Article
Polymer Science
Aftab Alam, Ahmed I. Foudah, Mohammad Ayman Salkini, Mohammad Raish, Jyotiram Sawale
Summary: Antimicrobial resistance is a significant global threat, and fennel essential oils encapsulated in nanoparticles can be used as antibacterial agents against Staphylococcus aureus, with promising drug release and antimicrobial efficacy.
Review
Biochemistry & Molecular Biology
Isabella Hernandez-Aristizabal, Ivan Dario Ocampo-Ibanez
Summary: The emergence of bacteria resistant to conventional antibiotics, especially VRSA and VISA strains, poses a serious threat to global health. Developing new antimicrobial alternatives, such as antimicrobial peptides (AMPs), is urgently needed as a promising therapeutic strategy to combat resistant strains. Evaluating natural, artificial, and synthetic AMPs against VRSA and VISA strains shows great potential for clinical application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Infectious Diseases
Natalie K. Boyd, Grace C. Lee, Chengwen Teng, Christopher R. Frei
Summary: The study found that four non-antibiotic drugs demonstrated varying degrees of in vitro activity against clinical isolates of Staphylococcus aureus, with ebselen showing the most potent effect.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2021)
Article
Microbiology
Siheng Wang, Chang Cai, Yingbo Shen, Chengtao Sun, Qingxin Shi, Ningjun Wu, Shufang Zheng, Jiao Qian, Rong Zhang, Hongwei Zhou
Summary: Contezolid exhibits potent activity against MRSA and VRE strains. It shows similar or slightly better antimicrobial activity compared to linezolid. Contezolid may have potential benefits for treating infections caused by MRSA and VRE pathogens.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Marta Woroszylo, Daria Ciecholewska-Jusko, Adam Junka, Radoslaw Drozd, Marcin Wardach, Pawel Migdal, Patrycja Szymczyk-Ziolkowska, Daniel Styburski, Karol Fijalkowski
Summary: The combination of rotating magnetic field (RMF) with beta-lactam antibiotics shows promising results in enhancing the antibacterial effects against methicillin-resistant Staphylococcus aureus (MRSA) by causing morphological alterations in bacterial cells. This study provides potential new treatment options for MRSA infections by utilizing the disruptive effect of RMF on bacterial cell walls.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Jianye Zeng, Dandan Chen, Chunli Lv, Kening Qin, Qin Zhou, Na Pu, Shanshan Song, Xiaomin Wang
Summary: The aqueous extract of Polygonum chinense L. has a significant bacteriostatic effect on Staphylococcus aureus and can destroy its cell wall as well as inhibit biofilm formation. Flow cytometry results show that the extract can disrupt the cell membrane and promote apoptosis. Confocal laser scanning microscopy images demonstrate the dose-dependent inhibition of biofilm formation by the extract.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Biomedical
Matilde Concilio, Ramon Garcia Maset, Laia Pasquina Lemonche, Vito Kontrimas, Ji-Inn Song, Santhosh Kalash Rajendrakumar, Freya Harrison, C. Remzi Becer, Sebastien Perrier
Summary: Antimicrobial-resistant pathogens have become a significant global health concern, demanding the development of new treatments. Synthetic nanoengineered antimicrobial polymers (SNAPs) show promise as an alternative to antimicrobial peptides, with high activity against Staphylococcus aureus and good biocompatibility. The lead compounds disrupt the cell membrane of S. aureus, while leaving the cell wall unaffected. In addition, there is a potential interaction of the compounds with bacterial DNA, suggesting implications on bacterial division. Finally, one of the compounds exhibits high efficacy in vivo in an insect infection model.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Marta Woroszylo, Daria Ciecholewska-Jusko, Adam Junka, Marcin Wardach, Grzegorz Chodaczek, Bartlomiej Dudek, Karol Fijalkowski
Summary: This study analyzed the impact of combining rotating magnetic field (RMF) with various classes of antibiotics on nine strains of Staphylococcus aureus. The results showed that combining RMF with antibiotics that interfere with cell walls, particularly beta-lactams, led to favorable changes in growth inhibition zones or minimal inhibitory concentration values, especially for methicillin-resistant strains. The study suggests that the application of magnetic fields could be an important strategy in combating infections caused by methicillin-resistant staphylococci due to the increased effectiveness of antibiotics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Denis Swolana, Robert D. Wojtyczka
Summary: The article introduces the effects of Staphylococcus epidermidis and Staphylococcus aureus on human health, as well as silver nanoparticles as a potential new substance for neutralizing bacterial cells. By reviewing the data on the activity of silver nanoparticles in inhibiting bacterial growth and biofilm formation, it provides insights for future research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Getha Krishnasamy, Muhammad-Syamil Azahar, Shariffah-Nurhidayah S. A. Rahman, Vimalah Vallavan, Noraziah M. Zin, Mazlyzam A. Latif, Masahiro Hatsu
Summary: Aurisin A, a dimeric sesquiterpenoid isolated from wild bioluminescent basidiomycetes, showed strong anti-MRSA activity, with a higher potency than fusidic acid. It also displayed synergy with other antibiotics against MRSA.
SAUDI PHARMACEUTICAL JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Manohar Radhakrishnan, Malathy Palayam, Ammar B. Altemimi, Lakshminarayanan Karthik, Gunasekaran Krishnasamy, Francesco Cacciola, Lakshmanan Govindan
Summary: In this study, a 24 kDa leucine-rich protein with anti-bacterial activity against both Gram-negative and Gram-positive bacteria was purified from Solanum trilobatum. Mass spectrometry analysis identified a luminal binding protein and circular dichroism suggested its main secondary structure composition. Scanning electron microscopy visualized the morphological and structural changes in bacteria treated with the purified protein. Further in vitro studies showed the protein's ability to inhibit hemagglutination of rat red blood cells. These findings highlight the potential of this protein in targeting the sugar moieties on bacterial surfaces and maintaining the structural integrity of bacteria.
Article
Biochemistry & Molecular Biology
Hosein Khabaz, Mehdi Rahimi-Nasrabadi, Amir Homayoun Keihan
Summary: In this study, a hierarchical machine learning model was developed to classify peptides with antimicrobial activity against Staphylococcus aureus. The final model showed high accuracy on the test set, utilizing a comprehensive set of features and feature selection steps.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Public, Environmental & Occupational Health
Khaloud M. Alarjani, Milan Skalicky
Summary: This study investigated the biofilm forming ability of drug resistant S. aureus strains isolated from hospital wastewater. The isolated strains showed resistance against various antibiotics. The essential oil extracted from T. polium demonstrated antibacterial and anti-biofilm activity.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2021)
Article
Biochemistry & Molecular Biology
Iva Sovadinova, Kenichi Kuroda, Edmund F. Palermo
Summary: Cationic and amphiphilic polymers exhibit broad-spectrum antibacterial activity by disrupting cell membranes. While nonspecific binding to hydrophobic components in serum was thought to hinder their effectiveness, it was unexpectedly found that the addition of fetal bovine serum actually enhances their antimicrobial activity against S. aureus but not E. coli.
Article
Microbiology
Maureen Kleinhenz, Pavani Beesetty, Ching Yang, Zhaotao Li, Christopher P. Montgomery
Summary: Recurrent Staphylococcus aureus infections are common, but no approved vaccine is available. Antibiotic therapy resolves infection but fails to elicit protective immunity. Combined vaccination and antibiotics can treat infection and generate durable protective immunity.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
