Article
Radiology, Nuclear Medicine & Medical Imaging
Tuncer Tascioglu
Summary: This study found that optic nerve tortuosity, flattening of the posterior globe, and optic nerve protrusion are the best parameters to distinguish between patients with IIH and those with optic nerve subarachnoid space enlargement. A scoring system developed based on these data may aid in the preliminary diagnosis of IIH.
Article
Multidisciplinary Sciences
Karin Pola, Elsa Bergstrom, Johannes Toger, Goran Radegran, Per M. Arvidsson, Marcus Carlsson, Hakan Arheden, Ellen Ostenfeld
Summary: Hemodynamic force analysis provides complementary information to established parameters in precapillary pulmonary hypertension, showing differences in ventricular HDF between patients and healthy controls. The right ventricle compensates for the increased afterload by augmenting transverse forces, while left ventricular abnormalities are mainly a result of underfilling.
SCIENTIFIC REPORTS
(2022)
Article
Peripheral Vascular Disease
Marcos Vinicius Fernandes, Mariana Rosso Melo, Francesca Elisabeth Mowry, Gabriela Maria Lucera, Mariana Ruiz Lauar, Gustavo Frigieri, Vinicia Campana Biancardi, Jose Menani, Debora Simoes Almeida Colombari, Eduardo Colombari
Summary: The mechanisms of intracranial pressure changes during hypertension remain unclear, especially in the 2K1C hypertensive model. This study found that as mean arterial pressure increased in 2K1C hypertensive rats, intracranial pressure also significantly increased with changes in pulse waveforms. Additionally, blood-brain barrier disruption in key central cardioregulatory nuclei was observed during the development of 2K1C hypertension. Losartan, an AT1R antagonist, partially reduced the increase in intracranial pressure in hypertensive rats, indicating that AT1R activation may play a role in elevated intracranial pressure during hypertension.
Article
Neurosciences
William Robert Kwapong, Le Cao, Ruosu Pan, Hang Wang, Chen Ye, Wendan Tao, Junfeng Liu, Bo Wu
Summary: This study aimed to evaluate retinal microvascular and structural changes in intracranial hypertension (IH) patients compared with controls, and to investigate the association between clinical parameters and retinal changes in IH patients. The results showed that IH patients had reduced microvascular densities and thinner retinal thicknesses compared with controls. There was also a correlation between clinical parameters and retinal changes in IH patients.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Clinical Neurology
Arhem F. Barkatullah, Lakshmi Leishangthem, Heather E. Moss
Summary: This review discusses the significance of negative and positive neuroimaging findings in the diagnosis of idiopathic intracranial hypertension (IIH). Recent advances in MRI techniques have allowed for better characterization of intracranial changes associated with IIH, potentially serving as MRI biomarkers of increased intracranial pressure. Empty sella turcica, optic nerve protrusion, and other specific findings have been identified as promising diagnostic markers for IIH.
CURRENT OPINION IN NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Kassi Ackerman, Akram Mohammed, Lokesh Chinthala, Robert L. Davis, Rishikesan Kamaleswaran, Nadeem Shafi
Summary: A machine learning approach was used to identify novel features associated with elevated intracranial pressure events in children with severe brain injuries. The study found that hemodynamic changes can be observed up to 4 hours prior to elevated intracranial pressure events, with blood pressure and intracranial pressure data being the most significant indicators.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Priyantha Wijayatunga, Lars-Owe D. Koskinen, Nina Sundstrom
Summary: This study aimed to develop a model that could predict future intracranial pressure (ICP) levels of individual patients in the intensive care unit (ICU) in order to warn treating clinicians. The model, based on a probabilistic Markov model and a prediction enhancement method, was able to reliably predict increases in ICP and had a straightforward expandability.
SCIENTIFIC REPORTS
(2022)
Article
Urology & Nephrology
Christine Y. Bakhoum, Manali Phadke, Yanhong Deng, Joshua A. Samuels, Pranav S. Garimella, Susan L. Furth, F. Perry Wilson, Joachim H. Ix
Summary: This study found no significant association between non-dipping blood pressure and progression to kidney failure or changes in proteinuria in children with chronic kidney disease.
KIDNEY INTERNATIONAL REPORTS
(2022)
Review
Clinical Neurology
Benson S. Chen, John O. T. Britton
Summary: This review provides an overview of the expanding clinical spectrum of idiopathic intracranial hypertension (IIH). Unusual presentations of IIH, such as highly asymmetric or unilateral papilledema, IIH without papilledema, and IIH associated with cranial nerve involvement, are discussed. The review also highlights the radiological signs of intracranial hypertension and possible associations with osseous changes in the skull base.
CURRENT OPINION IN NEUROLOGY
(2023)
Article
Clinical Neurology
W. Dai, H. Liu, Y. Chen, Z. Chen
Summary: This retrospective study summarized the clinical and imaging characteristics of 5 patients with primary intracranial pure yolk sac tumors. It was found that the tumors were mainly located in the posterior fossa and supratentorial region, and showed significant enhancement on MR or CT scans after contrast agent administration. Surgery combined with radiation therapy and/or chemotherapy had a better prognosis.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Hong-Qi Li, Xun Wang, Hui-Fu Wang, Wei Zhang, Jing-Hui Song, Song Chi, Yan-Ping Sun, Xiao-Ling Zhong, Teng Ma, Guo-Zheng Dai, Lan Tan, Qiang Dong, Jin-Tai Yu
Summary: The study found that for every 10 mmHg increase in blood pressure, the odds of ICAS increased by 32%, 28%, and 35% respectively; an increase in systolic blood pressure and pulse pressure were also associated with higher risk of ICAS burden.
Review
Clinical Neurology
Aku L. Kaipainen, Erik Martoma, Tero Puustinen, Joona Tervonen, Henna-Kaisa Jyrkkanen, Jussi J. Paterno, Anna Kotkansalo, Susanna Rantala, Ulla Vanhanen, Ville Leinonen, Soili M. Lehto, Matti Iso-Mustajarvi, Antti-Pekka Elomaa, Sara Qvarlander, Terhi J. Huuskonen
Summary: IIH patients exhibit elevated CSF pressure, respiratory wave power, and pressure constant, often with inadequate treatment of antipsychotic drugs. Patients with IIH without acetazolamide treatment show higher RAP index and slow waves, potentially indicating autoregulation issues.
ACTA NEUROCHIRURGICA
(2021)
Article
Clinical Neurology
Silvia Hernandez-Duran, Leonie Meinen, Veit Rohde, Christian von der Brelie
Summary: This study found that in patients with malignant cerebral infarction, an intracranial pressure (ICP) persistently above 10 mm Hg in the first 72 hours after decompressive hemicraniectomy predicts mortality. The research also calls for a redefinition of ICP thresholds for further treatment.
Article
Biology
Per Kristian Eide
Summary: This study found that abnormal pulsatile intracranial pressure (ICP) persists in patients with idiopathic intracranial hypertension (IIH) refractory to conservative medical therapy, despite normalized static ICP. The abnormal pulsatile ICP may reflect changes at the glia-neurovascular interface resulting in impaired astrocytic pulsation absorber mechanisms.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yupeng Zhang, Chao Ma, Shikai Liang, Changxuan Li, Haoyu Zhu, Zhiye Li, Zhongrong Miao, Xu Tong, Kehui Dong, Chuhan Jiang, Binbin Sui, Dapeng Mo
Summary: This study aimed to explore a non-invasive method to estimate pressure drop in patients with idiopathic intracranial hypertension (IIH) undergoing venous sinus stenting. The work-energy equation can be used to accurately estimate the trans-stenotic pressure drop in IIH.
EUROPEAN RADIOLOGY
(2023)
Article
Clinical Neurology
Ebru Arhan, Yilmaz Akbas, Ayse Serdaroglu, Meltem Cobanogullari Direk, Cetin Okuyaz, Cengiz Havali, Kursad Aydin
Summary: Subacute sclerosing panencephalitis is a rare neurodegenerative encephalitis with atypical clinical manifestations and imaging findings that can be confused with metabolic disorders. Patients typically present with dystonia, syncopal attacks, involuntary limb movements, meaningless speech, and ataxia. MRI abnormalities include involvement of the putamen, posterior periventricular white matter, and corpus callosum, which are uncommon in SSPE but seen in metabolic disorders. Elevated CSF Ig G measles antibodies are common in SSPE patients.
ACTA NEUROLOGICA BELGICA
(2021)
Article
Behavioral Sciences
Ebru Arhan, Habibe Koc Ucar, Kursad Aydin, Tugba Hirfanoglu, Ayse Serdaroglu
Summary: The study aimed to assess sleep architecture and problems among different groups of children with epilepsy. Results showed that children with drug-resistant epilepsy experienced the most severe sleep disturbances, while those with newly diagnosed epilepsy also had significant sleep issues compared to healthy children.
EPILEPSY & BEHAVIOR
(2021)
Article
Endocrinology & Metabolism
Cengiz Havali, Sevil Dorum, Arzu Ekici, Ozlem Gorukmez
Summary: Neurotransmitter disorders are caused by disturbances of neurotransmitter metabolism and diagnosing patients can be challenging. Investigating neurotransmitters in cerebrospinal fluid and analyzing related genes is crucial for accurate diagnosis. Treatment should combine drugs targeting these disturbances to achieve appropriate responses.
METABOLIC BRAIN DISEASE
(2021)
Article
Clinical Neurology
Cengiz Havali, Arzu Ekici, Sevil Dorum, Ozlem Gorukmez, Ali Topak
Summary: This study evaluated six newly diagnosed patients with WWOX-related epileptic encephalopathy, identifying biallelic pathogenic variants in the WWOX gene. Three variations and two novel mutations in the WWOX gene were detected. Pathogenic WWOX mutations are associated with early-onset epileptic encephalopathy.
NEUROLOGICAL RESEARCH
(2021)
Article
Pediatrics
Sevil Dorum, Cengiz Havali
Summary: This study describes the clinical and molecular details of six patients diagnosed with argininemia, including two patients with hyperargininemia carrying two novel variations of the Arginase-1 gene. The patients exhibited neuromotor retardation and spastic paraparesis, and all had hyperargininemia.
PEDIATRICS INTERNATIONAL
(2022)
Article
Clinical Neurology
Cengiz Havali, Hulya Ince, Elif Basaran Gundogdu, Esra Gurkas, Yasemin Karal, Arzu Ekici, Ercan Gundogdu
Summary: This study reviewed the experience of treating sigmoid sinus thrombosis and elevated intracranial pressure in children at four medical centers over a five-year period. Common symptoms included fever, ear pain, headache, visual disorders, and vomiting, while common neurological findings included papilledema, strabismus, and sixth cranial nerve palsy. Treatment modalities included anticoagulant therapy, antibiotics, lumbar puncture, and lumboperitoneal shunt.
CHILDS NERVOUS SYSTEM
(2022)
Article
Endocrinology & Metabolism
Ozlem Gorukmez, Cengiz Havali, Orhan Gorukmez, Sevil Dorum
Summary: Peroxisomal disorders are a group of diseases caused by mutations in various genes. ACBD5 gene mutations are known to be one of the genetic disorders leading to this condition. This study reports two siblings with a novel homozygous nonsense variation in the ACBD5 gene.
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2022)
Article
Neurosciences
Ahmet Burak Civan, Arzu Ekici, Cengiz Havali, Nevin Kilic, Muharrem Bostanci
Summary: This study examined the clinical and sociodemographic characteristics of patients diagnosed with febrile seizure (FS) and found that age, complex FS, and neurodevelopmental delay were risk factors for recurrence. Additionally, neurodevelopmental delay and long-term use of antiepileptic drugs were associated with the development of epilepsy. Abnormal electroencephalogram (EEG) readings were also an important risk factor for epilepsy development. The study concluded that long-term prophylactic treatment did not reduce the recurrence of FS or the development of epilepsy.
ARQUIVOS DE NEURO-PSIQUIATRIA
(2022)
Article
Clinical Neurology
Esra Sarigecili, Habibe Koc Ucar, Cengiz Havali, Ali Cansu, Kursad Aydin
Summary: Acute necrotizing encephalopathy (ANEC) is a rare brain disease characterized by encephalopathy following a febrile illness. This article presents nine pediatric cases diagnosed with ANEC and with at least one variation in the RANBP2 gene. Well-defined MRI findings are crucial for early diagnosis and treatment.
ACTA NEUROLOGICA BELGICA
(2023)
Article
Clinical Neurology
Hakan Ercelebi, Pinar Ozbudak, Tugba Hirfanoglu, Ayse Serdaroglu, Unsal Yilmaz, Ebru Arhan
Summary: The study examined the semiological features of Psychogenic Nonepileptic Seizures (PNES) in children and evaluated the interobserver reliability of two different classifications. The results showed that ictal eye closure was the most common seizure semiology, and the new classification system had higher interobserver reliability compared to the old classification system.
Article
Pediatrics
Serap Bilge, Gulen Gul Mert, Ozlem Herguner, Duygu Ozcanyuz, Sevcan Tug Bozdogan, Omer Kaya, Cengiz Havali
Summary: This study presents the clinical and radiological manifestations of genetically diagnosed PCH patients. PCH is a rare neurodegenerative disease with heterogeneous features. PCH7 and PCH11 show gender-specific characteristics.
ITALIAN JOURNAL OF PEDIATRICS
(2022)
Meeting Abstract
Clinical Neurology
D. Menderes, E. Serdaroglu, E. Arhan, T. Hirfanoglu, A. Serdaroglu
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Pharmacology & Pharmacy
H. K. Ucar, E. Arhan, K. Aydin, T. Hirfanoglu, A. Serdaroglu
Summary: The study aims to evaluate epilepsy classification in children before and after monitoring, comparing the ILAE and SSC systems. The results show that parents can generally describe seizures well, and both systems can be applied in daily practice.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Neurosciences
Habibe Ucar, Ebru Arhan, Kuersad Aydin, Tugba Hirfanoglu, Ayse Serdaroglu
Summary: This study aimed to determine the significance of SWI calculation during electrical status epilepticus during slow sleep (ESES). The evaluation of EEG findings revealed a strong positive correlation between the short method and long conventional method, and the SWI short method was found to predict typical ESES. Therefore, utilizing measurements such as SWP and SF allows for the comparison of epileptiform activities among different patient groups.
NEUROLOGICAL SCIENCES AND NEUROPHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
H. K. Ucar, E. Arhan, K. Aydin, T. Hirfanoglu, A. Serdaroglu
Summary: This study examined the development and resolution of ESES in children with BCECTS and evaluated the clinical and EEG parameters associated with prognosis. The results showed that the resolution rate of ESES was 87.9%, with a median time to resolution of 10.5 months. Age at ESES diagnosis, the time between BCECTS diagnosis and the onset of ESES, time to resolution of ESES, ESES remission, and seizure freedom after ESES were found to be significantly associated with prognosis.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Ani Gok, Seha Kamil Saygili, Sebuh Kurugoglu, Sema Saltik, Nur Canpolat
Summary: This study examines the occurrence of nephrolithiasis in children with type 1 SMA and identifies hypercalciuria and high urine specific gravity as common risk factors. The study suggests that children with SMA type 1 may have an increased risk of nephrolithiasis compared to the general population.
PEDIATRIC NEUROLOGY
(2024)
Article
Clinical Neurology
Glenn S. Rivera, Jesse A. Stokum, Janet Dean, Cristina L. Sadowsky, Allan J. Belzberg, Matthew J. Elrick
Summary: This study evaluated the surgical efficacy of nerve transfer surgery in patients with acute flaccid myelitis (AFM) and found that preoperative clinical and neurophysiological data play a valuable role in preoperative planning and patient selection. The postoperative outcomes demonstrated that nerve transfer surgery is an effective strategy to restore strength.
PEDIATRIC NEUROLOGY
(2024)
Review
Clinical Neurology
Tristan T. Sands, Jennifer N. Gelinas
Summary: This review explores the concept of epileptic encephalopathy (EE) in pediatric epilepsy, discussing the potential impact of epileptic activity on normal brain development and mechanisms underlying cognitive and behavioral impairments. The findings highlight the threat of epileptic activity to normal brain physiology and development.
PEDIATRIC NEUROLOGY
(2024)
Editorial Material
Clinical Neurology
Grace Gombolay, Melissa A. Walker
PEDIATRIC NEUROLOGY
(2024)
Article
Clinical Neurology
Salman Rashid, Monisha Goyal, Kathryn Lalor, Khaled Al-Robaidi, Vivek Shukla, Fazlur Rahman, Manimaran Ramani
Summary: This study investigated the seizure risk in asymptomatic preterm infants with high-grade intraventricular hemorrhage who underwent long-term video electroencephalographic monitoring. The findings showed that approximately 16% of these infants had seizures, and those with seizures were younger and more likely to be remonitored.
PEDIATRIC NEUROLOGY
(2024)
Letter
Clinical Neurology
Bernadeta Zabielska, Natalia Rzewuska, Sergiusz Jozwiak
PEDIATRIC NEUROLOGY
(2024)
Article
Clinical Neurology
Kelly C. Burk, Maki Kaneko, Catherine Quindipan, My H. Vu, Maritza Feliz Cepin, Jonathan D. Santoro, Michele Van Hirtum-Das, Deborah Holder, Gordana Raca
Summary: This study compared the diagnostic yields of chromosomal microarray (CMA) and epilepsy-genes sequencing (EGS) for genetic epilepsy etiologies. It found that EGS had a significantly higher diagnostic yield than CMA, especially for patients with infantile seizure onset and additional neurological findings.
PEDIATRIC NEUROLOGY
(2024)
Article
Clinical Neurology
Ursula Thome, Larissa A. Batista, Renata P. Rocha, Vera C. Terra, Ana Paula A. Hamad, Americo C. Sakamoto, Antonio C. Santos, Marcelo Santos, Helio R. Machado
Summary: Rasmussen encephalitis (RE) is a characterized by pharmacoresistant epilepsy and progressive neurological deficits. Surgical disconnection of the affected hemisphere is considered the treatment of choice, although the precise etiology is still unknown. This study reports the clinical, electrographic, and neuroimaging features of children and adolescents who underwent hemispheric surgery (HS) for the treatment of RE.
PEDIATRIC NEUROLOGY
(2024)
Article
Clinical Neurology
Michal Tzadok, Rotem Gur-Pollack, Hadar Florh, Yael Michaeli, Tal Gilboa, Mirit Lezinger, Eli Heyman, Veronika Chernuha, Irina Gudis, Andreea Nissenkorn, Tally Lerman-Sagie, Bruria Ben Zeev, Shimrit Uliel-Sibony
Summary: Purified CBD is well-tolerated and effective in reducing seizure frequency in children and young adults with drug-resistant epilepsy.
PEDIATRIC NEUROLOGY
(2024)
Editorial Material
Clinical Neurology
Zimeng Ye, Sufang Lin, Xia Zhao, Mathew Wallis, Xinyi Gao, Li Sun, Jiarui Wu, Jing Duan, Yi Yao, Lin Li, Li Chen, Dezhi Cao, Zhanqi Hu, Victor W. Zhang, Samuel F. Berkovic, Ingrid E. Scheffer, Jianxiang Liao, Michael S. Hildebrand
PEDIATRIC NEUROLOGY
(2024)
Article
Clinical Neurology
Nicolas J. Abreu, Madeline Chiujdea, Shanshan Liu, Bo Zhang, Sarah J. Spence
Summary: This study found a low completion rate of chromosomal microarray (CMA) testing for patients with autism spectrum disorder (ASD). Provider recommendation and more follow-up visits were associated with CMA completion. Age, intellectual disability or global developmental delay, first-degree relative with ASD, and public insurance were all related to CMA completion. Parental concern and cost/insurance coverage were the most frequently documented barriers.
PEDIATRIC NEUROLOGY
(2024)
Article
Clinical Neurology
Wafa Bouchaala, Sirine Laroussi, Yosra Mzid, Imen Maaloul, Olfa Jallouli, Salma Zouari, Sihem Ben Nsir, Zeineb Mnif, Fatma Kammoun, Chahnez Triki
Summary: Moyamoya angiopathy is a rare but serious cerebrovascular disease in children, which may result in arterial ischemic stroke. The clinical and radiological presentations can vary and are often overlooked. Early diagnosis and treatment are crucial.
PEDIATRIC NEUROLOGY
(2024)
Letter
Clinical Neurology
Eline M. C. Hamilton, Pinar Topaloglu, Jigyasha Sinha, Francesco Nicita, Genevieve Bernard, S. Ali Fatemi, Marjo S. van der Knaap
PEDIATRIC NEUROLOGY
(2024)
Article
Clinical Neurology
Muhamad Azamin Anuar, Muhammad'Adil Zainal Abidin, Soo Hong Tan, Cai Fong Yeap, Nor Azni Yahaya
Summary: This study conducted in Malaysia found that most infants with epilepsy can achieve seizure remission. However, poor seizure control and developmental delay are associated with abnormal EEG background and neuroimaging abnormalities.
PEDIATRIC NEUROLOGY
(2024)