Article
Pediatrics
Si-Lu Wang, Chun Chen, Xin-Yue Gu, Zhao-Qing Yin, Le Su, Si-Yuan Jiang, Yun Cao, Li-Zhong Du, Jian-Hua Sun, Jiang-Qin Liu, Chuan-Zhong Yang
Summary: This study reviewed the intensity of delivery room resuscitation in Chinese tertiary neonatal intensive care units and investigated its association with short-term outcomes in preterm infants. The results showed that increased resuscitation intensity was associated with higher mortality and morbidities. There is wide variation in resuscitative approaches across delivery centers, highlighting the need for ongoing quality improvement to standardize resuscitation practices.
WORLD JOURNAL OF PEDIATRICS
(2023)
Letter
Medicine, General & Internal
Olivier C. Manintveld, Stefan Roest, Yannick J. H. J. Taverne
Summary: In the study by Suverein et al., the use of extracorporeal cardiopulmonary resuscitation (CPR) in patients with refractory out-of-hospital cardiac arrest was examined. The results showed similar survival rates with a favorable neurologic outcome between extracorporeal CPR and conventional CPR. This raises questions about the role of extracorporeal CPR as an adjunct to conventional CPR.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Obstetrics & Gynecology
Javier Rodriguez-Fanjul, Luis Perez-Baena, Alberto Perez
Summary: Point of care ultrasound is a useful tool in adult cardiac arrest situations, but there is still a lack of specific protocol in the delivery room for newborns. Using ultrasound to help diagnose the cause of cardiac arrest may be beneficial in newborn resuscitation.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Education & Educational Research
Jesus Lopez-Herce, Angel Carrillo, Javier Urbano, Gema Manrique, Santiago Mencia
Summary: Pediatric and neonatal CPR instructor courses are essential for training quality and homogeneity. Most participants passed the tests and evaluated the course positively.
BMC MEDICAL EDUCATION
(2021)
Article
Pediatrics
S. Bobillo-Perez, M. Balaguer, I Jordan, A. Batista-Munoz, M. Ramon, O. Otero, C. Sorribes, J. Rodriguez-Fanjul
Summary: The study evaluated the accuracy and speed of ultrasound compared to auscultation, pulse oximetry, and electrocardiography in measuring neonatal heart rate. Results showed that ultrasound is a faster and more accurate method for detecting heart rate in newborns, with a strong correlation with auscultation and electrocardiography.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Multidisciplinary Sciences
Martin Hermann, Markus Isser, Valentin Bilgeri, Andreas Klinger, Wolfgang Lederer
Summary: This experimental study investigates the characteristics of blood drops dispersed on four different foil surfaces and finds differences in the characteristics compared to paper towel. Delayed clotting is associated with larger areas of contamination, indicating a higher likelihood of coming into contact with potential germs but a lower chance of contracting an infection. Space blankets, as obligatory components of first aid kits, serve as a mechanical barrier between rescuers and patients during resuscitation.
SCIENTIFIC REPORTS
(2022)
Article
Pediatrics
Megan O'Reilly, Tze-Fun Lee, Po-Yin Cheung, Georg M. Schmolzer
Summary: Machine chest compression leads to significant improvements in hemodynamic parameters during resuscitation of asphyxiated neonatal piglets, including greater stroke volume and left ventricular contractility, compared to manual compression techniques. This suggests that mechanical chest compression devices may offer better outcomes in neonatal and pediatric asphyxia-induced cardiac arrest.
PEDIATRIC RESEARCH
(2023)
Review
Pediatrics
M. Kaufmann, L. Mense, L. Springer, J. Dekker
Summary: Current resuscitation guidelines recommend tactile stimulation for infants with insufficient respiratory efforts after birth, but there is no clear recommendation regarding the timing, method, and relationship with gestational age. Existing evidence suggests that repetitive stimulation within the first few minutes of resuscitation improves oxygenation. However, there is wide variation in the management of tactile stimulation among different centers, calling for further research to optimize strategies.
PEDIATRIC RESEARCH
(2022)
Article
Critical Care Medicine
Cecilie Halling, Tia Raymond, Larry Steven Brown, Anne Ades, Elizabeth E. Foglia, Emilie Allen, Myra H. Wyckoff
Summary: This study identified risk factors and resuscitation interventions associated with increased and decreased odds of achieving return of spontaneous circulation (ROSC) in newborns receiving chest compressions in the delivery room. The findings suggest that early initiation of cardiac compressions, successful endotracheal intubation, and timely administration of adrenaline may improve outcomes of delivery room CPR. Further research should focus on reducing time to critical interventions to enhance outcomes.
Editorial Material
Cardiac & Cardiovascular Systems
Laurie-Anne Boivin-Proulx, Amelie Doherty, Nicolas Rousseau-Saine, Serge Doucet, Hung Q. Ly, Patrick Lavoie, Nicolas Thibodeau-Jarry
Summary: Cardiac arrest is common in critically ill patients with COVID-19 and often leads to poor survival rates. Simulation training for code teams can help improve outcomes, but there are still challenges in adhering to guidelines and maintaining the efficacy of resuscitation efforts.
CANADIAN JOURNAL OF CARDIOLOGY
(2021)
Article
Obstetrics & Gynecology
Payam Vali, Gary M. Weiner, Deepika Sankaran, Satyan Lakshminrusimha
Summary: The neonatal resuscitation program recommends a wide range of epinephrine doses for newborns receiving chest compressions, causing challenges for care providers in determining the optimal initial dose. To reduce dosing errors, it is suggested to use specified epinephrine doses and syringes based on animal data.
JOURNAL OF PERINATOLOGY
(2021)
Article
Critical Care Medicine
Yohei Okada, Nur Shahidah, Yih Yng Ng, Michael Y. C. Chia, Han Nee Gan, Benjamin S. H. Leong, Desmond R. Mao, Wei Ming Ng, Nausheen Edwin, Takeyuki Kiguchi, Norihiro Nishioka, Tetsuhisa Kitamura, Taku Iwami, Marcus Eng Hock Ong
Summary: This study evaluated the outcomes of OHCA patients with initial shockable rhythm in Singapore and Osaka, and found that the outcomes for patients without prehospital ROSC in Singapore were worse than expected based on Osaka data, even when using population-based databases.
Review
Pediatrics
B. Simma, M. den Boer, B. Nakstad, H. Kuester, H. M. Herrick, M. Ruediger, H. Aichner, M. Kaufmann
Summary: The use of video recording in delivery room management plays a significant role in improving the quality of care provided and has implications for education, training, and research. However, concerns regarding privacy and ethical-legal issues should be considered when implementing this technology.
PEDIATRIC RESEARCH
(2021)
Article
Multidisciplinary Sciences
So Jin Yoon, Joohee Lim, Jung Ho Han, Jeong Eun Shin, Ho Seon Eun, Min Soo Park, Kook In Park, Soon Min Lee
Summary: The study found significant trends in neonatal resuscitation practices for very-low-birth-weight infants, with an increase in positive pressure ventilation and a decrease in intubation rates. Different gestational ages had varying rates of PPV, and higher levels of resuscitation were associated with increased risk of mortality and morbidities. Changes in the highest level of resuscitation were significantly associated with reducing mortality and morbidities, emphasizing the need for more thorough delivery room resuscitation for extremely premature infants.
SCIENTIFIC REPORTS
(2021)
Article
Obstetrics & Gynecology
Alyssa R. Thomas, Amy L. Ma, Danielle D. Weinberg, Matthew Huber, Anne Ades, Jack Rychik, Elizabeth E. Foglia
Summary: This retrospective study characterized SpO(2) trajectories and respiratory interventions for newborns with cyanotic congenital heart disease, showing differences in SpO(2) values and frequency of interventions among different phenotypes. Results can inform delivery room management for these high-risk populations.
JOURNAL OF PERINATOLOGY
(2021)
Article
Obstetrics & Gynecology
Giselle Valerio Teixeira da Silva, Marina Carvalho de Moraes Barros, Juliana do Carmo Azevedo Soares, Lucas Pereira Carlini, Tatiany Marcondes Heiderich, Rafael Nobre Orsi, Rita de Cassia Xavier Balda, Carlos Eduardo Thomaz, Ruth Guinsburg
Summary: The study aimed to analyze the gaze fixation of pediatricians during the decision process regarding the presence/absence of pain in pictures of newborn infants. The results showed that when determining the presence of pain in newborn infants' faces, pediatricians primarily fixate on the mouth, and longer duration of gaze fixation in the mouth and forehead is associated with an increased perception of moderate/severe pain.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Article
Engineering, Biomedical
Fernanda G. Tamanaka, Lucas Pereira Carlini, Tatiany M. Heiderich, Rita C. X. Balda, Marina C. M. Barros, Ruth Guinsburg, Carlos E. Thomaz
Summary: This study compared the ranking importance of neonatal facial features proposed by clinical scales with the visual perception of professionals and non-professionals. The results showed that the most relevant facial features according to clinical scales did not correlate with the visual perception of the participants, regardless of their expertise. The rankings of all participant groups were highly correlated.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING-IMAGING AND VISUALIZATION
(2023)
Article
Engineering, Industrial
Kelly Hinckfuss, Penelope M. Sanderson, Birgit Brecknell, Robert G. Loeb, David Liu, Helen Liley
Summary: Standard pulse oximeter auditory tones do not clearly indicate departures from the target range of oxygen saturation in preterm neonates. Acoustically enhanced tones significantly improve clinicians' and non-clinicians' ability to identify the SpO2 range. The accuracy of range identification was higher in the enhanced conditions compared to the standard condition, with the tremolo-enhanced tones showing the highest accuracy.
APPLIED ERGONOMICS
(2023)
Article
Obstetrics & Gynecology
Poliana de Barros Medeiros, Helen Liley, Christine Andrews, Adrienne Gordon, Alexander E. P. Heazell, Alison L. Kent, Susannah H. Leisher, Vicki Flenady
Summary: Neonatal near-miss (NNM) audit is viewed as a valuable tool to reduce adverse neonatal outcomes. The survey results showed that the main characteristics of NNM according to most participants include birth asphyxia needing therapeutic hypothermia, unexpected resuscitation at birth, need for intubation/chest compression/adrenaline, and metabolic acidosis at birth. Despite the importance of NNM for identifying cases for perinatal morbidity audits, only a few institutions used a NNM definition.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2023)
Article
Neurosciences
Alex M. Pagnozzi, Liza van Eijk, Kerstin Pannek, Roslyn N. Boyd, Susmita Saha, Joanne George, Samudragupta Bora, DanaKai Bradford, Michael Fahey, Michael Ditchfield, Atul Malhotra, Helen Liley, Paul B. Colditz, Stephen Rose, Jurgen Fripp
Summary: Infants born very preterm face neurodevelopmental challenges and early identification through clinical assessment and MRI can enable targeted interventions. This study used a prospective cohort of preterm infants and identified early MRI biomarkers for neurodevelopmental outcomes using advanced imaging techniques. The results demonstrated the utility of MRI prior to term equivalent age for predicting outcomes and initiating early interventions.
Article
Pediatrics
Caroline Kaori Tomo, Olukunmi Omobolanle Balogun, Josy Davidson, Ruth Guinsburg, Maria Fernanda Branco de Almeida, Jose Maria de Andrade Lopes, Marina Carvalho de Moraes Barros, Kenji Takehara, Masashi Mikami, Tetsuya Isayama, Ai Hoshino, Rintaro Mori, Masashi Mizuguchi
Summary: This study aimed to compare the mortality and survival without major morbidities among very premature and very low birth weight infants between neonatal intensive care units (NICUs) in Brazil and Japan. The study analyzed surveys conducted in 2014 and 2015, including 187 NICUs. The findings showed that infants from Brazil had higher odds of mortality and lower odds of survival without major morbidities compared to those from Japan.
REVISTA PAULISTA DE PEDIATRIA
(2023)
Article
Pediatrics
Renato Oliveira de Lima, Sergio Tadeu Martins Marba, Maria Fernanda Branco de Almeida, Ruth Guinsburg
Summary: The implementation of the Neonatal Resuscitation Program of the Brazilian Society of Pediatrics improved the structure of delivery rooms, increased the knowledge level of healthcare professionals, and significantly reduced neonatal mortality.
JORNAL DE PEDIATRIA
(2023)
Review
Pediatrics
Tatiany M. Heiderich, Lucas P. Carlini, Lucas F. Buzuti, Rita de C. X. Balda, Marina C. M. Barros, Ruth Guinsburg, Carlos E. Thomaz
Summary: Automated neonatal pain assessment faces challenges in replacing human eye. Existing computational methods need further testing under natural movement and different lighting conditions. More neonatal facial image databases are required for research advancement.
JORNAL DE PEDIATRIA
(2023)
Article
Pediatrics
Maria Fernanda B. de Almeida, Adriana Sanudo, Kelsy N. Areco, Rita de Cassia X. Balda, Daniela T. Costa-Nobre, Mandira D. Kawakami, Tulio Konstantyner, Ana Silvia S. Marinonio, Milton H. Miyoshi, Paulo Bandiera-Paiva, Rosa M. V. Freitas, Liliam C. C. Morais, Monica L. P. Teixeira, Bernadette Waldvogel, Carlos Roberto V. Kiffer, Ruth Guinsburg
Summary: This study analyzed the temporal trend, causes, and timing of neonatal mortality of moderate and late preterm infants in Sao Paulo State, Brazil from 2004-2015. The results showed a decrease in neonatal mortality rate over the past decade, but highlighted the need for improvement in perinatal healthcare.
Article
Pediatrics
Anne Synnes, Thuy Mai Luu, Jehier Afifi, May Khairy, Cecilia de Cabo, Diane Moddemann, Leonora Hendson, Amber Reichert, Kevin Coughlin, Kim Anh Nguyen, Lindsay L. Richter, Fabiana Bacchini, Khalid Aziz
Summary: This study tested the feasibility of using the Evidence-based Practice to Improve Quality (EPIQ) to improve language abilities in very preterm populations. Eight of ten sites completed at least four intervention cycles, and 85% of the cycles met their aim. Despite challenges like COVID-19, parent involvement, champions, and institutional support facilitated success.
Review
Pediatrics
Vix Monnelly, Justin B. Josephsen, Tetsuya Isayama, Maria Fernanda B. de Almeida, Ruth Guinsburg, Georg M. Schmolzer, Yacov Rabi, Myra H. Wyckoff, Gary Weiner, Helen G. Liley, Anne Lee Solevag
Summary: Objective measurement of exhaled carbon dioxide (ECO2) during non-invasive ventilation at birth may provide information about lung aeration, but the evidence supporting the use of an ECO2 monitor is lacking. The International Liaison Committee on Resuscitation (ILCOR) has prioritized the need to evaluate the effectiveness of ECO2 measurement in guiding non-invasive ventilation of newborn infants. More research is needed to determine whether the use of an ECO2 monitor can improve outcomes in delivery room resuscitation.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2023)
Review
Critical Care Medicine
V. V. Ramaswamy, J. A. Dawson, M. F. de Almeida, D. Trevisanuto, F. L. Nakwa, C. O. F. Kamlin, J. Trang, M. H. Wyckoff, G. M. Weiner, H. G. Liley
Summary: This study evaluated delivery room interventions to prevent hypothermia and improve outcomes in preterm newborn infants. The findings suggest that increasing the delivery room temperature, using a radiant warmer in manual mode, using a plastic bag or wrap, and covering the head can improve temperature outcomes in preterm infants. However, some interventions may also increase the risk of hyperthermia.
Article
Medicine, General & Internal
Mariana Ferreira Carvalho Westerstahl de Abreu, Joice Fabiola Meneguel Ogata, Marcelo Cunio Machado Fonseca, Dayan Sansone, Ruth Guinsburg
Summary: This study evaluated the hospital costs of newborn infants diagnosed with sepsis in the Brazilian Public Health System over an 11-year period. The results showed that from 2008 to 2018, a total of 47,554 newborns were hospitalized with sepsis, with an average cost of US$ 3345.59 per hospitalization. The costs varied among different geographic regions and etiologic agents, and patients who died from sepsis incurred higher costs. The study highlights the importance of improving neonatal care to reduce the economic burden of sepsis.
Proceedings Paper
Computer Science, Artificial Intelligence
Leonardo Antunes Ferreira, Lucas Pereira Carlini, Gabriel de Almeida Sa Coutrin, Tatiany Marcondes Heideirich, Marina Carvalho de Moraes Barros, Ruth Guinsburg, Carlos Eduardo Thomaz
Summary: This paper reevaluates the Neonatal Convolutional Neural Network (N-CNN) by optimizing its hyperparameters and discusses their potential impact in clinical practice. The Tuned N-CNN shows improvements in classification metrics and explainability, but does not directly translate to calibration performance.
PREDICTIVE INTELLIGENCE IN MEDICINE, PRIME 2023
(2023)
Review
Pediatrics
P. B. Medeiros, C. Bailey, D. Pollock, H. Liley, A. Gordon, C. Andrews, V. Flenady
Summary: This review evaluates the effectiveness of neonatal near-miss (NNM) audits for reducing perinatal mortality and morbidity and explores related contextual factors. The available data on NNM audits are limited, and further research is needed to determine their effectiveness and influencing factors.
