, Amal M. Alsubaiyel, Maram H. Abduljabbar, Mohammed A. S. Abourehab
Summary: The solubility of Metoprolol in supercritical CO2 was measured and correlated using various empirical models. The Adachi and Lu model showed the highest correlation precision. Additionally, the total mixing heat, vaporization enthalpy, and solvation enthalpy of the Metoprolol-scCO2 binary mixture were obtained.
CASE STUDIES IN THERMAL ENGINEERING
(2023)
Article
Chemistry, Physical
Mohammed A. S. Abourehab, Sameer Alshehri, Rami M. Alzhrani, Majed Ahmed Algarni, Atiah H. Almalki, Mohammed Alqarni, Amal M. Alsubaiyel, Maram H. Abduljabbar, Kareem M. AboRas
Summary: The solubility of Febuxostat in supercritical carbon dioxide was experimentally determined at various temperatures and pressures. The obtained data were correlated by different empirical models, and the most accurate models were identified. The study also calculated the total mixing heat, vaporization enthalpy, and solvation enthalpy of the system.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Thermodynamics
Kumar Venkatesan, Saad M. Alshahrani, Amal M. Alsubaiyel, Maram H. Abduljabbar, Manal E. Alosaimi, Maria Grishina, Saeed Shirazian
Summary: Metformin, the main medicine for treating type II diabetes, has incomplete absorption and a short half-life, which causes high dosage and digestive problems. Supercritical carbon dioxide (scCO(2)) method can be used to achieve controlled release and increased bioavailability of Metformin. This study determined the solubility of Metformin in scCO(2) at different temperatures and pressures, and correlated the data using various models. The results showed that the Peng-Robinson (PR-EoS) model had satisfactory precision, and the models by Jafari Nejad and Keshmiri had the highest correlation accuracy.
CASE STUDIES IN THERMAL ENGINEERING
(2023)
Article
Thermodynamics
Kumar Venkatesan, Saad M. Alshahrani, Amal M. Alsubaiyel, Maram H. Abduljabbar, Manal E. Alosaimi, Maria Grishina, Saeed Shirazian
Summary: The solubility of Metformin in supercritical carbon dioxide (scCO2) was evaluated at different temperatures and pressures, and correlated using an equation of state (Peng-Robinson (PR-EoS)) and several empirical models. The PR-EoS model and the models defined by Jafari Nejad and Keshmiri showed high accuracy in predicting the solubility of Metformin in scCO2.
CASE STUDIES IN THERMAL ENGINEERING
(2023)
Article
Chemistry, Physical
Edgar T. de Souza, Paula B. Staudt, Rafael de P. Soares
Summary: This study compares the performance of CSP and other predictive models in calculating solubility, and the results show that CSP has high accuracy and significant improvement compared to other models.
JOURNAL OF SUPERCRITICAL FLUIDS
(2022)
Article
Biochemistry & Molecular Biology
Ratna Surya Alwi, Chandrasekhar Garlapati, Kazuhiro Tamura
Summary: Two new models were developed in this study to improve the correlation of solubility of several anthraquinone derivatives in supercritical carbon dioxide based on solid-liquid phase equilibria. The proposed models showed good accuracy with an overall deviation of less than 11.46% in averaged absolute relative deviation (AARD) when correlating 25 binary systems. Existing solubility models were also evaluated for comparison.
Article
Chemistry, Physical
Yun Zhang, Xiaojie Xu
Summary: A Gaussian process regression model was developed to study the relationship between solute molecular weight, solute melting point, temperature, pressure, sc-CO2 density, and solubilities of 30 bioactive compounds in over 1,000 scenarios. The model demonstrated high accuracy and stability, allowing for fast and low-cost estimations of solubilities for a variety of bioactive compounds.
Article
Pharmacology & Pharmacy
Phuong Tran, Jeong-Sook Park
Summary: Many newly discovered chemical entities in the pharmaceutical industry suffer from low aqueous solubility, leading to poor bioavailability, which poses a challenge for pharmaceutical scientists. Solid dispersion (SD) technology, particularly the use of supercritical fluid (SCF) technology, has been successful in overcoming these challenges and enhancing dissolution and bioavailability of poorly water-soluble drugs.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Instruments & Instrumentation
Rahul Kumar, Amit K. K. Thakur, Gergely Kali, Kancharlapalli Chinaraga Pitchaiah, Raj Kumar Arya, Anurag Kulabhi
Summary: In this review, the utilization of supercritical carbon dioxide (SC CO2) as an antisolvent in particle engineering approaches is critically discussed. Different SC CO2-based antisolvent processes, including GAS, SAS, and SEDS, are described. The effects of process parameters on particle size, distribution, and morphology are discussed, as well as the applications of SAS process in improving dissolution rate, solubility, and bioavailability in different formulation approaches.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Environmental Sciences
S. M. R. Seyedein Ghannad, M. N. Lotfollahi
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2019)
Article
Engineering, Chemical
Hossein Rostamian, Mohammad Nader Lotfollahi
PARTICULATE SCIENCE AND TECHNOLOGY
(2020)
Article
Engineering, Chemical
Hossein Rostamian, Mohammad Nader Lotfollahi
PERIODICA POLYTECHNICA-CHEMICAL ENGINEERING
(2020)
Article
Chemistry, Physical
Hossein Jalaei Salmani, Mohammad Nader Lotfollahi, Seyed Hossein Mazloumi
JOURNAL OF MOLECULAR LIQUIDS
(2020)
Article
Physics, Multidisciplinary
Hossein Rostamian, Mohammad Nader Lotfollahi
PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS
(2020)
Article
Chemistry, Applied
Somaye Seraj, Mohammad Nader Lotfollahi, Ali Nematollahzadeh
REACTIVE & FUNCTIONAL POLYMERS
(2020)
Article
Chemistry, Physical
Hossein Jalaei Salmani, Mohammad Nader Lotfollahi, Seyed Hossein Mazloumi
JOURNAL OF MOLECULAR LIQUIDS
(2020)
Article
Engineering, Chemical
Mohammad Taghi Fouladvand, Javad Asadi, Mohammad Nader Lotfollahi
Summary: Simulation and optimization of aromatic extraction process using furfural as a solvent were conducted by linking Aspen Plus and MATLAB. Increasing the solvent to feed ratio and extraction temperature decreases extraction efficiency and refractive index, while increasing the energy consumption of the process.
CHEMICAL ENGINEERING RESEARCH & DESIGN
(2021)
Article
Thermodynamics
Abtin Raeispour Shirazi, Mohammad Nader Lotfollahi
FLUID PHASE EQUILIBRIA
(2020)
Article
Chemistry, Multidisciplinary
Hossein Rostamian, Mohammad Nader Lotfollahi, Ali Mohammadi
KOREAN JOURNAL OF CHEMICAL ENGINEERING
(2020)
Article
Engineering, Petroleum
Ronak Parvaneh, Siavash Riahi, Mohammad Nader Lotfollahi
Summary: This study aimed to compare the factors influencing foam stability, and found that under experimental conditions, the stabilizer of nanosilica has a better stability than the hydroxyethyl cellulose polymer; also, an optimal salinity concentration can enhance the performance and stability of the foam.
Article
Materials Science, Ceramics
Bita Chaghomi, Mohammad Nader Lotfollahi
Summary: This study aims to fabricate a low-cost ceramic microfiltration membrane and investigate its performance for copper ions removal from an aqueous solution. The fabricated ceramic membrane exhibits excellent chemical resistance and hydrophilicity. Combining the ceramic membrane with an electrolysis process results in effective and fast copper ions removal, with a high yield. The regenerated composite membrane shows good reusability.
CERAMICS INTERNATIONAL
(2022)
Article
Chemistry, Physical
Hamide Mohammad Aliha, Abbas Ali Khodadadi, Yadollah Mortazavi, Mohammad Nader Lotfollahi
Summary: The aim of this study is to investigate a new method of fabricating SnO2/polyaniline (PAni) nanocomposite sensors for detecting ammonia at room temperature. The synthesis of PAni is conducted through oxidative polymerization, and SnO2/PAni hybrid nanocomposites with varying percentages of polymer are fabricated using a deposition-precipitation method in the presence of SnCl4 solution. XRD, BET, FTIR, Raman, TGA, and FESEM tests are carried out to characterize the produced powders. The results show that increasing the PAni content in the nanocomposites leads to a decrease in SnO2 crystallite size, an increase in surface area, and improved thermal stability. The SnO2/8 wt% PAni exhibits the highest sensitivity, with a response of approximately 187% for 100 ppm NH3 at room temperature. The optimal heteronucleation and decoration of SnO2 on the PAni surface enhance the sensor's response. Additionally, the sensor demonstrates selectivity in the presence of interfering gases such as CO, ethanol, methane, toluene, and trichloroethylene.
APPLIED SURFACE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Hossein Rostamian, Mohammad Nader Lotfollahi, Ali Mohammadi
Summary: The study aimed to enhance the dissolution rate of poorly water-soluble drug aspirin by producing micronized aspirin and aspirin/PEG4000 composite using the PPRGEL method. The technique was found to reduce the particle size of aspirin significantly, leading to faster dissolution rates of the composite. Additionally, it was observed that about 80% of aspirin in the composite was dissolved within the first 9.5 minutes, compared to 60 minutes for unprocessed aspirin.
Article
Chemistry, Multidisciplinary
Hossein Rostamian, Mohammad Nader Lotfollahi
