Review
Infectious Diseases
Susanna Esposito, Giacomo Biasucci, Andrea Pasini, Barbara Predieri, Gianluca Vergine, Antonella Crisafi, Cristina Malaventura, Luca Casadio, Marcello Sella, Luca Pierantoni, Claudia Gatti, Letizia Paglialonga, Chiara Sodini, Claudio La Scola, Luca Bernardi, Giovanni Autore, Giulia Dal Canto, Alberto Argentiero, Sante Cantatore, Martina Ceccoli, Alessandro De Fanti, Agnese Suppiej, Marcello Lanari, Nicola Principi, Andrea Pession, Lorenzo Iughetti
Summary: Febrile urinary tract infection (UTI) is a common and serious bacterial illness in children. Early effective antibiotic treatment is essential, but antibiotic resistance is increasing, making it more difficult to choose the best therapy. Efforts to reduce and rationalize antibiotic consumption, as well as antibiotic stewardship, are important in limiting the emergence of resistance.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2022)
Article
Microbiology
Monika Wanke-Rytt, Tomasz Sobierajski, Dominika Lachowicz, Dominika Seliga-Gasior, Edyta Podsiadly
Summary: Urinary tract infections (UTIs) are common in both outpatients and hospitalized patients. This study analyzed the resistance patterns and prevalence of uropathogens causing UTIs in pediatric patients at a teaching hospital in Warsaw from 2020 to 2022. E. coli, Klebsiella spp., and Enterococcus spp. were the most frequently isolated species. Resistance to certain antibiotics was observed, while carbapenems, nitrofurantoin, and fosfomycin showed low resistance. Monitoring infection trends is crucial for controlling and limiting bacterial resistance.
Article
Pediatrics
Yasmina Dejonckheere, Stefanie Desmet, Noel Knops
Summary: This study retrospectively analyzed the prevalence of uropathogens in hospitalized children with febrile UTIs between 2000 and 2019, and found an increasing trend of antimicrobial resistance in Escherichia coli. This trend was observed not only in children with risk factors, but also in the general population, highlighting a significant problem.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Infectious Diseases
Laura Belmont-Monroy, Rosa Maria Ribas-Aparicio, Edgar Gonzalez-Villalobos, Jose Alejandro Perez-Ramos, Gerardo Aparicio-Ozores, Carlos A. Eslava-Campos, Ulises Hernandez-Chinas, Alejandra Aquino-Andrade, Jose Luis Balcazar, Jose Molina-Lopez
Summary: This study characterized uropathogenic Escherichia coli strains isolated from patients with community-acquired urinary tract infections. The majority of these pathogenic strains belonged to specific phylogenetic groups, with the main uropathogenic serogroups being O8, O25, and O75. These strains showed high resistance to multiple antibiotics and carried various virulence genes associated with adhesion, iron acquisition, toxins, and pathogenicity-associated islands.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Infectious Diseases
Stephanie Larramendy, Aurelie Gaultier, Jean-Pascal Fournier, Jocelyne Caillon, Leila Moret, Francois Beaudeau
Summary: The prevalence of ESBL-producing E. coli in community-acquired UTI varies significantly worldwide, and in this study, various anthropogenic factors were found to be associated with the local ESBL-E. coli rate, providing useful information for improving risk management.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Microbiology
S. J. Ryan Arends, Deborah Butler, Nicole Scangarella-Oman, Mariana Castanheira, Rodrigo E. Mendes
Summary: The in vitro activities of gepotidacin against a large collection of Escherichia coli and Staphylococcus saprophyticus strains, including those resistant to other standard-of-care antibiotics, were determined. Gepotidacin exhibited potent activity, inhibiting the majority of isolates at low concentrations.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Infectious Diseases
Kanit Assawatheptawee, Pornpit Treebupachatsakul, Taradon Luangtongkum, Pannika R. Niumsup
Summary: This study found that being a farmer is an independent risk factor for MDRE-associated CA-UTIs, and the first report of mcr-9-positive Enterobacter cloacae from a Thai patient in the community.
Article
Microbiology
Funke F. Assouma, Haziz Sina, Tomabu Adjobimey, Agossou Damien Pacome Noumavo, Akim Socohou, Bawa Boya, Ange D. Dossou, Lauriane Akpovo, Basile Boni Saka Konmy, Jacques F. Mavoungou, Adolphe Adjanohoun, Lamine Baba-Moussa
Summary: The study aimed to characterize the resistance profile and virulence of Enterobacteriaceae strains causing urinary tract infections (UTIs) in Benin. A total of 390 UTI urine samples were collected, and Enterobacteriaceae strains were identified and tested for antibiotic susceptibility, biofilm production, and ESBL production. Multiplex PCR was used to detect uro-virulence genes. The results revealed a high prevalence of Enterobacteriaceae strains, with E. coli being the most frequently isolated species.
Article
Infectious Diseases
Leah J. Toombs-Ruane, Jonathan C. Marshall, Jackie Benschop, Dragana Drinkovi, Anne C. Midwinter, Patrick J. Biggs, Zoe Grange, Michael G. Baker, Jeroen Douwes, Mick G. Roberts, Nigel P. French, Sara A. Burgess
Summary: This study aimed to assess whether having a pet in the home is a risk factor for community-acquired urinary tract infections associated with extended-spectrum β-lactamase (ESBL)-or AmpC β-lactamase (ACBL)-producing Enterobacterales. Through telephone questionnaire and logistic regression analysis, it was found that pet ownership was not associated with ESBL-or ACBL-producing Enterobacterales-related urinary tract infections, while the main risk factors included recent antimicrobial treatment, travel to Asia in the previous year, and a doctor's visit in the last 6 months.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Pediatrics
Mohammed A. Alsubaie, Abdullah Z. Alsuheili, Mohammed N. Aljehani, Abdulrahman A. Alothman, Abdulaziz S. Alzahrani, Hamza A. Mohammedfadel, Abeer A. Alnajjar
Summary: This study evaluated demographics, clinical characteristics, risk factors, and antibiotic resistance of pediatric community-acquired UTIs caused by ESBL-producing and non-ESBL-producing uropathogens. It was found that renal abnormalities and male gender were independent risk factors for ESBL UTIs.
PEDIATRICS INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Adeline Paumier, Antoine Asquier-Khati, Sonia Thibaut, Thomas Coeffic, Olivier Lemenand, Stephanie Larramendy, Brice Leclere, Jocelyne Caillon, David Boutoille, Gabriel Birgand
Summary: This cross-sectional study found that the occurrence of community-acquired ESBL E coli UTI is associated with multiple human health, animal health, and environmental factors, including the proportion of children, overcrowded households, consumption of fluoroquinolones and tetracyclines, and poultry density.
Article
Infectious Diseases
Rohan M. Shah, Shan Sun, Emily Shteynberg, Tonya Scardina, Grant Whitmer, Sameer J. Patel
Summary: Younger age, Medicaid insurance, emergency department visits, and convenient care settings are associated with longer antibiotic therapy duration. Medical residents and fellows are less likely to administer long durations.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2022)
Review
Infectious Diseases
Giovanni Autore, Luca Bernardi, Filippo Ghidini, Claudio La Scola, Alberto Berardi, Giacomo Biasucci, Federico Marchetti, Andrea Pasini, Maria Elena Capra, Claudia Castellini, Vera Cioni, Sante Cantatore, Andrea Cella, Francesca Cusenza, Alessandro De Fanti, Elisa Della Casa Muttini, Margherita Di Costanzo, Alessandra Dozza, Claudia Gatti, Cristina Malaventura, Luca Pierantoni, Giovanni Parente, Gabriella Pelusi, Serafina Perrone, Laura Serra, Francesco Torcetta, Enrico Valletta, Gianluca Vergine, Francesco Antodaro, Andrea Bergomi, Jennifer Chiarlolanza, Laura Leoni, Franco Mazzini, Roberto Sacchetti, Agnese Suppiej, Lorenzo Iughetti, Andrea Pession, Mario Lima, Susanna Esposito
Summary: Low-dose continuous antibiotic prophylaxis (CAP) is commonly used to prevent urinary tract infections (UTIs) in children, but its efficacy is controversial. This systematic review found that CAP has a limited role in preventing UTI recurrences and complications in children, while also posing a risk of emerging antimicrobial resistances.
Article
Immunology
Mohamed Kettani Halabi, Fatima Azzahra Lahlou, Idrissa Diawara, Younes El Adouzi, Rabiaa Marnaoui, Rachid Benmessaoud, Imane Smyej
Summary: ESBL-EC infections pose challenges due to limited treatment options, increased hospital costs, reduced microbiological and clinical responses, and a threat to patient's life. Majority of ESBL-EC isolates were from female adult patients over 50, resistant to third-generation cephalosporins and quinolones, but sensitive to carbapenems and fosfomycin.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Hui Zhang, Ge Zhang, Yang Yang, Jingjia Zhang, Dongxue Li, Simeng Duan, Qiwen Yang, Yingchun Xu
Summary: The study details the antibiotic resistance trends of Klebsiella pneumoniae causing urinary tract infections and intra-abdominal infections in China between 2014 and 2017, showing an overall increase in resistance rates, especially in hospital-acquired infections.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Hematology
Marion Lenglet, Florence Robriquet, Klaus Schwarz, Carme Camps, Anne Couturier, David Hoogewijs, Alexandre Buffet, Samantha J. L. Knight, Sophie Gad, Sophie Couve, Franck Chesnel, Mathilde Pacault, Pierre Lindenbaum, Sylvie Job, Solenne Dumont, Thomas Besnard, Marine Cornec, Helene Dreau, Melissa Pentony, Erika Kvikstad, Sophie Deveaux, Nelly Burnichon, Sophie Ferlicot, Mathias Vilaine, Jean-Michael Mazzella, Fabrice Airaud, Celine Garrec, Laurence Heidet, Sabine Irtan, Elpis Mantadakis, Karim Bouchireb, Klaus-Michael Debatin, Richard Redon, Stephane Bezieau, Brigitte Bressac-de Paillerets, Bin Tean Teh, Francois Girodon, Maria-Luigia Randi, Maria Caterina Putti, Vincent Bours, Richard VanWijk, Joachim R. Goethert, Antonis Kattamis, Nicolas Janin, Celeste Bento, Jenny C. Taylor, Yannick Arlot-Bonnemains, Stephane Richard, Anne-Paule Gimenez-Roqueplo, Holger Cario, Betty Gardie
Review
Oncology
Elpis Mantadakis, Eleftherios Chatzimichael, Eftychia Kontekaki, Maria Panopoulou, Georges Martinis, Aggelos Tsalkidis
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
(2019)
Review
Dermatology
Elpis Mantadakis, Zoe Dorothea Pana, Theoklis Zaoutis
Editorial Material
Oncology
Elpis Mantadakis
PEDIATRIC BLOOD & CANCER
(2018)
Editorial Material
Immunology
Elpis Mantadakis, Athanassios Tragiannidis
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2019)
Review
Hematology
Elpis Mantadakis, Eleftherios Chatzimichael, Panagiota Zikidou
MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES
(2020)
Review
Microbiology
Elpis Mantadakis
Review
Pediatrics
Paraskevi Panagopoulou, Sonia Alexiadou, Maria Ntoumpara, Anna Papazoglou, Alexandros Makis, Athanasios Tragiannidis, Maria Fotoulaki, Elpis Mantadakis
Summary: This study investigated the safety of using FCM in children with iron deficiency and/or iron deficiency anemia. The results showed that FCM had a good safety profile in children, supported by both the patient cohort and the literature review.
Editorial Material
Pediatrics
Elpis Mantadakis
JOURNAL OF PEDIATRICS
(2022)
Review
Oncology
Ioannis Kyriakidis, Elpis Mantadakis, Eftichia Stiakaki, Andreas H. Groll, Athanasios Tragiannidis
Summary: Targeted therapies in children with hematological malignancies have been shown to moderate the effects of cytotoxic therapy and are being used in combination with or after the failure of conventional chemotherapy. However, the impact of these therapies on the compromised immune system and the risk of infections is not yet fully understood. Further research is needed to determine the mechanisms and safety profiles of these targeted agents in pediatric patients.
Review
Hematology
Elpis Mantadakis, Paraskevi Panagopoulou, Eftychia Kontekaki, Zoe Bezirgiannidou, Georges Martinis
Summary: This review aims to raise awareness about the association of blood donation with iron deficiency, and provides methods for its prevention and management. Iron deficiency without anemia and iron deficiency anemia are common consequences of regular blood donation, especially in younger people, females, and high-intensity donors. Blood donation screening can help identify donors with iron deficiency anemia, but often fails to detect iron deficiency without anemia. Measures such as limiting blood volume collected, screening and deferral of donors with iron deficiency, prolonging interdonation intervals, and iron supplementation can help prevent and manage iron deficiency. However, there are risks and limitations associated with blood testing and iron supplementation. It is crucial to intensify educational efforts to increase physicians' awareness of blood donation as a primary cause of iron deficiency.
JOURNAL OF BLOOD MEDICINE
(2022)
Review
Infectious Diseases
Dimitra Dimopoulou, Elpis Mantadakis, Christos Koutserimpas, George Samonis
Summary: Dalbavancin is a promising treatment option for bone and joint infections, offering a good safety profile and high bactericidal activity. Clinical studies have shown its non-inferiority compared to conventional therapies in BJI and the potential to shorten hospitalization. However, further research is needed to evaluate its role in children.
Article
Medicine, General & Internal
Maria Nivatsi, Ilona Aslanidou, Elpis Mantadakis
Summary: Cyclic vomiting syndrome is a debilitating gastrointestinal disorder without evidence-based guidelines for treatment, but medications like ondansetron and aprepitant may be effective. Futuring studies are needed to assess the efficacy of different treatment options.
Article
Pediatrics
Elpis Mantadakis, Panagiota Zikidou, Emmanouela Tsouvala, Stavros Thomaidis, Athanassios Chatzimichael
TURKISH JOURNAL OF PEDIATRICS
(2019)
Article
Medicine, General & Internal
Elpis Mantadakis, Chrysostomos Soultanidis, Athanasia Christidou, Sofia Maraki