Article
Emergency Medicine
Jie Li, Yan Li, Yunchuan Wang, Xiang He, Jing Wang, Weixia Cai, Yanhui Jia, Dan Xiao, Jian Zhang, Ming Zhao, Kuo Shen, Zichao Li, Wenbin Jia, Kejia Wang, Yue Zhang, Linlin Su, Huayu Zhu, Dahai Hu
Summary: MicroRNA-101 (miR-101) is a tumor suppressor microRNA associated with various diseases, but its role in hypertrophic scars (HS) remained unclear. Research showed that low miR-101 expression in HS and HSF, overexpressing miR-101 reduced collagen expression in HSF, while high EZH2 expression was detected in HS and HSF. MiR-101 targeted EZH2 to suppress collagen deposition in HS.
Article
Biochemistry & Molecular Biology
Kento Takaya, Noriko Aramaki-Hattori, Shigeki Sakai, Keisuke Okabe, Toru Asou, Kazuo Kishi
Summary: Skin wounds in developing mouse fetuses can heal without scar formation, unlike adult mammalian wounds. It has been found that the fibroblast growth factor (FGF) family plays a crucial role in fetal wound healing, with FGF7 potentially being associated with scar formation. Administration of FGF7 can inhibit fibrosis and promote epithelialization, providing a potential therapeutic option for scarless wound healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Veterinary Sciences
Fabian Gomez-Torres, Amparo Ruiz-Sauri
Summary: The His bundle was found to be longer in horses and pigs than in dogs or humans, with larger area and diameters in His bundle cells in pigs and horses than in humans or dogs. Two organizational patterns of His bundle components were identified: group I with large cells and high collagen fiber content in ungulates, and group II with smaller cells and lower collagen fiber abundance in humans and dogs.
VETERINARY RESEARCH COMMUNICATIONS
(2021)
Article
Gastroenterology & Hepatology
Adam Watson, Louis Petitjean, Mathieu Petitjean, Michael Pavlides
Summary: In this study, we used digital pathology techniques to calculate four fibrosis severity scores that quantify fibrosis architecture, collagen content, and fiber morphometry. These scores provide additional insight into the progression of architectural changes and accumulation of collagen in liver fibrosis.
LIVER INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Biswajoy Ghosh, Subhashree Chatterjee, Ramgopal Dhakar, Saylee Muley, Pabitra Mitra, Jyotirmoy Chatterjee
Summary: The habit of chewing arecanut can lead to fibrosis in oral tissues, potentially causing cancer. Fibrosis is a progressive condition with limited clinical success, influenced by organ-specific variations and genetic predispositions. Research on the early and late phases of arecanut-induced fibrosis in skin revealed changes in extracellular matrix molecules, such as proteins and glycans, impacting the severity of the matrix state.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Multidisciplinary Sciences
Lianglong Chen, Chaoyang Huang, Yu Zhong, Yujia Chen, Huihui Zhang, Zijun Zheng, Ziwei Jiang, Xuerong Wei, Yujie Peng, Lei Huang, Libin Niu, Yanbin Gao, Jun Ma, Lei Yang
Summary: In this study, a compound network with physical-chemical double cross-linking was constructed using chemical cross-linking and the intertwining of ADM and chito-san chains under freezing conditions. The heparin-modified composite scaffold with good biocompatibility and cell/tissue affinity significantly promoted cell adhesion and proliferation to achieve adequate fixation and slow down the release of CGF. Polydopamine nanoparticles with excellent photothermal conversion ability promoted the survival of rat autologous skin grafts. In conclusion, this multifunctional composite scaffold shows great potential in delivering CGF to promote healing of full-thickness skin defects.
Article
Biochemistry & Molecular Biology
Qin Zou, Xue Wang, Rong Yuan, Zhengyin Gong, Chenggang Luo, Ying Xiong, Yanzhi Jiang
Summary: Skin thickness is influenced by the expression of collagen I in fibroblasts. Using Chenghua pigs as model animals, this study identified significant morphological differences between Chenghua pigs and Large White pigs at the transcript level. Additionally, a circRNA called circ0044633 was found to promote fibroblast proliferation and collagen I synthesis by sponging miR-23b and regulating CADM3 and MAP4K4 expression. Over-expression of circ0044633 increased skin thickness and collagen I content in vivo.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Dongsheng Jiang, Yuval Rinkevich
Summary: The mobilization of fascia plays a crucial role in wound healing by assembling various cell types and matrix components for rapid repair. Factors affecting fascial mobility directly impact chronic skin wounds and excessive skin scarring.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Manja Newe, Theresa A. Kant, Maximilian Hoffmann, Johanna S. E. Rausch, Luise Winter, Karolina Kuenzel, Erik Klapproth, Claudia Gunther, Stephan R. Kunzel
Summary: Skin fibrosis is a complex biological process occurring in diseases like systemic sclerosis, and currently lacks effective therapy for prevention or reversal. This study explores the role of PLK2 and OPN in the pathogenesis of cutaneous fibrosis and demonstrates the antifibrotic effects of systemic mesalazine treatment.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Editorial Material
Chemistry, Multidisciplinary
David M. Dolivo, Adrian E. Rodrigues, Thomas A. Mustoe, Robert D. Galiano, Seok Jong Hong
Summary: Cellular therapies hold promise for fibrosis treatment. A recent article presents a strategy and proof-of-concept for delivering stimulated cells to degrade hepatic collagen in vivo. The discussion highlights the strengths of this approach and its potential to generalize to treat other forms of fibrosis.
Article
Biochemistry & Molecular Biology
Sergei Butenko, Nofar Ben Jashar, Tsofiya Sheffer, Edmond Sabo, Sagie Schif-Zuck, Amiram Ariel
Summary: The atypical chemokine receptor ACKR2 plays a crucial role in limiting inflammatory skin fibrosis by promoting IFN-beta production to resolve inflammation and minimize tissue scarring.
Article
Dermatology
Shao-hai Chang, Zhuo-shan Huang, Wei-liang Chen
Summary: Reconstruction of cheek skin defects using remaining cheek skin in the scar area for treating donor site wounds following full-thickness skin repair showed satisfactory outcomes. Postoperative esthetic results were good with no major complications noted.
DERMATOLOGIC THERAPY
(2021)
Review
Oncology
Tjasa Bensa, Stavroula Tekkela, Emanuel Rognoni
Summary: Fibroblasts are the major cell population involved in depositing and remodeling the extracellular matrix in connective tissues. Recent advances in single-cell RNA-sequencing have revealed the diversity of fibroblast subtypes in the skin and other organs, and understanding their functional relevance in health and disease is a key challenge. This article discusses the distinct fibroblast subtypes in skin homeostasis and repair, and their potential roles in fibrotic diseases and cancer.
JOURNAL OF PATHOLOGY
(2023)
Article
Multidisciplinary Sciences
Kellen Chen, Sun Hyung Kwon, Dominic Henn, Britta A. Kuehlmann, Ruth Tevlin, Clark A. Bonham, Michelle Griffin, Artem A. Trotsyuk, Mimi R. Borrelli, Chikage Noishiki, Jagannath Padmanabhan, Janos A. Barrera, Zeshaan N. Maan, Teruyuki Dohi, Chyna J. Mays, Autumn H. Greco, Dharshan Sivaraj, John Q. Lin, Tobias Fehlmann, Alana M. Mermin-Bunnell, Smiti Mittal, Michael S. Hu, Alsu Zamaleeva, Andreas Keller, Jayakumar Rajadas, Michael T. Longaker, Michael Januszyk, Geoffrey C. Gurtner
Summary: Tissue repair and healing are complex processes, with large animals and humans forming fibrotic scar tissue during healing. Disrupting mechanical signaling in large animals accelerates healing, prevents fibrosis, and enhances skin regeneration.
NATURE COMMUNICATIONS
(2021)
Review
Rehabilitation
Jessica Killey, Megan Simons, Zephanie Tyack
Summary: The study aimed to identify adherence interventions used with people receiving treatments to prevent or manage scarring, evaluate their effectiveness, and examine the theoretical frameworks behind these interventions. Results indicated that education or technology-based interventions may improve adherence in burn scar treatment, but further research is needed to explore outcomes important to patients and identify core components of effective adherence interventions.
CLINICAL REHABILITATION
(2021)
Article
Critical Care Medicine
K. J. Zheng, E. Middelkoop, M. Stoop, P. P. M. van Zuijlen, A. Pijpe
Summary: This study assessed the validity of Laser Speckle Contrast Imaging (LSCI) for measuring burn wound healing potential (HP) in comparison to the reference standard of Laser Doppler Imaging (LDI). The results showed that LSCI was able to accurately discriminate between burn wounds with different healing potentials.
Article
Cell Biology
Floyd W. Timmermans, Sterre E. Mokken, Jan-Maerten Smit, Mark-Bram Bouman, Timotheus C. van de Grift, Margriet G. Mullender, Esther Middelkoop
Summary: This study investigated the effects of incisional negative pressure wound therapy (iNPWT) on scar outcomes. The results showed that while there were some positive effects in qualitative scar outcomes, there were no significant benefits in quantitative outcomes. Therefore, this study suggests that iNPWT has limited effectiveness as a therapy for improving scars.
WOUND REPAIR AND REGENERATION
(2022)
Article
Physics, Fluids & Plasmas
Eamonn A. Gaffney, Mohit P. Dalwadi, Clement Moreau, Kenta Ishimoto, Benjamin J. Walker
Summary: In this study, we demonstrate that Jeffery's orbits, traditionally used to describe the rotation of ellipsoids in shear Stokes flow, also apply to high-frequency shape-deforming swimmers in a shear flow plane. Through a multiple-scales asymptotic analysis, we support the use of these simple models in studying shape-changing swimmer dynamics in active matter and highlight the prevalence of ellipsoid-like dynamics in complex systems. Our result remains robust even with weak confounding effects and is applicable in the low-frequency limit as well.
PHYSICAL REVIEW FLUIDS
(2022)
Article
Physics, Fluids & Plasmas
Benjamin J. Walker, Kenta Ishimoto, Eamonn A. Gaffney, Clement Moreau, Mohit P. Dalwadi
Summary: In this study, the long-term effects of high-frequency oscillations on translational and angular motion are systematically evaluated. It is shown that rapid oscillations can cause a bias in the average direction of progression, and the impact of yawing on propulsion speed and hydrodynamic shape is quantified.
PHYSICAL REVIEW FLUIDS
(2022)
Article
Mechanics
B. J. Walker, K. Ishimoto, E. A. Gaffney, C. Moreau
Summary: This study explores the application and feasibility of geometric control theory in controlling the interaction of multiple particles in Stokesian fluids. Through specific problem examples, it demonstrates how control schemes can be constructed using this control theory, and contributes to the understanding of mechanical efficiency and hydrodynamic interactions.
JOURNAL OF FLUID MECHANICS
(2022)
Article
Engineering, Biomedical
Patrick P. G. Mulder, Rajiv S. Raktoe, Marcel Vlig, Anouk Elgersma, Esther Middelkoop, Bouke K. H. L. Boekema
Summary: The study validates the use of full skin equivalents (FSEs) generated from de-epidermalized dermis (DED) and collagen matrices MatriDerm and Mucomaix as in vitro models for wound healing research. After a burn injury, both DED and MatriDerm-based FSEs showed re-epithelization similar to ex vivo human skin, while Mucomaix-based FSEs degraded rapidly. The animal-free in vitro models can be used as tools for studying skin regeneration and testing therapeutic interventions.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Critical Care Medicine
Charlotte I. Cords, Margriet E. van Baar, Marianne K. Nieuwenhuis, Anouk Pijpe, Cornelis H. van der Vlies
Summary: The study aimed to assess the inter-rater reliability and validity of the Clinical Frailty Scale (CFS) in patients with burn injuries. The CFS was found to be predictive of adverse outcomes and associated with factors such as age and total body surface area burned.
Article
Critical Care Medicine
Hennie Schouten, Marianne Nieuwenhuis, Cees van der Schans, Anuschka Niemeijer, Paul van Zuijlen
Summary: Scar contractures after burn injuries can impair joint mobility and restrict daily activities and social participation. However, there is no established method to determine the severity of these contractures in burn care. This study analyzed various approaches to evaluate limited mobility in the knee joint due to scar contracture. Depending on the approach used, either limitations in knee flexion or extension were found to cause the most problems. A function-based classification system that considers range of motion impairment, activity limitations, and participation restrictions is recommended to accurately assess the severity of burn scar contractures.
JOURNAL OF BURN CARE & RESEARCH
(2023)
Article
Critical Care Medicine
Jaco Suijker, Lisca Wurfbain, Anouk M. L. H. Emmen, Anouk Pijpe, Kelly A. A. Kwa, Cornelis H. van der Vlies, Marianne K. Nieuwenhuis, Paul P. M. van Zuijlen, Annebeth Meij-de Vries
Summary: This study examines patients with Necrotizing Soft-Tissue Infections (NSTI) treated at burn centers, describing their characteristics, outcomes, and diagnostic challenges. The study finds that patients referred from other centers tend to have more severe infections and longer hospital stays compared to those primarily admitted to the study hospitals. Although there is a high incidence of septic shock, the mortality rate remains low for those primarily admitted. The study also highlights the need for better recognition and diagnosis of NSTI upon presentation.
JOURNAL OF BURN CARE & RESEARCH
(2023)
Article
Biology
Ginger Egberts, Fred Vermolen, Paul van Zuijlen
Summary: This study focuses on the stability analysis of a two-dimensional model that combines morphoelasticity for permanent deformations and a chemical-biological model incorporating cellular densities, collagen density, and chemoattractant concentration. Stability conditions are formulated based on the decay rate of signaling molecules for both the continuous partial differential equations-based problem and the semi-discrete representation. The difference and convergence between the spatial eigenvalues obtained from the continuous and semi-discrete problems are analyzed.
JOURNAL OF MATHEMATICAL BIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
L. van Haasterecht, M. Zhou, Y. Ma, L. Bartolini, F. Van Mourik, P. P. M. Van Zuijlen, M. L. Groot
Summary: In clinical practice, plastic surgeons often face the challenge of closing large skin defects that cannot be closed primarily. To understand the management of such wounds, it is necessary to study the biomechanical properties of the skin. Previous research on skin microstructural adaptation to mechanical deformation has been limited to static regimes. In this study, we combined uniaxial stretch tests with fast second harmonic generation imaging to investigate dynamic collagen rearrangement in reticular human dermis. The results showed significant variability in collagen alignment across samples, with a significant increase in alignment during the linear part of the mechanical response. Fast SHG imaging during uniaxial extension is a promising research tool for future studies on skin biomechanic properties.
BIOMEDICAL PHYSICS & ENGINEERING EXPRESS
(2023)
Article
Dermatology
Kim L. M. Gardien, Anouk Pijpe, Katrien M. Brouwer, Matthea Stoop, Simarjeet K. Singh, Floyd W. Timmermans, Marcel Vlig, Paul P. M. Van Zuijlen, Esther Middelkoop
Summary: This study investigated the safety and efficacy of an acellular dermal substitute in patients with full-thickness wounds. The results showed that the dermal substitute was a safe treatment modality for full-thickness wounds, with slightly increased time to wound healing compared to split-thickness skin graft alone. However, scar quality at 12 months seemed somewhat improved in the wounds treated with the dermal substitute, indicative of enhanced scar maturation. Overall, the final scar quality was similar for both treatment modalities.
ADVANCES IN SKIN & WOUND CARE
(2023)
Article
Immunology
Patrick P. G. Mulder, Marcel Vlig, Anouk Elgersma, Lotte Rozemeijer, Leonore S. Mastenbroek, Esther Middelkoop, Irma Joosten, Hans J. P. M. Koenen, Bouke K. H. L. Boekema
Summary: This study established a human full skin equivalent burn wound model and incorporated human peripheral blood-derived monocytes and T cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Dermatology
H. Ibrahim Korkmaz, Frank B. Niessen, Anouk Pijpe, Vivek M. Sheraton, Fred J. Vermolen, Paul Aj Krijnen, Hans Wm Niessen, Peter Ma Sloot, Esther Middelkoop, Susan Gibbs, Paul Pm van Zuijlen
Summary: This article discusses the complexity of scar formation after burn injury and introduces the potential of complexity science in this field. Current understanding of scar formation is limited to small parts of the process, hindering the comprehension of underlying mechanisms and system behavior. Complexity science can integrate relevant biological mechanisms and data, providing a better understanding of the complexity of scar formation as a whole, and advancing research and treatment approaches.
JOURNAL OF WOUND CARE
(2022)
Article
Surgery
Catherine M. Legemate, Kelly A. A. Kwa, Harold Goei, Anouk Pijpe, Esther Middelkoop, Paul P. M. van Zuijlen, Gerard I. J. M. Beerthuizen, Marianne K. Nieuwenhuis, Margriet E. van Baar, Cornelis H. van der Vlies
Summary: Hydrosurgical debridement showed better scar quality and pliability compared to conventional debridement one year post-surgery, likely due to enhanced histological preservation of dermis. Complication rates did not differ between the two treatments.
BRITISH JOURNAL OF SURGERY
(2022)