Article
Microbiology
Tzu-Chuan Ho, Yung-Hsuan Wang, Yi-Ling Chen, Wan-Chi Tsai, Che-Hsin Lee, Kuo-Pin Chuang, Yi-Ming Arthur Chen, Cheng-Hui Yuan, Sheng-Yow Ho, Ming-Hui Yang, Yu-Chang Tyan
Summary: The systematic review found that chloroquine (CQ) and hydroxychloroquine (HCQ) do not show efficacy in treating severe COVID-19 patients, and may cause serious adverse reactions, particularly during treatment of severe cases.
Article
Infectious Diseases
Berit Troost-Kind, Martijn J. van Hemert, Denise van de Pol, Heidi van der Ende-Metselaar, Andres Merits, Malte Borggrewe, Izabela A. Rodenhuis-Zybert, Jolanda M. Smit
Summary: The study investigated the antiviral mechanism of tomatidine against Chikungunya virus, revealing that it reduces viral protein expression and production of virus particles without readily inducing viral resistance. These findings bolster the potential of tomatidine as a treatment strategy against Chikungunya virus.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Multidisciplinary Sciences
Sebastiao Rogerio da Silva Neto, Thomas Tabosa de Oliveira, Igor Vitor Teixiera, Leonides Medeiros Neto, Vanderson Souza Sampaio, Theo Lynn, Patricia Takako Endo
Summary: This study presents a unified data set of clinical, sociodemographic, and laboratorial data on patients with Dengue and Chikungunya. The data can be utilized for investigating the antecedents of arbovirus emergence and transmission, as well as training and testing machine learning models.
Article
Multidisciplinary Sciences
Wenjing Guo, Bohu Pan, Sugunadevi Sakkiah, Zuowei Ji, Gokhan Yavas, Yanhui Lu, Takashi E. Komatsu, Madhu Lal-Nag, Weida Tong, Tucker A. Patterson, Huixiao Hong
Summary: The study evaluated the safety concerns of 296 drugs used in COVID-19 clinical trials by analyzing adverse events reported in post-market surveillance. Z-scores were calculated to quantify the relative frequency of adverse events associated with the drugs, showing different significantly frequent adverse events. The results suggest that Z-scores may serve as a tool to inform selection of drugs with favorable safety profiles for COVID-19 patients in clinical practices, with caution advised for drugs with high Z-scores.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Diana Laila Ramatillah, Suri Isnaini
Summary: This study found that the combination of Oseltamivir + Hydroxychloroquine is the most effective antiviral agent for treating COVID-19. Gender and age did not have a significant correlation with treatment duration or clinical outcomes, while comorbidities showed a significant correlation with both treatment duration and clinical outcomes for COVID-19 patients.
Article
Infectious Diseases
Edgar JG. Peters, Didier Collard, Sander Van Assen, Martijn Beudel, Marije K. Bomers, Jacqueline Buijs, Lianne R. De Haan, Wouter De Ruijter, Renee A. Douma, Paul WG. Elbers, Abraham Goorhuis, Niels C. Gritters Van den Oever, Lieve GHH. Knarren, Hazra S. Moeniralam, Remy Lm. Mostard, Marian Jr. Quanjel, Auke C. Reidinga, Roos Renckens, Joop PW. Van den Bergh, Imro N. Vlasveld, Jonne J. Sikkens
Summary: The study found that the routine use of hydroxychloroquine or chloroquine in hospitals treating COVID-19 patients did not significantly affect the survival rate. Although there was a slightly higher 21-day mortality rate in hospitals that routinely prescribed (hydroxy)chloroquine, this difference disappeared in the overall model. The research provides further evidence against the use of (hydroxy)chloroquine in hospitalized COVID-19 patients.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Medicine, General & Internal
Oriol Mitja, Marc Corbacho-Monne, Maria Ubals, Andrea Alemany, Clara Suner, Cristian Tebe, Aurelio Tobias, Judith Penafiel, Ester Ballana, Carla A. Perez, Pol Admella, Nuria Riera-Marti, Pep Laporte, Jordi Mitja, Mireia Clua, Laia Bertran, Maria Sarquella, Sergi Gavilan, Jordi Ara, Josep M. Argimon, Gabriel Cuatrecasas, Paz Canadas, Aleix Elizalde-Torrent, Robert Fabregat, Magi Farre, Anna Forcada, Gemma Flores-Mateo, Cristina Lopez, Esteve Muntada, Nuria Nadal, Silvia Narejos, Aroa Nieto, Nuria Prat, Jordi Puig, Carles Quinones, Ferran Ramirez-Viaplana, Juliana Reyes-Uruena, Eva Riveira-Munoz, Lidia Ruiz, Sergi Sanz, Alexis Sentis, Alba Sierra, Cesar Velasco, Rosa M. Vivanco-Hidalgo, Juani Zamora, Jordi Casabona, Marti Vall-Mayans, Camila Gonzalez-Beiras, Bonaventura Clotet
Summary: In a trial involving asymptomatic contacts of patients with PCR-confirmed Covid-19 in Spain, the authors compared the use of hydroxychloroquine with usual care. Postexposure therapy with hydroxychloroquine did not prevent SARS-CoV-2 infection or symptomatic Covid-19 in healthy persons.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Microbiology
Anitha Jagadesh, Anup Jayaram, Naren Babu, Piya Paul Mudgal, Robin Sudandiradas, Shahin Sheik, Ujwal Shetty, Dileep Kumar Verma, Shakuntala Mahilkar, Sujatha Sunil, Sylvester Agha Ibemgbo, Prabhudutta Mamidi, Sharad Singh, Soma Chattopadhyay, Sweta Smita Pani, Bijayanthimala Mishra, R. K. Ratho, Jayanthi S. Shastri, Sachee Agarwal
Summary: Chikungunya fever is a disease caused by the Chikungunya virus, with chronic and acute stages presenting challenges for diagnosis and treatment. India has a long history with this disease, with efforts being made to develop vaccines and antivirals.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Infectious Diseases
Megan O'Driscoll, Henrik Salje, Aileen Y. Chang, Hugh Watson
Summary: This study estimated the average rate of arthralgia resolution and the expected prevalence of arthralgia over time post-CHIKV infection by analyzing 16 cohort studies. These findings provide information to understand the long-term public health burdens associated with CHIKV epidemics.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Shipra Kartik, Rishi Pal, Manju J. Chaudhary, Rajendra Nath, Madhu Kumar, Monika Binwal, D. U. Bawankule
Summary: Parkinson's disease is a neuro-motor ailment that causes motor and non-motor impairments. Recent research suggests that the disease is related to dysregulated autophagy and cerebral inflammation. Chloroquine, an anti-malarial drug, has been shown to inhibit autophagy in various diseases, including Parkinson's.
INFLAMMOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Hany M. Dabbous, Manal H. El-Sayed, Gihan El Assal, Hesham Elghazaly, Fatma F. S. Ebeid, Ahmed F. Sherief, Maha Elgaafary, Ehab Fawzy, Sahar M. Hassany, Ahmed R. Riad, Mohamed A. TagelDin
Summary: The study demonstrated that favipiravir is a potential treatment for COVID-19 with efficacy and safety in mild and moderate cases, showing better outcomes in viral infection than hydroxychloroquine in certain aspects.
SCIENTIFIC REPORTS
(2021)
Review
Virology
Denise Maria do Nascimento Costa, Pedro Alves da Cruz Gouveia, Gyl Eanes de Barros Silva, Precil Diego Miranda de Menezes Neves, Gisele Vajgel, Maria Alina Gomes de Mattos Cavalcante, Camila Barbosa Lyra de Oliveira, Lucila Maria Valente, Vera Magalhaes da Silveira
Summary: Atypical forms of CHIK, such as neurological, cardiac, and renal involvement, have been described with high morbidity and mortality rates. Data on kidney injury related to CHIK is scarce, with only acute phase studies conducted, lacking further characterization.
REVIEWS IN MEDICAL VIROLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Juan I. Cotella, Ana L. Sauce, Clara I. Saldarriaga, Gonzalo E. Perez, Juan M. Farina, Fernando Wyss, Alvaro Sosa Liprandi, Ivan Mendoza, Ana G. Munera, Bryce Alexander, Adrian Baranchuk
Summary: Neglected tropical diseases are a group of communicable diseases occurring in tropical and subtropical regions, closely linked to poverty and inadequate sanitation. Chikungunya, a widely spread disease, can lead to cardiovascular involvement with potentially severe manifestations, highlighting the importance of timely diagnosis and appropriate management.
Article
Infectious Diseases
Mwenda C. Mulenga, Lungowe Sitali, Ilinca I. Ciubotariu, Moonga B. Hawela, Busiku Hamainza, James Chipeta, Sungano Mharakurwa
Summary: The study showed a complete recovery of chloroquine-sensitive parasites in Katete District, Eastern Zambia by 2016, 13 years after the withdrawal of chloroquine in the country. These findings provide additional evidence for a fitness cost in chloroquine-resistant Plasmodium falciparum in Zambia and elsewhere. Further research is recommended to monitor resistance nationwide and explore the feasibility of integrating chloroquine into combination therapy in the future.
Review
Biotechnology & Applied Microbiology
Amin Gasmi, Massimiliano Peana, Sadaf Noor, Roman Lysiuk, Alain Menzel, Asma Gasmi Benahmed, Geir Bjorklund
Summary: Chloroquine and hydroxychloroquine are considered promising agents against the new coronavirus, with antiviral effects demonstrated in vitro. These drugs can reduce immune reactions, inhibit inflammation, and potentially treat viral infections and related ailments. Studies are ongoing to determine their efficacy and safety in treating COVID-19.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)