Article
Multidisciplinary Sciences
Akram Azimi, Farhad Rezaei, Mehdi Yaseri, Sirus Jafari, Mohammad Rahbar, Masoumeh Douraghi
Summary: Stenotrophomonas maltophilia demonstrates a wide spectrum of fluoroquinolone resistance through various mechanisms such as multidrug efflux pumps and Smqnr alleles. The presence of efflux pumps like SmeDEF, SmeVWX and Smqnr genes significantly contribute to fluoroquinolone resistance. Smqnr8 is the most common allele found in ciprofloxacin-resistant isolates, indicating a role in low-level levofloxacin resistance.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Rebecca Horch, Diana Rasp, Annika Dietz, Ronald Ebbert, Joerg Steinmann, Ulrich E. Schaible, Uwe Mamat, Ralph Bertram
Summary: Stenotrophomonas maltophilia is an important nosocomial pathogen with intrinsic resistance to antibiotics. The implementation of tet regulation allows for the regulation of gene expression and provides a deeper understanding of its physiology and virulence.
MICROBIOLOGY SPECTRUM
(2023)
Review
Medicine, General & Internal
Maryam Banar, Azin Sattari-Maraji, Ghazal Bayatinejad, Elahe Ebrahimi, Leila Jabalameli, Reza Beigverdi, Mohammad Emaneini, Fereshteh Jabalameli
Summary: This study conducted a comprehensive analysis of the global prevalence and antibiotic resistance of Stenotrophomonas maltophilia. The results showed an increasing trend in the prevalence of S. maltophilia infections, with higher prevalence in the Western Pacific Region and lower prevalence in the American regions. The analysis of antibiotic resistance revealed high resistance to cefuroxime and low resistance to minocycline. Trimethoprim-sulfamethoxazole was still considered effective for treating S. maltophilia infections.
FRONTIERS IN MEDICINE
(2023)
Review
Microbiology
Ali Delgarm Shams-Abadi, Abdollah Mohammadian-Hafshejani, David L. Paterson, Rezvan Arash, Elham Asadi Farsani, Asieh Taji, Hamid Heidari, Milad Shahini Shams Abadi
Summary: This study aimed to conduct a systematic review and meta-analysis to examine the prevalence of colistin resistance in clinical S. maltophilia isolates worldwide. The pooled prevalence for colistin resistance was 42%, ranging from 0.1% to 97%. Alternative antibiotics should be considered for the treatment of serious S. maltophilia infections.
Article
Virology
Dragica Damnjanovic, Xabier Vazquez-Campos, Lisa Elliott, Mark Willcox, Wallace J. Bridge
Summary: This study investigated the infection capacity of Stenotrophomonas phage vB_SmaM_Ps15 on ocular S. maltophilia strains, finding that the phage had lytic activity and was resistant to multiple antibiotics and disinfectant solutions. Genomic analysis classified vB_SmaM_Ps15 as a new species of the Menderavirus genus, suggesting its potential use for treating S. maltophilia eye infections.
Article
Environmental Sciences
Shuhong Zhang, Guangli Yang, Yali Jiang
Summary: Whole-genome sequencing of Stenotrophomonas maltophilia from permafrost revealed lower maximum minimum inhibitory concentration (MIC) of antibiotics and metals, as well as fewer antibiotic resistance genes and metal resistance genes compared to clinical strains. This suggests that the occurrence of antibiotic and metal resistance in permafrost strains is due to inherent resistance rather than human-induced selective pressure.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Microbiology
Arianna Pompilio, Marco Ranalli, Alessandra Piccirilli, Mariagrazia Perilli, Dragana Vukovic, Branislava Savic, Marcela Krutova, Pavel Drevinek, Daniel Jonas, Ersilia V. Fiscarelli, Vanessa Tuccio Guarna Assanti, Maria M. Tavio, Fernando Artiles, Giovanni Di Bonaventura
Summary: The ability of Stenotrophomonas maltophilia to form biofilms is a significant factor in the pathogenesis of infections, especially in deep infections. Biofilm formation is positively correlated with clinical outcomes such as mechanical ventilation, and negatively correlated with antibiotic resistance, particularly in pathogenic strains. Mature biofilms of S. maltophilia are much more resistant to antibiotics compared to planktonic cells, especially in the case of bloodborne strains. Additional studies with larger patient cohorts and isolates are warranted to further investigate this phenomenon.
Article
Infectious Diseases
ChengCheng Yue, WeiHua Shen, LiFen Hu, YanYan Liu, YaHong Zheng, Ying Ye, Yuhao Zhang, JiaBin Li
Summary: The study demonstrated that the combination of azithromycin and tigecycline effectively inhibited biofilm formation by S. maltophilia. Specifically, the combination of 2x MIC azithromycin with 1x MIC tigecycline showed the best inhibitory effect, significantly reducing biofilm thickness.
INFECTION AND DRUG RESISTANCE
(2021)
Review
Pharmacology & Pharmacy
Ashlan J. Kunz Coyne, Shelbye Herbin, Kaylee Caniff, Michael J. Rybak
Summary: Stenotrophomonas maltophilia is a dangerous pathogen that commonly causes nosocomial infections. Patients with compromised immune systems, chronic respiratory illnesses, and prior exposure to carbapenems are at higher risk. The complex virulence and resistance profile of this bacteria make treatment difficult due to limited antibiotics options and lack of data for dose optimization.
Article
Microbiology
Megan Y. Nas, Jeffrey Gabell, Nicholas P. Cianciotto
Summary: Previously, it was found that Stenotrophomonas maltophilia possesses a T4SS that can kill other bacteria, with two effectors, RS14245 and RS14255, identified as key components in killing pathogenic Pseudomonas aeruginosa. These findings represent a significant advancement in understanding S. maltophilia, T4SS function, clinically relevant interactions, and bactericidal activities.
Article
Infectious Diseases
Patchrapa Boonmee, Worapong Nasomsong, Narisorn Lorchirachoonkul, Supanun Pungcharoenkijkul, Piraporn Juntanawiwat, Suphatthra Chaemchaeng, Wichai Santimaleeworagun
Summary: This retrospective study examined the antimicrobial susceptibility profile and clinical outcomes of S. maltophilia infections at three tertiary care hospitals in Central Thailand. The results showed a high mortality rate and identified severity of illness and non-use of TMP-SMX as predictive factors for treatment failure. A TMP-SMX-based regimen was recommended for the treatment of S. maltophilia infections.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Infectious Diseases
Orathai Yinsai, Manu Deeudom, Kwanjit Duangsonk
Summary: This study investigated the demographic, genotypic, and phenotypic characteristics of Stenotrophomonas maltophilia isolates from a hospital in Thailand. Male and aged patients were more susceptible to infection with this bacterium. The bacteria exhibited various drug resistance patterns, genetic profiles, and phenotypes, supporting their virulence and pathogenicity. Understanding the characteristics of this bacterium is important for controlling and preventing its spread in Thailand.
Article
Microbiology
Lanjun Shao, Xiaojing Liu, Yi Liu, Jie Shen, Ruishan Liu, Pingnan Chen
Summary: This study investigated the genetic relationship among Stenotrophomonas maltophilia strains in fecal samples from dairy cows in northeast China and identified the dominant 13-lactamase genotype. The results showed clonal diversity of S. maltophilia in these two regions and clonal relatedness of the strains from these regions. Furthermore, it provided evidence of the dissemination and characterization of S. maltophilia isolates from dairy cows in northeast China.
POLISH JOURNAL OF MICROBIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
J. Kardan-Yamchi, A. Hajihasani, M. Talebi, S. Khodaparast, A. Azimi, M. Rahbar, F. Fallah, M. Douraghi
Summary: This study revealed clonal relatedness between clinical and environmental isolates of S. maltophilia in three hospitals in Tehran, Iran. A small cluster of isolates was found to be shared between the clinic and environment within a hospital, demonstrating intra-hospital dissemination of certain S. maltophilia isolates.
LETTERS IN APPLIED MICROBIOLOGY
(2021)
Article
Immunology
Weina Shi, Junwan Lu, Chunlin Feng, Mengdi Gao, Anqi Li, Shuang Liu, Lei Zhang, Xueya Zhang, Qiaoling Li, Hailong Lin, Xi Lin, Kewei Li, Hailin Zhang, Yunliang Hu, Guangli Wang, Qiyu Bao, Weiyan Jiang
Summary: The study aimed to identify a novel chromosome-encoded antimicrobial resistance gene in clinical isolates. Gene cloning and antibiotic susceptibility tests confirmed the function of the predicted resistance gene. The newly identified aminoglycoside (AG) resistance genes aph(9)-Ic and aph(9)-Ic1 confer resistance to spectinomycin. Whole-genome sequencing and bioinformatic analysis revealed the genetic context of the resistance gene. The study contributes to the understanding of resistance mechanisms in microbial populations.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)