Article
Materials Science, Multidisciplinary
Fangwei Qi, Zhihui Wang, Yang Shuai, Shuping Peng, Cijun Shuai
Summary: By constructing strontium substituted hydroxyapatite (SrHA), a sustained release system for polymer bone scaffolds was achieved. The released strontium ion (Sr2+) significantly promoted cell proliferation and differentiation. PLLA/SrHA scaffolds also exhibited improved mechanical properties, indicating their considerable potential for bone repair.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Koichiro Hayashi, Toshiki Yanagisawa, Ryo Kishida, Kunio Ishikawa
Summary: This study investigates the effects of scaffold shape on tissue generation. The results show that even tiny protuberances on the scaffold surface can affect the percentage of interscaffold space, thereby exerting dominant effects on osteogenesis.
Article
Biophysics
Wu Di, Yang Shuai, Wang Bo, Tan Wei, Jinpeng He, Guowen Qian, Youwen Deng
Summary: The study focuses on the preparation of PLLA/SBA15NH2-ZOL scaffold via selective laser sintering technology, which can address the challenges of bone defect and tumor recurrence in postoperative treatment of bone tumors. The scaffold has the ability of local release of zoledronate (ZOL) to inhibit osteosarcoma cell proliferation and induce osteoclast differentiation through competitive binding of RANK.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Review
Biotechnology & Applied Microbiology
Baoqing Pei, Mengyuan Hu, Xueqing Wu, Da Lu, Shijia Zhang, Le Zhang, Shuqin Wu
Summary: Bone tissue engineering (BTE) is crucial for bone defect repair. Loading bioactive factors into scaffolds allows for controlled release, with scaffold microstructure playing a significant role. This review examines how scaffold microstructure affects the release rate of bioactive factors, with variables including pore size, shape, and porosity. The study concludes that pore size and porosity impact the release rate, providing valuable insights for developing new treatment strategies for bone disease.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Materials Science, Ceramics
Naren Raja, Aram Sung, Honghyun Park, Hui-suk Yun
Summary: A novel low-temperature fabrication process of calcium deficient hydroxyapatite (CDHA) scaffolds was proposed, combining material extrusion type 3D printing and bone cement chemistry, resulting in high-porosity scaffolds with excellent mechanical properties. The method allows for accurate control of size and 3D architecture, non-brittle scaffolds, and direct loading of heat-sensitive drugs and biomolecules. This low-temperature fabrication process shows great potential for bone tissue engineering applications.
CERAMICS INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Ronja Finze, Markus Laubach, Mairim Russo Serafini, Ulrich Kneser, Flavia Medeiros Savi
Summary: Large-volume bone defect regeneration is a complex and time-consuming process with multiple interdependent regeneration phases. Scaffold-guided bone regeneration has shown efficacy in both preclinical and clinical studies. Immunohistochemistry analysis provides valuable insights into the complex bone regeneration processes.
Article
Nanoscience & Nanotechnology
Yihan Wang, Changnan Xie, Zhiming Zhang, Haining Liu, Haixia Xu, Ziyue Peng, Chun Liu, Jianjun Li, Chengqiang Wang, Tao Xu, Lixin Zhu
Summary: In this study, a novel integrated bionic oxygenated scaffold was successfully fabricated using low-temperature molding 3D printing technology. The scaffold exhibited excellent mechanical properties and bionic hierarchical porous structures. It could release sustained oxygen and significantly enhance the survival, growth, and osteogenic differentiation of stem cells under hypoxia. The scaffold also facilitated efficient bone repair in a rabbit calvarial defect model. This research provides a promising clinical strategy for bone defect repair.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Mathematics
Karel Hasik, Jana Kopfova, Petra Nabelkova, Olena Trofymchuk, Sergei Trofimchuk
Summary: This study proves the existence of minimal propagation speed for wavefronts in the Belousov-Zhabotinsky system with spatiotemporal interaction defined by the kernel function K. The model assumes non-degenerate monostability and shows that the slowest wavefront is pushed or nonlinearly determined under certain conditions. The findings suggest that large positive system parameter b or spatial asymmetry in the kernel K contribute to the appearance of pushed wavefronts.
JOURNAL OF DIFFERENTIAL EQUATIONS
(2023)
Article
Pharmacology & Pharmacy
Hala Jarrar, Damla Cetin Altindal, Menemse Gumusderelioglu
Summary: The study revealed that combining low doses of BMP-2 with MEL in a dual release system significantly enhanced the osteogenic activity of MC3T3-E1 cells, leading to increased cell number, ECM density, expression of differentiation markers, and mineralization compared to other groups.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Mathematics, Applied
Margaret K. McGuire, Chase A. Fuller, John F. Lindner, Niklas Manz
Summary: Geographic tongue, also known as benign migratory glossitis, is a condition characterized by chronic lesions that slowly move across the tongue surface. Mathematical modeling shows that the observed patterns of geographic tongue lesions can be explained by propagating reaction-diffusion waves on curved surfaces.
Article
Engineering, Biomedical
Morshed Khandaker, Reuben Lane, Shannon Yeakley, Hussein Alizereej, Sadegh Nikfarjam, Abdellah Ait Moussa, Melville B. Vaughan, Amgad M. Haleem
Summary: In this study, a scaffold and fixation system for the reconstruction of long-bone segmental defects in a rabbit tibia model were designed and manufactured. Biocompatible and biodegradable materials, polycaprolactone (PCL) and PCL soaked with sodium alginate (PCL-Alg), were used to manufacture the scaffold, interlocking nail, and screws. Degradation and mechanical tests showed that both PCL and PCL-Alg scaffolds were suitable for faster degradation and early weight-bearing capacity. A surgical jig was designed and 3D-printed using biocompatible resin to ensure accurate placement of the scaffold and fixation system. Cadaver tests confirmed the potential of the designed jigs, nails, and screws for future reconstructive surgeries.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Mathematics
Shangjiang Guo
Summary: In this paper, a Lotka-Volterra competition-diffusion system with a focus on the nonlinear balance between interior reaction and boundary flux is studied. The global dynamics, including the existence, stability, and bifurcation of steady-state solutions, are analyzed based on competition coefficients, growth rate functions, and boundary reaction functions. The results significantly extend the existing literature on Lotka-Volterra competition-diffusion systems, including those with homogeneous boundary conditions.
JOURNAL OF DIFFERENTIAL EQUATIONS
(2023)
Article
Mathematics
Laurent Desvillettes, Kim Dang Phung
Summary: In this paper, we study a system of two reaction-diffusion equations originating from reversible chemistry. We demonstrate that exponential convergence to equilibrium holds when the reaction takes place on either the entire domain or a given open set of a ball, thanks to an observation estimate deduced by logarithmic convexity.
JOURNAL OF DIFFERENTIAL EQUATIONS
(2022)
Article
Engineering, Biomedical
Yanan Zhao, Honglei Kang, Xiaopei Wu, Pengzhen Zhuang, Rong Tu, Takashi Goto, Feng Li, Honglian Dai
Summary: A drug carrier system composed of gelatin-coated hollow mesoporous silica nanoparticles loaded with pro-osteogenic parathyroid (PTH) and anti-osteoclastogenic alendronate (ALN) is constructed and compounded into calcium magnesium phosphate cement (MCPC). It enhances osteoporotic bone regeneration in ovariectomized rats by promoting osteogenic differentiation, inhibiting osteoclastogenesis, and accelerating vascularization. The MCPC/HMSNs@ALN-PTH/GM demonstrates a synergistic effect on osteogenesis, osteoclastogenesis, and angiogenesis, holding potential for other biomaterials design and clinical management.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Mechanical
Linhe Zhu, Le He
Summary: This paper analyzes the diffusion behavior of the suspicious and infected cabins in cyberspace using a rumor propagation reaction-diffusion model. The effects of time delay and changing diffusion coefficient are considered to study the stability and instability of the system. The existence of Hopf bifurcation induced by time delay is proven, and the necessary conditions for Turing instability are studied. Numerical simulations show that variations in diffusion coefficient and time delay can change the pattern type and affect the arrangement of crowd gathering areas.
NONLINEAR DYNAMICS
(2022)
Review
Orthopedics
Juan J. Vaca-Gonzalez, Johana M. Guevara, Miguel A. Moncayo, Hector Castro-Abril, Yoshie Hata, Diego A. Garzon-Alvarado
Article
Biochemistry & Molecular Biology
J. J. Vaca-Gonzalez, J. F. Escobar, J. M. Guevara, Y. A. Hata, G. Gallego Ferrer, D. A. Garzon-Alvarado
BIOELECTROCHEMISTRY
(2019)
Article
Biophysics
Andres Felipe Carrera-Pinzon, Kalenia Marquez-Florez, Reuben H. Kraft, Salah Ramtani, Diego Alexander Garzon-Alvarado
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2020)
Article
Medicine, General & Internal
Johana M. Guevara-Morales, Michael Frohbergh, Hector Castro-Abril, Juan J. Vaca-Gonzalez, Luis A. Barrera, Diego A. Garzon-Alvarado, Edward Schuchman, Calogera Simonaro
Article
Biochemistry & Molecular Biology
Juan Jairo Vaca-Gonzalez, Sandra Clara-Trujillo, Maria Guillot-Ferriols, Joaquin Rodenas-Rochina, Maria J. Sanchis, Jose Luis Gomez Ribelles, Diego Alexander Garzon-Alvarado, Gloria Gallego Ferrer
BIOELECTROCHEMISTRY
(2020)
Article
Computer Science, Interdisciplinary Applications
Juan Felipe Sanchez Gutierrez, Mercedes Olaya-C, Jorge Andres Franco, Johana Guevara, Diego Alexander Garzon-Alvarado, Maria Lucia Gutierrez Gomez
Summary: This study used a computational model to simulate the effects of different umbilical cord lengths on early fetal movement dynamics. Results showed that the shortest umbilical cord length significantly increased linear velocity and tension on the fetus body wall.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
(2021)
Article
Mathematics, Applied
David Hernandez-Aristizabal, Diego A. Garzon-Alvarado, Anotida Madzvamuse
Summary: The purpose of this article was to study Turing pattern formation in one- and two-dimensional domains under heterogeneous distributions of parameters for an activator-depleted model. The results revealed that wave modes of adjacent subsets evolve locally with continuity across the interface, and emphasized the crucial role of initial conditions in the selection of excitable wave modes and formation of inhomogeneous patterns.
JOURNAL OF NONLINEAR SCIENCE
(2021)
Article
Biophysics
S. M. Velez-Muriel, E. Talma, D. L. Romanyk, E. B. Las Casas, J. A. Guerrero-Vargas, D. A. Garzon-Alvarado
Summary: Cleft lip and palate is a congenital defect requiring alveolar graft surgery and maxillary orthopedic therapies as part of the treatment. Research suggests that maxillary therapies can impact the biomechanical response of the graft and bone remodeling processes.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2021)
Article
Biology
Yesid Villota-Narvaez, Diego A. Garzon-Alvarado, Angelica M. Ramirez-Martinez
Summary: This study introduced a mathematical model to predict muscle size variations under different activity conditions, tested the model in various scenarios, and found a high agreement with experimental reports, indicating its suitability for developing training and therapeutic protocols.
Article
Multidisciplinary Sciences
Juan Jose Saiz Culma, Juan Felipe Escobar Huertas, Diego Alexander Garzon-Alvarado, Juan Jairo Vaca-Gonzalez
Summary: EFs and MFs are widely used in tissue engineering to enhance cell dynamics, but the variables of stimuli strength and stimulation times need to be considered. There is currently a lack of evidence regarding the calculation and distribution when applying biophysical stimuli, making it challenging to build devices that can generate adequate biophysical stimuli.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Biochemistry & Molecular Biology
Hector Castro-Abril, Jonathan Heras, Jesus del Barrio, Laura Paz, Clara Alcaine, Marina Perez Aliacar, Diego Garzon-Alvarado, Manuel Doblare, Ignacio Ochoa
Summary: Mechanical interactions between cells and their microenvironment are crucial in determining cell fate, especially in the process of metastasis. Type I collagen hydrogels are commonly used to model the microenvironment in vitro due to their prevalence in the human body. This study analyzes the combined effects of hydrogel stiffness and ultrastructure on the migration patterns of colorectal cancer spheroids. Different types of collagen hydrogels are prepared with varying collagen concentration and gelation temperature, and their stiffness and ultrastructure are characterized. It is found that changes in these parameters result in differences in matrix stiffness and ultrastructural organization, which in turn influence the migration behavior of the spheroids.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Physics, Fluids & Plasmas
Andres Santiago Espinosa-Moreno, Carlos Alberto Duque-Daza, Diego Alexander Garzon-Alvarado
Summary: This study found that the bifurcation angle and carina rounding radius have a significant impact on the flow dynamics of human airways during respiration, affecting velocity profiles, pressure drop, flow patterns, and wall shear stresses. Increasing the bifurcation angle led to a 20% increase in pressure, especially near the bifurcation, while increasing the carina rounding radius reduced peak shear stresses by up to 70%.
Article
Materials Science, Multidisciplinary
Alejandro Garcia Rodriguez, Edgar Espejo Mora, Marco Antonio Velasco, Carlos Alberto Narvaez Tovar
Summary: The study investigates the impact of wall thickness and build direction on the mechanical properties of PA 12 parts manufactured via SLS. It suggests that parts with a thickness of 2.5 mm manufactured in the horizontal and transverse directions exhibit the highest mechanical properties.
MATERIALS RESEARCH EXPRESS
(2023)
Article
Engineering, Electrical & Electronic
Santiago Salazar, Dionisio Malagon, Edwin Forero-Garcia, Maria Josefina Torres, Marco Antonio Velasco Pena
Summary: Hybrid electric scooters using hydrogen fuel cells can reduce charging time and increase the range, making them competitive with traditional electric scooters.
Article
Multidisciplinary Sciences
A. Alexiadis, A. Albano, A. Rahmat, M. Yildiz, A. Kefal, M. Ozbulut, N. Bakirci, D. A. Garzon-Alvarado, C. A. Duque-Daza, J. H. Eslava-Schmalbach
Summary: This study develops a modelling framework that simulates the spread of infectious diseases within digital copies of real cities. By using high-performance computing and massively parallel algorithms, millions of individuals, their encounters, and the spread of the disease can be accurately reproduced, providing policymakers with a virtual laboratory for testing, predicting, and comparing policies aimed at containing epidemics.
PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
(2021)
