Article
Biochemistry & Molecular Biology
Zhipeng Wang, Sven-Bastiaan Haange, Volker Haake, Maike Huisinga, Hennicke Kamp, Roland Buesen, Kristin Schubert, Sebastian Canzler, Joerg Hackermueller, Ulrike Rolle-Kampczyk, Martin von Bergen
Summary: Thyroid hormones play a crucial role in regulating various physiological mechanisms in mammals. The therapeutic drugs PTU and phenytoin have been found to induce hypothyroidism and decrease blood thyroid hormone levels. This study aimed to analyze the impact of these drugs on systemic metabolism by investigating the metabolome of thyroid and liver tissue, as well as blood plasma, in a rat model.
Review
Biochemistry & Molecular Biology
Klaudia Ciesielska-Figlon, Karolina Wojciechowicz, Anna Wardowska, Katarzyna Aleksandra Lisowska
Summary: Background: Nigella sativa has been traditionally used for medicinal purposes and has known antibacterial, virucidal, fungicidal, and antiparasitic properties. However, studies on its immunomodulatory effects are limited. This review examines in vitro and in vivo research supporting the role of Nigella sativa in modulating immune responses. The results suggest its potential as a therapeutic agent for regulating immune reactions.
Article
Pediatrics
Alon Haim, Tamar Wainstock, Shlomo Almashanu, Neta Loewenthal, Eyal Sheiner, Eli Hershkovitz, Daniela Landau
Summary: There is no additional clinical benefit in retesting newborns of hypothyroid mothers for thyroid function at 2 weeks of age, in addition to the newborn screening program. Both testing methods found the same number of babies with congenital hypothyroidism.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Nutrition & Dietetics
Mona S. Almujaydil, Reham M. Algheshairy, Raghad M. Alhomaid, Hend F. Alharbi, Hoda A. Ali
Summary: This study assessed the protective effects of Nigella sativa floral honey (NS floral honey) and multi-floral honey (M-floral honey) compared to Nigella sativa oil (NS oil) against azathioprine-induced testicular degeneration in rats. Both NS floral honey and NS oil partially restored testicular function and improved sperm quality, while the effects of M-floral honey were inconclusive. Further clinical studies are needed to investigate the bioactive constituents of these substances.
Article
Chemistry, Medicinal
Hadi Emamat, Seyyed Hossein Mousavi, Jalal Kargar Shouraki, Ebrahim Hazrati, Sayid Mahdi Mirghazanfari, Esmaeil Samizadeh, Maryam Hosseini, Vahid Hadi, Saeid Hadi
Summary: This study found that N. sativa oil can improve vascular NO and FMD levels in participants with cardiovascular risk factors, but more research is needed to confirm its benefits on vascular inflammation.
PHYTOTHERAPY RESEARCH
(2022)
Article
Environmental Sciences
Tauseef Alam, Sana Rizwan, Zeba Farooqui, Subuhi Abidi, Iqbal Parwez, Farah Khan
Summary: Arsenic is a potent hepatotoxin, while studies have shown that Nigella sativa oil has a protective effect on acute liver injury and can improve liver function. Experimental findings suggest that Nigella sativa oil can alleviate liver damage caused by arsenic, and improve the antioxidant and metabolic status of the liver.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Hussah Abdullah Alshwyeh, Sahar Khamees Aldosary, Muna Abdulsalam Ilowefah, Raheem Shahzad, Adeeb Shehzad, Saqib Bilal, In-Jung Lee, Jannah Ahmed Al Mater, Fatima Najf Al-Shakhoari, Waad Abdulrahman Alqahtani, Nurkhalida Kamal, Ahmed Mediani
Summary: Nigella species, particularly the roasted seeds, have been found to have various health benefits due to the presence of bioactive components. This study investigated the effect of roasting on the composition and biological activities of Nigella arvensis and Nigella sativa seed extracts. The results showed that roasted seeds exhibited strong antimicrobial activities and extracts significantly decreased cancer cell viability.
Review
Biochemistry & Molecular Biology
Mohammed Dalli, Oussama Bekkouch, Salah-eddine Azizi, Ali Azghar, Nadia Gseyra, Bonglee Kim
Summary: This review analyzes the bioactive compounds and pharmacological activities of Nigella sativa, based on a multitude of research articles. It provides guidance for future studies in this field.
Review
Plant Sciences
Shadma Wahab, Abdulrhman Alsayari
Summary: Chronic inflammatory diseases are a leading cause of death worldwide, and traditional medicinal plant Nigella sativa (NS) shows potential as an anti-inflammatory agent with minimal side effects. However, more research is needed to explore the multi-targeting characteristics and mechanisms of NS in various chronic inflammatory diseases.
Article
Food Science & Technology
Mehmet Kemal, Ulku Zeynep Ureyen Esertas, Esra Demir Kanbur, Yakup Kara, Ali Erdem Ozcelik, Zehra Can, Sevgi Kolayli
Summary: This study investigated the compositions, antioxidant and antimicrobial properties of black cumin honey from the Burdur region of Turkiye. The honey samples had various physicochemical properties, phenolic contents, and exhibited high antimicrobial activities against several bacteria. They also showed significant antioxidant capacities. The phenolic composition of the samples was analyzed using HPLC-PDA method and several common components were identified.
Review
Food Science & Technology
Mahdi Vajdi, Melika Darzi, Hadi Bazyar, Zahra Hajhashemy, Shirin Hassanizadeh, Arash Karimi, Gholamreza Askari
Summary: This study systematically summarized the effects of N. sativa supplementation on anthropometric indices among adults. A total of 32 studies were included in the analysis, showing significant reductions in body weight, body mass index, waist circumference, and hip circumference following N. sativa supplementation. However, no changes were observed in waist-to-hip ratio.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Polymer Science
Tamer M. Shehata, Mervt M. Almostafa, Heba S. Elsewedy
Summary: Research focused on the development of pioglitazone-loaded nanoemulsion (NE) and its impact on blood glucose levels, demonstrating promising results in lowering blood glucose levels in vivo.
Article
Pharmacology & Pharmacy
Mahmoud Abd-Elkareem, Mahmoud Soliman, Mokhless A. M. Abd El-Rahman, Nasser S. Abou Khalil
Summary: The study found that Nigella sativa seeds can alleviate MSG-induced renal toxicity in rats. Nigella sativa seeds improved oxidative stress and histopathological damage caused by MSG through their antioxidant and anti-apoptotic effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Alessandro Cattoni, Silvia Molinari, Giulia Capitoli, Nicoletta Masera, Maria Laura Nicolosi, Silvia Barzaghi, Giulia Marziali, Alessandra Lazzerotti, Alessandra Gazzarri, Chiara Vimercati, Debora Sala, Andrea Biondi, Stefania Galimberti, Chiara Fossati
Summary: This study longitudinally assessed TFT in 548 pediatric patients with DS and established syndrome-specific reference ranges for TSH, FT3, and FT4. Median TSH levels were significantly higher than non-syndromic patients at any age, while FT3 and FT4 levels were only significantly lower in specific age groups. TSH levels showed significant fluctuations over time with poor agreement between sequential assessments of TSH centile classes. The 75th centile was identified as the optimal threshold for predicting the future onset of overt hypothyroidism using TSH values.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Environmental Sciences
Farwah Shamshir, Ghulam Abbas, Muhammad Amjad, Muhammad Rizwan, Muhammad Akram, Sajjad Ahmad, Muhammad Tahir, Shafaqat Ali, Abu Bakr Umer Farooq
Summary: Arsenic has varying degrees of toxicity in plants, with As(0) being the least toxic but can be readily oxidized into more toxic forms under certain conditions. The experiment evaluated the effects of As(0) on Nigella sativa, showing that the plant's biomass and yield were generally unaffected by As levels except at the highest concentration. Despite increased antioxidant activities and arsenic accumulation in plant organs, N. sativa displayed tolerance to moderate As stress, suggesting it can be grown in moderately contaminated soils without significant economic risks or food chain contamination.
ENVIRONMENTAL POLLUTION
(2022)
Article
Chemistry, Medicinal
Roghayeh Rashidi, Farideh Boroomand Jahed Avval, Shirin Ghasemian, Hamid Reza Sadeghnia, Seyed Hadi Mousavi, Sara Hooshmand, Mohammad Jalili-Nik, Mohammad Sadegh Amiri, Ahmad Ghorbani
Summary: The study evaluated the effects of Psoralea drupacea extract (PDE) on HepG2 liver cancer cells. The results showed that PDE inhibited the proliferation, migration, and angiogenesis of liver cancer cells, and enhanced the antiproliferative and proapoptotic activities of doxorubicin.
LETTERS IN DRUG DESIGN & DISCOVERY
(2023)
Article
Behavioral Sciences
S. Mohammad Ahmadi-Soleimani, Hossein Azizi, Farimah Beheshti, Omid Azizi, Alireza Abbasi-Mazar
Summary: Adolescence is a critical period during which significant neurodevelopmental changes occur, and substance abuse during this stage can induce persistent changes in brain responsiveness. Binge-drinking behavior among adolescents is a growing concern, as alcohol is known to act as a gateway drug. This study aimed to assess the impact of adolescent ethanol exposure on tolerance and dependence to morphine, and found that it facilitates morphine tolerance but does not significantly alter dependence. Additionally, treatment with omega-3 fatty acids was found to prevent these ethanol-induced changes.
BEHAVIORAL NEUROSCIENCE
(2023)
Article
Behavioral Sciences
Elham Akbari, Dawood Hossaini, Ghulam Yahya Amiry, Mustafa Ansari, Murtaza Haidary, Farimah Beheshti, S. Mohammad Ahmadi-Soleimani
Summary: There is increasing evidence that the adolescent brain is affected by the use of psychostimulant agents, such as alcohol. Long-term alcohol exposure has been found to impair cognitive functions, and this is thought to be mediated by oxidative damage to the central nervous system. However, treatment with Vitamin B12 has been shown to improve cognitive performance by suppressing oxidative parameters. In this study, the researchers aimed to test whether Vitamin B12 treatment could prevent ethanol-induced complications in adolescent mice. The results indicated that adolescent ethanol intake impairs learning and memory function through exacerbation of oxidative stress, but treatment with Vitamin B12 improves these complications by restoring the oxidant/antioxidant balance. Additionally, Vitamin B12 was found to prevent the reduction of BDNF and the enhancement of GFAP and acetylcholinesterase activity induced by ethanol. In conclusion, Vitamin B12 supplementation could be an effective therapeutic strategy to prevent learning and memory defects caused by chronic alcohol intake during adolescence.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Neurosciences
Elham Akbari, Farimah Beheshti, Hassan Azhdari Zarmehri, Seyed Yousof Mousavi, Masoumeh Gholami, S. Mohammad Ahmadi-Soleimani
Summary: Various analgesic medications, including opioids and non-steroidal anti-inflammatory drugs, are commonly used for pain management. However, prolonged administration of these drugs often leads to the development of analgesic tolerance. This study investigates the analgesic effects of taurine alone or in combination with sodium salicylate or morphine, and also explores the role of muscarinic receptors in these effects. The results suggest that the combination of taurine and sodium salicylate has a more potent analgesic effect and less tolerance development compared to taurine alone.
NEUROSCIENCE LETTERS
(2023)
Article
Neurosciences
Maryam Moghimian, Sohrab Azin, Seyed Sajjad Alavi-Kakhki, Masoumeh Kourosh-Arami, Masoumeh Gholami, Farimah Beheshti, Masoumeh Fani
Summary: The present study examined the impact of vitamin C on memory function and oxidative stress in the hippocampal area of rats. The results showed that vitamin C treatment reversed the memory impairment caused by stress.
NUTRITIONAL NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Mohaddeseh Sadat Alavi, Hamid Reza Sadeghnia, Niloufar Nikpasand, Sajad Sahab Negah, Roghayeh Rashidi, Gholamreza Naseri, Ahmad Ghorbani
Summary: This study investigated the effects of mephedrone exposure on the proliferation, differentiation, and apoptosis of rat embryonic NS/PC. The results showed that mephedrone significantly decreased the proliferation of NS/PC, induced cell cycle arrest, and increased the percentage of apoptotic and necrotic cells.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Sanaz Salaramoli, Hamed Amiri, Hamid Reza Joshaghani, Mahmoud Hosseini, Seyed Isaac Hashemy
Summary: Parkinson's disease is a common degenerative disease that affects the elderly, and oxidative stress is one of the main causes. This study found that Selenium Nano Particles (SeNPs) can protect brain cells from oxidative stress and improve motor function.
METABOLIC BRAIN DISEASE
(2023)
Article
Immunology
Ali Abbaszade-Cheragheali, Samaneh Kakhki, Seyed Reza Khatibi, Mahmoud Hosseini, Farzaneh Navari, Farimah Beheshti
Summary: The aim of this study was to investigate the mechanism and effect of crocin on brain oxidative damage and memory deficits induced by unpredictable chronic mild stress (UCMS). The results showed that crocin could reduce oxidative stress and inflammation, and improve learning and memory abilities in rats. Therefore, crocin may have potential as an antioxidant and anti-inflammatory agent for the treatment of memory impairment.
INFLAMMOPHARMACOLOGY
(2023)
Article
Physiology
Mahmoud Hosseini, Farimah Behehsti, Narges Marefati, Akbar Anaeigoudari
Summary: Hypothyroidism can lead to oxidative stress, while Nano-selenium has antioxidant effects. This study investigated the effects of Nano-selenium on hepatic and renal oxidative damage in rats induced by hypothyroidism. The results showed that administration of Nano-selenium can ameliorate the adverse effects of hypothyroidism on liver and kidney function by improving the oxidative stress status.
PHYSIOLOGICAL REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Mahmoud Hosseini, Zohreh Arab, Farimah Beheshti, Akbar Anaeigoudari, Farzaneh Shakeri, Arezoo Rajabian
Summary: The study found that Zataria multiflora and carvacrol have protective effects on LPS-induced cardiovascular injury by improving redox hemostasis and reducing the production of nitric oxide.
ANIMAL MODELS AND EXPERIMENTAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Rasul Saberi, Naser Mirazi, Sabiheh Amirahmadi, Zahra Kioumarsi Darbandi, Farzaneh Vafaee, Arezoo Rajabian, Mahmoud Hosseini
Summary: The study found that thiamine supplementation can improve learning and memory impairments in hypothyroid rats. Thiamine enhances the ability to remember locations and recognition in memory tests, while mitigating oxidative stress and acetylcholinesterase activity damage.
METABOLIC BRAIN DISEASE
(2023)
Article
Neurosciences
Seyed Hossein Hosseini, Zahra Sadat Khabbazhosseini, Seyedamirsadra Khatibi, Amirreza Yahosseini, Nafiseh Borhaninejad, Farimah Beheshti, Samaneh Kakhki
Summary: This study aimed to assess the potential of folic acid (FA) in preventing memory impairment caused by nicotine withdrawal in adolescent male rats. The results showed that administration of FA significantly improved the adverse effects of nicotine withdrawal. This suggests that FA may be used to prevent or ameliorate memory impairment caused by nicotine withdrawal.
NEUROSCIENCE LETTERS
(2023)
Article
Chemistry, Medicinal
Zohreh Arab, Hossein Salmani, Narges Marefati, Farimah Beheshti, Akbar Anaeigoudari, Farzaneh Shakeri, Narges Tajmazinani, Mahmoud Hosseini
Summary: This study investigated the effects of Zataria multiflora extract on liver damage and inflammation caused by lipopolysaccharide in rats. The results showed that the extract reduced liver damage, inflammation and oxidative stress.
AVICENNA JOURNAL OF PHYTOMEDICINE
(2023)
Article
Pharmacology & Pharmacy
Mohaddeseh Sadat Alavi, Hamid Reza Sadeghnia, Niloufar Nikpasand, Sajad Sahab Negah, Roghayeh Rashidi, Gholamreza Naseri, Ahmad Ghorbani
Summary: This study found that mephedrone exposure negatively affects the proliferation, differentiation, and apoptosis of rat embryonic neural stem/progenitor cells (NS/PC). Mephedrone at concentrations of 20-640 μM significantly reduced NS/PC proliferation, induced cell cycle arrest, and increased apoptosis and necrosis. Additionally, mephedrone decreased the expressions of DCX and NeuN neuronal markers. These findings suggest that mephedrone exposure during fetal or neonatal life may impair neurogenesis and subsequent brain development.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2023)
