Article
Food Science & Technology
Nikolaos Goutzourelas, Dimitrios Phaedon Kevrekidis, Sofia Barda, Paraskevi Malea, Varvara Trachana, Stavroula Savvidi, Alkistis Kevrekidou, Andreana N. Assimopoulou, Andreas Goutas, Ming Liu, Xiukun Lin, Nikolaos Kollatos, Grigorios D. Amoutzias, Dimitrios Stagos
Summary: The extracts of 14 macroalgae species from the Aegean Sea, Greece, were found to have strong antioxidant and anticancer potential. Among them, the extract of G. teedei exhibited the highest antioxidant activity, while P. pavonica showed the highest inhibition against HepG2 cell growth.
Review
Biochemistry & Molecular Biology
Teodora Daria Pop, Zorita Diaconeasa
Summary: Skin cancer is a common and growing type of cancer with multifactorial resistance to various treatments. Polyphenols, as chemopreventive agents, demonstrate therapeutic effects in skin melanoma, but limitations include poor bioavailability and stability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Jose Lopes, Manuel Teixeira, Suiane Cavalcante, Marisol Gouveia, Ana Duarte, Miriam Ferreira, Maria I. Simoes, Maria Conceicao, Ilda P. Ribeiro, Ana C. Goncalves, Cristine Schmidt, Bruno Bernardes de Jesus, Ramiro Almeida, Sofia Viamonte, Mario Santos, Fernando Ribeiro
Summary: This study aimed to evaluate the circulating levels of EPCs, CECs, and HSPCs among patients with HFrEF. The results showed significantly decreased levels of circulating EPCs and CECs in HFrEF patients compared to age-matched subjects, while there was no significant difference in HSPC levels. Additionally, overweight/obese patients had significantly higher numbers of EPCs and CECs.
ARCHIVES OF MEDICAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Yousef A. Al-Dashti, Roberta R. Holt, Carl L. Keen, Robert M. Hackman
Summary: Research on cardioprotective foods like dates is essential for addressing global public health needs. While animal studies show promising results, more human research is needed to fully understand the potential benefits of date fruit on vascular health. Conducting thorough clinical trials and assessing functional markers of vascular disease will provide valuable information for human health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Michele Pellegrino, Emilia Bevacqua, Luca Frattaruolo, Anna Rita Cappello, Stefano Aquaro, Paola Tucci
Summary: Prostate cancer is the second most common cancer in men. Higher intake of polyphenols, curcumin, and quercetin has been associated with lower prostate cancer risk. In this study, the combination of curcumin and quercetin showed synergic anticancer and anti-inflammatory effects, inhibiting proliferation, inducing apoptosis, and modulating inflammation-mediated signaling pathways.
Review
Food Science & Technology
Cristina Torres-Fuentes, Manuel Suarez, Gerard Aragones, Miquel Mulero, Javier Avila-Roman, Anna Arola-Arnal, Maria Josepa Salvado, Lluis Arola, Francisca Isabel Bravo, Begona Muguerza
Summary: Cardiovascular diseases (CVD) are the leading cause of deaths worldwide, and the risk factors of CVD are influenced by biological rhythms. Phenolic compounds have potential cardioprotective properties, but their effects are influenced by administration time and photoperiod.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
J. P. Jose Merlin, Sabateeshan Mathavarajah, Graham Dellaire, Kieran P. J. Murphy, H. P. Vasantha Rupasinghe
Summary: Antioxidants can act as radioprotectants to reduce DNA damage caused by radiation or chemical carcinogens, potentially lowering the risk of malignancies such as lung cancer.
Review
Biochemistry & Molecular Biology
Pasquale Marino, Giacomo Pepe, Manuela Giovanna Basilicata, Vincenzo Vestuto, Stefania Marzocco, Giuseppina Autore, Alfredo Procino, Isabel Maria Gomez-Monterrey, Michele Manfra, Pietro Campiglia
Summary: Nutrition plays a crucial role in disease prevention, especially cancer. The consumption of fruits and vegetables and a sedentary lifestyle are closely linked to cancer. Nutraceuticals, with their pleiotropic effects and non-toxic behaviors, have gained attention in cancer research. Recent clinical studies highlight the efficacy of dietary phytochemicals in cancer prevention and treatment.
Review
Chemistry, Medicinal
Bianca Enaru, Sonia Socaci, Anca Farcas, Carmen Socaciu, Corina Danciu, Andreea Stanila, Zorita Diaconeasa
Summary: Liposome-based delivery systems have become increasingly popular due to their low toxicity, specificity, and ability to protect encapsulated substances. Encapsulating polyphenols in liposomes has been found to increase their bioavailability and stability, leading to more significant effects on targeted cells. This review focuses on the chemopreventive effects of polyphenols on cancer through liposomes, providing insights for future research in this area.
Review
Biochemistry & Molecular Biology
Ivana Buljeta, Anita Pichler, Josip Simunovic, Mirela Kopjar
Summary: Polyphenols are important constituents in red wines that contribute to the sensory properties and antioxidant activity of wines. They can be characterized using advanced analytical devices, and include flavanols, stilbenes, flavonols, and hydroxybenzoic acids. Polyphenols have beneficial effects on human health, such as anti-inflammatory, anticarcinogenic, and cardio-protective effects. Numerous studies have explored the impact of red wine polyphenols on human health, including cancer chemopreventive activities, neuroprotective effects, cardiovascular diseases, and gut microbiota.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Idolo Tedesco, Carmela Spagnuolo, Stefania Bilotto, Angelo A. Izzo, Francesca Borrelli, Daniela Rigano, Maria Russo, Fabrizio Tarricone, Gian Luigi Russo
Summary: Experimental and clinical studies have shown that moderate consumption of beer can have health benefits due to the presence of bioactive compounds such as polyphenols, vitamins, and fibers. A new beverage, Aliophen(R), based on barley malts and hops, has been designed with a high polyphenolic content. Research has demonstrated that Aliophen(R) has antioxidant properties and can potentially prevent colon cancer in animal models.
Article
Nutrition & Dietetics
Maria Annunziata Carluccio, Rosanna Martinelli, Marika Massaro, Nadia Calabriso, Egeria Scoditti, Michele Maffia, Tiziano Verri, Valentina Gatta, Raffaele De Caterina
Summary: Research showed that HT influences the whole-genome expression at the transcriptional level in endothelial cells, affecting various immune, inflammatory, proliferative, and metabolic pathways. It also revealed previously unsuspected genes and related gene pathways affected by HT, broadening our understanding of its biological properties.
Review
Medicine, Research & Experimental
Gaetano Leto, Carla Flandina, Marilena Crescimanno, Marco Giammanco, Maria Vittoria Sepporta
Summary: Oleuropein, the main bioactive phenolic compound in olive products, has shown beneficial effects in preventing tumor progression by modulating various signaling molecules involved in malignant processes, suggesting a potential therapeutic role in cancer-related bone diseases.
Article
Biochemistry & Molecular Biology
Cornelia Schmutz, Frank Will, Elisabeth Varga, Carola Jaunecker, Gudrun Pahlke, Walter Berger, Doris Marko
Summary: This study investigated the cytotoxic and DNA-damaging properties of anthocyanin-rich extracts from blackberry, bilberry, black currant, and elderberry, as well as their main anthocyanins. The results showed that blackberry extract had potent cytotoxic effects, while the other extracts had minimal effects on cell viability. Single anthocyanins could not induce comparable effects. The study also found that blackberry extract enhanced the cytotoxicity of the chemotherapeutic agent SN-38 and inhibited cell adhesion, but had no effect on DNA damage.
Article
Plant Sciences
Marzieh Moeenfard, Maria Joao Pena, Pedro Barata, Raquel Soares, Raquel Costa
Summary: The study found that both raw and roasted date seed polyphenols extracts can inhibit angiogenesis features, possess antioxidant activity, and show potential anti-angiogenic properties.
PLANT FOODS FOR HUMAN NUTRITION
(2022)
Article
Ecology
Roberto Simonini, Federica Maggioni, Federica Zanetti, Sergio Fai, Luca Forti, Daniela Prevedelli, Sara Righi
Summary: Marine fireworms are known for their stinging dorsal bristles, which may be the result of a synergy between mechanical injury and toxin release. This unique defense mechanism allows fireworms to thrive in marine benthic environments.
JOURNAL OF EXPERIMENTAL MARINE BIOLOGY AND ECOLOGY
(2021)
Review
Clinical Neurology
Paola Perin, Alex Mabou Tagne, Paolo Enrico, Franca Marino, Marco Cosentino, Roberto Pizzala, Cinzia Boselli
FRONTIERS IN NEUROLOGY
(2020)
Article
Engineering, Chemical
Fabrizio Roncaglia, Luca Forti, Sara D'Anna, Laura Maletti
Summary: Utilizing bisulfate on silica as a catalyst, and with the assistance of proper anhydrification technique, glycerol can be efficiently converted into solketal with isolated yields of 96% achieved in mild conditions on a 100 g scale.
Article
Food Science & Technology
Laura Arru, Francesca Mussi, Luca Forti, Annamaria Buschini
Summary: The research found that spinach extracts and the components of the phytocomplex have certain regulatory effects on the proliferation, antioxidant defense, and genotoxicity of human colorectal cells, with a certain dose-dependent and extraction method-related correlation. In the presence of oxidative stress, their effects vary depending on the specific oxidizing agent involved.
Article
Cell Biology
Paola Perin, Riccardo Rossetti, Carolina Ricci, Daniele Cossellu, Simone Lazzarini, Philipp Bethge, Fabian F. Voigt, Fritjof Helmchen, Laura Batti, Ivana Gantar, Roberto Pizzala
Summary: The choroid plexus serves as a regulated gate between blood and cerebrospinal fluid in the brain. Despite its simple histology, this organ has remarkably complex functions, with local heterogeneities and interactions. Advanced techniques like iDISCO-based clearing and light-sheet microscopy help in understanding the intricate structure of the choroid plexus.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Gianmaria Calisesi, Daniele Ancora, Carlotta Tacconi, Alessandro Fantin, Paola Perin, Roberto Pizzala, Gianluca Valentini, Andrea Farina, Andrea Bassi
Summary: Three-dimensional fluorescence microscopy is an important technology for inspecting biological samples. We propose a new method that suppresses illumination artifacts and reduces the required number of measurements. This method is applicable for imaging large transparent specimens or chemically cleared tissues. Using a tailored image reconstruction method, we demonstrate significant improvement in resolution.
MICROSCOPY AND MICROANALYSIS
(2022)
Article
Chemistry, Medicinal
Sara Righi, Luca Forti, Roberto Simonini, Valentina Ferrari, Daniela Prevedelli, Adele Mucci
Summary: This study used analytical chemistry techniques to investigate the natural products produced by Mediterranean specimens of the amphinomid fireworm, Hermodice carunculata. It identified and characterized eight novel compounds, named carunculines. The study also conducted preliminary investigations into the adaptive features of these compounds and found a correlation between their abundance and the evolutionary history of the worms.
Review
Plant Sciences
Filippo Del Stabile, Vittoria Marsili, Luca Forti, Laura Arru
Summary: Traditionally, plants have been seen as passive and unchanging organisms, but recent research suggests that they are aware of their surroundings and can modify their growth and development in response to stimuli. Plants communicate extensively with their environment, and sound perception and communication have become an emerging field of study.
Article
Chemistry, Multidisciplinary
Carla Condo, Igor Anfelli, Luca Forti, Carla Sabia, Patrizia Messi, Ramona Iseppi
Summary: The antimicrobial properties of lichens extracts were investigated against various microorganisms and the results showed promising effect against Candida albicans. Activity-guided fractionation and LC-MS analysis revealed the presence of a scabrosin derivative associated with the antimicrobial activity. These findings could potentially lead to a solution for fungal infections caused by drug-resistant strains in immunocompromised patients.
APPLIED SCIENCES-BASEL
(2023)
Article
Biotechnology & Applied Microbiology
Biagio Anderlini, Alberto Ughetti, Emma Cristoni, Luca Forti, Luca Rigamonti, Fabrizio Roncaglia
Summary: This paper presents a novel continuous-flow process for converting CO2 to glycerol carbonate using urea, which allows for the conversion of waste streams into valuable chemicals and improves the efficiency of biodiesel production.
BIOENGINEERING-BASEL
(2022)
Article
Chemistry, Multidisciplinary
Alberto Ughetti, Fabrizio Roncaglia, Biagio Anderlini, Veronica D'Eusanio, Andrea Luca Russo, Luca Forti
Summary: Microalgae have high photosynthetic efficiency and show minimal competition with land-based crops, making them a promising solution for CO2 biofixation from waste sources. The integrated carbonate-based carbon capture and algae biofixation system is an innovative alternative to traditional carbon capture and sequestration methods, offering advantages such as cost savings and simplified photobioreactor development. Further research is needed to evaluate different microorganisms and optimal growth conditions. This study demonstrated the successful performance of Spirulina strains in the integrated system, achieving high biomass productivity and CO2 utilization efficiency.
APPLIED SCIENCES-BASEL
(2023)
Review
Biochemistry & Molecular Biology
Sara Allievi, Laura Arru, Luca Forti
Summary: This study summarizes the latest discoveries in the field of plant perception, with a focus on the link between mechanical stimuli (such as sound vibrations) and changes in plant physiology leading to emission of Volatile Organic Compounds (VOCs).
PLANT SIGNALING & BEHAVIOR
(2021)
Review
Biochemistry & Molecular Biology
Francesca Frongia, Luca Forti, Laura Arru
PLANT SIGNALING & BEHAVIOR
(2020)
Article
Biotechnology & Applied Microbiology
Sara Filippucci, Giorgia Tasselli, Fatima-Zohra Kenza Labbani, Benedetta Turchetti, Maria Rita Cramarossa, Pietro Buzzini, Luca Forti
FERMENTATION-BASEL
(2020)
Meeting Abstract
Chemistry, Medicinal
Sara Righi, Martina Savioli, Luca Forti, Daniela Prevedelli, Roberto Simonini
