Article
Immunology
Eric R. Houpt, Tahsin Ferdous, Rifat Ara, Momena Ibrahim, Md Masud Alam, Mamun Kabir, James Platts-Mills, Tahmeed Ahmed, Abu Syed Golam Faruque, Mami Taniuchi, Rashidul Haque
Summary: The study found that infection with Shigella with decreased susceptibility to azithromycin was significantly associated with persistent diarrhea, positive culture results, and higher hospitalization rates. Additionally, poor clinical outcomes were linked to S. sonnei, which is an emerging drug-resistant threat. The study supports the use of susceptibility testing and clinical breakpoints for azithromycin.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Infectious Diseases
Mohd Zulkifli Salleh, Nik Mohd Noor Nik Zuraina, Khalid Hajissa, Mohamad Ikram Ilias, Kirnpal Kaur Banga Singh, Zakuan Zainy Deris
Summary: Shigellosis remains a major cause of morbidity and mortality worldwide, and the emergence of antimicrobial-resistant strains poses a significant challenge in its treatment. This systematic review and meta-analysis provide an updated picture of the prevalence of antimicrobial-resistant Shigella species in Asia. The study found that multidrug-resistant and extended-spectrum beta-lactamase-producing Shigella strains are prevalent among Asian patients.
Article
Immunology
A. Stefanovic, N. Matic, G. Ritchie, C. F. Lowe, V. Leung, M. Hull, M. Alam, M. Dawar, S. Champagne, M. G. Romney
Summary: Increased invasive bloodstream infections caused by multidrug resistant Shigella sonnei were observed in Vancouver, British Columbia, Canada, between 2021 and 2023. Whole-genome sequencing revealed clonal transmission of genotype 3.6.1.1.2 (CipR.MSM5) among homeless individuals. Improvements in identifying Shigella species, expanding treatment options for multidrug resistant infections, and developing public health partnerships are necessary.
EMERGING INFECTIOUS DISEASES
(2023)
Article
Genetics & Heredity
Sajjad Zamanlou, Pooya Omidnia, Farhad Babaie, Arefeh Mehraban, Pooneh Koochaki, Khalil Azizian, Hossein Hosseini Nave, Abed Zahedi Bialvaei, Younes Khalili
Summary: This study investigated the antimicrobial susceptibility and resistance mechanisms of Shigella flexneri and Shigella sonnei in four cities in Iran. The results showed that due to the numerous mechanisms of antibiotic resistance, the selection of appropriate antimicrobial agents for the treatment of shigellosis in children is limited and difficult.
Article
Microbiology
Gordon Ritchie, Victor Leung, Chelsea G. Himsworth, Kaylee A. Byers, Lisa K. F. Lee, Samuel D. Chorlton, Aleksandra Stefanovic, Marc G. Romney, Nancy Matic, Christopher F. Lowe
Summary: This article presents a new molecular method to demonstrate the relationship between bacterial infections that are unable to grow in the lab due to antibiotic treatment or specific growth conditions. It applied this technique to Shigella isolates from human and rat samples in an underserved community. The study found that the rat Shigella species strains were closely related to the human strains in the cluster, indicating a potential transmission between humans and rats in the community.
MICROBIOLOGY SPECTRUM
(2023)
Article
Environmental Sciences
Jianbin Zhao, Chaonan Zhang, Yanbin Xu, Xinyan Li, Xiaojun Lin, Zitao Lin, Tiangang Luan
Summary: Multidrug-resistant bacteria pose a serious threat to disease treatment and recovery, but their potential toxicity to animal development is not entirely clear. In this study, the impact of multidrug-resistant Shigella on the intestinal health of Xenopus tropicalis was investigated. The intake of Shigella led to neutral mucus secretion, inhibited intestinal development and weight gain, and caused intestinal lesions. Additionally, the presence of Shigella altered the expression of cytokines and antioxidant enzyme activities in the gut, and increased the abundance of antibiotic resistance genes.
ENVIRONMENTAL POLLUTION
(2023)
Article
Agriculture, Dairy & Animal Science
Shengnan Ma, Jiaxing Shen, Yakun Xu, Pengyun Ding, Dandan He
Summary: This study aimed to investigate the prevalence and antimicrobial resistance characteristics of P. mirabilis strains in chicken farms and the mechanism of resistance gene transfer. A total of 187 P. mirabilis isolates were obtained, and all showed multidrug resistance (MDR). The resistance genes blaOXA-1, blaCTX-M-1G, blaCTX-M-9G, and mcr-1 were highly carried by the isolates. An MDR strain W47 was selected for whole genome sequencing and conjugation experiment, revealing the presence of 23 resistance genes and 64 virulence genes. ICEPmiChn5-like ICEs were found in 144 isolates, indicating the potential role of ICEs in resistance gene transmission among chicken P. mirabilis strains. These findings provide insights into the resistance mechanism and offer a theoretical basis for the treatment of MDR P. mirabilis infections in veterinary clinics.
Article
Genetics & Heredity
Shakti Kumar, Tanshi Mehrotra, Daizee Talukdar, Jyoti Verma, Bipul Chandra Karmakar, Sangita Paul, Sujit Chaudhuri, Agila Kumari Pragasam, Susmita Bakshi, Shashi Kumari, Meenal Chawla, Ayushi Purohit, Sonali Porey Karmakar, Ankur Mutreja, Sayantan Banerjee, Animesh Ray, Thandavarayan Ramamurthy, Asish K. Mukhopadyay, Bhabatosh Das
Summary: This study analyzed the whole genome sequences of 143 Helicobacter pylori strains isolated from different regions of India and found distinct genomic signatures and antimicrobial resistance phenotypes. The strains from Eastern India showed higher resistance to metronidazole and clarithromycin, while lower resistance to amoxicillin and furazolidone. Moreover, more antimicrobial resistance genes were observed in the Eastern Indian strains compared to the Southern Indian strains. The study also revealed phylogenetic differences among the H. pylori strains based on their geographical locations, with conditionally beneficial functions, including antibiotic resistance phenotypes, being linked to faster evolution rates in the Indian isolates.
Article
Microbiology
Mingze Cao, Weiwei Wang, Liwei Zhang, Guanhui Liu, Xuzheng Zhou, Bing Li, Yuxiang Shi, Zhen Zhu, Jiyu Zhang
Summary: This study investigated fluoroquinolone resistance and molecular characteristics of S. dysenteriae 1 isolated from calves. The study identified new sequence types ST228 and ST229, with 76.32% of isolates showing fluoroquinolone resistance and multidrug resistance. Continuous surveillance is necessary to control the increasing emergence of multidrug-resistant isolates.
Article
Microbiology
Gabriela Guerrera Soares, Emeline Boni Campanini, Roumayne Lopes Ferreira, Marcelo Silva Folhas Damas, Saulo Henrique Rodrigues, Leslie Camelo Campos, Jucimaria Dantas Galvao, Andrea Soares da Costa Fuentes, Caio Cesar de Melo Freire, Iran Malavazi, Andre Pitondo-Silva, Anderson Ferreira da Cunha, Maria-Cristina da Silva Pranchevicius
Summary: This study characterized an isolated Brevundimonas strain from the cerebrospinal fluid of a patient in a neonatal intensive care unit, identifying it as a new species, Brevundimonas brasiliensis sp. nov. The strain exhibited multidrug resistance and contained various antimicrobial resistance genes and virulence-associated genes. The findings provide insights into the genomic diversity, adaptation, evolution, and pathogenicity of multidrug-resistant Brevundimonas.
MICROBIOLOGY SPECTRUM
(2023)
Article
Infectious Diseases
Zarrin Basharat, Muhammad Jahanzaib, Noor Rahman
Summary: This study analyzed the genome information of Shigella sonnei, identified core genes and screened for drug candidates. Two potential inhibitors should be tested in vitro against the pathogen.
INFECTION GENETICS AND EVOLUTION
(2021)
Article
Immunology
Radhika Gharpure, Cindy R. Friedman, Veronica Fialkowski, Jennifer P. Collins, Jonathan Strysko, Zachary A. Marsh, Jessica C. Chen, Elizabeth H. Meservey, Azizat A. Adediran, Morgan N. Schroeder, Ashutosh Wadhwa, Kathleen E. Fullerton, Louise Francois Watkins
Summary: A study investigated a multi-drug resistant Shigella outbreak where 4 patients were treated with azithromycin, all of whom experienced treatment failure, with 2 also showing microbiologic failure; 2 patients who received ciprofloxacin treatment also failed. The findings underscore the importance of identifying alternative treatment options for resistant strains.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Microbiology
Bert Bogaerts, Raf Winand, Julien Van Braekel, Wesley Mattheus, Sigrid C. J. De Keersmaecker, Nancy H. C. Roosens, Kathleen Marchal, Kevin Vanneste, Pieter-Jan Ceyssens
Summary: Shigellosis is an acute enteric infection caused by Shigella flexneri and Shigella sonnei. The study in Belgium found an increase in ciprofloxacin-resistant samples, with all samples showing perfect correspondence between observed phenotypes and WGS-based resistance prediction. The research highlights the importance of WGS for surveillance of shigellosis.
Article
Fisheries
M. S. Nithin, K. B. Kushala, S. K. Girisha, S. B. Dheeraj, H. Harshitha, N. S. Sowndarya, T. Suresh, K. Rakesh, T. N. Vinay
Summary: In this study, a bacterium causing severe mortality in mascara barb was identified as extensively drug-resistant (XDR) virulent Aeromonas dhakensis. It showed multiple antibiotic resistance and high virulence. The PCR test confirmed its identity and it was found that ten natural ingredients and five disinfectants can effectively inhibit the growth of this bacterium.
Letter
Immunology
Souheil Zayet, Timothee Klopfenstein, Alix Pierron, Pierre-Yves Royer, Lynda Toko, Pauline Garnier, Vincent Gendrin
Summary: This study describes three cases of multidrug-resistant S. sonnei in MSM and emphasizes the increased risk of S. sonnei infection among MSM due to different sexual behaviors. The emergence of this pathogen among MSM in Franche-Comte, France, and its association with certain sexual behaviors are highlighted.
EMERGING MICROBES & INFECTIONS
(2021)
Article
Chemistry, Analytical
Pandiyaraj Kanagavalli, Sivaprakasam Radhakrishnan, Gaurav Pandey, Velayutham Ravichandiran, Gururaja Perumal Pazhani, Murugan Veerapandian, Gurumurthy Hegde
Editorial Material
Urology & Nephrology
Rakesh Kumar Pilania, Deepanjan Bhattacharya, Neelam Taneja, Amit Rawat, Deepti Suri, Raja Ramachandran, Karalanglin Tiewsoh
JOURNAL OF NEPHROLOGY
(2021)
Article
Medicine, Research & Experimental
Olawale Salami, Philip Horgan, Catrin E. Moore, Abhishek Giri, Asadu Sserwanga, Ashish Pathak, Buddha Basnyat, Francois Kiemde, Frank Smithuis, Freddy Kitutu, Gajanan Phutke, Halidou Tinto, Heidi Hopkins, James Kapisi, Myo Maung Maung Swe, Neelam Taneja, Rita Baiden, Shanta Dutta, Adelaide Compaore, David Kaawa-Mafigiri, Rashida Hussein, Summita Udas Shakya, Vida Kukula, Stefano Ongarello, Anjana Tomar, Sarabjit S. Chadha, Kamini Walia, Cassandra Kelly-Cirino, Piero Olliaro
Article
Infectious Diseases
Vinay Modgil, Jaspreet Mahindroo, Chandradeo Narayan, Manmohit Kalia, Md Yousuf, Varun Shahi, Meenakshi Koundal, Pankaj Chaudhary, Ruby Jain, Kawaljeet Singh Sandha, Seema Tanwar, Pratima Gupta, Kamlesh Thakur, Digvijay Singh, Neha Gautam, Manish Kakkar, Bhavneet Bharti, Balvinder Mohan, Neelam Taneja
PLOS NEGLECTED TROPICAL DISEASES
(2020)
Article
Immunology
Megan E. Carey, Ruby Jain, Mohammad Yousuf, Mailis Maes, Zoe A. Dyson, Trang Nguyen Hoang Thu, To Nguyen Thi Nguyen, Thanh Ho Ngoc Dan, Quynh Nhu Pham Nguyen, Jaspreet Mahindroo, Duy Thanh Pham, Kawaljeet Singh Sandha, Stephen Baker, Neelam Taneja
Summary: The study in Northern India identified 66 S. Typhi organisms with antimicrobial resistance, including 7 strains with R717Q mutation in the acrB gene conferring resistance to azithromycin and 6 strains with triple mutations in gyrA and parC genes leading to ciprofloxacin resistance. This findings suggest an urgent need for typhoid conjugate vaccines introduction in South Asia as an emerging broader problem of antimicrobial resistance.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Pediatrics
Vinay Modgil, Pankaj Chaudhary, Bhavneet Bharti, Jaspreet Mahindroo, Md Yousuf, Meenakshi Koundal, Balvinder Mohan, Neelam Taneja
Summary: The study aimed to investigate the role of enteroaggregative Escherichia coli (EAEC) in childhood diarrhea and as a commensal in children younger than five years old. EAEC detection was higher in children with acute diarrhea compared to nourished and malnourished controls. Adhesive variants like adhesion fimbriae IV and II were significantly associated with diarrhea, and aggR and aar genes showed associations with disease severity. High rates of multidrug resistance were observed in the diarrheal group. Phylogenetic analysis revealed differences in EAEC strains between diarrheal and non-diarrheal groups.
JOURNAL OF PEDIATRICS
(2021)
Article
Immunology
Harpreet Kaur, Manmohit Kalia, Neelam Taneja
Summary: The study identified novel drug targets for the treatment of infections caused by multidrug-resistant Acinetobacter baumannii through three phases of analysis, and discovered some new drug targets.
MICROBIAL PATHOGENESIS
(2021)
Article
Immunology
Naveen Chaudhary, Chandradeo Narayan, Balvinder Mohan, Neelam Taneja
Summary: The study characterized a phage RDN37 isolated from community sewage water in Chandigarh, which showed activity against multidrug-resistant Uropathogenic E. coli. The phage demonstrated stability, lytic activity against resistant strains, and potential therapeutic application for treating drug-resistant urinary tract infections.
INDIAN JOURNAL OF MEDICAL MICROBIOLOGY
(2021)
Article
Immunology
Neelam Taneja, Jutang Babat Ain Tiewsoh, Swati Gupta, Balvinder Mohan, Ritu Verma, Pinky Shankar, Chandradeo Narayan, Vivek Kumar Yadav, Muralidharan Jayashree, Surjit Singh
Summary: The study conducted at a tertiary care center in North India found that the most common serogroup of Shigella isolated was Shigella flexneri, with increasing drug resistance observed. Children under 5 years old had the highest incidence rate, while males were also significantly affected.
INDIAN JOURNAL OF MEDICAL MICROBIOLOGY
(2021)
Article
Microbiology
Naveen Chaudhary, Dharminder Singh, Chandradeo Narayan, Bhaskar Samui, Balvinder Mohan, Ravimohan S. Mavuduru, Neelam Taneja
Summary: Escherichia phage 590B, isolated from community sewage water in Chandigarh, India, shows lytic activity against extensively drug-resistant uropathogenic Escherichia coli. The phage has a linear, double-stranded genome of 44.39 kb and belongs to the Siphoviridae family, with closest similarity to phage vB_EcoS_XY2 isolated in China.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2021)
Article
Biochemistry & Molecular Biology
Harpreet Kaur, Vikram Singh, Manmohit Kalia, Balvinder Mohan, Neelam Taneja
Summary: Urinary tract infections are a serious health concern worldwide, especially in developing countries. The highly virulent Escherichia coli strain CFT073 contains 992 hypothetical proteins. Computational tools were used to analyze and classify these proteins, revealing their roles in various functional categories and metabolic pathways. Further analysis identified 35 non-homologous proteins as potential drug design targets, with 8 proteins showing virulence factors and 6 proteins successfully modelled for three-dimensional structures. The study provides valuable insights for understanding disease mechanisms and developing new drug targets against CFT073.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Review
Health Care Sciences & Services
Mahbub-Ul Alam, Sharika Ferdous, Ayse Ercumen, Audrie Lin, Abul Kamal, Sharmin Khan Luies, Fazle Sharior, Rizwana Khan, Md Ziaur Rahman, Sarker Masud Parvez, Nuhu Amin, Birkneh Tilahun Tadesse, Niharu Akter Moushomi, Rezaul Hasan, Neelam Taneja, Mohammad Aminul Islam, Mahbubur Rahman
Summary: This study aims to determine effective treatment strategies for the removal of antibiotic-resistant bacteria, antibiotic-resistance genes, and residual antibiotics in wastewater treatment plant effluent. Methods include searching for full-text peer-reviewed articles in English and synthesizing data. The results will inform the development of proper treatment methods to reduce the levels of antibiotic residues in wastewater.
JMIR RESEARCH PROTOCOLS
(2021)
Editorial Material
Public, Environmental & Occupational Health
Neelam Taneja, Swati Gupta, Jutang Babat Ain Tiewsoh, Sonakshi Srivastava
Summary: Cholera, a diarrheal disease causing major health issues in developing countries, is most prevalent in India, where vaccination and improved sanitation are key in controlling outbreaks.
INDIAN JOURNAL OF PUBLIC HEALTH
(2021)
Article
Immunology
Vinay Modgil, Harpreet Kaur, Balvinder Mohan, Neelam Taneja
INDIAN JOURNAL OF MEDICAL MICROBIOLOGY
(2020)
Article
Immunology
Balvinder Mohan, Neha Gautam, Nandini Sethuraman, Harsimran Kaur, Neelam Taneja
INDIAN JOURNAL OF MEDICAL MICROBIOLOGY
(2020)
