Review
Pediatrics
Abdul Razak, Maheer Faden
Summary: The study found that maternal diabetes was not significantly associated with in-hospital mortality and severe neonatal morbidities in preterm infants. Future research should further explore the relationship between the severity of maternal diabetes and preterm infant outcomes.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2021)
Review
Food Science & Technology
Awole Seid, Desta Dugassa Fufa, Misrak Weldeyohannes, Zuriyash Tadesse, Selamawit Lake Fenta, Zebenay Workneh Bitew, Getenet Dessie
Summary: Inadequate dietary diversity during pregnancy in Africa is significantly associated with maternal anemia and low birth weight, according to a systematic review and meta-analysis of observational studies.
FOOD SCIENCE & NUTRITION
(2023)
Article
Pediatrics
Tarannum Fatima, Mohammad Moonis Akbar Faridi, Geetika Srivastava
Summary: This study aimed to investigate the effect of maternal iron supplementation on the iron status of exclusively breastfed low-birth-weight infants. The study found that 26.6% of infants developed anemia at 6 months of age, with no difference in the number of anemic infants whether mothers received iron for 3 or 6 months. However, infants whose mothers received iron for 6 months had significantly higher levels of hemoglobin and serum ferritin.
FRONTIERS IN PEDIATRICS
(2022)
Review
Obstetrics & Gynecology
Melissa F. Young, Brietta M. Oaks, Hannah Paige Rogers, Sonia Tandon, Reynaldo Martorell, Kathryn G. Dewey, Amanda S. Wendt
Summary: This study reviewed 148 studies and found that both low and high maternal hemoglobin (Hb) concentrations during pregnancy are associated with adverse maternal and infant health outcomes. Low Hb is associated with low birth weight, preterm birth, and postpartum hemorrhage, while high Hb is associated with macrosomia, gestational hypertension, and stillbirth.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Nutrition & Dietetics
Malgorzata Lewandowska
Summary: The study found that maternal pre-pregnancy obesity is associated with an increased risk of low birth weight, fetal growth restriction, and macrosomia in newborns. Additionally, the risk of macrosomia was three times higher for obese mothers, while the risk of low birth weight was 17 times higher, particularly in the subgroup of normal gestational weight gain. The risk profile showed that higher BMI values were associated with a higher risk of these outcomes, with specific threshold BMI values identified.
Article
Biochemistry & Molecular Biology
Xiangrong Guo, Leilei Zhou, Jian Xu, Zhiwei Liu, Junxia Liu, Chonghuai Yan
Summary: The study revealed a non-linear association between maternal selenium status and TSH levels, suggesting that low selenium status during pregnancy may be associated with low thyroid function and low birth weight.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Nutrition & Dietetics
Xiaotong Wang, Jiajia Jing, Saijun Huang, Xiaoying He, Pingming Gao, Hailin Li, Zongyu Lin, Per Torp Sangild, Yanna Zhu
Summary: Early anemia in very-low-birth-weight (VLBW) preterm infants is negatively correlated with neurodevelopment, especially with behavioral ability, but is not associated with brain injury.
Article
Environmental Sciences
Jovine Bachwenkizi, Cong Liu, Xia Meng, Lina Zhang, Weidong Wang, Aaron van Donkelaar, Randall Martin, Melanie S. Hammer, Renjie Chen, Haidong Kan
Summary: This multicountry study in Africa found significant associations between maternal exposure to PM2.5 and higher odds of low birth weight and preterm birth. These findings may contribute to the development of air quality control strategies to address adverse birth outcomes in low- and middle-income countries.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Cardiac & Cardiovascular Systems
Soichiro Henmi, Yasin Essa, Mahmut Ozturk, Aybala Tongut, Manan Desai, Can Yerebakan, Yves d'Udekem
Summary: This study retrospectively evaluated the outcomes of cardiovascular surgery in very low birth weight patients. The study found that the occurrence of postoperative intracerebral hemorrhage was significantly higher in low birth weight patients compared to slightly higher weight patients. The early and late mortality rates were also higher in the low birth weight group. Early surgery was acceptable for simple lesions, while delayed surgery may provide better long-term outcomes for complex lesions.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Environmental Sciences
Qiong Wang, Huazhang Miao, Joshua L. Warren, Meng Ren, Tarik Benmarhnia, Luke D. Knibbs, Huanhuan Zhang, Qingguo Zhao, Cunrui Huang
Summary: Ozone exposure during the second trimester was found to be associated with an increased risk of term LBW in a retrospective cohort study conducted in Guangzhou. Monthly ozone exposure during the 4th-6th month (O-3-1 h) and the 6th month (O-3-8 h) was also correlated with LBW risk. Critical exposure windows were identified at the 15th-26th gestational weeks for O-3-1 h exposure and the 20th-26th weeks for O-3-8 h exposure, suggesting a potential vulnerability during these periods.
ENVIRONMENT INTERNATIONAL
(2021)
Review
Obstetrics & Gynecology
Catherine C. Cibulskis, Akhil Maheshwari, Rakesh Rao, Amit M. Mathur
Summary: Anemia of prematurity is a common condition with unclear pathophysiology and impact on infant development. It can lead to poor weight gain, inability to take oral feeds, and has varying treatment thresholds for RBC transfusion.
JOURNAL OF PERINATOLOGY
(2021)
Article
Pediatrics
Alejandra Rodriguez-Fernandez, Marcela Ruiz-De la Fuente, Ximena Sanhueza-Riquelme, Julio Parra-Flores, Maria Dolores Marrodan, Eduard Maury-Sintjago
Summary: The study found that maternal factors, such as educational attainment and age, are associated with preterm and low-birthweight births in Chile. Mothers with less than 12 years of education and mothers aged 35 or older were found to be at a higher risk for preterm and low-birthweight newborns.
Article
Psychology, Developmental
Adelar Pedro Franz, Arthur Caye, Barbara Calil Lacerda, Flavia Wagner, Rita C. Silveira, Renato Soibelmann Procianoy, Carlos Renato Moreira-Maia, Luis Augusto Rohde
Summary: The study developed an individualized risk calculator for ADHD in VP/VLBW newborns, which showed good performance in identifying high-risk children at 6 years old. This tool could offer more effective early intervention compared to traditional approaches.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2022)
Article
Environmental Sciences
Weeberb J. Requia, Petros Koutrakis, Stefania Papatheodorou
Summary: This study examines the association between Low Birth Weight (LBW) and ambient temperature exposure in Brazil, the largest county in South America. The results indicate that there is a significant positive association between LBW and ambient temperature, specifically in the northern region where the Amazon is located.
ENVIRONMENTAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Xiao Song Liu, Xiu Juan Su, Guo Hua Li, Shi Jia Huang, Yang Liu, Han Xiang Sun, Qiao Ling Du
Summary: This study found an association between FT4 and birth weight as well as birth weight discordance in twins, while TSH was not associated with birth weight. These findings have implications for obstetricians in preventing birth weight discordance in twin pregnancies.
Article
Obstetrics & Gynecology
Erin A. Plummer, Ivana Ninkovic, Anna Rees, Raghavendra Rao, Catherine M. Bendel, Erin C. Stepka
Summary: This study examined the implementation of hypoglycemia algorithms for managing neonatal hypoglycemia and found that this approach improved short-term outcomes and reduced hospital costs.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Pediatrics
David J. Askenazi, Patrick J. Heagerty, Robert H. Schmicker, Patrick Brophy, Sandra E. Juul, Stuart L. Goldstein, Sangeeta Hingorani
Summary: ELGANs have high rates of in-hospital AKI and kidney-related problems at 22-26 months of cGA. Recombinant erythropoietin may protect ELGANs against long-term elevated SBP but does not appear to protect from AKI, low eGFR, albuminuria, or elevated DBP at 22-26 months of cGA.
JOURNAL OF PEDIATRICS
(2021)
Review
Neurosciences
Andrea M. Maxwell, Raghavendra B. Rao
Summary: The growing evidence suggests that prenatal iron deficiency may serve as an important mechanism underlying the early risk factor for schizophrenia. Prenatal iron deficiency can impact neurodevelopment processes and be associated with an increased risk of developing schizophrenia in adulthood.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Pediatrics
David J. Askenazi, Patrick J. Heagerty, Robert H. Schmicker, Patrick Brophy, Sandra E. Juul, Sangeeta Hingorani, Stuart L. Goldstein
Summary: Our understanding of normative concentrations of urine biomarkers in premature neonates is limited. Gestational age and sex have an impact on urine biomarker concentrations. Some biomarkers increase over time, while others decrease. Most biomarkers differ by gestational age at 27 weeks PMA, but are similar by 34 weeks PMA. Epo treatment does not affect urine biomarkers.
PEDIATRIC RESEARCH
(2022)
Correction
Pediatrics
David J. Askenazi, Brian A. Halloran, Patrick J. Heagerty, Robert H. Schmicker, Patrick Brophy, Sandra E. Juul, Sangeeta Hingorani, Stuart L. Goldsteinon
PEDIATRIC RESEARCH
(2022)
Article
Physiology
Brian J. Sandri, Jonathan Kim, Gabriele R. Lubach, Eric F. Lock, Candace Guerrero, LeeAnn Higgins, Todd W. Markowski, Pamela J. Kling, Michael K. Georgieff, Christopher L. Coe, Raghavendra B. Rao
Summary: The study demonstrates the adverse effects of iron deficiency on infant brain health, but sensitive biomarkers of this condition are lacking in humans. Using a nonhuman primate model, the researchers identified changes in protein and metabolite profiles that indicate metabolic dysfunction and disrupted synaptogenesis in the brain. These changes can potentially serve as measurable biomarkers in both the pre-anemic and anemic stages of iron deficiency.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2022)
Article
Pediatrics
Catarina Saiote, Ellen Sutter, Annette Xenopoulos-Oddsson, Raghavendra Rao, Michael Georgieff, Kyle Rudser, Colleen Peyton, Douglas Dean, Ryan M. McAdams, Bernadette Gillick
Summary: This protocol aims to study brain development and motor function in infants following perinatal brain injury through multimodal longitudinal assessment, including measuring CST functional and structural integrity noninvasively. By assessing the association between cortical excitability, integrity, and motor function, it helps identify bioindicators of motor outcome and neuroplasticity.
PEDIATRIC PHYSICAL THERAPY
(2022)
Article
Pediatrics
Melissa R. Garcia, Bryan A. Comstock, Ravi M. Patel, Veeral N. Tolia, Cassandra D. Josephson, Michael K. Georgieff, Raghavendra Rao, Sarah E. Monsell, Sandra E. Juul, Kaashif A. Ahmad
Summary: This study aimed to investigate the relationship between iron exposure and the development of bronchopulmonary dysplasia (BPD). The study found that lower volume of red blood cell transfusions in the first 28 days after birth and higher enteral iron exposure in the first 28 days after birth were associated with lower rates of BPD.
PEDIATRIC RESEARCH
(2023)
Article
Endocrinology & Metabolism
Debra Kulhanek, Juan E. Abrahante Llorens, Lauren Buckley, Ivan Tkac, Raghavendra Rao, Megan E. Paulsen
Summary: Maternal obesity is strongly associated with offspring obesity and metabolic disease. This study explored the potential hypothalamic mechanisms explaining this link. It was found that adult offspring exposed to a maternal obesogenic diet had increased fat mass, decreased glucose tolerance, decreased insulin sensitivity, and altered hormone levels. Additionally, there were changes in energy intake, activity, and hypothalamic neurochemical profile. These findings suggest that altered hypothalamic function may contribute to obesity development.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Developmental Biology
Lauren McClure Yauch, Kathleen Ennis-Czerniak, William H. I. I. I. I. Frey, Ivan Tkac, Raghavendra B. Rao
Summary: Hyperglycemia due to relative hypoinsulinism is common in extremely preterm infants and is associated with long-term cognitive impairment mediated by the hippocampus. This study found that intranasal insulin administration improved hippocampal development in neonatal hyperglycemia, reducing oxidative stress and abnormal synaptogenesis. These findings suggest that insulin treatment may be beneficial in preventing cognitive impairment in preterm infants with hyperglycemia.
DEVELOPMENTAL NEUROSCIENCE
(2022)
Article
Nutrition & Dietetics
Raghavendra B. Rao, Gabriele R. Lubach, Kathleen M. Ennis-Czerniak, Eric F. Lock, Pamela J. Kling, Michael K. Georgieff, Christopher L. Coe
Summary: This study investigated the predictive accuracy of red blood cell indices, RET-He, and iron indices for assessing the risk of iron deficiency and iron deficiency anemia (IDA) in a nonhuman primate model. They found that RET-He can be used as a hematological parameter to screen for infantile iron deficiency and IDA.
JOURNAL OF NUTRITION
(2023)
Article
Multidisciplinary Sciences
Brian J. Sandri, Jonathan Kim, Gabriele R. Lubach, Eric F. Lock, Candace Guerrero, LeeAnn Higgins, Todd W. Markowski, Pamela J. Kling, Michael K. Georgieff, Christopher L. Coe, Raghavendra B. Rao
Summary: Early-life iron deficiency anemia (IDA) has adverse effects on various tissues, including the brain. However, a sensitive biomarker for iron-dependent brain health is currently lacking. Proteomic and metabolomic analysis identified potential serum and CSF biomarkers associated with ID-induced metabolic dysfunction.
Article
Biophysics
Katherine M. Satrom, Raghavendra B. Rao, Ivan Tkac
Summary: Neonatal hyperbilirubinemia can cause brain injury in specific regions such as the cerebellum and hippocampus in newborn infants. Extremely preterm infants are more susceptible to bilirubin neurotoxicity, but the exact mechanism and extent of the injury are not well understood. A study using a preterm rat model found that the cerebellum is more severely affected by hyperbilirubinemia than the hippocampus, with significant morphological changes and alterations in neurochemical profiles.
NMR IN BIOMEDICINE
(2023)
Article
Cell & Tissue Engineering
Raghavendra B. Rao, Maple L. Shiao, Kathleen M. Ennis-Czerniak, Walter C. Low
Summary: The administration of human nonhematopoietic umbilical cord blood-derived stem cells (nh-UCBSCs) in neonatal rats with periventricular-intraventricular hemorrhage (PIVH) reduced the severity of brain injury and improved motor and behavioral function.
CELL TRANSPLANTATION
(2023)
Article
Public, Environmental & Occupational Health
Swathi Sunil Rao, Rutuja Agadi, Sukanya Shetty, Raghavendra Rao, Rathika D. Shenoy
Summary: The cord serum ferritin and fetal iron status were compared in newborns with and without maternal occupational smokeless tobacco exposure. It was found that fetal nicotine absorption exacerbated fetal iron depletion.
INDIAN JOURNAL OF COMMUNITY MEDICINE
(2022)
