Article
Immunology
Chih-Hsien Chuang, Rajendra Prasad Janapatla, Yi-Hsin Wang, Hsin-Ju Chang, Chyi-Liang Chen, Cheng-Hsun Chiu
Summary: It was found that infants had a higher gut colonization rate of Pseudomonas aeruginosa than children. Among patients with P. aeruginosa-associated diarrheal diseases, children with blood group A and Le(a+b+) phenotype were more prone to the disease.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2023)
Article
Multidisciplinary Sciences
Li Li, Zuxian Xu, Ruipin Cao, Jiaxin Li, Chang-Jer Wu, Yinglu Wang, Hu Zhu
Summary: We investigated the influence of hydroxyl groups on the anti-quorum-sensing (anti-QS) and anti-biofilm activity of cyclic dipeptides against Pseudomonas aeruginosa PAO1. The presence of hydroxyl groups improved the inhibition of virulence factors and cytotoxicity, but reduced the ability to inhibit biofilm formation. These cyclic dipeptides interacted with the QS-related protein LasR, and the introduction of hydroxyl groups enhanced their self-assembly ability.
Article
Biochemistry & Molecular Biology
Markus Kraemer, Ann-Kathrin Kissmann, Heinz Fabian Raber, Hu Xing, Patrizia Favella, Ingrid Muller, Barbara Spellerberg, Tanja Weil, Dennis Kubiczek, Susanne Sihler, Ulrich Ziener, Frank Rosenau
Summary: Systemic blood stream infections are increasing worldwide, with Pseudomonas aeruginosa being a major multi-resistant pathogen of concern. Early diagnosis of sepsis significantly improves survival chances in septicemia patients. The use of affinity materials like aptamer-functionalized beads for specific pathogen binding in blood shows promising potential for fast and reliable diagnosis of bloodstream infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Chao Wang, Jingjing Zhou, Lili Wang, Tongyu Xing, Hongji Dai, Yao Zhou, Lisha Qi, Yanrui Zhao, Caiyun Huang, Ding Li, Haixin Li, Mulin Jun Li, Ben Liu, Hong Zheng, Kexin Chen, Lian Li
Summary: Blood group A is associated with increased risk of epithelial ovarian cancer (EOC) in Chinese women. Immunohistochemistry results show a higher frequency of aberrant expression of histo-blood group antigens in patients with blood group A, and ABO gene expression is down-regulated in ovarian tumor tissues. In addition, ABO gene expression is positively correlated with NFYB and inversely correlated with DNA methylation level of specific CpG sites on ABO gene in ovarian tumor tissues.
Article
Chemistry, Multidisciplinary
Zhaofei Guo, Yining Zhu, Guangsheng Du, Ming Qin, Chunting He, Penghui He, Yuanshuai Song, Wenfei Chen, Shuting Bai, Fuhua Wu, Nan Qiao, Min Jiang, Xianjin Luo, Yuandong Zhang, Tao Gong, Zhirong Zhang, Xun Sun
Summary: This study reports a facile strategy for the rapid development of a highly effective cross-protective Pseudomonas aeruginosa vaccine. By loading cytosolic antigens derived from bacterial lysates into mesoporous silica nanospheres and fusing membrane antigens onto the surface, the engineered nano-vaccines induced potent humoral and cellular immune responses and protected against different strains of Pseudomonas aeruginosa infection.
Review
Hematology
Salah Elsherif, Ali Zidan, Olivia Saville, Maha Othman
Summary: Cancer-associated thrombosis, especially venous thromboembolism, is associated with ABO blood groups, with non-O blood type and increased VWF levels showing a strong correlation with increased VTE risk. However, there are varying results in different studies and more research is needed to understand the role of ABO blood groups and other risk factors in different cancer types.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2023)
Article
Immunology
Jhansi L. Leslie, Erin Weddle, Lauren K. Yum, Ye Lin, Matthew L. Jenior, Benjamin Lee, Jennie Z. Ma, Beth D. Kirkpatrick, Uma Nayak, James A. Platts-Mills, Herve F. Agaisse, Rashidul Haque, William A. Petri
Summary: The study revealed that infants lacking the Lewis histo-blood group antigen are more susceptible to shigellosis. Inhibition of fucosylation in epithelial cells in vitro was found to decrease invasion by Shigella flexneri, indicating a role for fucosylated glycans in susceptibility to shigellosis.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Eman NasrEldin, Safaa A. A. Khaled, Nada O. Abdelhameed, Maha Atwa, Marwa M. Thabet, Khalid I. Elsayh, Sahar A. Elgammal
Summary: The study compared genotyping with phenotyping of non-ABO erythrocyte antigens in patients with Mediterranean hemopathic syndromes (MHS) and found significant discrepancies and mixed field results in patients undergoing transfusion therapy. The results suggest that molecular typing is a powerful tool for pre-transfusion testing in chronically transfused MHS patients.
Article
Immunology
Christy Tabarani, Carol J. Baker
Summary: Pseudomonas aeruginosa is a rare cause of early-onset sepsis in neonates, especially among infants without identifiable risk factors. We report the first case, to our knowledge, of P. aeruginosa early-onset sepsis in a term infant with no identifiable risk factor and propose that maternal healthcare occupation could predispose to gastrointestinal/genital colonization with this potential pathogen.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Article
Microbiology
Xu Yang, Anwarul Haque, Shigenobu Matsuzaki, Tetsuya Matsumoto, Shigeki Nakamura
Summary: The study investigated the use of bacteriophage KPP10 for treating Pseudomonas aeruginosa-induced pneumonia in mouse models. Results showed that phage treatment significantly improved survival rate, reduced bacterial count and inflammation, suggesting the potential of phage therapy for P. aeruginosa lung infections.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Moon Young Oh, Haeryoung Kim, Nam-Joon Yi, Suyoung Hong, Jeong-Moo Lee, Sola Lee, Suk Kyun Hong, YoungRok Choi, Kwang-Woong Lee, Kyung-Suk Suh
Summary: This study found that the expression of dABOAg decreased over time in ABOi ALDLT, but patients with early rejection showed sustained expression. Therefore, dABOAg expression may be involved in the accommodation mechanism in ABOi transplantation.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Pathology
Asmaa El-Heneidy, Catherine Cheung, Stephen B. Lambert, Claire Y. T. Wang, David M. Whiley, Peter D. Sly, Robert S. Ware, Keith Grimwood
Summary: This study found no association between HBGA phenotype and RV5 vaccine virus shedding in Australian infants.
Article
Public, Environmental & Occupational Health
Taikan Nanao, Hideo Nishizawa, Junichi Fujimoto
Summary: This study aimed to clarify the epidemiological data and examine whether the detection rate of multidrug-resistant (MDR) bacteria differed depending on the presence or absence of the risk of MDR bacterial infections. The study found that MDR bacteria are unlikely to be detected in patients without the risk of MDR bacterial infections, suggesting the use of empiric narrow-spectrum antimicrobial therapy for such patients.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2023)
Article
Gastroenterology & Hepatology
Cliff A. Magwira, Duncan Steele, M. L. Seheri
Summary: The study found that harboring high levels of histo-blood group antigen-expressing Enerobactero cloacae is a risk factor for norovirus diarrhea. Infants with norovirus diarrhea had significantly higher counts of E. cloacae compared to non-diarrheic infants, and harboring higher counts of E. cloacae poses a significant risk for norovirus diarrhea.
Article
Critical Care Medicine
Theis S. Itenov, Daniel I. Sessler, Ashish K. Khanna, Sisse R. Ostrowski, Par I. Johansson, Christian Erikstrup, Ole B. Pedersen, Sofie L. Rygard, Lars B. Holst, Morten H. Bestle, Lars Hein, Anne Lindhardt, Hami Tousi, Mads H. Andersen, Thomas Mohr, Jens D. Lundgren, Jens-Ulrik Jensen
Summary: The study aimed to determine if ABO blood types carry different risks of 30-day mortality, AKI, and endothelial damage in critically ill patients with sepsis. Results showed that patients with blood type B had lower 30-day mortality risk and less endothelial damage compared to those with blood type A, with no significant difference in the risk of AKI.
ANNALS OF INTENSIVE CARE
(2021)
Article
Immunology
Mindy Ming-Huey Guo, Ying-Hsien Huang, Feng-Sheng Wang, Ling-Sai Chang, Kuang-Den Chen, Ho-Chang Kuo
Summary: CD36 plays a crucial role in the immunopathogenesis of Kawasaki disease by clearing plasma mitochondrial DNA and amplifying the immune response via the AIM2 pathway. Additionally, the expression level of CD36 is associated with the development of coronary artery lesions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Ying-Hsien Huang, Kuang-Den Chen, Kuang-Che Kuo, Mindy Ming-Huey Guo, Ling-Sai Chang, Ya-Ling Yang, Ho-Chang Kuo
Summary: This study focused on suppressed genes in the acute stage of Kawasaki disease (KD) and identified novel targets with clinical significance and potential prognostic value. By analyzing human transcriptome arrays, the researchers identified CDR2 as a suppressed gene in KD and found that DDX24 is associated with CAL formation.
Article
Health Care Sciences & Services
Liang-Jen Wang, Chia-Yu Yang, Ho-Chang Kuo, Wen-Jiun Chou, Ching-Shu Tsai, Sheng-Yu Lee
Summary: This study aimed to examine the effects of probiotics supplements using Bifidobacterium bifidum (Bf-688) on patients with attention-deficit/hyperactivity disorder (ADHD) and their gut microbiomes. The results showed that the Bf-688 supplement improved clinical symptoms and weight gain in ADHD children, and significantly altered the composition of their gut microbiota.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Pediatrics
Mindy Ming-Huey Guo, Kuender D. Yang, Shih-Feng Liu, Ho-Chang Kuo
Summary: The study found that non-pharmaceutical interventions during the COVID-19 pandemic can not only prevent transmissible viral infections, but also reduce the risk of Kawasaki disease.
Article
Pediatrics
Ya-Ling Yang, Ho-Chang Kuo, Kuang-Den Chen, Chi-Hsiang Chu, Kuang-Che Kuo, Mindy Ming-Huey Guo, Ling-Sai Chang, Ying-Hsien Huang
Summary: A novel predictor using the hemoglobin-for-age z-score and plasma hepcidin has been developed to differentiate Kawasaki disease from febrile children. This predictor shows a better discriminatory ability and can assist front-line physicians in recognizing and providing early treatment for Kawasaki disease.
Article
Biochemistry & Molecular Biology
Ling-Sai Chang, Kuang-Den Chen, Ying-Hsien Huang, Ho-Chang Kuo
Summary: This study investigated the marker expression of eosinophilic subtypes in patients with Kawasaki disease (KD) and found that after 6 months of treatment, the expression of SELL in KD patients was significantly higher than in febrile controls. Additionally, KD patients with coronary artery lesions (CAL) exhibited higher SELL expression levels before treatment compared to those without CAL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Tsung-Hsun Yang, Po-Cheng Chen, Yun-Chung Lin, Yan-Yuh Lee, Yu-Hsuan Tseng, Wen-Hsin Chang, Ling-Sai Chang, Chia-Hsuan Lin, Ho-Chang Kuo
Summary: Adolescents with atopic dermatitis have lower exercise capacity and exercise volume, and lack negative feelings towards inactivity and self-confidence to plan regular exercise independently. Therefore, encouraging regular indoor exercise for these adolescents is necessary.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Shih-Feng Liu, Hui-Chuan Chang, Jui-Fang Liu, Ho-Chang Kuo
Summary: This study analyzed the impact of the COVID-19 pandemic on population mobility and found that the Alpha variant affected more individuals, with the population visits in transit locations being most impacted.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Psychology, Developmental
Liang-Jen Wang, Sung-Chou Li, Yuan-Ming Yeh, Sheng-Yu Lee, Ho-Chang Kuo, Chia-Yu Yang
Summary: This study used high-throughput sequencing to explore the dysbiosis of the gut mycobiome in children with ADHD. The results showed that ADHD patients had abnormal fungal community composition and increased abundance of Candida, especially Candida albicans. The in vitro cell assay also demonstrated that C. albicans secretions enhanced intestinal permeability.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2023)
Article
Pediatrics
Ya-Ling Yang, Jung-Chan Chang, Shu-Chen Ho, Chien-Ning Yeh, Ho-Chang Kuo
Summary: This study examines the correlation between exposure to general anesthesia under three years old and the subsequent course of asthma in children. The study found that the incidence of asthma onset was significantly reduced in children with exposure to general anesthesia under three years old. Furthermore, regardless of the timing of asthma onset, patients with general anesthesia exposure had fewer clinical visits than those without exposure.
Article
Pediatrics
Sheng-Yu Lee, Sung-Chou Li, Chia-Yu Yang, Ho-Chang Kuo, Wen-Jiun Chou, Liang-Jen Wang
Summary: This study investigated the role of gut leakage biomarkers in the susceptibility of ADHD. The results showed that DEFA1 levels were significantly lower in ADHD group compared to the healthy control group. There was no significant difference in serum levels of zonulin and occludin. DEFA1 levels were negatively correlated with inattention scores, while occludin levels were positively correlated with detectability subtest scores. This study provides new insights into the relationship between gut leakage markers and cognition, advancing research on the pathophysiology of ADHD.
Article
Pediatrics
Ling-Sai Chang, Ying-Hsien Huang, Hsin-Yu Chang, Zon-Min Lee, Wei-Ling Feng, Ho-Chang Kuo
Summary: This study analyzed the specific IgE levels against food and inhalant allergens in patients with Kawasaki disease (KD). The results suggested a correlation between specific IgE and the age at KD diagnosis and the basophils in KD patients. Further prospective studies are needed to clarify the unique profile of specific IgE in KD patients.
Editorial Material
Pediatrics
Ying-Hsien Huang, Ho-Chang Kuo
Review
Chemistry, Medicinal
Ho-Chang Kuo, Kuang-Den Chen, Ping-Chia Li
Summary: Molecular hydrogen is considered a promising treatment option for stroke management, with its antioxidant, anti-inflammatory, and antiapoptotic functions. It can be administered through inhalation of hydrogen gas, intravenous or intraperitoneal injection of hydrogen-enriched solution, or drinking hydrogen-enriched water.
CHEMICAL RESEARCH IN TOXICOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ho-Chang Kuo
Summary: This review article discusses several important aspects of Kawasaki disease (KD) diagnosis and management. It highlights the limitations of current diagnostic methods based on clinical criteria and suggests the need for updates to account for atypical cases. The review also compares KD with Multisystem Inflammatory Syndrome in Children (MIS-C) associated with COVID-19 and explores the potential role of new diagnostic methods and treatment approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)