Article
Pharmacology & Pharmacy
Linhu Ye, Lei Cheng, Yan Deng, Sen Wang, Xinyu Wu, Shuiping Ou, Qi Chang, Xinqian Zhao, Wen Zhou, Jinghua Yu, Zuqiang Wu
Summary: Licorice (Glycyrrhiza uralensis Fisch) is widely used in China as a food and herbal medication. The present study investigated the pharmacokinetic profile of Glycycoumarin (GCM), a major coumarin in licorice, in rats. The results showed that GCM was rapidly absorbed and transformed into its conjugated metabolites, with low bioavailability and widespread distribution in various tissues except the brain.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Plant Sciences
Fan Zhang, Yu Yan, Kang Ding, Wen-Wen Lian, Li Li, Wen-Ping Wang, Cong-Yuan Xia, Hua Yang, Jun He, Wei-Ku Zhang, Jie-Kun Xu
Summary: This study aimed to investigate the pharmacokinetic characteristics and tissue distribution of loganin after oral administration in rats. The results showed that loganin was quickly absorbed and eliminated in rats, with low bioavailability. Loganin was highly distributed in the cortex compared to the hippocampus.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Satyavert, Sumeet Gupta, Hira Choudhury, Shery Jacob, Anroop B. Nair, Meenakshi Dhanawat, Kavita Munjal
Summary: In the experiment, it was found that intraperitoneal administration of HZC has better bioavailability and absorption rate compared to oral administration, indicating that intraperitoneal administration is a more effective route of administration.
PHARMACOLOGICAL REPORTS
(2021)
Article
Chemistry, Medicinal
Liping Dong, Wenjuan Liu, Xiaoyuan Zhao, Feng Yu, Yungen Xu, Mengxiang Su
Summary: This study synthesized a novel limonin derivative, HY-071085, with strong anti-inflammatory and analgesic activity. The pharmacokinetics, bioavailability, distribution, and excretion of HY-071085 were evaluated in rats and beagle dogs. The results showed nonlinear dynamic characteristics and gender differences in the pharmacokinetics of HY-071085, as well as tissue distribution and excretion patterns.
Article
Pharmacology & Pharmacy
Haihua Shang, Xiaohan Dai, Mi Li, Yueyi Kai, Zerong Liu, Min Wang, Quansheng Li, Yuan Gu, Changxiao Liu, Duanyun Si
Summary: This study provides the first systematic elucidation of the absorption and distribution characteristics of Rotundic acid (RA) in rats, which can provide valuable information for the further development and evaluation of RA in drug metabolism and pharmacokinetic studies.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2022)
Review
Biochemistry & Molecular Biology
Liping Liu, Qin Wu, Yuping Chen, Guoxiang Gu, Runan Gao, Bo Peng, Yue Wang, Anbang Li, Jipeng Guo, Xinru Xu, Xiaochen Shao, Lingxing Li, Ya Shen, Jihu Sun
Summary: Geniposide, a novel natural product, has multiple pharmacological effects and biological activities, and can be used for the treatment of various diseases. This study systematically describes the latest research progress of geniposide, summarizes its pharmacological effects, pharmacokinetics, and toxicity, and emphasizes the major pathways modulated by geniposide.
Article
Pharmacology & Pharmacy
Seo-Yeon Kim, Byung Hoon You, Mingoo Bae, Seung Yon Han, Kiwon Jung, Young Hee Choi
Summary: This study aimed to characterize the pharmacokinetic profiles of co-amorphous dispersions of Mirabegron (MBR) in rats and mice. The results showed that these co-amorphous dispersions can improve the relative bioavailability and area under the curve of MBR.
Review
Biochemistry & Molecular Biology
Vaibhav Kumar Maurya, Amita Shakya, Manjeet Aggarwal, Kodiveri Muthukaliannan Gothandam, Torsten Bohn, Sunil Pareek
Summary: Nanotechnology has provided new opportunities for beta-carotene delivery, with various nanocarriers promising improved solubilization, protection, shelf-life, bioavailability, and controlled release. Despite the benefits, they also come with limitations, and the future prospects in this field remain to be explored.
Article
Chemistry, Analytical
Ying Zhang, Jing Chen, Huan Gong, Yuju Zhou, Jiaxuan Zhang, Meng Li, Yan Cui
Summary: In this study, the cytotoxicity and pharmacokinetics of chlorphenesin enantiomers were examined. The results showed that S-chlorphenesin exhibited higher cytotoxicity and plasma concentration compared to R-chlorphenesin. Additionally, the two enantiomers showed differential tissue distribution.
MICROCHEMICAL JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Manoli Vourvahis, Wonkyung Byon, Cheng Chang, Vu Le, Annette Diehl, Daniela Graham, Sakambari Tripathy, Nancy Raha, Lina Luo, Sumathy Mathialagan, Martin Dowty, A. David Rodrigues, Bimal Malhotra
Summary: Abrocitinib has the potential to inhibit certain drug transporters, leading to increased plasma exposure of certain medications when co-administered. However, not all drug transporters are affected by abrocitinib.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Biochemical Research Methods
Binbin Ge, Xuejian Wang, Wan Li, Sha Li, Yanmei Du, Tengfei Ji, Guanhua Du, Chunyan Fang, Jinhua Wang
Summary: The goal of this study was to develop a sensitive and accurate method for determining the concentration of the Sinomenine derivative SWX in rat plasma and tissue using high performance liquid chromatography with tandem mass spectrometry (LC-MS) detection. The results showed that SWX was widely distributed in the rat body and could pass the blood-brain barrier.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2022)
Article
Nutrition & Dietetics
Yonghwan Jung, Jin Sook Song, Sunjoo Ahn
Summary: This study provides the first pharmacokinetic evaluation of succinic acid after a single dose in mice, demonstrating its clearance, volume of distribution, terminal half-life, as well as tissue distribution in different organs.
Article
Chemistry, Applied
Orhan Corum, Ertugrul Terzi, Duygu Durna Corum, Yigit Tastan, Ruby C. Gonzales, Osman Nezih Kenanoglu, Dan M. Arriesgado, Victor R. Navarro, Soner Bilen, Adem Yavuz Sonmez, Kamil Uney
Summary: The aim of this study was to investigate the pharmacokinetics of enrofloxacin (ENR) and its active metabolite ciprofloxacin (CIP) in Nile tilapia (Oreochromis niloticus) after intravascular (IV), intraperitoneal (IP), or oral (PO) administration. The results showed that ENR could be detected up to 120 h after treatment, indicating its potential efficacy against infections caused by susceptible bacteria in tilapia.
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2022)
Article
Agriculture, Multidisciplinary
Yue Li, Teng Wang, Hao-Hao Shi, Yu-Ming Wang, Chang-Hu Xue, Qing-Rong Huang, Tian-Tian Zhang
Summary: Sea cucumber-derived sulfated sterols showed more significant bioactivities due to the unique structure of the sulfate group, but their absorption, pharmacokinetics, and tissue distribution remain unknown. This study investigated the absorption characteristics, pharmacokinetics, and tissue distribution of sea cucumber sterols, finding that they are absorbed quickly and mainly accumulate in the liver. These results provide insights for the development of functional foods and nutraceuticals containing sea cucumber sterols.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Tehmina Bibi, Shahar Bano, Fakhar ud Din, Hussain Ali, Salman Khan
Summary: In this study, oral Honokiol-loaded solid lipid nanoparticles (SLNs) were formulated and characterized to enhance bioavailability and to evaluate their effectiveness in experimental diabetic neuropathy (DN). The study found that Honokiol-SLNs provided better neuroprotection in DN due to higher oral bioavailability.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)