Article
Immunology
Winnie W. Y. Tso, Mike Y. W. Kwan, Yu Liang Wang, Lok Kan Leung, Daniel Leung, Gilbert T. Chua, Patrick Ip, Daniel Y. T. Fong, Wilfred H. S. Wong, Sophelia H. S. Chan, Jasper F. W Chan, Malik Peiris, Yu Lung Lau, Jaime S. Rosa Duque
Summary: This study investigated the severity and clinical outcomes of Omicron BA.2 infection in uninfected, unvaccinated hospitalized children and compared it with influenza and parainfluenza viral infections. The findings showed that Omicron BA.2 was associated with higher risk of neurological complications and targeted the upper airways more than influenza virus.
EMERGING MICROBES & INFECTIONS
(2022)
Review
Virology
Rukshan A. M. Rafeek, Maduja V. M. Divarathna, Faseeha Noordeen
Summary: Human parainfluenza viruses (HPIVs) are a significant cause of acute respiratory tract infections (ARTIs) in children under 5 years old in Asia, with a prevalence ranging from 1% to 66%. HPIVs, particularly HPIV-3, contribute to a substantial disease burden in children in Asian countries, prompting the need for further research on preventive measures such as vaccines and antiviral drugs.
REVIEWS IN MEDICAL VIROLOGY
(2021)
Article
Multidisciplinary Sciences
Augustina K. K. Arjarquah, Evangeline Obodai, Hannah Ayettey Anie, Michael Aning Osei, John Kofi Odoom, Joseph H. K. Bonney, Eric Behene, Erasmus N. Kotey, James Aboagye, Stephen O. O. Nyarko, Jeannette Bentum, Clara Yeboah, Selassie Kumordjie, Bright Agbodzi, Keren Attiku, Gifty Mawuli, Andrew Letizia, William K. K. Ampofo, Osbourne Quaye
Summary: This study investigated upper-torso cancer patients receiving radiotherapy in Ghana, and found that many of these patients had influenza and bacterial infections, with many also developing ARI-like symptoms, which were significantly associated with various factors.
Article
Environmental Sciences
Eun Ju Oh, Jang Mook Kim, You Hyun Joung, Jae Kyung Kim
Summary: Studying the relationship between meteorological conditions and respiratory virus infections can help interpret disease outbreak causality and seasonal virus distribution. The analysis of three human parainfluenza virus infections indicated a meaningful relationship with climatic factors, suggesting that climate changes might affect infection rates and preventive strategies.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Immunology
Nitipong Permpalung, Afrah S. Sait, Katrina Bazemore, Robin K. Avery, Joby Mathew, Pali D. Shah
Summary: The study found that lung transplant recipients infected with HMPVi and PIVi had similar baseline characteristics, infection parameters, treatment allocation, and allograft function outcomes. Additionally, one-third of the patients developed CLAD stage progression within 1 year post-infection.
Article
Public, Environmental & Occupational Health
Sari T. Alhoufie, Naif H. Alsharif, Khalid O. Alfarouk, Nadier A. Ibrahim, Ali M. Kheyami, Alanoud A. Aljifri
Summary: The emergence of the COVID-19 pandemic poses a global challenge to the public health system, with coinfections potentially exacerbating disease severity and mortality risks, highlighting the importance of screening for coinfecting pathogens among COVID-19 patients.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2021)
Article
Immunology
Damien Foo, Mohinder Sarna, Gavin Pereira, Hannah C. Moore, Annette K. Regan
Summary: The study demonstrates that maternal influenza vaccination effectively reduces the risk of infant influenza during the first six months, but has no impact on respiratory infections in children above two years old.
Review
Virology
Manika Suryadevara, Joseph B. Domachowske
Summary: RSV infections in young children are a major global health concern, with seasonal patterns of activity playing a crucial role in guiding resource allocation for treatment and prevention strategies. Surveillance data from developed countries have been instrumental in advancing public health initiatives, while surveillance in tropical regions still needs improvement.
Article
Infectious Diseases
Leigh M. Howard, Danielle A. Rankin, Andrew J. Spieker, Wenying Gu, Zaid Haddadin, Varvara Probst, Herdi Rahman, Rendie McHenry, Claudia Guevara Pulido, John Williams, Samir Faouri, Asem Shehabi, Najwa Khuri-Bulos, Natasha B. Halasa
Summary: PIV is a common cause of hospitalization for ARI in young children in Jordan, with PIV-3 being the most commonly detected serotype. Clinical features of PIV infections show little variation among individual serotypes, and there is significant overlap with other viral infections.
BMC INFECTIOUS DISEASES
(2021)
Article
Immunology
Anthony Bosco
Summary: Respiratory syncytial virus (RSV) and Rhinovirus (RV) infections are major triggers of severe lower respiratory illnesses (sLRI) in infants and children and are strongly associated with the subsequent development of asthma. Recent findings highlight novel aspects of the interferon response in sLRI pathogenesis and provide new directions for mechanistic studies and drug development.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Jade Lee Lee Teng, Ulrich Wernery, Hwei Huih Lee, Joshua Fung, Sunitha Joseph, Kenneth Sze Ming Li, Shyna Korah Elizabeth, Jordan Yik Hei Fong, Kwok-Hung Chan, Honglin Chen, Susanna Kar Pui Lau, Patrick Chiu Yat Woo
Summary: A study conducted in a herd of nine dromedary calves in UAE revealed the presence of MERS coronavirus as well as a novel species of paramyxovirus named DcPIV3. Phylogenetic analysis showed close relation to bovine parainfluenza virus 3 and species demarcation within the Paramyxoviridae family.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Virology
Hatice Bolek, Lale Ozisik, Zafer Caliskan, Mine Durusu Tanriover
Summary: This study aimed to investigate the clinical outcomes and cost of illness due to respiratory virus infections in hospitalized adult patients. The results showed that patients infected with influenza had higher rates of clinical support, intensive care unit admission, and mortality, as well as higher average hospitalization costs.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Virology
Edin J. Mifsud, Miku Kuba, Ian G. Barr
Summary: The innate immune system is the host's first defense against pathogens and activates the adaptive immune system to clear viruses, but excessive response may lead to immunopathology.
Article
Infectious Diseases
Dhanya Dharmapalan, Julia Bielicki, Mike Sharland
Summary: Pediatric guidelines for amoxicillin dosing in common respiratory infections vary. Harmonization of dosing and formulation of amoxicillin across multiple clinical respiratory infections would facilitate program delivery, taking into consideration various factors. The World Health Organization recommends higher dose amoxicillin given twice daily for uncomplicated respiratory infections and emphasizes the need for easier access to essential antibiotics.
Article
Medicine, General & Internal
Ji Yoon Han, Seung Beom Han
Summary: Although febrile seizures are the most common neurological complication of influenza, studies comparing seizure characteristics and outcomes between patients with influenza and other respiratory virus (RV) infections are limited. This study found that patients with influenza were older than those with other RV infections and showed a higher percentage of patients aged >= 5 years. Complex febrile seizure characteristics were more frequent in patients with other RV infections, but the frequency of epilepsy was comparable between the two groups.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pediatrics
Mohsen Saleh Elalfy, Ahmed Samir Ibrahim, Ghada Samir Ibrahim, Hanaa Midhat Abdel Gader Hussein, Hend Galal Eldeen Mohammed, Fatma Soliman Elsayed Ebeid
Summary: Children and young adults with sickle cell disease (SCD) are at a high risk for neurocognitive impairment and have high levels of iron overload in the brain. While brain iron deposition may impact neurocognitive functions in patients with SCD, neurocognitive dysfunction in SCD cannot be solely explained by brain iron overload.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Retraction
Multidisciplinary Sciences
Hany M. Dabbous, Manal H. El-Sayed, Gihan El Assal, Hesham Elghazaly, Fatma F. S. Ebeid, Ahmed F. Sherief, Maha Elgaafary, Ehab Fawzy, Sahar M. Hassany, Ahmed R. Riad, Mohamed A. TagelDin
SCIENTIFIC REPORTS
(2021)
Article
Genetics & Heredity
Sara H. A. Agwa, Marwa Mostafa Kamel, Hesham Elghazaly, Aya M. Abd Elsamee, Hala Hafez, Samia Abdo Girgis, Hoda Ezz Elarab, Fatma S. E. Ebeid, Safa Matbouly Sayed, Lina Sherif, Marwa Matboli
Summary: This study investigated the impact of host genetic variation on COVID-19 infection and disease severity, revealing that certain genotypes may make individuals more susceptible and lead to a more severe illness. The A allele in the DDR1 gene rs4618569 variant was associated with disease deterioration.
Article
Otorhinolaryngology
Mohsen Saleh ElAlfy, Azaa Abdel Gawad Tantawy, Badr Eldin Mostafa Badr Eldin, Mohamed Amin Mekawy, Yasmeen Abd ElAziz Mohammad, Fatma Soliman Elsayed Ebeid
Summary: A simple assessment tool for pediatric patients with epistaxis was investigated to subgroup those with possible bleeding tendencies. The tool was found useful in identifying patients with underlying bleeding disorders, especially those with positive family history, referred from primary care physicians, and presenting with low platelet count.
INTERNATIONAL ARCHIVES OF OTORHINOLARYNGOLOGY
(2022)
Retraction
Virology
Hany M. Dabbous, Sherief Abd-Elsalam, Manal H. El-Sayed, Ahmed F. Sherief, Fatma F. S. Ebeid, Mohamed Samir Abd El Ghafar, Shaimaa Soliman, Mohamed Elbahnasawy, Rehab Badawi, Mohamed Awad Tageldin
ARCHIVES OF VIROLOGY
(2022)
Article
Oncology
Sara Makkeyah, Ayat Manzour, Azza Tantawy, Ashraf Mohamed, Fatma Ebeid, Nayera El-Sherif, Shereen Abd El-Ghany, Mahmoud Shawiesh, Heba Ali, Safa Sayed, Iman Ragab
Summary: The study found that using risk-based protocols and double delayed intensification (DDI) treatment at Ain Shams University Children's Hospitals can achieve acceptable survival outcomes in resource-limited settings.
CANCER EPIDEMIOLOGY
(2021)
Article
Oncology
Sheena Mukkada, Nickhill Bhakta, Guillermo L. Chantada, Yichen Chen, Yuvanesh Vedaraju, Lane Faughnan, Maysam R. Homsi, Hilmarie Muniz-Talavera, Radhikesh Ranadive, Monika Metzger, Paola Friedrich, Asya Agulnik, Sima Jeha, Catherine Lam, Rashmi Dalvi, Laila Hessissen, Daniel C. Moreira, Victor M. Santana, Michael Sullivan, Eric Bouffet, Miguela A. Caniza, Meenakshi Devidas, Kathy Pritchard-Jones, Carlos Rodriguez-Galindo
Summary: The study found that around one fifth of children and adolescents with cancer infected with SARS-CoV-2 developed severe or critical illness, with a higher death rate than in the general pediatric population. Factors associated with treatment modification were different from those associated with disease severity, highlighting the need to raise global awareness of the high risk of severe COVID-19 illness in children and adolescents with cancer. These findings could inform clinical guidelines and improve care practices for this vulnerable population.
Article
Oncology
Azza Abdel Gawad Tantawy, Amira Abdel Moneam Adly, Heba Mohamed Atif, Sherihane Said Madkour, Nouran Yousef Salah
Summary: ALN is a prevalent complication in patients with Gaucher disease, with a wide clinical spectrum and its presence is related to severity, NLR, and Lyso-GL1 in children with the disease.
PEDIATRIC HEMATOLOGY AND ONCOLOGY
(2022)
Article
Hematology
Janet L. Kwiatkowski, Mona Hamdy, Amal El-Beshlawy, Fatma S. E. Ebeid, Mohammed Badr, Abdulrahman Alshehri, Julie Kanter, Baba Inusa, Amira A. M. Adly, Suzan Williams, Yurdanur Kilinc, David Lee, Fernando Tricta, Mohsen S. Elalfy
Summary: This open-label study evaluated the efficacy and safety of deferiprone in patients with SCD or other anemias. The results showed that deferiprone was not inferior to deferoxamine in reducing liver iron concentration, as well as in improving cardiac T2* MRI and serum ferritin levels. The overall adverse event rates were similar between the two treatment groups.
Article
Hematology
Mohsen S. Elalfy, Mona Hamdy, Amal El-Beshlawy, Fatma S. E. Ebeid, Mohamed Badr, Julie Kanter, Baba Inusa, Amira A. M. Adly, Suzan Williams, Yurdanur Kilinc, David Lee, Caroline Fradette, Anna Rozova, Noemi Toiber Temin, Fernando Tricta, Janet L. Kwiatkowski
Summary: Long-term therapy with deferiprone was safe and effective in reducing iron load in patients with sickle cell disease and other anemias, without new safety concerns. Liver iron concentration and serum ferritin levels decreased over time, and responder rates increased each year. Cardiac T2* remained normal in all patients.
Article
Hematology
Azza Tantawy, Nayera El-Sherif, Sara Makkeyah, Nahed Salah Eldeen, Noura Bahaa El-Din Farghal, Nanies Soliman, Fatma S. E. Ebeid
Summary: Sleep disordered breathing (SDB) is a common yet underdiagnosed complication of sickle cell disease (SCD), and it is associated with the frequency of vaso-occlusive crises. A study on thirty children with SCD revealed that 60% of them had sleep apnea defined as apnea (AHI) > 1 event/hour, and 18 subjects had moderate to severe obstruction. The severity of sleep apnea was found to be related to tricuspid regurge velocity (TRV) and cerebral blood flow velocity.
ANNALS OF HEMATOLOGY
(2023)
Article
Oncology
Fatma S. E. Ebeid, Galila Mohamed Mokhtar, Eman Ahmed Zaky, Reham Ibrahim Abdelmageed, Nermeen Mohamed Elkamel, Heba G. A. Ali
Summary: This study aimed to assess the psychosocial profile and quality of life of sickle cell disease patients and their caregivers, and determine the association with disease severity. The study found that children with sickle cell disease and their caregivers experienced higher levels of depression and anxiety symptoms, lower self-esteem, and poorer quality of life compared to the control group. These negative psychological effects were correlated with the age of the child, duration of illness, number and duration of hospitalizations, disease severity score, and occurrence of complications.
PEDIATRIC HEMATOLOGY AND ONCOLOGY
(2023)
Meeting Abstract
Hematology
M. Rakha, S. Adolf, M. Elekiaby, G. Sobhy, I. Morad, A. El-Beshlawy, G. Mokhtar, M. Elalfy, A. Tantawy, M. Mattar, M. Talat, M. Hamdy, L. M. Sherief, H. Hassab, N. Tawfik, N. Shaheen, S. Ragab, M. El-Hawy, N. Omar, K. Eid, E. Ragab, M. Zakria, E. Attia
Article
Oncology
Manal H. El-Sayed, Zeinab N. A. Said, Enas K. Abo-Elmagd, Fatma S. E. Ebeid, Iman I. Salama
Summary: The study found that polytransfused children with malignancies, especially those receiving chemotherapy, have a significant risk of HBV infection and lower immunity against HBV. The coexistence of anti-HBs with HBsAg and/or HBV-DNA may indicate a residual transfusion-transmission risk with mutant HBV strains.
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
(2021)