Article
Multidisciplinary Sciences
Fan Jiang, Kunlun Yin, Kun Wu, Mingmin Zhang, Shiqiang Wang, Heping Cheng, Zhou Zhou, Bailong Xiao
Summary: The Piezo1 channel serves as a key cardiac mechanotransducer for converting mechanical stretch of cardiomyocytes into Ca2+ and ROS signaling to maintain normal heart function.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Xin Chen, Ali Momin, Siyi Wanggou, Xian Wang, Hyun-Kee Min, Wenkun Dou, Zheyuan Gong, Jade Chan, Weifan Dong, Jerry J. Fan, Yi Xiong, Kamilia Talipova, Hongyu Zhao, Yuki X. Chen, Kelly Veerasammy, Adam Fekete, Sachin A. Kumar, Hongwei Liu, Qi Yang, Joe Eun Son, Zhengchao Dou, Malini Hu, Parnian Pardis, Kyle Juraschka, Laura K. Donovan, Jiao Zhang, Vijay Ramaswamy, Hayden J. Selvadurai, Peter B. Dirks, Michael D. Taylor, Lu-Yang Wang, Chi-chung Hui, Rinat Abzalimov, Ye He, Yu Sun, Xuejun Li, Xi Huang
Summary: The major obstacles in brain cancer treatment, including the blood-tumor barrier (BTB) and quiescent tumor cells, have been addressed in this study. Sox2+ tumor cells in mouse medulloblastoma (MB) project cellular processes to ensheathe capillaries, which depend on the mechanosensitive ion channel Piezo2. Targeting Piezo2 not only compromises the BTB and reduces the quiescence of tumor cells, but also enhances the response to chemotherapy, improving the treatment outcome for brain cancer patients.
Review
Gastroenterology & Hepatology
Vikram Joshi, Peter R. Strege, Gianrico Farrugia, Arthur Beyder
Summary: Mechanosensation is crucial for gastrointestinal function, with various cell types in the GI tract sensing and transducing mechanical forces into physiological responses. Mechanosensitive cells like sensory neurons and smooth muscle cells play important roles in detecting and responding to mechanical stimuli. This process involves mechano-gated and mechanosensitive ion channels, contributing to rapid mechanotransduction responses.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Review
Hematology
Elmina Mammadova-Bach, Thomas Gudermann, Attila Braun
Summary: Blood flow-induced hemodynamic changes result in mechanical stress on blood cells and vessel walls. Increased shear stress can activate platelets and other circulating cells, triggering the rapid activation of receptors, calcium channels, and related signaling mechanisms. Mechanosensitive platelet receptors and their cross talk with calcium channels in shear-dependent platelet activation and arterial thrombus formation are discussed in this review.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Julia Karska, Szymon Kowalski, Jolanta Saczko, Mihaela G. G. Moisescu, Julita Kulbacka
Summary: Mechanical forces are essential elements in the world around us, and they have observable effects at both macro and molecular levels. The presence of mechanosensitive ion channels (MIChs), such as the Piezo and TRP families, plays a major role in the tissues and cells of animals, contributing to various physiological processes in the human body. Recent research has also connected these channels to the development of malignant tumors.
Article
Cell Biology
Ziyi Wang, Jiyuan Chen, Aleksandra Babicheva, Pritesh P. Jain, Marisela Rodriguez, Ramon J. Ayon, Keeley S. Ravellette, Linda Wu, Francesca Balistrieri, Haiyang Tang, Xiaomin Wu, Tengteng Zhao, Stephen M. Black, Ankit A. Desai, Joe G. N. Garcia, Xin Sun, John Y-J Shyy, Daniela Valdez-Jasso, Patricia A. Thistlethwaite, Ayako Makino, Jian Wang, Jason X-J Yuan
Summary: The upregulation of Piezo1 in PAH and PH may impact the cell signaling pathways in pulmonary arterial endothelial cells and smooth muscle cells, leading to pulmonary vascular remodeling, and the findings from the study provide new insights for potential therapeutic approaches.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Review
Plant Sciences
Anshika Tyagi, Sajad Ali, Suvin Park, Hanhong Bae
Summary: Mechanosensitive channels are integral membrane proteins that convert mechanical tension into biological responses. Their study in plant mechanobiology is of great significance.
Review
Biochemistry & Molecular Biology
Felix P. Hartmann, Erwan Tinturier, Jean-Louis Julien, Nathalie Leblanc-Fournier
Summary: Research on how plants sense and respond to mechanical stress has flourished in the past three decades. While the pivotal role of mechanosensing in organogenesis and acclimation has been demonstrated, it remains unclear how plant cells convert physical signals into chemical signals. Tissue-specific expression studies of MS channels could help elucidate their functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Saranyaraajan Varadarajan, Shahana A. Chumki, Rachel E. Stephenson, Eileen R. Misterovich, Jessica L. Wu, Claire E. Dudley, Ivan S. Erofeev, Andrew B. Goryachev, Ann L. Miller
Summary: Epithelial cell-cell junctions undergo remodeling in response to mechanical stimuli, with local RhoA activation and intracellular calcium flashes playing important roles in repairing tight junction leaks. Mechanosensitive calcium channels are also crucial for maintaining barrier function.
JOURNAL OF CELL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Beatrix Dienes, Tamas Bazso, Laszlo Szabo, Laszlo Csernoch
Summary: Since the discovery of Piezo1 channels, studies have investigated their role in various physiological and pathological processes in different organs. However, our understanding of their effects on the musculoskeletal system is still limited. This review summarizes the current knowledge regarding their impact on skeletal muscles, bones, joints and cartilage, tendons and ligaments, and intervertebral discs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Heidi Peussa, Chiara Fedele, Huy Tran, Mikael Marttinen, Julia Fadjukov, Elina Maentylae, Arri Priimaegi, Soile Nymark, Teemu O. Ihalainen
Summary: Epithelial cells interact with their extracellular environment through continuous biochemical and physical interactions, which guide physiological processes. This study demonstrates that light-responsive materials can modify the physical niche of cells and trigger rapid intracellular calcium transients. Moreover, the research reveals that the mechanosensitive cation channel Piezo1 plays a major role in generating these transients after nanoscale mechanical deformation. The findings also show that Piezo1 preferentially responds to shear deformation at the cell-material interphase rather than absolute topographical changes of the substrate.
Article
Biochemistry & Molecular Biology
Edward J. Calabrese
Summary: This paper provides a thorough assessment of hormetic dose responses in embryonic stem cells, suggesting that this response may serve as a fundamental and highly conserved evolutionary strategy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Review
Physiology
Mengning Zheng, Niyati A. Borkar, Yang Yao, Xianwei Ye, Elizabeth R. Vogel, Christina M. Pabelick, Y. S. Prakash
Summary: Mechanosensitive channels play a crucial role in cell sensing and response, and the mechanical activation of ion channels and downstream signaling pathways is important for maintaining physiological homeostasis and the development of diseases. Understanding TRP and Piezo channels in the lung can provide new insights for pulmonary disease treatment.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Cell Biology
Pritha Mukherjee, Suneha G. Rahaman, Rishov Goswami, Bidisha Dutta, Manisha Mahanty, Shaik O. Rahaman
Summary: Mechanical forces play a critical role in cellular processes and are especially important in the vascular system. They are involved in both physiological functions and pathological conditions, such as atherosclerosis. The role of mechanosensitive ion channels/receptors in atherosclerosis is not well understood, but recent studies have shed light on their specific roles in inflammation, endothelial dysfunction, foam cell formation, and lesion development.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Endocrinology & Metabolism
Perla C. Reyes C. Fernandez, Christian S. Wright, Mary C. Farach-Carson, William R. Thompson
Summary: In addition to their role in cell excitability, voltage-sensitive calcium channels (VSCCs) are critical for the secretion of paracrine and endocrine factors, including those produced in bone. Activation of VSCCs modulates cellular processes such as cell proliferation, differentiation, and bone adaptation. The role of VSCCs in the control of bone and calcium homeostasis through secreted factors is not well understood. Understanding the multiple functions of VSCCs in the skeleton can lead to the development of new therapies for bone enhancement and improving systemic health.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Review
Biotechnology & Applied Microbiology
Abdelkrim Hmadcha, Alejandro Martin-Montalvo, Benoit R. Gauthier, Bernat Soria, Vivian Capilla-Gonzalez
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2020)
Correction
Immunology
Barbara Soria-Juan, Natalia Escacena, Vivian Capilla-Gonzalez, Yolanda Aguilera, Lucia Llanos, Juan R. Tejedo, Francisco J. Bedoya, Veronica Juan, Antonio De la Cuesta, Rafael Ruiz-Salmeron, Enrique Andreu, Lukas Grochowicz, Felipe Prosper, Fermin Sanchez-Guijo, Francisco S. Lozano, Manuel Miralles, Lourdes Del Rio-Sola, Gregorio Castellanos, Jose M. Moraleda, Robert Sackstein, Mariano Garcia-Arranz, Damian Garcia-Olmo, Franz Martin, Abdelkrim Hmadcha, Bernat Soria
FRONTIERS IN IMMUNOLOGY
(2020)
Review
Immunology
E. Eduardo Sanchez-Castro, Cecilia Pajuelo-Reyes, Rebeca Tejedo, Barbara Soria-Juan, Rafael Tapia-Limonchi, Etelvina Andreu, Ana B. Hitos, Franz Martin, Gladys M. Cahuana, Clara Guerra-Duarte, Thamyres C. Silva de Assis, Francisco J. Bedoya, Bernat Soria, Carlos Chavez-Olortegui, Juan R. Tejedo
Summary: Snakebite envenoming is a neglected global disease with limited treatment options, potentially leading to permanent sequelae from local damage. Using mesenchymal stromal cells or their cell-free products may induce skeletal muscle regeneration in snakebite victims, improving treatment outcomes. Applying MSCs-based therapies to snakebite victims holds promise for providing a safe and cost-effective treatment option for this neglected health issue, particularly in areas with limited healthcare resources.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
C. Ferreras, B. Pascual-Miguel, C. Mestre-Duran, A. Navarro-Zapata, L. Clares-Villa, C. Martin-Cortazar, R. De Paz, A. Marcos, J. L. Vicario, A. Balas, F. Garcia-Sanchez, C. Eguizabal, C. Solano, M. Mora-Rillo, B. Soria, A. Perez-Martinez
Summary: The study found the existence of specific memory T cells capable of fighting the SARS-CoV-2 virus in the blood of convalescent donors, which can help reduce the severity of COVID-19 symptoms.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Leticia Alvarez-Amor, Amparo Luque Sierra, Antonio Cardenas, Lucia Lopez-Bermudo, Javier Lopez-Beas, Eloisa Andujar, Monica Perez-Alegre, Rocio Gallego-Duran, Lourdes M. Varela, Alejandro Martin-Montalvo, Genoveva Berna, Anabel Rojas, Ma Jose Robles-Frias, Abdelkrim Hmadcha, Manuel Romero-Gomez, Robert Kleemann, Franz Martin
Summary: The study found that diets containing extra-virgin olive oil improved weight gain and insulin sensitivity, but did not significantly impact liver inflammation and fibrosis.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Mehrdad Vakilian, Abdelkrim Hmadcha, Bernat Soria, Kamran Ghaedi
Summary: Traditional methods for obtaining pancreatic beta cells involve simulating embryonic development through pluripotent stem cell differentiation. This study proposes a modification in the differentiation protocol to obtain insulin-secreting cells, suggesting that ductal cells may trans-differentiate into endocrine and exocrine cells through a partial EMT process.
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
(2021)
Article
Medicine, Research & Experimental
Barbara Soria-Juan, Mariano Garcia-Arranz, Lucia Llanos Jimenez, Cesar Aparicio, Alejandro Gonzalez, Ignacio Mahillo Fernandez, Luis Riera del Moral, Lukasz Grochowicz, Enrique J. Andreu, Pedro Marin, Gregorio Castellanos, Jose Maria Moraleda, Ana Maria Garcia-Hernandez, Francisco S. Lozano, Fermin Sanchez-Guijo, Eva Maria Villaron, Miriam Lopez Parra, Rosa Maria Yanez, Antonio de la Cuesta Diaz, Juan Rigoberto Tejedo, Francisco J. Bedoya, Franz Martin, Manuel Miralles, Lourdes del Rio Sola, Maria Eugenia Fernandez-Santos, Jose Manuel Ligero, Francisco Morant, Luis Hernandez-Blasco, Etelvina Andreu, Abdelkrim Hmadcha, Damian Garcia-Olmo, Bernat Soria
Summary: This study aims to evaluate the feasibility, safety, and efficacy of cell therapy based on mesenchymal stromal cells derived from adipose tissue in patients with type 2 diabetes mellitus and critical limb ischemia without possibility of revascularization. The primary outcome is safety, while secondary outcomes include clinical, analytical, and imaging-test parameters. Quality of life will also be assessed using specific scales. The research could provide valuable evidence for the development of treatments for chronic lower limb ischemia.
Article
Biochemistry & Molecular Biology
Estefania Caballano-Infantes, Irene Diaz, Ana Belen Hitos, Gladys Margot Cahuana, Antonio Martinez-Ruiz, Barbara Soria-Juan, Rosario Rodriguez-Grinolo, Abdelkrim Hmadcha, Franz Martin, Bernat Soria, Juan R. Tejedo, Francisco Javier Bedoya
Summary: The study demonstrates that NO can mimic hypoxia response in human PSCs under normoxic conditions, enhancing their stemness properties and altering their metabolic profile, including upregulation of genes like HIF-1 alpha, HIF-2 alpha, NANOG, OCT-4, and increased expression of glycolysis and mitochondrial fusion regulators.
Article
Medicine, Research & Experimental
Said Lhamyani, Adriana-Mariel Gentile, Rosa M. Giraldez-Perez, Monica Feijoo-Cuaresma, Silvana Yanina Romero-Zerbo, Mercedes Clemente-Postigo, Hatem Zayed, Wilfredo Oliva Olivera, Francisco Javier Bermudez-Silva, Julian Salas, Carlos Lopez Gomez, Abdelkrim Hmadcha, Nabil Hajji, Gabriel Olveira, Francisco J. Tinahones, Rajaa El Bekay
Summary: The study found higher levels of miR-21 in WAT of non-diabetic obese individuals and mice and in 3T3-L1 adipocytes, miR-21 mimic affected genes involved in WAT functionality regulation and significantly increased genes related to browning and thermogenesis. In vivo treatment with miR-21 mimic blocked weight gain induced by high-fat diet in obese mice, associated with metabolic enhancement, WAT browning, and brown AT thermogenic programming through specific signaling pathways.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Editorial Material
Cell Biology
Abdelkrim Hmadcha, Bernat Soria, Robert C. Zhao, Tarik Smani, Israel Valverde
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Carmen Salguero-Aranda, Amparo Beltran-Povea, Fatima Postigo-Corrales, Ana Belen Hitos, Irene Diaz, Estefania Caballano-Infantes, Mario F. Fraga, Abdelkrim Hmadcha, Franz Martin, Bernat Soria, Rafael Tapia-Limonchi, Francisco J. Bedoya, Juan R. Tejedo, Gladys M. Cahuana
Summary: This study reveals that EGR-1 plays a negative role in regulating Pdx1 expression in mESCs, and its binding to the Pdx1 promoter depends on the methylation level and acetylation state of its DNA binding site. Targeting EGR-1 at early stages may be important for directing pluripotent cells towards Pdx1-dependent cell lineages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Benoit R. Gauthier, Diana Rubio-Contreras, Juan Carlos Gomez-Rosado, Luis Cristobal Capitan-Morales, Abdelkrim Hmadcha, Bernat Soria, Christian Claude Lachaud
Summary: Mesothelial cells are a type of epithelial cells that line serous cavities and visceral organs. They have immunoregulatory properties and can inhibit lymphocyte proliferation and suppress activated B cells. They can also modify macrophage activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Isabel Mayoral-Gonzalez, Eva M. Calderon-Sanchez, Isabel Galeano-Otero, Marta Martin-Bornez, Encarnacion Gutierrez-Carretero, Maria Fernandez-Velasco, Nieves Domenech, Maria Generosa Crespo-Leiro, Ana Maria Gomez, Antonio Ordonez-Fernandez, Abdelkrim Hmadcha, Tarik Smani
Summary: Ucn-2 has been found to exert cardioprotective effects through the regulation of miR-29a, reducing fibrosis and apoptosis caused by myocardial I/R injury. Furthermore, elevated expression of Hmox-1 in the ventricle of ischemic patients with heart failure was observed, which was inversely correlated with left ventricle ejection fraction.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Engineering, Biomedical
Isabel Mayoral, Elisa Bevilacqua, Gorka Gomez, Abdelkrim Hmadcha, Ignacio Gonzalez-Loscertales, Esther Reina, Julio Sotelo, Antonia Dominguez, Pedro Perez-Alcantara, Younes Smani, Patricia Gonzalez-Puertas, Ana Mendez, Sergio Uribe, Tarik Smani, Antonio Ordonez, Israel Valverde
Summary: In this study, a patient-specific patch was designed using a hybrid 3D printing technique and VSMC differentiation. Through computational modeling and experimental evaluation, the patch demonstrated favorable hemodynamic characteristics, mechanical properties, cell infiltration, viability, and functionality. This innovative 3D biotechnology holds great potential for applications in regenerative medicine and heart disease prevention.
MATERIALS TODAY BIO
(2022)
Article
Medicine, General & Internal
Fermin Sanchez-Guijo, Mariano Garcia-Arranz, Miriam Lopez-Parra, Pablo Monedero, Carmen Mata-Martinez, Arnoldo Santos, Victor Sagredo, Jose-Manuel Alvarez-Avello, Jose Eugenio Guerrero, Cesar Perez-Calvo, Miguel-Vicente Sanchez-Hernandez, Jose Luis Del-Pozo, Enrique J. Andreu, Maria-Eugenia Fernandez-Santos, Barbara Soria-Juan, Luis M. Hernandez-Blasco, Etelvina Andreu, Jose M. Sempere, Agustin G. Zapata, Jose M. Moraleda, Bernat Soria, Francisco Fernandez-Aviles, Damian Garcia-Olmo, Felipe Prosper
