Article
Biophysics
Xiao Ma, Caihong Yang, Ruirui Zhang, Jie Yang, Yan Zu, Xin Shou, Yongxiang Zhao
Summary: A novel natural biomass-based hydrogel microparticle was developed using microfluidic electrospray technology. The microparticles showed enhanced chemotherapy effect, inhibited tumor growth, and exhibited good biocompatibility and sustained drug release.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Seungyeon Lee, Jihye Lee, Kanghyun Choi, Hyoseon Kim, Youngkum Park, Juhee Yoon, June Hyun Kim, Seongwoo Ryu
Summary: Coated-type microneedles were developed for direct delivery of hispidin to the skin, enhancing skin permeability and showing various activities such as antioxidant, anti-inflammatory, and antimicrobial effects. The system demonstrated potential as a prototype platform for more effective subcutaneous delivery of vaccines, oligonucleotides, insulin, and cosmetic applications.
APPLIED SCIENCES-BASEL
(2021)
Review
Chemistry, Multidisciplinary
Ying Wei, Yaxin Deng, Shuting Ma, Meixin Ran, Yannan Jia, Jia Meng, Fei Han, Jingxin Gou, Tian Yin, Haibing He, Yanjiao Wang, Yu Zhang, Xing Tang
Summary: Periodontitis is a common chronic inflammatory disease affecting nearly 60% of the global population, leading to significant oral health issues. Local drug delivery systems (LDDS) show promise as an adjunctive therapy to traditional treatments, offering higher efficacy and fewer side effects in the management of periodontitis.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Polymer Science
Se Min Kim, Madhumita Patel, Rajkumar Patel
Summary: Core-shell particles are well known for their unique structure and promising biomedical applications. PLGA, an FDA-approved polymer, is recognized as a vehicle material for drug delivery systems based on these particles. These systems are utilized for cancer therapy and tissue regeneration, particularly bone, cartilage, and periodontal regeneration.
Article
Medicine, Research & Experimental
Ningrong Chen, Rongguo Ren, Xin Wei, Roshni Mukundan, Guojuan Li, Xiaoke Xu, Gang Zhao, Zhifeng Zhao, Subodh M. Lele, Richard A. Reinhardt, Dong Wang
Summary: SIM is an effective anti-inflammatory and bone anabolic agent, but challenges including poor water solubility hinder its local delivery into periodontal pockets. Researchers developed a novel thermoresponsive hydrogel based on PF127 to dissolve SIM and mitigate periodontal bone loss.
MOLECULAR PHARMACEUTICS
(2021)
Article
Engineering, Biomedical
Lu Wang, Yuzhou Li, Mingxing Ren, Xu Wang, Lingjie Li, Fengyi Liu, Yiqing Lan, Sheng Yang, Jinlin Song
Summary: This study designed a novel dual responsive and dual drug-loading nanocarrier system for precise and controlled drug delivery to treat periodontitis in patients with diabetes. In vitro and in vivo studies confirmed the effectiveness of this nanocarrier, which can inhibit the formation of subgingival microbial colonies and promote osteogenic differentiation of cells, ameliorating periodontal bone resorption.
BIOACTIVE MATERIALS
(2022)
Article
Cell Biology
Ziba Naghizadeh, Akbar Karkhaneh, Hanieh Nokhbatolfoghahaei, Saeed Farzad-Mohajeri, Maryam Rezai-Rad, Mohammad M. Dehghan, Pouyan Aminishakib, Arash Khojasteh
Summary: An injectable hydrogel/microparticle system containing melatonin and methylprednisolone was developed for chondrogenesis in vitro and in vivo. The system showed promising results in promoting cartilage regeneration, with improved properties and gene expression when loaded with cells. Overall, the study demonstrated the potential of the developed system for cartilage regeneration.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Tara Shabab, Onur Bas, Bronwin L. Dargaville, Akhilandeshwari Ravichandran, Phong A. Tran, Dietmar W. Hutmacher
Summary: This study combines melt-extrusion based 3D printing and porogen leaching to develop tunable multiphasic scaffolds for dental tissue regeneration. The scaffolds are highly adjustable in terms of mechanical properties, degradation kinetics, and surface morphology. The research also demonstrates improved cell attachment, proliferation, and extracellular matrix production on these multiscale scaffolds compared to single-scale counterparts, indicating their potential for enhanced tissue regeneration. Furthermore, the study explores the use of these scaffolds as drug delivery devices and shows that sustained drug release can be achieved. These findings strongly support further development of these scaffolds for dental tissue regeneration applications.
Article
Materials Science, Multidisciplinary
Azin Rashidy Ahmady, Kavoos Razmjooee, Vida Nazar, Saeed Saber-Samandari
Summary: This study compared alginate microparticles and nanoparticles as thymol delivery systems. The results showed that thymol-loaded alginate nanoparticles released thymol in a more sustainable and controllable manner, and both carriers exhibited good cell viability and antibacterial properties.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Chuanhui Song, Xiangyi Wu, Yu Wang, Jinglin Wang, Yuanjin Zhao
Summary: Inspired by the behavior of cuttlefish expelling ink, this study developed thermal-responsive melanin-integrated porous microparticles for periodontitis treatment. These microparticles can release melanin nanoparticles under near-infrared irradiation, exhibiting antibacterial activity and anti-inflammatory properties, demonstrating promising therapeutic effects.
Article
Pharmacology & Pharmacy
Faiza Hasan, Rahila Ikram, Abeer Ade, Afshan Abbas, Qurrat Ul Ain Bukhari, Kamran Asadullah
Summary: The idea of local drug delivery system is increasingly popular for treating periodontal diseases, providing an easy method to reduce gingivitis and periodontitis while minimizing side effects of oral drugs. The use of Chlorhexidine gel has been found effective in lowering plaque formation and the system allows the drug to retain in the periodontal pocket for prolonged periods.
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Polymer Science
Mohammed Ahmad Wsoo, Saiful Izwan Abd Razak, Shafinaz Shahir, Hafedh Ahmed Abdullah Al-Moalemi, Mohammed Rafiq Abdul Kadir, Nadirul Hasraf Mat Nayan
Summary: The study successfully developed an IDDS composed of CA and PCL nanofibers, with the PCL membrane playing a crucial role in enhancing the mechanical properties of the implant and drug release kinetics.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2021)
Article
Biophysics
Yin Xiao, Yuhong Gu, Li Qin, Lin Chen, Xiaoliang Chen, Weiheng Cui, Fuling Li, Ni Xiang, Xiaoai He
Summary: Injectable thermosensitive hydrogel is an attractive drug delivery system that has become increasingly important in cancer therapy due to its ability to provide high local drug concentration, sustained release, minimal invasiveness, and low systemic toxicities. This review highlights its extensive application in local cancer therapy, including chemotherapy, photothermal therapy, photodynamic therapy, gene therapy, chemo-photothermal combined therapy, and chemo-/immuno- combined therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Chemistry, Physical
Daorun Hu, Congkai Zhang, Chao Sun, Haijing Bai, Jialiang Xie, Yawen Gu, Mengyuan Li, Junkai Jiang, Aiping Le, Jiaxuan Qiu, Xiaolei Wang
Summary: This study developed a near-infrared light-responsive nano-drug delivery system based on carvacrol, which has antibacterial, anti-inflammatory, and immunoregulatory capacities, showing great promise in the clinical practice of periodontitis.
Article
Dentistry, Oral Surgery & Medicine
Markus Reise, Stefan Kranz, Andre Guellmar, Ralf Wyrwa, Tobias Rosenbaum, Juergen Weisser, Aileen Jurke, Matthias Schnabelrauch, Markus Heyder, David C. Watts, Bernd W. Sigusch
Summary: The aim of this study was to prepare resorbable polylactide fibers for periodontitis treatment using coaxial electrospinning, and to optimize the release of metronidazole (MNA) by reducing the initial burst effect. The results showed that the coaxial electrospun mats exhibited a retarded drug release compared to conventional fibers, and had a significantly higher antibacterial effect. The biocompatibility test also demonstrated that the coaxial mats had higher numbers of vital cells. These findings suggest that coaxial electrospun fibers can be potential drug delivery systems for local periodontitis treatment.