Article
Physics, Applied
W. Milestone, Q. Hu, A. M. Loveless, A. L. Garner, R. P. Joshi
Summary: A distributed circuit approach was used to simulate the effects of voltage pulses on cell membrane potentials and poration dynamics, showing strong heating and power dissipation, increasing membrane temperature with successive pulses, and large temperature gradients.
JOURNAL OF APPLIED PHYSICS
(2022)
Article
Biochemistry & Molecular Biology
Sayak Bhattacharya, Mantas Silkunas, Emily Gudvangen, Uma Mangalanathan, Olga N. Pakhomova, Andrei G. Pakhomov
Summary: Electroporation, particularly with nanosecond pulses, is an efficient technique for creating nanometer-size membrane lesions without toxins. Membrane restoration involves both fast, calcium-independent resealing and slow, calcium-dependent processes. Additional calcium can advance resealing and reduce dye uptake, while blocking calcium does not prevent full membrane recovery.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2022)
Article
Chemistry, Multidisciplinary
David Roesel, Maksim Eremchev, Chetan S. Poojari, Jochen S. Hub, Sylvie Roke
Summary: A direct link between membrane potential fluctuations and divalent ion transport has been discovered, and it has been shown through molecular dynamics simulations and experimental results that pore formation induced by an ion-induced electrostatic field is a viable mechanism for unassisted ion transport.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Multidisciplinary Sciences
Md. Kabir Ahamed, Marzuk Ahmed, Mohammad Abu Sayem Karal
Summary: Electropermeabilization is a promising phenomenon that can rupture cells/vesicles using high-frequency pulsed electric fields. We quantified the required electric field values for the rupture of GUVs under different conditions, finding that the electric field necessary decreases with increased surface charge density but increases with increased cholesterol. Additionally, we observed the destabilization of GUVs under higher osmotic pressures.
Article
Oncology
Kitt Vestergaard, Mille Vissing, Julie Gehl, Christina Louise Lindhardt
Summary: Cutaneous metastases can significantly impact the quality of life of cancer patients, and calcium electroporation treatment can alleviate symptoms and improve health-related quality of life.
Article
Biophysics
Josette Zaklit, Gale L. Craviso, Normand Leblanc, P. Thomas Vernier, Esin B. Sozer
Summary: The cellular effects of nanosecond-pulsed electric field exposures can be attenuated by bipolar pulse cancellation using equal duration and amplitude positive and negative phases, with response restoration achieved through appropriate interphase intervals. The modulation of Ca2+ responses in neural-type cells with ultrashort pulses demonstrates the potential for using nanosecond bipolar pulse technologies for neuromodulation applications.
BIOPHYSICAL JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Paolo Marracino, Laura Caramazza, Maria Montagna, Ramin Ghahri, Marco D'Abramo, Micaela Liberti, Francesca Apollonio
Summary: Electroporation is a technique that enhances cell membrane permeability by inducing reversible membrane pores using an electric field. This study proposes a three-state kinetic model based on the mechanism of water defects intruding at the water/lipid interface under electric field intensities. The model, supported by robust statistical sampling, provides kinetic constants for transitions from an intact bilayer state to a hydrophobic pore state.
BIOELECTROCHEMISTRY
(2022)
Review
Environmental Sciences
Ilija Sazdovski, Alba Bala, Pere Fullana-i-Palmer
Summary: The paper reviewed and analyzed the relationship between circular economy and packaging waste, and provided recommendations for enhancing future scientific LCA development practices, such as considering all direct and indirect factors, simulating recycling scenarios to improve accuracy of recycling rate assessments, etc.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Engineering, Chemical
Miu Lun Lau, Nathan Linton, Jagoda Urban-Klaehn, Donna Post Guillen, Min Long
Summary: This study explores the effect of binder/zeolite type and weight percentages on the adsorption capacities and mechanical strength of zeolite for additive manufacturing applications. It is found that a certain ratio of binder/zeolite weight percentages can optimize the N2 adsorption capabilities. Furthermore, the addition of a binder alters the morphology of the zeolite and reduces the open-volume area significantly.
CHEMICAL ENGINEERING SCIENCE
(2023)
Article
Biochemical Research Methods
Md Habibur Rahman, Chung Hong Nathaniel Wong, Marianne M. Lee, Michael K. Chan, Yi-Ping Ho
Summary: By controlling membrane deformation in a microfluidic channel, a method to encapsulate protein payloads into red blood cells has been developed, leading to significantly increased loading efficiency and maintenance of enzymatic activity and membrane integrity. Compared to traditional osmotic entrapment, this shear-mediated encapsulation strategy offers key advantages.
Article
Green & Sustainable Science & Technology
Hailong Huo, Xunliang Liu, Zhi Wen, Guofeng Lou, Ruifeng Dou, Fuyong Su, Juan Fang, Zeyi Jiang
Summary: This study provides a comprehensive analysis of the environmental performance of CaC2 production in China using life cycle assessment. It finds that the semi-closed furnace process has a higher environmental load than the closed furnace process, with electricity supported by thermal power being the most sensitive factor. Developing sustainable scenarios and increasing the proportion of renewable power in the electric grid have obvious environmental benefits for CaC2 production.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Green & Sustainable Science & Technology
Suisui Zhang, Jingying Li, Gang Li, Yan Nie, Luyao Qiang, Boyang Bai, Xiaoxun Ma
Summary: This study conducted a life cycle assessment to evaluate the environmental impact of acetylene production methods in China. The partial oxidation method showed the best environmental performance under current electric power generation structure, but with increasing use of renewable energy, the plasma method will eventually have more advantages. The study aimed to compare these methods and provide reference for sustainable development of the acetylene industry in China.
JOURNAL OF CLEANER PRODUCTION
(2021)
Article
Construction & Building Technology
Shuyan Yang, B. Cansu Acarturk, Lisa E. Burris
Summary: This study tested the resistance to physical sulfate damage of various cementitious mixtures, finding that the incorporation of fly ash reduced cumulative pore volumes and slightly increased micropore sizes, leading to failure; the use of an air-entraining agent produced more, smaller, and more uniform pores without affecting the material's performance; both CSAB and air-entrained CSAB mixtures showed good resistance to physical sulfate damage.
CEMENT AND CONCRETE RESEARCH
(2022)
Article
Multidisciplinary Sciences
Chetan Aditya, Francois Bertaux, Gregory Batt, Jakob Ruess
Summary: Artificial microbial consortia utilize division-of-labour to optimize production. The authors have developed an optogenetic differentiation system in yeast to generate consortia from a single strain with tunable composition.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Physical
Yi Dong, Lei Fu, Junjie Song, Shan Zhang, Xiangyuan Li, Weihai Fang, Qiang Cui, Lianghui Gao
Summary: The study revealed that calcium ions have the highest binding affinity to a zwitterionic phospholipid bilayer, while magnesium and zinc ions' binding processes are exothermic and less preferred. Calcium ions release coordinated water upon binding, with less influence; while magnesium and zinc ions remain fully hydrated when interacting with lipids, making binding less favorable.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Meeting Abstract
Biophysics
Federica Castellani, Esin B. Sozer, P. Thomas Vernier
BIOPHYSICAL JOURNAL
(2019)
Article
Biochemistry & Molecular Biology
Esin B. Sozer, P. Thomas Vernier
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2019)
Review
Physics, Fluids & Plasmas
Martin Gundersen, P. Thomas Vernier, Stephen B. Cronin, Sanjana Kerketta
IEEE TRANSACTIONS ON PLASMA SCIENCE
(2020)
Article
Biochemistry & Molecular Biology
Nadica Ivosevic DeNardis, Galja Pletikapic, Ruza Frkanec, Lucija Horvat, P. Thomas Vernier
BIOELECTROCHEMISTRY
(2020)
Article
Biophysics
Esin B. Sozer, Sourav Haldar, Paul S. Blank, Federica Castellani, P. Thomas Vernier, Joshua Zimmerberg
BIOPHYSICAL JOURNAL
(2020)
Article
Biophysics
Josette Zaklit, Gale L. Craviso, Normand Leblanc, P. Thomas Vernier, Esin B. Sozer
Summary: The cellular effects of nanosecond-pulsed electric field exposures can be attenuated by bipolar pulse cancellation using equal duration and amplitude positive and negative phases, with response restoration achieved through appropriate interphase intervals. The modulation of Ca2+ responses in neural-type cells with ultrashort pulses demonstrates the potential for using nanosecond bipolar pulse technologies for neuromodulation applications.
BIOPHYSICAL JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Esin B. Sozer, Andrei G. Pakhomov, Iurii Semenov, Maura Casciola, Vitalii Kim, P. Thomas Vernier, Christian W. Zemlin
Summary: Short-duration, strong electric field pulses can be used for various applications, but nanosecond pulses require high field strengths. A theoretical model is presented to describe the effects of pulse trains on membranes, providing a method to calculate membrane charging time constant. Nanosecond pulses are found not more effective than longer pulses in charging nerve fibers, but considering multiple charging time constants improves the model's predictability for stimulating cardiomyocytes. The model also shows that pulse trains can cause significant oscillations of intracellular membrane potential.
BIOELECTROCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Josette Zaklit, Alex Cabrera, Aaron Shaw, Rita Aoun, P. Thomas Vernier, Normand Leblanc, Gale L. Craviso
Summary: The study found that under certain conditions, ultra-short electric pulses can stimulate the release of catecholamines through exocytosis, with real-time observations showing that the release is Ca2+-dependent and the release events are relatively prolonged. Furthermore, the effectiveness of this stimulation method was demonstrated, indicating its potential as a novel electrostimulation modality for neurosecretion.
BIOELECTROCHEMISTRY
(2021)
Meeting Abstract
Biophysics
Flavia Mazzarda, Esin B. Sozer, Claudia Muratori, P. Thomas Vernier
BIOPHYSICAL JOURNAL
(2022)
Meeting Abstract
Biophysics
Federica Castellani, Maria Laura Fernandez, Marcelo Risk, P. Thomas Vernier
BIOPHYSICAL JOURNAL
(2022)
Meeting Abstract
Biophysics
Flavia Mazzarda, Esin B. Sozer, Julia L. Pittaluga, Claudia Muratori, P. Thomas Vernier
BIOPHYSICAL JOURNAL
(2021)
Meeting Abstract
Biophysics
Federica Castellani, Tatiana Zvoraneva, Esin B. Sozer, P. Thomas Vernier
BIOPHYSICAL JOURNAL
(2021)
Article
Physics, Fluids & Plasmas
C. Jiang, E. B. Sozer, S. Song, N. Lai, P. T. Vernier, S. Guo
PHYSICS OF PLASMAS
(2020)
Meeting Abstract
Biophysics
Esin B. Sozer, Sourav Haldar, Federica Castellani, P. Thomas Vernier, Joshua Zimmerberg
BIOPHYSICAL JOURNAL
(2020)
Meeting Abstract
Biophysics
Federica Castellani, Esin B. Sozer, P. Thomas Vernier
BIOPHYSICAL JOURNAL
(2020)