Journal
JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY
Volume 11, Issue 2, Pages 307-323Publisher
WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S0219519411004046
Keywords
CFD; tissue engineering; scaffold; bioreactor; hydrodynamic environment
Categories
Funding
- National High Technology Research and Development Program [2009AA043801]
- Fundamental Research Funds for the Central Universities, China [08142008]
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Hydrodynamic cellular environment plays an important role in translating engineered tissue constructs into clinically useful grafts. However, the cellular fluid dynamic environment inside bioreactor systems is highly complex and it is normally impractical to experimentally characterize the local flow patterns at the cellular scale. Computational fluid dynamics (CFD) has been recognized as an invaluable and reliable alternative to investigate the complex relationship between hydrodynamic environments and the regeneration of engineered tissues at both the macroscopic and microscopic scales. This review describes the applications of CFD simulations to probe the hydrodynamic environment parameters (e. g., flow rate, shear stress, etc.) and the corresponding experimental validations. We highlight the use of CFD to optimize bioreactor design and scaffold architectures for improved ex-vivo hydrodynamic environments. It is envisioned that CFD could be used to customize specific hydrodynamic cellular environments to meet the unique requirements of different cell types in combination with advanced manufacturing techniques and finally facilitate the maturation of tissue-engineered constructs.
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