Article
Pharmacology & Pharmacy
Mohammed Amran, El-Sayed Khafagy, Hatem Mokhtar, Sawsan A. Zaitone, Yasser M. Moustafa, Shadeed Gad
Summary: This study established a simple method to produce additive-free triamcinolone acetonide (TAA) microspheres suitable for pulmonary delivery. The results indicated that additive-free spray-dried TAA microspheres were promising for treating lung diseases.
Article
Materials Science, Coatings & Films
A. Gutierrez-Perez, M. T. Ayala-Ayala, A. G. Mora-Garcia, B. Moreno-Murguia, H. Ruiz-Luna, J. Munoz-Saldana
Summary: This study reports on the deposition of visible-light photoactive thermally sprayed coatings using spray-dried NBT microspheres. The optimization of spray drying and sintering processes allowed for the production of NBT microspheres suitable for flame spray deposition. The resulting heterojunction of NBT with TiO2 formed by the flame spray process showed a direct band gap of 1.93 eV, making it an excellent combination for visible light photoactive applications.
SURFACE & COATINGS TECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Priyanka Biswas, Debasis Sen, Meenu Prasher, Sudip Kumar Sarkar, Kinshuk Dasgupta
Summary: In this study, well-defined powder micro-granules with interstitial nanopores were achieved through one-step evaporative jamming of colloidal silica particles in contact-free spray droplets. The anomalous freezing behavior of confined water in these microspheres synthesized using spray drying was investigated, revealing a significant lowering of the freezing point to around -45 degrees C due to the confinement effect. The results from thermoporometry were supported by structural details obtained through gas adsorption measurements and small-angle x-ray scattering.
Review
Food Science & Technology
Ruchi Sharma, Ali Rashidinejad, Seid Mahdi Jafari
Summary: The alteration in human micro-flora leads to an increase in pathogenic bacteria, causing gastrointestinal diseases. Supplementing food products with probiotics can eliminate pathogenic bacteria and stimulate specific genes to regulate immune response. Spray drying bacteria is a sustainable method that allows bulk production and improved resistance through encapsulation in protective matrices.
FOOD AND BIOPROCESS TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Mirella Miranko, Judit Toth, Andrea Fodor-Kardos, Krisztina Moricz, Antal Balazs Szenes-Nagy, Attila Gacsi, Tamas Spaits, Janos Gyenis, Tivadar Feczko
Summary: Levocetirizine dihydrochloride microparticles were prepared using nano spray-drying technology, resulting in a topical gel with high active ingredient content and small particle size. The addition of menthol enhanced the penetration of levocetirizine in the skin.
Article
Pharmacology & Pharmacy
Patricia Henriques, Ana Fortuna, Slavomira Doktorovova
Summary: Powders for nasal delivery have advantages over liquids and can be manufactured by spray drying. This review provides an overview of nasal powder formulation and processing, with a focus on the variables that impact on performance.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Zitong Shao, Waiting Tai, Yingshan Qiu, Rico C. H. Man, Qiuying Liao, Michael Y. T. Chow, Philip C. L. Kwok, Jenny K. W. Lam
Summary: This study developed an inhaled dry powder formulation of capreomycin targeting the lung using spray drying technique, showing promising pharmacokinetic performance with sustained drug concentration in the lungs. Compared to intravenous injection, inhaled capreomycin exhibited superior pharmacokinetics in both the lungs and plasma, indicating its potential as a more effective treatment option for MDR-TB.
Article
Pharmacology & Pharmacy
Jiajia Jin, Jun Chen, Xin Shou, Keqing Shi, Xingjie Zan, Yan Zu, Xiaoying Huang
Summary: Monoammoniuma Glycyrrhizinate is a promising alternative to antibiotics for treating acute lung injury and combating antibiotic resistance. However, its limited clinical use is attributed to poor water solubility and potential adverse reactions from high dosage administration. To address these issues, we have developed inhalable microspheres using electrostatic spray technology that enable slow release of the drug in the lungs, exhibiting smooth surface and good biocompatibility. Animal testing shows that the MAG-encapsulated microspheres group has the best treatment effect and may modulate the LPS-activated Nuclear Factor signaling pathway. This therapeutic strategy holds great potential for precise drug delivery to the lungs and provides a more effective approach to treating pulmonary diseases.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Applied
Alberto Baldelli, Diana Yumeng Liang, Yigong Guo, Anubhav Pratap-Singh
Summary: Iron fortification through spray-dried microparticles can alleviate iron deficiency. The optimal formulation consists of equal weight percentages of iron compound, bulk material, and wall material, resulting in small particle size and high bioavailability. Encapsulation of iron gluconate reduces toxicity, while encapsulated iron fumarate decreases absorption.
FOOD HYDROCOLLOIDS
(2023)
Article
Food Science & Technology
Alberto Baldelli, Simon Wells, Anubhav Pratap-Singh
Summary: Different types of zinc compounds were successfully encapsulated using spray drying technique, with specific formulations showing high bioavailability. The ratios between different components were found to affect zinc bioavailability, highlighting the importance of ingredient selection and ratios. These encapsulated zinc microcapsules have potential applications in food fortification for treating iron deficiency.
FOOD AND BIOPROCESS TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Mellissa Gomez, Joseph McCollum, Hui Wang, Mani Ordoubadi, Chester Jar, Nicholas B. Carrigy, David Barona, Isobel Tetreau, Michelle Archer, Alana Gerhardt, Chris Press, Christopher B. Fox, Ryan M. Kramer, Reinhard Vehring
Summary: This study aimed to develop a stable inhalable dry powder vaccine for respiratory infectious diseases like tuberculosis. Results showed that different additives in the formulations had varying effects on the stability and aerosol performance of the vaccine, providing important insights for vaccine preparation.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Richard Schutzman, Nian-Qiu Shi, Karl F. Olsen, Rose Ackermann, Jie Tang, Ya-Yuan Liu, Justin K. Y. Hong, Yan Wang, Bin Qin, Anna Schwendeman, Steven P. Schwendeman
Summary: Spray-dried poly(lactic-co-glycolic acid) (PLGA) peptide-loaded microspheres have similar long-term in vitro release kinetics, but the difficult-to-control initial burst release is an obstacle to product development. This study investigates the mechanism and extent of the initial burst release using various formulations and techniques.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Food Science & Technology
Prajya Arya, Pradyuman Kumar
Summary: Fenugreek seeds contain an important compound called diosgenin, which has impressive health benefits. Diosgenin is bitter in taste, but through spray drying and the use of maltodextrin and whey protein concentrate as wall materials, the bitterness can be masked. The optimal conditions for spray drying were determined, and encapsulated diosgenin powder with improved properties was successfully produced.
Article
Chemistry, Multidisciplinary
Francyelle Calegari, Isabel Sousa, Mario G. S. Ferreira, Marcos A. C. Berton, Claudia E. B. Marino, Joao Tedim
Summary: Sodium carboxymethylcellulose (CMC-Na) microparticles containing corrosion inhibitor benzotriazole (BTA) were successfully prepared using spray drying processing parameters. The study found that the inlet temperature and spray flow rate significantly affected the release properties and process yields of the microparticles.
APPLIED SCIENCES-BASEL
(2022)
Article
Biotechnology & Applied Microbiology
Vanda Sargautiene, Darius Sargautis, Anton Podjava, Ida Jakobsone, Vizma Nikolajeva
Summary: The feasibility of integrating oat beta-glucan dried by freeze drying and spray drying into a synbiotic formulation with Akkermansia muciniphila was investigated. The study found that oat beta-glucan can effectively function as prebiotic substrates in a synbiotic composition, promoting the growth and fermentation process of A. muciniphila.
FERMENTATION-BASEL
(2023)