Journal
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
Volume 22, Issue 10, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/0960-1317/22/10/105037
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- BioSystems and Micromechanics Interdisciplinary Research Group (BioSyM IRG) under Singapore-MIT Alliance for Research and Technology (SMART)
- National University of Singapore
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Mechanical properties of cells can be correlated with various cell states and are now considered as an important class of biophysical markers. Effectiveness of existing high-throughput microfluidic techniques for investigating cell mechanical properties is adversely affected by cell-size variation in a given cell population. In this work, we introduce a new microfluidic system with real-time feedback control to evaluate single-cell deformability while minimizing cell-size dependence of the measurement. Using breast cancer cells (MCF-7), we demonstrate the potential of this system for stiffness profiling of cells in complex, diverse cell populations.
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