Review
Geology
Samanta Serra-Varela, Nemesio Heredia, Raul Giacosa, Joaquin Garcia-Sansegundo, Pedro Farias
Summary: Metamorphic rocks along the North Patagonian Andes were affected by two different Palaeozoic tectono-metamorphic events, leading to their classification into the Colohuincul Complex and the Cushamen Complex. By distinguishing these units, researchers aim to better understand the geodynamic evolution of the Gondwana southwestern margin during the Palaeozoic.
INTERNATIONAL GEOLOGY REVIEW
(2022)
Article
Ecology
M. Y. Shah, Mohammad Sadiq, K. K. Ayemi, A. Dharwadkar, S. K. Roy
Summary: The Brattnevet Peninsula in Larsemann Hills consists of metamorphosed acidic rocks, sedimentary rocks, and basic igneous suite dating back to 920-478 Ma, with three phases of deformation and metamorphism. The study reveals a clockwise P-T path and suggests that crustal evolution in the Larsemann Hills area started during the Grenvillian Orogeny and was influenced by the Pan-African orogenic event.
Article
Geosciences, Multidisciplinary
Maria Di Rosa, E. Sanita, C. Frassi, J. M. Lardeaux, M. Corsini, M. Marroni, L. Pandolfi
Summary: This study presents the first P-T-d-t path for the Alpine Corsica's Lower Units, specifically the Tenda Massif representing fragments of the European continental margin involved in the east-dipping Alpine subduction. New thermobarometric data and 40Ar/39Ar dating of syn-kinematic muscovite were used to determine the P-T conditions and age of metamorphism of the Venaco Unit in Alpine Corsica's southernmost sector. The results show that the Venaco Unit reached its maximum pressure at approximately 33 km depth, and was later exhumed to a shallower level at around 26 km depth during the Priabonian period, suggesting fast exhumation unlike the stationary Tenda Massif.
GEOLOGICAL JOURNAL
(2023)
Article
Geology
D. Patias, L. F. Cury, F. M. Faleiros, M. Calderon, S. Siga Jr, T. Theye
Summary: The study reveals a clockwise Pressure-Temperature-time metamorphic evolution in the Paranagua Terrane and compares it with other tectonic belts, showing contrasting metamorphic evolutions between South America and Africa during West Gondwana assembly. The Paranagua Terrane experienced three tectonometamorphic stages, with the first two associated with collisional processes and the third with post-collisional processes. This dataset provides insights into the evolution of southwest Gondwana units.
INTERNATIONAL GEOLOGY REVIEW
(2021)
Article
Geology
Jeremie Soldner, Pavla Stipska, Karel Schulmann, Chao Yuan, Robert Anczkiewicz, Yingde Jiang, Marta Koziarska, Le Zhang, Yunying Zhang, Xinyu Wang
Summary: In this study, the P-T-t-D paths of Early Palaeozoic HP granulite facies rocks from the Dunhuang block in northwest China were investigated to understand the tectonic setting and geodynamic evolution of a modern hot orogenic system. The results revealed the different tectonic environments and metamorphic evolution processes between the granulites and migmatitic metapelites, providing important insights into the dynamics of active margin settings.
JOURNAL OF METAMORPHIC GEOLOGY
(2023)
Article
Geosciences, Multidisciplinary
Augusto F. Morosini, Eliel Enriquez, Alina M. Tibaldi, Juan M. Peron Orrillo, Eber A. Cristofolini, Damian A. Manchento, Diego S. Pagano, Andres O. Carugno Duran, Joshua J. Schwartz, Juan E. Otamendi, Ariel E. Ortiz Suarez
Summary: The Nogoli Metamorphic Complex, located in the western Sierras Pampeanas of San Luis, is an important geological area for understanding the construction of the western Gondwana margin in South America. This study presents new petrological and geochronological data to assess the age and origin of the protoliths in order to shed light on their geodynamic evolution. The findings support a ridge-trench collision as the most plausible explanation for the origin of the Pampean orogeny, contrary to previous models invoking continent-continent collision in western Gondwana during the early Cambrian.
INTERNATIONAL JOURNAL OF EARTH SCIENCES
(2023)
Article
Geology
Shah Wali Faryad, Josef Jezek, Jan Kulhanek
Summary: This study presents the petrological observations and diffusion modelling results of garnet from high-pressure to ultrahigh-pressure metamorphic rocks in the Western Gneiss Region. The results reveal the evolution of Pre-Caledonian granulite facies and Caledonian eclogite facies metamorphic events in these rocks, with preservation of compositional gradients and relaxation processes. Calculations indicate a pressure of up to 2.6 GPa and a temperature of 650 degrees C during the eclogite facies event. The study also provides insights into the cooling rate and exhumation rate of the rocks during their geological history.
JOURNAL OF METAMORPHIC GEOLOGY
(2022)
Article
Geosciences, Multidisciplinary
C. Casquet, C. Ramacciotti, M. A. Larrovere, S. Verdecchia, J. Murra, E. G. Baldo, R. J. Pankhurst, C. W. Rapela
Summary: A regional tectonometamorphic event during the Silurian period in NW Argentina and the Precordillera has been identified, with distinct characteristics in three domains. Despite its regional significance, the importance of this event has been overlooked until now. No Cordilleran-type magmatism of this age has been recorded in the study area.
JOURNAL OF SOUTH AMERICAN EARTH SCIENCES
(2021)
Article
Geochemistry & Geophysics
Ines Pereira, Emilie Bruand, Christian Nicollet, Kenneth T. Koga, Alberto Vitale Brovarone
Summary: This study investigates the natural occurrence and chemistry of Ti-bearing minerals in gabbroic rocks and basalts that record different degrees of metamorphism. It is found that rutile is stable at lower pressure in ocean-floor amphibole-bearing gabbros than previously thought, and can be chemically distinguished from LP rutile. Titanite, instead of rutile, is stable in blueschist metagabbros from the Western Alps and eclogitic metabasalts from Corsica. These findings can be useful for studying the HP metamorphic record using detrital Ti-bearing minerals.
JOURNAL OF PETROLOGY
(2023)
Article
Geochemistry & Geophysics
Liang-Peng Deng, Yi-Can Liu, Chiara Groppo, Franco Rolfo, Yang Yang, Xiao-Feng Gu, An-Dong Wang
Summary: Deciphering the P-T-t path of ultrahigh-pressure rocks is crucial for reconstructing the evolution of continental crustal terranes involved in very deep subduction followed by exhumation. This study focuses on the migmatitic North Dabie complex Zone (NDZ) in the Dabie-Sulu orogenic belt of central-eastern China, integrating P-T pseudosection modeling, geothermometry, zircon U-Pb dating, and trace element analysis to constrain the ages and metamorphic stages of the eclogites in the NDZ. The results provide new P-T-t estimates and age data, contributing to precisely reconstruct the whole P-T-t path of the NDZ.
Article
Geosciences, Multidisciplinary
Stefania Radice, Alfonso M. Sola, M. Natalia Maffini, Fernando J. D'Eramo, Roberto F. Weinberg, Lucio P. Pinotti, Manuel Demartis, Jorge E. Coniglio, M. Alejandra Boffadossi, Eugenia Muratori
Summary: The study utilized U-Pb dating of zircon, monazite and apatite to constrain the tectono-thermal evolution of the footwall in the Guacha Corral shear zone, revealing major anatexis around 475 million years ago. The footwall reached upper greenschist facies conditions around 400 million years ago, with a cooling rate of -3-4°C/Ma during retrogression. This cooling process was temporally related to the waning of the Famatinian Orogeny during the Early Devonian, and late motion on the shear zone facilitated fluid influx for retrogression of the footwall.
JOURNAL OF SOUTH AMERICAN EARTH SCIENCES
(2021)
Article
Geochemistry & Geophysics
Drazen Balen, Hans-Joachim Massonne
Summary: The metamorphic sole of the Jurassic Krivaja-Konjuh ultramafic massif in central Bosnia and Herzegovina consists mainly of garnet amphibolites and pargasite amphibolites, with different P-T paths indicating distinct formation histories. The rocks formed during intra-oceanic subduction, with pargasite amphibolites cooling by subducting oceanic crust and garnet amphibolites exhumed in a subduction channel before coming in contact with the former.
Article
Geosciences, Multidisciplinary
Laixi Tong, Chao Li, Zhao Liu, Mingguo Zhai, Wuxian Li
Summary: Recent investigations in the Longyou paragneiss in the Wuyi-Yunkai orogen of South China revealed the presence of high-pressure metamorphic phengites, indicating an Early Palaeozoic high-pressure metamorphic event during continent-continent collisional orogeny. This study suggests a typical collisional orogenic process in the region, with peak high-pressure metamorphic conditions followed by post-peak retrograde conditions. The SIMS zircon U-Pb age data support the metamorphic age of the Longyou garnet amphibolite and suggest a continent-continent collision likely occurred along the Zhenghe-Dapu fault.
JOURNAL OF ASIAN EARTH SCIENCES
(2021)
Article
Mathematics, Applied
Jianzhang Wu, Jiabin Yuan, Haci Mehmet Baskonus, Wei Gao
Summary: The existence of factor and fractional factor in network graph in various settings has garnered significant attention. This implies the availability of data transmission and network segmentation in specific scenarios. The paper focuses on the study of P-=2-factor and P-=3-factor, which are two special cases of the general H-factor. It investigates the existence of these path factors when certain subgraphs are forbidden and provides conclusions regarding network parameters such as factor-deleted graph, factor critical-covered graph, and factor uniform graph. The paper also demonstrates that these bounds are optimal in some sense.
JOURNAL OF FUNCTION SPACES
(2023)
Article
Geosciences, Multidisciplinary
Han Wang, Xu-Ping Li, Juergen Reinhardt, Fan-Mei Kong, Hans-Peter Schertl, Guang-Ming Sun
Summary: The Bushmanland Domain in the western Namaqua-Natal Metamorphic Province includes Paleoproterozoic to Mesoproterozoic intrusives and metamorphosed volcano-sedimentary supracrustal rocks. High-grade metamorphism is prevalent, with evidence of peak conditions reaching transitional to ultrahigh temperatures. The zircon and monazite geochronology reveals two distinct age groups, indicating both an older metamorphic cycle predating the established 1040-1020 Ma Namaquan cycle, and a Late Mesoproterozoic group confirming the similar to 1040-1020 Ma metamorphic age associated with the Namaquan orogeny.
PRECAMBRIAN RESEARCH
(2021)
Article
Endocrinology & Metabolism
Desiree Bartolini, Iva Arato, Francesca Mancuso, Daniela Giustarini, Catia Bellucci, Carmine Vacca, Maria Chiara Aglietti, Anna Maria Stabile, Ranieri Rossi, Gabriele Cruciani, Mario Rende, Riccardo Calafiore, Giovanni Luca, Francesco Galli
Summary: Melatonin (MLT) has a cytoprotective effect on porcine pre-pubertal Sertoli cells (SCs) against cadmium (Cd) toxicity, reducing oxidative stress and reductive stress by regulating Nrf2 activity.
JOURNAL OF PINEAL RESEARCH
(2022)
Article
Environmental Sciences
Marta Lazzaroni, Marino Vetuschi Zuccolini, Barbara Nisi, Jacopo Cabassi, Stefano Caliro, Daniele Rappuoli, Orlando Vaselli
Summary: The study investigates the water, suspended particulates, and stream sediments of a creek in a mining area in Italy. The results show high concentrations of mercury and arsenic, especially in the sediments. The study also calculates the total mass load of these toxic elements entering another creek.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Chemistry, Medicinal
Fang Xie, Mark Reid Groseclose, Sara Tortorella, Gabriele Cruciani, Stephen Castellino
Summary: In this study, MALDI IMS was used to map specific lipids in minipig skin, identifying lipid markers associated with sebaceous glands and hair follicles. Biochemical pathway analysis revealed potential drug-targeting strategies for reducing sebum overproduction. This research highlights the ability of MALDI IMS to link molecular distribution with both morphological features and physiological state in skin tissue, providing a basis for drug discovery and dermatological research.
Article
Pharmacology & Pharmacy
Laura Goracci, Arianna Loregian, Beatrice Mercorelli, Jenny Desantis, Marta Celegato, Alessandro Bazzacco, Lydia Siragusa, Paolo Benedetti, Michela Eleuteri, Federico Croci, Gabriele Cruciani
Summary: Two years after its emergence, SARS-CoV-2 still poses a serious global threat to human health. In this study, researchers used a virtual screening platform to identify new chemical scaffolds with potential as inhibitors of the SARS-CoV-2 main protease (M-pro). Several of these compounds exhibited antiviral activity against SARS-CoV-2 and other human coronaviruses in different cell lines. Time-of-addition experiments showed that these compounds had an antiviral effect during the viral replication cycle. By optimizing one of the hit compounds, the researchers obtained two potent SARS-CoV-2 inhibitors with increased activity against M-pro in vitro and in infected cells. This study significantly expands the chemical diversity of SARS-CoV-2 M-pro inhibitors and provides new scaffolds for pan-coronavirus antiviral drug development.
ANTIVIRAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Tommaso Palomba, Massimo Baroni, Simon Cross, Gabriele Cruciani, Lydia Siragusa
Summary: Proteolysis-targeting chimeras (PROTACs) are novel therapeutics that utilize E3 ligases to degrade target proteins. Existing databases on E3 ligases have limited information on their structures and ligands. This study presents an accurate and comprehensive platform, ELIOT, to navigate and select new E3 ligases and ligands for the design of new PROTACs.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Article
Biochemistry & Molecular Biology
Giulia D'Arrigo, Ida Autiero, Eleonora Gianquinto, Lydia Siragusa, Massimo Baroni, Gabriele Cruciani, Francesca Spyrakis
Summary: Nuclear receptors (NRs) are transcription factors that play an important role in multiple diseases and their intrinsic dynamics make them a challenging target in drug discovery. This study proposes a methodology based on the computation and comparison of protein cavities in NR structures to uncover their dynamic profile. This approach can guide research on NR intrinsic dynamics, aid in selecting reference structures for drug design, and facilitate the identification of alternative binding sites.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Lydia Siragusa, Gabriele Menna, Fabrizio Buratta, Massimo Baroni, Jenny Desantis, Gabriele Cruciani, Laura Goracci
Summary: The study utilizes a high-resolution and non-redundant database of protein cavities to identify similarities among SARS-CoV-2, SARS-CoV, and MERS-CoV, highlighting potential opportunities for multitarget therapy strategies.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2022)
Article
Biochemistry & Molecular Biology
Roberta Pacifico, Nunzio Del Gaudio, Guglielmo Bove, Lucia Altucci, Lydia Siragusa, Gabriele Cruciani, Menotti Ruvo, Rosa Bellavita, Paolo Grieco, Mauro F. A. Adamo
Summary: We have developed a synthetic method to produce two types of triazole compounds. Through virtual screening and experimental validation, one of the triazole compounds showed specific binding and inhibition towards KAT2A, laying the foundation for a new class of KAT2A inhibitors.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2022)
Article
Geology
Gabriele Cruciani, Lorenzo Dulcetta, Marcello Franceschelli, Chiara Frassi, Giovanni Musumeci
Summary: The Mt. Filau Orthogneiss is a part of the Sulcis Metamorphic Complex and shows signs of metamorphic peak and partial melting. The P-T conditions suggest the presence of a thermal anomaly in the foreland zone, possibly caused by the tectonic activity of the Tuerredda ductile shear zone.
ITALIAN JOURNAL OF GEOSCIENCES
(2022)
Article
Environmental Sciences
Marco Taussi, Caterina Gozzi, Orlando Vaselli, Jacopo Cabassi, Matia Menichini, Marco Doveri, Marco Romei, Alfredo Ferretti, Alma Gambioli, Barbara Nisi
Summary: In recent decades, global groundwater resources have faced significant deterioration due to nitrate pollution caused by agricultural fertilizers, manure, sewage, and untreated urban and industrial effluents. Surface and shallow reservoirs, which are crucial for supplying water to civil, agricultural, and industrial activities, are the most affected. The Metauro River plain in central Italy, along the Adriatic Sea coastline, is home to a strategic phreatic aquifer that, along with the river's surface water, provides water to the local population. This coastal aquifer has been contaminated by nitrates since the 1970s, with high pollution levels resulting from increased use of agricultural fertilizers. Local authorities have implemented remediation measures, including pumping NO3--poor waters from the river directly into the shallow aquifer. This study aims to analyze the nitrate contamination of this important water resource by examining its geochemical characteristics and temporal evolution between 2009 and 2020, using classical geochemical analyses and multivariate methods to assess the effectiveness of in-situ remediation.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Geosciences, Multidisciplinary
D. Fancello, S. Columbu, G. Cruciani, L. Dulcetta, M. Franceschelli
Summary: This paper presents the geological, archaeological, and touristic potential of the south-western coastal area of Sardinia, Italy. It proposes a seven-stage itinerary, describing and assessing each site based on its geology, archaeological sites, and touristic attractions. The study highlights the high potential and importance of this area for scientific, educational, and touristic purposes.
FRONTIERS IN EARTH SCIENCE
(2022)
Article
Geochemistry & Geophysics
Marco Taussi, Barbara Nisi, Andrea Brogi, Domenico Liotta, Martina Zucchi, Stefania Venturi, Jacopo Cabassi, Gabriele Boschi, Marika Ciliberti, Orlando Vaselli
Summary: High-temperature geothermal areas are influenced by regional faults, and the geochemical and isotopic signature of discharged fluids provides important information about the pathways and fluid-rock interaction in geothermal reservoirs. The study of the Larderello geothermal area and surroundings reveals the control of transfer and normal faults on geothermal circulation, including the influence of a cooling magmatic intrusion. The results suggest the presence of deep regional pathways and interaction with shallow aquifers in the peripheral zone emissions.
GEOCHEMISTRY GEOPHYSICS GEOSYSTEMS
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Desiree Bartolini, Daniela Giustarini, Giada Marcantonini, Ranieri Rossi, Anna Maria Stabile, Mario Rende, Antimo Gioiello, Linda Zatini, Antonella Mencacci, Gabriele Cruciani, Francesco Galli
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Kay Hemmings, Konstantino Prokopidis, Anna Migni, Antognelli Cinzia, Desiree Bartolini, Consuelo Borras, Gabriele Cruciani, Gabriele Di Sante, Marcantonini Giada, Cristina Mas Bargues, Roberto Modena, Anna Pedrinolla, Marta Piroddi, Alessandra Pistilli, Mario Rende, Federico Shena, Sebastiani Bartolomeo, Anna Maria Stabile, Nicola Talesa Vincenzo, Sara Tortorella, Massimo Venturelli, Jose Vina, Eivind Wang, Linda Zatini, Francesco Galli, Masoud Isanejad, Malcolm Jackson, Anne McArdle
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Engineering, Environmental
Franco Tassi, Paolo S. Garofalo, Filippo Turchetti, Davide De Santis, Francesco Capecchiacci, Orlando Vaselli, Jacopo Cabassi, Stefania Venturi, Stefano Vannini
Summary: This study focuses on the geochemical features of thermal and cold springs in the upstream portion of the Reno river basin in central-northern Italy. It investigates the sources of modern and fossil fluids, as well as the interactions between deep and shallow aquifers. The study suggests a genetic link between quartz-hosted paleofluid and thermal waters in the area.
ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
(2022)