Journal
JOURNAL OF MEDICINAL FOOD
Volume 14, Issue 10, Pages 1159-1166Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/jmf.2010.0254
Keywords
anti-inflammatory activity; antinociceptive activity; antioxidant activity; Morinda citrifolia
Funding
- Fundacao de Amparo a Pesquisa do Estado de Sergipe (FAPITEC-SE)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) of Brazil
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Herbal drugs have been used since ancient times to treat a wide range of diseases. Morinda citrifolia Linn (popularly known as Noni) has been used in folk medicine by Polynesians for over 2,000 years. It is reported to have a broad range of therapeutic effects, including effects against headache, fever, arthritis, gingivitis, respiratory disorders, infections, tuberculosis, and diabetes. The aim of this study was to investigate the antioxidant, anti-inflammatory, antinociceptive, and antibacterial properties of the aqueous extract from M. citrifolia leaves (AEMC). Antioxidant activity was observed against lipid peroxidation, nitric oxide, and hydroxyl radicals. The antinociceptive effect of AEMC was observed in the acetic acid-induced writhing test at the higher dose. Moreover, AEMC significantly reduced the leukocyte migration in doses of 200 and 400 mg/kg and showed mild antibacterial activity. Together, the results suggest that properties of M. citrifolia leaf extract should be explored further in order to achieve newer tools for managing painful and inflammation conditions, including those related to oxidant states.
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