Review
Pharmacology & Pharmacy
Xiaoli Pan, Junping Pei, Aoxue Wang, Wen Shuai, Lu Feng, Faqian Bu, Yumeng Zhu, Lan Zhang, Guan Wang, Liang Ouyang
Summary: This review provides an overview of the roles of the ERKs signaling pathway in cancer and the structure-activity relationships of small molecule inhibitors targeting ERKs. It offers important insights for drug design and optimization as well as potential therapeutic strategies to overcome drug resistance.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Pathology
Sridhar T. Narla, Daniel S. Bushnell, Joanne L. Duara, Carlton M. Bates
Summary: Keratinocyte growth factor (KGF) activates AKT in bladder urothelium, providing cytoprotection from cyclophosphamide. The study shows that KGF modifies AKT targets, suppresses apoptosis, and stabilizes mTORC1 signaling. AKT signaling is necessary for KGF-driven cytoprotection, and direct AKT activation blocks apoptosis. Thus, AKT may be a therapeutic target for preventing urothelial apoptosis.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Chemistry, Applied
Ana Luiza Fontes, Bruna Neves, Tiago Conde, Daniela Couto, Ligia Leao Pimentel, Luis Miguel Rodriguez-Alcala, M. Rosario Domingues, Ana Maria Gomes
Summary: This study investigated potential fatty acid byproducts during microbial enrichment of CLA/CLNA and found that no additional side-fatty acid metabolites were released except for stearic acid in the presence of linoleic acid.
Review
Chemistry, Applied
Suhong Li, Liangwei Xu, Junjun Qing, Xiaodan Wu, Haixing Li, Hongbing Chen, Xiaohua Liu
Summary: This article provides a review of the biological activities, biosynthesis mechanisms, and analytical methods of conjugated linoleic acid (CLA) isomers. The review focuses on the anti-obesity, cardiovascular protection, diabetes management, and anti-cancer activities of CLA isomers in both in vitro and in vivo studies. The production of specific CLA isomers is highlighted due to their biological activity. The article systematically introduces biosynthesis methods such as dietary modification in ruminants and fermentation by microorganisms & enzymes. Comparisons of various analysis methods, including UV spectrometry, GC, HPLC, MS, and CE, are discussed. The aim of this paper is to provide an overview of the current status and future trends in CLA isomer research.
Article
Cell & Tissue Engineering
Jie Zhou, Junying Yang, Yuan Dong, Yaru Shi, Endong Zhu, Hairui Yuan, Xiaoxia Li, Baoli Wang
Summary: Our study has for the first time established the direct role of OSMR in regulating osteogenic differentiation of marrow stromal progenitor cells through ERK-mediated autophagy signaling. OSMR thus contributes to bone homeostasis through dual regulation of osteoblasts and osteoclasts. It also suggests that OSMR may be a potential target for the treatment of metabolic disorders such as osteoporosis.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Psychology, Developmental
Craig A. Erickson, Charles R. Tessier, Christina Gross, Ernest Pedapati, Logan K. Wink, Kelli C. Dominick, Rebecca C. Shaffer, Hilary Rosselot, Michael P. Hong, Andrew P. Bantel, Elizabeth Berry-Kravis, Paul S. Horn, Ryan Adams, John A. Sweeney
Summary: This study investigated the activity of ERK1/2 in autism spectrum disorder (ASD). The results showed that lymphocytic ERK1/2 activation was faster in individuals with ASD, and this was correlated with greater social impairment. The differences in ERK1/2 activation were more pronounced in younger individuals.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Medicine, Research & Experimental
KyoungJoo Cho, Gyung Whan Kim
Summary: This study investigated the causes of selectively striatal cell loss in mice infused with 3-nitropropionic acid (3-NP). It found that mitochondrial dysfunction was higher in the striatum than in the cortex, and autophagy that may restore energy depletion occurred less in the striatum. Inhibition of ASK1 by NQDI1 regulates MAPK signaling, apoptosis, and autophagy, improving the damaged condition in the striatum.
Article
Medicine, Research & Experimental
Jieun Jeon, Tamanna Jahan Mony, Eunbi Cho, Huiyoung Kwon, Wan-Seob Cho, Ji Woong Choi, Byeong C. Kim, Jong Hoon Ryu, Se Jin Jeon, Kyoung Ja Kwon, Chan Young Shin, Se Jin Park, Dong Hyun Kim
Summary: In this study, it was found that rubrofusarin enhances learning and memory in mice and promotes neurite outgrowth. These effects may be achieved through activation of the ERK pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Hidenori Kanno, Sei Naito, Yutaro Obara, Hiromi Ito, Osamu Ichiyanagi, Takafumi Narisawa, Tomoyuki Kato, Akira Nagaoka, Norihiko Tsuchiya
Summary: ERK5 has been found to be highly expressed in clear cell renal cell carcinoma (ccRCC) and is associated with high grade, high recurrence rate, and high cancer-specific survival. The expression of ERK5 is regulated by miR-143. Inhibition of ERK5 holds promise as a potential target for ccRCC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Toxicology
Yujia Xie, Jixuan Ma, Meng Yang, Lieyang Fan, Weihong Chen
Summary: Silicosis is a scarring lung disease caused by inhaling fine particles of crystalline silica in the workplace. The underlying molecular mechanisms of silicosis are not fully understood, but recent studies have highlighted the role of the activated ERK signaling pathway in regulating oxidative stress, inflammatory response, fibroblast activation, and other processes involved in the formation and development of silicosis.
TOXICOLOGY RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Kanako Miyano, Seiya Hasegawa, Noriho Asai, Miaki Uzu, Wakako Yatsuoka, Takao Ueno, Miki Nonaka, Hideaki Fujii, Yasuhito Uezono
Summary: The Japanese herbal medicine Hangeshashinto (HST) has been shown to improve chemotherapy-induced oral ulcerative mucositis (OUM) through enhancing the migration of human oral keratinocytes (HOK) by upregulating CXCL12 via ERK.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ruoqi Yang, Guiping Zhao, Lili Zhang, Yu Xia, Huijuan Yu, Bin Yan, Bin Cheng
Summary: This study constructed an efficient and reliable multi-stage virtual screening-in vitro biological validation system to identify potential inhibitors targeting ERK2. By using machine learning models, ADME/T prediction, and molecular docking, several candidate inhibitors were identified from natural products, and one of them exhibited acceptable inhibitory activity in vitro.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Chikako Nakai, Sachiyo Mimaki, Koutatsu Matsushima, Eiji Shinozaki, Kentaro Yamazaki, Kei Muro, Kensei Yamaguchi, Tomohiro Nishina, Satoshi Yuki, Kohei Shitara, Hideaki Bando, Yutaka Suzuki, Kiwamu Akagi, Shogo Nomura, Satoshi Fujii, Masaya Sugiyama, Nao Nishida, Masashi Mizokami, Yasuhiro Koh, Takuya Koshizaka, Hideki Okada, Yukiko Abe, Atsushi Ohtsu, Takayuki Yoshino, Katsuya Tsuchihara
Summary: This study identified a BRAF L525R mutation in colorectal cancer patient, which renders cells sensitive to selumetinib and resistant to BRAF V600E. Inhibition of AKT overcomes selumetinib resistance. These findings provide important insights for identifying effective therapies.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Virology
Jie Ni, Shunlin Hu, Xiaoquan Wang, Xiaowen Liu, Zenglei Hu, Xiufan Liu
Summary: This study investigates the relationship between the ERK pathway and Newcastle disease virus (NDV) replication. It was found that activation of the ERK pathway is required for NDV replication, as specific blockage of this pathway significantly decreased viral gene expression, replication, and cytopathogenic effects caused by NDV.
ARCHIVES OF VIROLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Jinfeng Liu, Liang Ning
Summary: Emodin can significantly reduce the apoptosis rate of myocardial tissues and improve cardiac function in rats with post-MI HF, indicating its potential therapeutic effect in alleviating post-MI HF. The changes in cardiac parameters and protein expressions were dose-dependent on emodin administration.