Article
Chemistry, Multidisciplinary
Yan-Jun Huang, Wen-Huei Chang, Yi-Jui Chen, Chun-Hung Lin
Summary: The paper introduces a simple and cost-effective method for creating metal/SU-8 nanocomposites by applying a metal precursor drop onto the surface or nanostructure of SU-8 and exposing it to UV light. No pre-mixing or pre-synthesis of metal nanoparticles is required. TEM analysis confirms the composition and depth distribution of silver nanoparticles in the nanocomposites. The antibacterial properties of the nanocomposites are evaluated. Additionally, composite surfaces with customized colors and spectra are produced using gold and silver precursors.
Review
Chemistry, Analytical
Pooria Golvari, Stephen M. Kuebler
Summary: This review surveys the advances in fabricating functional microdevices using multi-photon lithography (MPL) with the SU-8 material system, focusing on the progress made in the last five years and discussing methods for improving resolution and functionalizing structures after fabrication.
Article
Engineering, Biomedical
Daeho Ryu, Youjin Lee, Yongseung Lee, Yena Lee, Seoyoung Hwang, Yong-Kweon Kim, Sang Beom Jun, Hyang Woon Lee, Chang-Hyeon Ji
Summary: This paper presents a conventional LED and polymer waveguide coupled silicon optrode array, which achieves high coupling efficiency through lens design and SU-8 photoresist. The experiment demonstrates the capability of optical stimulation and neural signal recording in vivo.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Chemistry, Analytical
Stefan Gassmann, Sathurja Jegatheeswaran, Till Schleifer, Hesam Arbabi, Helmut Schuette
Summary: The combination of PCB and microfluidics brings numerous advantages, and the integration of electrodes, sensors, and electronics is intrinsic when using PCB as a substrate. Vat polymerization with an LCD as a mask, known as mSLA, is a promising rapid prototype technique with affordable printers available. This paper presents a low-cost solution for combining PCBs and microfluidics by creating microfluidic devices on a PCB substrate using an mSLA printer.
Article
Engineering, Electrical & Electronic
Manu Garg, Dhairya Singh Arya, Sushil Kumar, Mujeeb Yousuf, Yi Chiu, Pushpapraj Singh
Summary: This paper introduces a SU-8 dielectric mu-bridge based polymer microelectromechanical systems (MEMS) Pirani gauge for hermetic characterization of packaged electronic sensors. The gauge achieves simplicity in fabrication, lower footprint, and superior thermal isolation from the substrate.
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
(2022)
Article
Chemistry, Analytical
Javier Melendez-Campos, Matias Vazquez-Pinon, Sergio Camacho-Leon
Summary: Dielectric characteristics are important for determining critical properties of liquids and distinguishing between similar liquid samples, with applications in various fields. This study presents a portable wireless sensor node for measuring the permittivity of liquids, utilizing advanced fabrication techniques to achieve high sensitivity and durability.
Article
Engineering, Electrical & Electronic
Awatef Khlifi, Aftab Ahmed, Brahim Mezghani, Rajul Patkar, Pradeep Dixit, Fares Tounsi, Maryam Shojaei Baghini
Summary: This paper investigates the static and dynamic performances of a new enhanced design of 3-axis MEMS polymer piezoresistive accelerometer. The key geometric parameters are optimized using a developed numerical finite element model (FEM). The results show that the proposed design has improvements in induced stress fields compared to similar silicon-based designs found in literature. With a low-cost and simple fabrication process-flow provided, this design shows potential for practical applications.
MICROELECTRONICS JOURNAL
(2022)
Article
Optics
Reza Gholamzadeh, Hassan Salarieh, Gholam Mohammad Parsanasab, Javad Akbari
Summary: A high sensitive optical MEMS accelerometer is proposed, which measures acceleration by changing the intensity modulation of light wave. The design includes a microring, waveguide, and a proof mass, and utilizes the displacement of the proof mass to change the refractive index of the microring. The proposed design has high sensitivity and can be applied in various fields.
OPTICAL ENGINEERING
(2022)
Article
Nanoscience & Nanotechnology
Jongmoon Jang, Giulia Panusa, Giovanni Boero, Juergen Brugger
Summary: Glass-like carbon (GC) is a novel material with a combination of various properties, including high hardness, low density, low thermal conductivity, high chemical inertness, biocompatibility, high electrical conductivity. Although its application in mechanical sensors has not been explored, our research reveals its potential in electromechanical microdevices.
MICROSYSTEMS & NANOENGINEERING
(2022)
Article
Materials Science, Multidisciplinary
Youlim Lee, Sehwan Song, Woochul Lee, Sang-Hee Yoon
Summary: There is an increasing demand for polymer-based electrical leads patterned on polymer substrates of any shape to connect two electrical components. However, electrical leads made of polymer nanocomposites that have high affinity to polymer substrates and outstanding applicability to curved surfaces are still challenging. This necessitates the development of photopatternable and electrically conductive polymer nanocomposites and comprehensive understanding of their constituent and processes involved in their development.
JOURNAL OF MATERIALS SCIENCE
(2023)
Review
Chemistry, Analytical
Ziyu Chen, Jeong-Bong Lee
Summary: SU-8, an epoxy-based negative-tone photoresist, has been widely used in fabricating biomedical devices. Despite its not complete biocompatibility, existing surface modification techniques can minimize biofouling. With proper treatments and surface modifications, SU-8 can be a unique choice for biomedical device fabrication.
Article
Chemistry, Multidisciplinary
Xander F. van Kooten, Yana Rozevsky, Yulia Marom, Efrat Ben Sadeh, Amit Meller
Summary: Most RNA-based COVID-19 diagnostic methods use enzymatic amplification for high sensitivity but rely on arbitrary thresholding. This study introduces a solid-state nanopore sensing technology for label-free quantification of SARS-CoV-2 RNA in clinical nasal swab samples. The method allows for ratiometric quantification of RNA abundance through single-molecule counting and length-based nanopore identification of dsDNA. The results show that this approach can provide quantitative positive outcomes in clinical samples classified as negative by RT-qPCR.
Article
Engineering, Electrical & Electronic
Jeongrak Lee, Hanseong Jo, Seonghyeon Kim, Eunji Lee, Youngbin Son, Anna Lee
Summary: This study proposes a novel approach to address the challenges in durability, mass production, and upscaling of existing micro-ignitors. By developing a membraneless micro-ignitor integrated onto a printed circuit board (PCB), this study demonstrates the potential of seamlessly integrating propulsion and satellite electronic control systems. The membraneless PCB micro-ignitor exhibits superior structural stability compared to conventional membrane-based micro-ignitors, as shown in rigorous durability tests and combustion experiments.
SENSORS AND ACTUATORS A-PHYSICAL
(2023)
Article
Chemistry, Multidisciplinary
Carla Fernandez-Rico, Jeffrey S. Urbach, Roel P. A. Dullens
Summary: Surface roughness plays a key role in determining mechanical properties, wettability, and self-assembly in colloidal systems. This study introduces a simple and fast method for producing rough colloidal SU-8 particles, controlling the size and density of asperities through nanoprecipitation reactions. Fluorescent labeling of the rough particles allows for confocal imaging and demonstrates their stability at high packing fractions, providing a valuable model system for studying the impact of surface roughness on materials composed of anisotropic particles.
Article
Nanoscience & Nanotechnology
Pooya Azizian, Jasmina Casals-Terre, Jordi Ricart, Joan M. Cabot
Summary: By manipulating the geometry and surface chemistry of microfluidic channels, capillary-driven microfluidics allow for spontaneous movement and control of fluids without external instrumentation. The design and validation of a novel diffusion-free capillary valve, the p-valve, is presented in this study. The p-valve eliminates unwanted diffusion and cross-contamination through its 3D structure and void area, achieving a 40% increase in fluorescence intensity compared to conventional valves in a proof-of-concept capillary-driven circuit.
MICROSYSTEMS & NANOENGINEERING
(2023)
Article
Engineering, Electrical & Electronic
Francisco Perdigones, Emilio Franco, Blas Salvador, Guadalupe Flores, Jose Manuel Quero
JOURNAL OF MICROELECTROMECHANICAL SYSTEMS
(2018)
Article
Engineering, Electrical & Electronic
Emilio Franco, Francisco Perdigones, Blas Salvador, Jose Manuel Quero
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
(2018)
Article
Engineering, Electrical & Electronic
Emilio Franco, Blas Salvador, Francisco Perdigones, Miguel Cabello, Jose Manuel Quero
MICROELECTRONIC ENGINEERING
(2018)
Article
Chemistry, Analytical
Miguel Cabello, Carmen Aracil, Francisco Perdigones, Marta Mozo, Berta de la Cerda, Jose M. Quero
SENSORS AND ACTUATORS B-CHEMICAL
(2018)
Article
Chemistry, Analytical
Miguel Cabello, Haobo Ge, Carmen Aracil, Despina Moschou, Pedro Estrela, Jose Manuel Quero, Sofia I. Pascu, Paulo R. F. Rocha
Review
Chemistry, Analytical
Francisco Perdigones
Summary: Lab-on-PCB devices have great potential for biomedical and biochemical applications, but face challenges in commercialization such as complex fabrication processes, integration of multiple materials, sealing processes, and use of various facilities for PCB chips. Different flow driving methods all have drawbacks, and the complexity increases with the number of integrated sensors and actuators in the PCB chips, as well as the biological applications requiring transparency, biocompatibility, and specific ambient conditions.
Article
Chemistry, Analytical
Jesus David Urbano-Gamez, Francisco Perdigones, Jose Manuel Quero
Summary: This paper presents a prototype of a semi-automatic lab-on-PCB for agarose gel preparation and electrophoresis, which includes various sensors and components for controlling the process. The device is intended for DNA amplification and detection, but can also be modified for larger agarose gels and electrophoresis.
Article
Chemistry, Analytical
Jesus David Urbano-Gamez, Lourdes Valdes-Sanchez, Carmen Aracil, Berta de la Cerda, Francisco Perdigones, Alvaro Plaza Reyes, Francisco J. Diaz-Corrales, Isabel Relimpio Lopez, Jose Manuel Quero
Summary: Printed circuit board (PCB) technology is widely used in biomedicine to create Lab-on-PCB systems, integrating microfluidics and electronics. The study found that the solder mask of a commercial PCB showed no cytotoxic effects on retinal cultures, indicating its potential for use as a substrate for customized microelectrode arrays (MEAs). Additionally, the biocompatibility of Uniz zSG amber resin, a 3D printer material, was also evaluated.
Article
Chemistry, Analytical
Francisco Perdigones, Jose Manuel Quero
Summary: This paper discusses the opportunities for fabricating electronic and biomedical engineering devices using Printed Circuit Boards (PCBs). PCB substrates have historically been used to support electronic device components and provide connectivity with copper lines. PCB substrates are also being increasingly used in biomedical engineering due to their commercial availability, low cost, tolerance, and versatility. The paper highlights the alternative uses of different layers and materials, such as copper, gold, FR4, silver, vias, solder masks, and rigid and flexible substrates. It also mentions various applications, including sensors, biosensors, actuators, and PCB-based lab-on-chip devices used in DNA amplification for Polymerase Chain Reaction (PCR).
Editorial Material
Chemistry, Analytical
Francisco Perdigones
Article
Engineering, Electrical & Electronic
Francisco Perdigones, Jesus David Urbano-Gamez, Miguel Cabello, Andrea Esteban-Perez, Alejandro Quintero, Alvaro Diaz-Campillejo, Jose Manuel Quero
Summary: This paper describes an automatic lab-on-PCB system with pre-stored reagents that features a biocompatible and debris-free method for releasing the reagents. The system is scalable for mass production and consists of a PMMA microfluidic circuit and a commercial PCB with integrated sensors and actuators. The experimental results demonstrate the correct functioning of the device, including the ability to release and mix liquids accurately. The proposed lab-on-PCB system, with its benefits of portability, low cost, and scalability, shows great market potential for biomedical applications.
JOURNAL OF MICROELECTROMECHANICAL SYSTEMS
(2022)
