Article
Immunology
Chunlei Guo, Wenkui Dai, Qian Zhou, Liming Gui, Han Cai, Di Wu, Jun Hou, Changzhong Li, Shuaicheng Li, Hui Du, Ruifang Wu
Summary: The microbial community in the lower female genital tract is associated with the risk of genital infection. This study found significant changes in the microbial community when squamous intraepithelial lesion (SIL) developed into high-grade SIL (HSIL).
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Endocrinology & Metabolism
Chaoyan Yue, Chunyi Zhang, Chunmei Ying, Hua Jiang
Summary: This study found that diabetes and prediabetes are associated with cervical cancer in patients with HR-HPV combined with HGSIL.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Nikki B. Thuijs, Willemijn A. M. Schonck, Linde L. J. Klaver, Guus Fons, Marc van Beurden, Renske D. M. Steenbergen, Maaike C. G. Bleeker
Summary: In this exploratory study, biomarker profiles in patients with multiple high-risk HPV-associated vulvar precursor lesions were compared. While the biomarkers generally showed similar expression between lesions, marked differences were occasionally observed, indicating heterogeneity within multifocal lesions. This study contributes to a better understanding of the potential diagnostic, prognostic, and predictive value of biomarkers in patients with multifocal HSIL.
Article
Biochemistry & Molecular Biology
Karen Cortes-Sarabia, Luz del Carmen Alarcon-Romero, Eugenia Flores-Alfaro, Berenice Illades-Aguiar, Amalia Vences-Velazquez, Miguel Angel Mendoza-Catalan, Napoleon Navarro-Tito, Jesus Valdes, Ma Elena Moreno-Godinez, Carlos Ortuno-Pineda
Summary: The study evaluated the expression of REST and RASSF1A in cervical cytological and histological samples, finding a significant decrease in nuclear expression of REST and RASSF1A in patients with high-grade SIL and SCC. These findings may contribute to the diagnosis, prognosis, and post-treatment follow-up of patients with SIL or SCC.
BIOMEDICAL JOURNAL
(2021)
Editorial Material
Medicine, General & Internal
Anne-Sophie Wegscheider, Nikolas Tauber, Kirsten Graubner, Gudrun Ziegeler, Michael Behr, Christoph Lindner, Axel Niendorf
Summary: This article describes a rare case of high-grade squamous intraepithelial lesion of the right fallopian tube in a 51-year-old woman who underwent abdominal hysterectomy. The presence of this lesion raises questions about the possibility of a virus-associated field effect and emphasizes the importance of examining the fallopian tube in routine settings.
Article
Oncology
Stephan Polterauer, Olaf Reich, Andreas Widschwendter, Laudia Hadjari, Gerhard Bogner, Alexander Reinthaller, Elmar Joura, Gerda Trutnovsky, Alexandra Ciresa-Koenig, Julia Ganhoer-Schimboeck, Ina Boehm, Regina Berger, Eva Langthaler, Stephan W. Aberle, Georg Heinze, Andreas Gleiss, Christoph Grimm
Summary: This study investigates the non-inferiority of topical IMQ therapy compared to LLETZ in patients diagnosed with HSIL. The results show that IMQ treatment leads to lower HPV clearance rates compared to LLETZ, suggesting that LLETZ remains the standard treatment for HSIL patients.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Biochemical Research Methods
Jixuan Liu, Teng Yang, Yubo Hu, Cong Ye
Summary: A quantitative analysis of HPV E6/E7 mRNA may be a valuable tool for distinguishing high-grade cervical squamous intraepithelial lesions (HSIL) and low-grade squamous intraepithelial lesions (LSIL). This study compared the expression levels of HPV E6/E7 mRNA between HSIL and LSIL and determined a new method for distinguishing cervical squamous intraepithelial lesions.
JOURNAL OF VIROLOGICAL METHODS
(2021)
Article
Obstetrics & Gynecology
Rikke Kamp Damgaard, David Jenkins, Mark H. Stoler, Miekel M. van de Sandt, Kathrine Dyhr Lycke, Maurits N. C. de Koning, Wim G. V. Quint, Torben Steiniche, Lone Kjeld Petersen, Anne Hammer
Summary: This study aimed to describe the distribution of HPV genotypes, age, and cytology in women undergoing active surveillance for CIN2. The results showed a high prevalence of HPV16 and high-grade cytology, implying that these women may be perceived as a high-risk population and non-eligible for active surveillance in countries outside Denmark.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Surgery
Jun Ding, Haiou Xu, Lihua Xia, Shanshan Cao, Qing Wu
Summary: The study compared the performance and outcomes of monopolar electrosurgical conization (MESC) and the loop electrosurgical excision procedure (LEEP) in the treatment of high-grade squamous intraepithelial lesion (HSIL). The results showed that MESC had better pathological outcomes in terms of margin status, tissue fragmentation, and cone depth.
FRONTIERS IN SURGERY
(2021)
Article
Medicine, General & Internal
Xiaopei Chao, Lan Wang, Shu Wang, Jinghe Lang, Xianjie Tan, Qingbo Fan, Honghui Shi
Summary: This study identified potential vaginal microbiome biomarkers associated with high-grade squamous intraepithelial lesion (HSIL), which can be used to predict the development of HSIL in HPV-infected patients and may help facilitate cervical cancer screening strategies.
FRONTIERS IN MEDICINE
(2021)
Letter
Dermatology
Camille Isnard, Johan Chanal, Christine Bergeron, Olivier Aynaud
Summary: We conducted the first study on cervical HPV lesions in female partners of males with PHSILs. In 81% of cases, histologically confirmed cervical SIL was observed, with high-grade SIL in more than two-thirds of cases and low-grade SIL in one-third. Screening of females with male partners who have PHSIL is important to detect and treat clinical HPV lesions early. Our results suggest that HPV testing and reflex cytology should be performed for female partners of males with PHSILs. Colposcopy should be done if there is an abnormal Pap smear.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Immunology
Takeo Shibata, Sumit Shah, Teresa Evans, Hannah Coleman, Benjamin J. Lieblong, Horace J. Spencer, Charles M. Quick, Toshiyuki Sasagawa, Owen W. Stephens, Erich Peterson, Donald Johann, Yong-Chen Lu, Mayumi Nakagawa
Summary: The use of high-throughput sequencing has shown that HPV vaccine can induce specific T cell expansion in both peripheral blood and cervical tissue. This approach not only confirms the presence of vaccine-specific T cells in the body, but also provides a novel method to assess vaccine-specific responses in various anatomical areas.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Obstetrics & Gynecology
Christian Markus Domroese, Ulrike Wieland, Henryk Pilch, Thomas Einzmann, Birgid Schoemig-Markiefka, Peter Mallmann, Steffi Silling, Michael Rudolf Mallmann
Summary: Despite the effectiveness of prophylactic human papillomavirus (HPV) vaccination, high-grade cervical intraepithelial neoplasia (CIN 3) can still occur in vaccinated women. This study aimed to identify characteristics of women with CIN 3 after HPV vaccination. The results showed that although the women had received the quadrivalent HPV vaccine (Q-HPV), there were other high-risk HPV types causing CIN 3, indicating the need for further screening after vaccination.
JOURNAL OF LOWER GENITAL TRACT DISEASE
(2022)
Article
Biotechnology & Applied Microbiology
Ziwen Zheng, Xiaorong Yang, Xinyu Yao, Ling Li
Summary: The study explored the prognostic value of HPV 16/18 genotyping and geminin mRNA quantification in predicting the progression of low-grade cervical squamous intraepithelial lesion (LSIL). Results showed that HPV 16/18 positivity rate and geminin mRNA levels can differentiate between high-grade and low-grade squamous intraepithelial lesions, suggesting a potential role of geminin in the progression of LSIL. Combining HPV genotyping and geminin mRNA qRT-PCR could improve clinical intervention efficacy for progressive LSIL.
Article
Oncology
A. Ranabhotu, N. Habibian, B. Patel, E. Farrell, J. Do, S. Sedghi, L. Sedghi
Summary: This case report presents a case of HPV infection-related intraepithelial neoplasia with concurrent syphilis coinfection. The syphilis coinfection may potentiate HPV-related squamous cell carcinoma. These findings provide new clues for further research on the role of sexually transmitted infection-associated bacteria and HPV coinfection in the development of intraepithelial neoplasia.
FRONTIERS IN ONCOLOGY
(2023)