Article
Agricultural Engineering
Goverdina C. H. Derksen, Frederique L. van Holthoon, Hendra M. Willemen, Cyrille A. M. Krul, Maurice C. R. Franssen, Teris A. van Beek
Summary: By adjusting extraction and fractionation parameters, the concentration of mutagenic compounds in madder can be minimized. The roots are stirred in water to reduce the concentration of specific mutagenic compounds to zero by endogenous enzymes, and further mutagenicity is reduced through heat treatment and chromatography.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Review
Environmental Sciences
Keshav Goyal, Harsh Goel, Pritika Baranwal, Aman Dixit, Fahad Khan, Niraj Kumar Jha, Kavindra Kumar Kesari, Pratibha Pandey, Avanish Pandey, Mercilena Benjamin, Ankit Maurya, Vandana Yadav, Rana Suryauday Sinh, Pranay Tanwar, Tarun Kumar Upadhyay, Sandeep Mittan
Summary: Environmental mutagens have the potential to induce a wide range of mutations in humans and can lead to physiological, biochemical, and genetic modifications. The genotoxic effects on germ cells can have lasting impacts on health, and understanding the molecular mechanisms of physical and chemical mutagens is crucial for preventing DNA damage, carcinogenesis, and other disorders affecting human health. Various tests, such as the Ames test and Mutatox test, are important for detecting mutagenic factors in the environment and ongoing research is needed to further explore the impact of environmental mutagens on humans and animals.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Chemistry, Medicinal
Byeong Wook Kim, Hwa Lee, Gyochang Keum, B. Moon Kim
Summary: By substituting alkyl groups at specific positions on 2,7-diaminofluorene and 2,7-diaminocarbazole structures, mutagenicity issues can be effectively avoided in drug discovery.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Biology
Maryam Zahin, Najat A. Bokhari, Iqbal Ahmad, Fohad Mabood Husain, Abdullah Safar Althubiani, Mashael W. Alruways, Kahkashan Perveen, Misfera Shalawi
Summary: Piper nigrum exhibits potential antioxidant and antimutagenic properties, with methanol extract showing high activity and significant antibacterial activity against methicillin-resistant Staphylococcus aureus. The study also found that plant compounds can interact with DNA, reducing the interaction of mutagens with DNA.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ihsan Obali, Ahmet Uysal, Mustafa Kul, Israa Nibras Qader Qader, Halil Ismet Ucan, Aslihan Yilmaz Obali
Summary: The study focused on the preparation and characterization of three Schiff base ligands with different substitutions, and their transition metal complexes, exploring their spectral properties and antimicrobial activities. Compounds 2-Cu and 3 showed strong antimicrobial potential, and were found to be non-mutagenic in the Ames test.
BIOORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Theng Choon Ooi, Farah Wahida Ibrahim, Shakirah Ahmad, Kok Meng Chan, Lek Mun Leong, Nihayah Mohammad, Ee Ling Siew, Nor Fadilah Rajab
Summary: The aqueous extract of Ficus deltoidea var. deltoidea showed no mutagenic effect on Salmonella typhimurium strains, but exhibited antimutagenic and cytoprotective effects, likely due to its antioxidant properties.
Article
Chemistry, Medicinal
Zeliha Aydogan, Fatma Zilifdar Foto, Egemen Foto, Ozlem Temiz-Arpaci, Nuran Diril
Summary: This study investigated the genotoxic potential of benzoxazole derivatives with broad antimicrobial and potent antitumor effects by conducting the Ames test. The results showed that these compounds did not exhibit mutagenic activity.
PHARMACEUTICAL CHEMISTRY JOURNAL
(2022)
Article
Plant Sciences
Kgomotso B. Sako, Tshepiso J. Makhafola, Roel Antonissen, Luc Pieters, Luc Verschaeve, Esam E. Elgorashi
Summary: This study investigated the antioxidant and antimutagenic activities of 16 Plectranthus species. The results showed that three plant extracts had the highest antioxidant activity, while four plant extracts exhibited strong antimutagenic properties. Overall, most of the plant extracts had both antioxidant and antimutagenic properties without a clear correlation between the two.
SOUTH AFRICAN JOURNAL OF BOTANY
(2023)
Article
Plant Sciences
Etil Guzelmeric, Piril Ugurlu, Cansel Celik, Nisa Beril Sen, Sinem Helvacioglu, Mohammad Charehsaz, Murat Erdogan, Mehmet Ali Ockun, Hasan Kirmizibekmez, Ahmet Aydin, Erdem Yesilada
Summary: This study compared the chemical compositions, antioxidant, anticancer, and anti/mutagenic activities of hydroalcoholic extracts prepared from different parts of Myrtle plants. The results showed that the leaves of Myrtle exhibited the highest anticancer and antimutagenic activities, while the floral buds extract showed the strongest antioxidant activity.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Plant Sciences
Dilek Akyil
Summary: The study aimed to examine the mutagenic and cytotoxic effects of Napoleon 4EC pesticide in Turkey by using two standard assays. Results showed that increasing concentrations of Napoleon 4EC led to a decrease in mitotic index and impacted the percentage of mitotic phases. The Ames test demonstrated a dose-dependent effect of the pesticide, with colony numbers doubling in the 800 μg/plate dose, indicating weak mutagenicity according to the parameters.
Article
Environmental Sciences
Ghania Bouguellid, Nadjet Debbache-Benaida, Dina Atmani-Kilani, Chiara Russo, Margherita Lavorgna, Concetta Piscitelli, Karima Ayouni, Meriem Berboucha-Rahmani, Marina Isidori, Djebbar Atmani
Summary: The extracts of Pistacia lentiscus L. fruits showed potential antigenotoxic and antimutagenic properties in in vitro and in vivo assays. They provided protection against common mutagenic and genotoxic agents and enhanced antioxidant enzyme activity in animal models.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2022)
Article
Chemistry, Medicinal
Farah Syahibah Mohd Hariri, Asmah Hamid, Nor Fadilah Rajab
Summary: Zingiber zerumbet (L.) Smith (lempoyang) has traditional applications in treating indigestion, worm infestation, loss of appetite, and postpartum conditions. This study found that extracts of Z. zerumbet exhibited mutagenic and cytotoxic activities, but also displayed promising anti-mutagenic potential, which could be utilized for cancer prevention purposes.
PHARMACOGNOSY MAGAZINE
(2023)
Article
Chemistry, Multidisciplinary
Amine Hafis Abdelsalam, Hasan Basri Ila
Summary: Myrrh oil from Commiphora myrrha has cytogenotoxic effects on human peripheral lymphocytes, with significant impact observed at higher concentrations. The oil showed varying levels of cellular damage depending on the concentration, but demonstrated protective effects on DNA against damaging factors.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
Article
Agriculture, Multidisciplinary
M. A. Rasheed, M. Ashraf, A. Javeed, A. A. Anjum
Summary: This study evaluated the in vitro toxicological effects of tilmicosin and found that it does not exhibit cytotoxicity, mutagenicity, and genotoxicity at low concentrations.
JOURNAL OF ANIMAL AND PLANT SCIENCES-JAPS
(2022)
Article
Toxicology
Su Zhou, Rui Li, Zhichao Zhang, Minyang Gu, Hongyan Zhu, Jing Fang, Zhiwen Ji, Xiaodong Xu, Liming Tang
Summary: Oxidative hair dyes consist of two components that require genotoxicity tests for approval in China. The study found that components I and II may contribute to the positive results in the Ames test.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Luiz Leonardo Saldanha, Pierre-Marie Allard, Adlin Afzan, Fernanda Pereira de Souza Rosa de Melo, Laurence Marcourt, Emerson Ferreira Queiroz, Wagner Vilegas, Claudia Maria Furlan, Anne Ligia Dokkedal, Jean-Luc Wolfender
Article
Agricultural Engineering
Max Vidal-Gutierrez, Ramon Enrique Robles-Zepeda, Wagner Vilegas, Gustavo Adolfo Gonzalez-Aguilar, Heriberto Torres-Moreno, Julio Cesar Lopez-Romero
INDUSTRIAL CROPS AND PRODUCTS
(2020)
Article
Biotechnology & Applied Microbiology
Julia Teixeira de Oliveira, Filipe Nogueira Franco, Kimberly Brito Tecchio, Alessandra Mirtes Marques Neves Goncalves, Camila de Souza Barbosa, Rosy Iara Maciel de Azambuja Ribeiro, Gustavo Henrique Ribeiro Viana, Vanessa J. da Silva Vieira dos Santos, Fabio Vieira dos Santos
Summary: The study evaluated the cytotoxic, genotoxic, and mutagenic effects of two synthetic 3-APA analogues on breast cancer, ovarian cancer, and lung fibroblast cell lines, with 3-APA 2 showing higher activity and selectivity index values, especially in the presence of metabolic activation. Cancer cell lines demonstrated higher genotoxic sensitivity to the compounds compared to non-tumor cell lines.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
(2021)
Article
Parasitology
Rafaela Regina Fantatto, Ana Carolina de Souza Chagas, Yousmel Aleman Gainza, Flavio Augusto Sanches Politi, Leonardo Mendes de Souza Mesquita, Wagner Vilegas, Humberto Ribeiro Bizzo, Ilio Montanari Junior, Rosemeire Cristina Linhari Rodrigues Pietro
Summary: Although Brazilian livestock is highly productive, the losses caused by parasites still greatly limit these activities. This study evaluated the anthelmintic and acaricidal activities of the ethanolic extract and essential oil from Achyrocline satureioides against important endo and ectoparasites in sheep and cattle. The results showed high efficacy and significant inhibition against the parasites.
EXPERIMENTAL PARASITOLOGY
(2022)
Review
Chemistry, Medicinal
Jessyane Rodrigues do Nascimento, Amanda de Jesus Alves Miranda, Felipe Costa Vieira, Carla Daniele Pinheiro Rodrigues, Luna Nascimento Vasconcelos, Jose Lima Pereira Filho, Auxiliadora Cristina Correa Barata Lopes, Marcelo Marucci Pereira Tangerina, Wagner Vilegas, Claudia Quintino da Rocha
Summary: The genus Arrabidaea consists of around 170 species and is primarily distributed in the Neotropics and temperate zone, particularly in Brazil. These plants have been traditionally used for their medicinal properties, including diuretic, antiseptic, and treatment for various ailments. They are chemically diverse, containing triterpenes, phenolic acids, and flavonoids, which possess valuable pharmacological properties such as anti-tumor, antioxidant, anti-inflammatory, and healing effects. However, the therapeutic potential of these plants has been underestimated.
Article
Biochemistry & Molecular Biology
Sikiru Olaitan Balogun, Amilcar Sabino Damazo, Eduarda Pavan, Fabiana de Freitas Figueiredo, Karuppusamy Arunachalam, Leonardo M. de Souza Mesquita, Wagner Vilegas, Domingos Tabajara de Oliveira Martins
Summary: This study found that the extract of Helicteres sacarolha leaves has a healing effect on gastric ulcers and can modulate cytokine levels to combat inflammation. Additionally, the extract has prokinetic properties, promoting gastric emptying and intestinal transit.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Plant Sciences
Miriam Sannomiya, Clenilson Martins Rodrigues, Giovanna Castro Araujo Oliveira, Juliana Cajado Souza Carvalho, Leticia Serafim da Costa, Cristina de Castro Spadari, Marcelo Jose Pena Ferreira, Wagner Vilegas, Kelly Ishida
Summary: The major compounds in the leaves of Byrsonima fagifolia were identified as galloylquinic acid derivatives, which exhibited antifungal activity and low toxicity.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Bryna Tieme Haraki Otaviano, Miriam Sannomiya, Fernando Soares de Lima, Marcelo Marucci Pereira Tangerina, Cinthia Indy Tamayose, Marcelo Jose Pena Ferreira, Harold S. Freeman, Juliana Pereira Flor, Silgia Aparecida da Costa, Sirlene Maria da Costa
Summary: The present study investigates the photoprotection properties of cotton fabric dyed with pomegranate peel extract. The dyed fabric samples showed good color fastness and moderate to good photoprotection. The pomegranate extract exhibited high antiradical activity due to its high content of antioxidants. Addition of ZnO did not significantly enhance the photoprotection properties of the dyed fabric.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Biochemistry & Molecular Biology
Matheus Lima Silva Vieira, Marcos Ryotaro Hara, Amanda Cruz Mendes, Rodrigo Hirata Willemart, Aline Bertinatto Cruz, Deborah Yara Alves Cursino dos Santos, Miriam Sannomiya
Summary: The subfamily Gonyleptinae is the second largest in Gonyleptidae, consisting of over 100 species. The chemical analysis of two species within the subfamily revealed the presence of various defensive secretions, providing important insights for the study of evolution and classification in Gonyleptidae.
Article
Chemistry, Multidisciplinary
Julia Teixeira De Oliveira, Kimberly Brito Tecchio, Marcela Silva Lopes, Silmara Nunes Andrade, Rosy Iara Maciel De Azambuja Ribeiro, Fernando De Pilla Varotti, Renata Barbosa De Oliveira, Gustavo Henrique Ribeiro Viana, Vanessa J. Da Silva Vieira Dos Santos, Fabio Vieira Dos Santos
Summary: In this study, three synthetic ortho-nitrobenzyl derivatives were evaluated for their cytotoxicity, genotoxicity, and mutagenicity in human breast and ovarian cancer cell lines. The compounds selectively affected cancer cell viability, induced chromosomal damage, and caused double-strand breaks in DNA structure. The compounds ON-2 and ON-3 showed high selectivity indices and potential as anticancer candidates.
DRUG AND CHEMICAL TOXICOLOGY
(2023)
Article
Oncology
Eduardo Davi Lima da Silva, Flaviana Alves dos Santos, Julia Teixeira de Oliveira, Fabio Vieira dos Santos, Francisco Jaime Bezerra Mendonca Junior, Maria do Carmo Alves de Lima, Maira Galdino da Rocha Pitta, Moacyr Barreto de Jesus de Melo Rego, Michelly Cristiny Pereira
Summary: This study evaluated the anticancer activities of three aminothiophene derivatives (SB-44, SB-83, and SB-200) in prostate and cervical adenocarcinoma cells. The results showed significant cytotoxicity in cell lines, inhibition of clone formation, and mutagenic potential. In silico analysis also revealed their potential for oral druggability.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2023)
Article
Tropical Medicine
Aline Garnevi-Favero, Karina Nascimento-da Silva, Willian Rodrigues-Ribeiro, Caroline Marcantonio-Ferreira, Patricia Sartorelli, Leonardo Cardili, Rita de Cassia-Sinigaglia, Joice Naiara Bertaglia-Pereira, Marcelo Aparecido-da Silva, Wagner Vilegas, Marcelo Jose Dias-Silva, Ana Paula Ribeiro-Paiotti
Summary: The study evaluated the effects of M. caesalpiniifolia pre-formulation on colitis model, and found that the pre-formulation can alleviate the symptoms and intestinal inflammation of colitis, but cannot repair the damage to the intestinal barrier.
Review
Biodiversity Conservation
Dulce Helena Siqueira Silva, Helena Mannochio-Russo, Joao Henrique Ghilardi Lago, Paula Carolina Pires Bueno, Rebeca Previate Medina, Vanderlan da Silva Bolzani, Wagner Vilegas, Wilhan Donizete Goncalves Nunes
Summary: With the support of FAPESP, Brazil has made significant progress in the research on natural products. The establishment of the Laboratory of Chemistry of Natural Products and the launch of the BIOTA-FAPESP program have contributed to the sustainable exploitation of biodiversity. Through chemical analysis, genetic assessment, and pharmacological research, a deeper understanding of the role of natural products in different biological models has been achieved. The development of omics approaches has provided new avenues for comprehensive research. The program also focuses on environmental protection and the principles of Green Chemistry, and has fostered international collaboration and industry partnerships, making important contributions to the development of the bioeconomy and support for public policies.
Article
Chemistry, Medicinal
Filipe N. Franco, Julia T. Oliveira, Kimberly B. Tecchio, Flaviana A. Santos, Moacyr J. B. M. Rego, Francisco J. B. Mendonca-Junior, Maira G. R. Pitta, Michelly C. Pereira, Rosy I. M. A. Ribeiro, Vanessa J. S. V. Santos, Fabio V. Santos
Summary: This study evaluated the cytotoxic, genotoxic, and mutagenic properties of synthetic thiophenes in vitro using cell lines derived from human solid tumors. The results showed that these compounds have anti-proliferative effects against cancer cells and induce cell death by apoptosis. One compound showed a high selectivity towards tumor cell lines.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY REPORTS
(2022)
