Article
Pharmacology & Pharmacy
Brandi N. Williamson, Lizzette Perez-Perez, Benjamin Schwarz, Friederike Feldmann, Myndi G. Holbrook, Manmeet Singh, Diane S. Lye, Darius Babusis, Raju Subramanian, Elaine Haddock, Atsushi Okumura, Patrick W. Hanley, Jamie Lovaglio, Catharine M. Bosio, Danielle P. Porter, Tomas Cihlar, Richard L. Mackman, Greg Saturday, Emmie De Wit
Summary: This study demonstrates that early subcutaneous administration of remdesivir can reduce the risk of lower respiratory tract disease caused by SARS-CoV-2 infection.
ANTIVIRAL RESEARCH
(2022)
Article
Virology
Raphael Wolfisberg, Kenn Holmbeck, Eva Billerbeck, Caroline E. Thorselius, Mariana N. Batista, Ulrik Fahnoe, Emma A. Lundsgaard, Matthew J. Kennedy, Louise Nielsen, Charles M. Rice, Jens Bukh, Troels K. H. Scheel
Summary: The lack of robust immunocompetent animal models for hepatitis C virus (HCV) hinders vaccine development and studies of immune responses. Norway rat hepacivirus (NrHV) infection in rats shares HCV-defining characteristics, and through adaptation to laboratory mice, specific determinants of NrHV mouse adaptation were identified. These findings provide valuable insights into species-specific interactions during HCV entry.
JOURNAL OF VIROLOGY
(2023)
Article
Veterinary Sciences
Chengzhi Yu, Yayu Huang, Xin Ren, Leqiang Sun
Summary: In this study, antiviral active ingredients were extracted from medicinal and edible plants to prepare a drug called Ren's oligopeptide through biotransformation and enzymatic hydrolysis. The analysis showed that Ren's oligopeptide could inhibit the replication of influenza virus and SARS-CoV-2 virus with high antiviral activities. In vitro experiments demonstrated that the antiviral activity of Ren's oligopeptide mainly targeted the replication process after virus enters the cell. Therefore, Ren's oligopeptide is a promising drug against influenza and COVID-19.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Review
Virology
Charles J. Russell
Summary: Genetically diverse influenza A viruses circulate in wild aquatic birds, causing outbreaks, epidemics, and pandemics in various species. Studies show that the stability of the HA surface glycoprotein can modulate host range, replication, pathogenicity, and transmissibility of the virus.
Review
Virology
Mostafa Javanian, Mohammad Barary, Sam Ghebrehewet, Veerendra Koppolu, VeneelaKrishnaRekha Vasigala, Soheil Ebrahimpour
Summary: Influenza is an acute viral respiratory infection that affects all age groups and is associated with high mortality. Vaccination is the most effective method for prevention, but antiviral drugs are also available for treatment.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Antoine Guillon, Deborah Brea-Diakite, Adeline Cezard, Alan Wacquiez, Thomas Baranek, Jerome Bourgeais, Frederic Picou, Virginie Vasseur, Lea Meyer, Christophe Chevalier, Adrien Auvet, Jose M. Carballido, Lydie Nadal Desbarats, Florent Dingli, Andrei Turtoi, Audrey Le Gouellec, Florence Fauvelle, Amelie Donchet, Thibaut Crepin, Pieter S. Hiemstra, Christophe Paget, Damarys Loew, Olivier Herault, Nadia Naffakh, Ronan Le Goffic, Mustapha Si-Tahar
Summary: Research has shown that influenza virus infection causes significant changes in lung metabolism, leading to the accumulation of succinate in respiratory fluids. Succinate exhibits powerful antiviral activity by inhibiting influenza virus replication and reducing metabolic disruptions and inflammatory responses. Administering succinate intranasally to mice reduces viral loads in the lungs and improves survival rates. The antiviral mechanism involves succinylation of viral nucleoproteins, which alters their interactions with viral RNA.
Article
Chemistry, Medicinal
Yejin Jang, Jinhe Han, Xiaoli Li, Hyunjin Shin, Won-Jea Cho, Meehyein Kim
Summary: Influenza viruses are major pathogens causing respiratory infections in humans. A newly discovered isoquinolone compound showed potential in inhibiting influenza A and B viruses, but exhibited cytotoxic effects. Through chemical optimization, compound 21 was developed with improved antiviral activity and reduced cytotoxicity.
Article
Biochemistry & Molecular Biology
Ming-Feng He, Jian-Hui Liang, Yan-Ni Shen, Chao-Wei Zhang, Kuang-Yang Yang, Li-Chu Liu, Qian Xie, Chun Hu, Xun Song, Yan Wang
Summary: This study screened Chinese herbs for their ability to activate human immunity and identified coptisine as a potent inhibitor of the influenza virus. Pre-treatment with coptisine was more effective at reducing viral replication than co-treatment or post-treatment. Coptisine upregulated the p21 signaling pathway in MDCK cells and inhibited MELK activity directly.
Article
Microbiology
Paulina Koszalka, Ankita George, Vijaykrishna Dhanasekaran, Aeron C. Hurt, Kanta Subbarao
Summary: Combination therapy with influenza drugs baloxavir and oseltamivir can reduce the selection of viruses with reduced drug susceptibility. In animal models, combination therapy and monotherapy have similar effectiveness in reducing viral titers, but combination therapy can decrease the selection of viruses with reduced susceptibility to baloxavir.
Article
Nutrition & Dietetics
Weimin Guo, Dayong Wu, Lijun Li, Samuel Ding, Simin Nikbin Meydani
Summary: Obesity may contribute to impaired immune function and increased susceptibility to infection.
FRONTIERS IN NUTRITION
(2022)
Review
Virology
Yaqin Bai, Jeremy C. Jones, Sook-San Wong, Mark Zanin
Summary: Hemagglutinin and neuraminidase are critical parts of influenza viruses, serving as targets for immune response and antiviral drugs. Neuraminidase inhibitors like oseltamivir are commonly used against influenza, while antivirals targeting hemagglutinin are newer with a higher resistance threshold.
Review
Virology
Ralph A. Tripp, David E. Martin
Summary: Viral replication and transmissibility are the main causes of endemic and pandemic disease threats. Broad-spectrum antiviral agents are needed. The most common respiratory viruses are coronaviruses, respiratory syncytial viruses, and influenza viruses. Probenecid has been shown to be safe and effective in limiting the replication of influenza A virus and SARS-CoV-2, as well as inhibiting RSV replication in vitro and in vivo.
Article
Biochemistry & Molecular Biology
Yuqiang Zhang, Yunpeng Dai, Jiaxin Wang, Yan Xu, Zhe Li, Jinfeng Lu, Yongfen Xu, Jin Zhong, Shou-Wei Ding, Yang Li
Summary: The entry of virus-derived small-interfering RNAs (vsiRNAs) into the bloodstream through extracellular vesicles (EVs) is a mechanism for systemic antiviral RNA interference (RNAi) in mice. Vaccination with a live-attenuated virus deficient in RNAi suppression induces the production of stable vsiRNAs that confer protective immunity against virus infection.
Article
Medicine, Research & Experimental
Won-Kyung Cho, Jin Yeul Ma
Summary: Epimedium koreanum Nakai (EKN) has shown significant inhibitory effects on influenza A virus infection by directly blocking viral attachment and having a virucidal effect. It can potentially be developed as a natural viral inhibitor against influenza virus infection.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Virology
Huimin Cheng, Liangbing Fu, Xia Yang, Yujian Yang, Zhening Zhang, Yuan Tao, Junting Wan, Zhengchao Tu, Jianxin Chen, Yingjun Li
Summary: This study explores the screening and identification of 3-aryl-quinolin-2-one derivatives as a novel class of antiviral agents. The derivatives were synthesized using an efficient copper-catalyzed reaction cascade. The most potent compound 34 exhibited IC50 values of 2.14 and 4.88 μM against H3N2 and H1N1 strains, respectively, without cytotoxicity on MDCK cells. The findings suggest the potential of these compounds as novel anti-influenza agents.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Biochemical Research Methods
Myung-Jin Mun, Joon-Yong Bae, Jin Hyuck Kim, Soo Bok Kim, Ilseob Lee, Jin Il Kim, Mee Sook Park, Man-Seong Park, Yong Suk Nam
MOLECULAR AND CELLULAR PROBES
(2019)
Article
Biochemistry & Molecular Biology
Jin Il Kim, Sehee Park, Hyuk Chu, Ilseob Lee, Joon-Yong Bae, Kirim Yoo, Juwon Kim, Joo-Yeon Lee, Namju Lee, Miseon Kim, Jun-Sub Kim, Kyung Wook Hong, Kyung Ran Jun, Jeong Nyeo Lee, Kisoon Kim, Man-Seong Park
MOLECULAR PHYLOGENETICS AND EVOLUTION
(2019)
Article
Virology
Jin Il Kim, Sangmoo Lee, Gong Yeal Lee, Sehee Park, Joon-Yong Bae, Jun Heo, Hong-Youb Kim, Seok-Hun Woo, Hae Un Lee, Chung Am Ahn, Hye Jin Bang, Hyun Soo Ju, Kiwon Ok, Youngjoo Byun, Dae-Jin Cho, Jae Soo Shin, Dong-Yeon Kim, Mee Sook Park, Man-Seong Park
JOURNAL OF VIROLOGY
(2019)
Article
Biochemistry & Molecular Biology
Jin Il Kim, Sehee Park, Joon-Yong Bae, Sunmi Lee, Jeonghun Kim, Gayeong Kim, Kirim Yoo, Jun Heo, Yong Seok Kim, Jae Soo Shin, Mee Sook Park, Man-Seong Park
Article
Infectious Diseases
Changmin Kang, Jin Il Kim, Jungmin Lee, Seongman Bae, Min Jae Kim, Ki-Joon Song, Jin-Won Song, Sung-Han Kim, Man-Seong Park
Summary: Among various rodent-borne hantaviruses, Seoul orthohantavirus (SEOV) is a significant cause of haemorrhagic fever with renal syndrome (HFRS) globally. A case study in Korea in 2019 demonstrated the importance of accurately distinguishing SEOV from other HFRS-causing hantaviruses, as misdiagnosis can lead to incorrect treatment. Next-generation sequencing technology proved crucial in identifying the specific hantavirus strain in the patient's serum, highlighting the need for accurate and timely diagnosis to prevent unnecessary medical costs.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Joon-Yong Bae, Gee Eun Lee, Heedo Park, Juyoung Cho, Jeonghun Kim, Jungmin Lee, Kisoon Kim, Jin Il Kim, Man-Seong Park
Summary: The novel coronavirus has caused widespread devastation since its outbreak, with limited access to vaccines and treatments. The anticancer drug pralatrexate shows promising efficacy against SARS-CoV-2, potentially offering a valuable repurposed treatment option for COVID-19.
BIOMOLECULES & THERAPEUTICS
(2021)
Review
Biochemistry & Molecular Biology
Jaehwan You, Jong Hyeon Seok, Myungsoo Joo, Joon-Yong Bae, Jin Il Kim, Man-Seong Park, Kisoon Kim
Summary: The most effective way to control emerging infectious diseases such as the SARS-CoV-2 pandemic is to strengthen preventative or therapeutic public health strategies before global spread. While social distancing and symptomatic therapy are crucial, understanding the molecular properties of SARS-CoV-2 infection and the viral entry process can pave the way for effective therapeutics and vaccines.
BIOMOLECULES & THERAPEUTICS
(2021)
Review
Immunology
Joon-Yong Bae, Jin Il Kim, Mee Sook Park, Gee Eun Lee, Heedo Park, Ki-Joon Song, Man-Seong Park
Summary: The zoonotic transmission of orthohantaviruses from rodent reservoirs to humans has caused severe fatalities, with vaccines approved only in China and Korea. The relative lack of urgency in orthohantavirus vaccine development has been attributed to few cases outside China and Korea, but the continuous evolution of the virus in hosts may render current vaccines less effective against new variants. Therefore, the need for a more effective vaccine against orthohantaviruses is emphasized.
Article
Virology
Jin Il Kim, Kwangsook Park, Hyunho Shin, Soo Min Choi, Ki-Joon Song
Summary: This study investigated the prevalence of parvoviruses in wild Manchurian chipmunks in South Korea and found a high detection rate of chipmunk parvovirus (ChpPV) in various organs of the captured specimens. The ChpPV sequence showed a close relationship with primate parvoviruses, erythroviruses, and bovine parvovirus.
Article
Infectious Diseases
Atanas V. Demirev, Heedo Park, Kyuyoung Lee, Sejik Park, Joon-Yong Bae, Man-Seong Park, Jin Il Kim
Summary: This study investigated the molecular evolution and phylodynamics of avian and human-isolated H5Nx viruses. The H5Nx lineages expanded since 2000 and diverged into sublineages with unique genetic mutations. Certain mutations in the HA gene of human-isolated viruses may contribute to H5 evolution and host adaptation. Positive selection was observed in certain amino acid sites of the HA gene in clades 2.3.4.1-4. Accumulated mutations in the HA protein may affect the genetic and antigenic diversity of H5Nx viruses and their compatibility with NA subtypes. Early detection of HA mutations and comprehensive assessment of H5Nx variants are important for pandemic preparedness.
TRANSBOUNDARY AND EMERGING DISEASES
(2023)
Article
Virology
Kyeongseok Jeon, Hyo-Jin Ro, Jun-Gu Kang, Da-Eun Jeong, Joowan Kim, Yebeen Lee, Ga-Yeon Yoon, Ju-Il Kang, Joon-Yong Bae, Jin Il Kim, Man-Seong Park, Keun Hwa Lee, Hyun-Soo Cho, Yuri Kim, Nam-Hyuk Cho
Summary: SFTS is an emerging tick-borne disease with high mortality in Eastern Asia. The study found significant differences in viral replication and virulence between two Korean isolates, and identified the viral RNA-dependent RNA polymerase (RdRp) as the key factor responsible for these differences.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Infectious Diseases
Kyuyoung Lee, Jong Hyeon Seok, Hyunbeen Kim, Sejik Park, Sohyun Lee, Joon-Yong Bae, Kyeongseok Jeon, Jun-Gu Kang, Jeong Rae Yoo, Sang Taek Heo, Nam-Hyuk Cho, Keun Hwa Lee, Kisoon Kim, Man-Seong Park, Jin Il Kim
Summary: This study investigated the molecular evolution and genetic reassortment of severe fever with thrombocytopenia syndrome virus (SFTSV). The results highlight the importance of SFTSV surveillance at the molecular level to fight against the virus.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Article
Multidisciplinary Sciences
Atanas V. Demirev, Kyuyoung Lee, Joon-Yong Bae, Heedo Park, Sejik Park, Hyunbeen Kim, Jungmin Lee, Junhyung Cho, Jeong-Sun Yang, Kyung-Chang Kim, Joo-Yeon Lee, Kisoon Kim, Philippe Lemey, Man-Seong Park, Jin Il Kim
Summary: In this study, the molecular evolution of SARS-CoV-2 in South Korea was characterized using a large number of genomic sequences. The variants in South Korea originated from globally identified variants of concern and showed genetic mutations mainly around the N-terminal domain (NTD) or receptor binding domain (RBD) in the spike protein. Positive selection of point mutation residues in key antigenic sites was observed with changing genetic clades of SARS-CoV-2. Genomic recombination was also detected, with some variants retaining mosaic genomes in the NTD or RBD. These findings suggest that point mutations and genomic recombination in the spike protein have contributed to the molecular evolution of SARS-CoV-2 in South Korea.
Review
Medicine, Research & Experimental
Mee Sook Park, Jin Il Kim, Joon-Yong Bae, Man-Seong Park
LABORATORY ANIMAL RESEARCH
(2020)
Article
Veterinary Sciences
Jin Il Kim, Sehee Park, Joon-Yong Bae, Man-Seong Park
JOURNAL OF VETERINARY SCIENCE
(2019)