Article
Microbiology
Michelle Coleman, Blair Armistead, Austyn Orvis, Phoenicia Quach, Alyssa Brokaw, Claire Gendrin, Kavita Sharma, Jason Ogle, Sean Merillat, Matthew Dacanay, Tsung-Yen Wu, Jeff Munson, Audrey Baldessari, Jay Vornhagen, Anna Furuta, Shayla Nguyen, Kristina M. Adams Waldorf, Lakshmi Rajagopal
Summary: Invasive bacterial infections during pregnancy, such as Group B streptococci (GBS), can lead to preterm birth, stillbirth, and fetal injury. Using a nonhuman primate model, researchers found that GBS expressing hyaluronidase can cause microbial invasion into the amniotic cavity and preterm labor, shedding light on virulence factors and potential therapeutic strategies. Understanding how bacteria evade host defenses during pregnancy is crucial for developing preventive therapies against adverse outcomes.
Review
Infectious Diseases
Hans R. W. Piazzolla, Frederikke Modin, Sofie Halkjaer, Andreas M. Petersen, Henrik Calum, Anne Holm
Summary: This systematic review and meta-analysis found an association between significant bacteriuria during pregnancy and three complications: preterm delivery, low birth weight, and preterm labor. However, the quality of available evidence is insufficient to determine if this association is solely due to confounding factors. There is a lack of high-quality evidence to support active identification and treatment of bacteriuria during pregnancy.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Review
Immunology
Alyssa Brokaw, Anna Furuta, Matthew Dacanay, Lakshmi Rajagopal, Kristina M. Adams Waldorf
Summary: Group B streptococcus colonization during pregnancy can lead to adverse outcomes, but there is currently no approved vaccine to prevent GBS infections. Understanding the pathogenesis of GBS disease may help in finding targeted therapeutic strategies to reduce the global burden of GBS infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Multidisciplinary Sciences
Sungju Lim, Shilpa Rajagopal, Ye Ryn Jeong, Dumebi Nzegwu, Michelle L. Wright
Summary: This study explored the frequency of GBS reporting in vaginal microbiome literature and found that considerable differences in study design and data formatting methods may contribute to the underrepresentation of GBS and other pathogens in existing literature. Sharing detailed methods, analysis code, and raw data may improve reproducibility and enhance the ability to compare microbial communities across studies more accurately.
Review
Nutrition & Dietetics
Daniela Menichini, Giuseppe Chiossi, Francesca Monari, Francesco De Seta, Fabio Facchinetti
Summary: The study found that probiotic supplementation during pregnancy can reduce maternal Group B streptococcus (GBS) recto-vaginal colonization in pregnant women at 35-37 weeks, especially when treatment starts after 30 weeks of gestation. Probiotic supplementation may help improve maternal and neonatal health during pregnancy.
Article
Cell Biology
Kristin Jahn, Patience Shumba, Phoenicia Quach, Mathias Musken, Jan Wesche, Andreas Greinacher, Lakshmi Rajagopal, Sven Hammerschmidt, Nikolai Siemens
Summary: This study investigates the effects of GBS pigment on human platelets and finds that the pigment can induce platelet activation and necrotic cell death.
Article
Microbiology
Michelle J. Vaz, Sophia Dongas, Adam J. Ratner
Summary: Late-onset disease is the most common clinical presentation of GBS infection in infants, and gastrointestinal colonization is an important precursor. This study found that capsular polysaccharides of GBS enhance GI colonization and different serotypes have competitive advantages.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Michelle J. Vaz, Sophia Dongas, Adam J. Ratner
Summary: Late-onset disease is the most common clinical presentation of Group B Streptococcus (GBS) infection during infancy, and gastrointestinal colonization is an important precursor. The presence of a capsule enhances GBS GI colonization, and type Ia capsule provides a competitive advantage over type III capsule in a GBS A909 strain background.
MICROBIOLOGY SPECTRUM
(2023)
Review
Immunology
Konstantinos Karampatsas, Hannah Davies, Maren Mynarek, Nick Andrews, Paul T. Heath, Kirsty Le Doare
Summary: Prematurity/low birth weight and maternal colonization are major risk factors for late-onset Group B streptococcal infection. Future vaccine studies should identify the optimal time for vaccination during pregnancy to protect preterm infants.
CLINICAL INFECTIOUS DISEASES
(2022)
Review
Obstetrics & Gynecology
Kristin Harris, Leslie K. Proctor, Shiri Shinar, Eleni Philippopoulos, Mark H. Yudin, Kellie E. Murphy
Summary: This study systematically reviews the outcomes and management strategies for pregnancy and puerperal group A streptococcus infections, aiming to provide guidance for prevention and treatment of this rare but lethal infection. The study emphasizes the importance of early recognition, diagnosis, and aggressive management in order to prevent the serious risks of infection and streptococcal toxic shock syndrome.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Immunology
Preeti P. John, Brady C. Baker, Santosh Paudel, Lauren Nassour, Hayden Cagle, Ritwij Kulkarni
Summary: The study found that exposure to moderate glycosuria significantly increased bacterial growth and virulence characteristics in a mouse model of UTI, enhancing bacterial adhesion to human bladder cells, increasing resistance to antimicrobial peptides, and enhancing bacterial hemolytic ability.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Denho Ravi, Erato Ntinopoulou, Nessim Guetta, Manuela Weier, Verena Vogel, Barbara Spellerberg, Parham Sendi, Sandrine Gremlich, Thierry Roger, Eric Giannoni
Summary: This study compares the response of newborn and adult macrophages to GBS. The findings show that newborn macrophages exhibit higher levels of cytokine release in response to GBS, and may play a significant role in the progression of GBS infection in newborns.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Jane P. Daniels, Emily Dixon, Alicia Gill, Jon Bishop, Mark Wilks, Michael Millar, Jim Gray, Tracy E. Roberts, Jane Plumb, Jonathan J. Deeks, Karla Hemming, Khalid S. Khan, Shakila Thangaratinam
Summary: This study evaluated the use of intrapartum rapid test to detect maternal GBS colonization in women with clinical risk factors for early neonatal infection. The results showed that the use of rapid test did not reduce the rates of antibiotics administered to prevent neonatal early-onset GBS infection compared to usual care. The accuracy of the rapid test is within acceptable limits.
Review
Medicine, General & Internal
Jianqiong Li, Meifang Zhou, Chaoman He, Fengbing Liang
Summary: This study described a case of a 35-year-old multiparous woman with gestational diabetes who developed placental abruption, stillbirth, ovarian vein thrombosis (OVT), septic shock, and renal failure due to severe Group B Streptococcus (GBS) infection. This case highlights the importance of early initiation of anticoagulant protocols, especially in cases of OVT with GBS infection as a predisposing factor. Further research and awareness are needed to better understand the relationship between GBS infection and OVT and to optimize management strategies in such cases.
Article
Immunology
Alyssa Brokaw, Shayla Nguyen, Phoenicia Quach, Austyn Orvis, Anna Furuta, Bengt Johansson-Lindbom, Per B. Fischer, Lakshmi Rajagopal
Summary: This study demonstrates the efficacy of the GBS-NN vaccine in murine systemic and perinatal GBS infections and suggests that maternal vaccination facilitates the transfer of protective antibodies to neonates.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Obstetrics & Gynecology
Shira Bitensky, Gali Pariente, Reut Rotem, Ruslan Sergienko, Adi Yehuda Weintraub
Summary: This study found that women with prior cesarean delivery due to first stage non-progressive labor are more likely to develop hypertensive disorders of pregnancy and have a repeated cesarean delivery in subsequent pregnancies, while those with prior cesarean delivery due to second stage non-progressive labor are more likely to experience preterm birth in subsequent pregnancies.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Ganit Goren, Doron Schwartz, Michael Friger, Hagar Banai, Ruslan Sergienko, Shirley Regev, Heba Abu-Kaf, Dan Greenberg, Anna Nemirovsky, Karny Ilan, Livnat Lerner, Alon Monsonego, Iris Dotan, Henit Yanai, Rami Eliakim, Shomron Ben Horin, Vered Slonim-Nevo, Shmuel Odes, Orly Sarid
Summary: COBMINDEX was effective in improving quality of life and reducing psychological symptoms and fatigue in patients with Crohn disease, especially those with severe baseline symptoms.
INFLAMMATORY BOWEL DISEASES
(2022)
Review
Gastroenterology & Hepatology
Shomron Ben-Horin, Lena Novack, Ren Mao, Jing Guo, Yue Zhao, Ruslan Sergienko, Jian Zhang, Taku Kobayashi, Toshifumi Hibi, Yehuda Chowers, Laurent Peyrin-Biroulet, Jean Frederic Colombel, Gilaad G. Kaplan, Min-hu Chen
Summary: Initiating biologic treatment early in the course of Crohn's disease may yield better treatment outcomes, while disease duration does not significantly impact results in ulcerative colitis.
Meeting Abstract
Gastroenterology & Hepatology
Shomron Ben-Horin, Lena Novack, Ren Mao, Jing Guo, Yue Zhao, Ruslan Sergienko, Jian Zhang, Taku Kobayashi, Toshihumi Hibi, Yehuda Chowers, Laurent Peyrin-Biroulet, Jean-Frederic Colombel, Gilaad Kaplan, Min-Hu Chen
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Pediatrics
Adva Bugaiski-Shaked, Eilon Shany, Oded Mesner, Ruslan Sergienko, Tamar Wainstock
Summary: The study suggests that phototherapy for neonatal jaundice may slightly increase the risk of childhood neoplasms, particularly hematopoietic cancers and leukemia. It is important to adhere to phototherapy treatment guidelines to minimize unnecessary exposure.
JOURNAL OF PEDIATRICS
(2022)
Article
Pediatrics
Judah Freedman, Eugene Leibovitz, Ruslan Sergienko, Amalia Levy
Summary: This study found that Bedouin children from low-income areas had a higher risk of PICU hospitalization after infectious diseases compared to Jewish children. Maternal multiparity, low birth weight, and younger age were identified as significant risk factors for PICU hospitalizations with infectious diseases.
PEDIATRICS AND NEONATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Shirley Regev, Doron Schwartz, Orly Sarid, Ganit Goren, Vered Slonim-Nevo, Michael Friger, Ruslan Sergienko, Dan Greenberg, Alon Monsonego, Anna Nemirovsky, Shmuel Odes
Summary: This study aimed to investigate the effectiveness of a CD-tailored cognitive-behavioral and mindfulness intervention (COBMINDEX) in reducing abdominal pain and fatigue in patients with CD, as well as the mediating role of changes in abdominal pain and fatigue on improvements in work productivity and daily activities. The results showed that the intervention group receiving COBMINDEX had significantly lower levels of abdominal pain, fatigue, and impairments in work and daily activities compared to the control group. Furthermore, changes in abdominal pain and fatigue mediated the beneficial effects of COBMINDEX on work productivity and daily activities.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Obstetrics & Gynecology
Tamar Wainstock, Ruslan Sergienko, Shani Orenshtein, Eyal Sheiner
Summary: This retrospective cohort study aimed to identify maternal background, medical and gynecological characteristics associated with COVID-19 vaccination likelihood among pregnant women. The study found that younger age, lower socioeconomic score, being Bedouin Arab, poor obstetric history, recurrent pregnancy loss, and insufficient prenatal care were associated with lower vaccination rates. The study also observed differences in risk factors between different ethnicities.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Medicine, General & Internal
Tal Shabtai, Eyal Sheiner, Tamar Wainstock, Arie Raziel, Roy Kessous
Summary: This study aimed to investigate the risk of childhood malignancy in twins conceived following infertility treatments. By comparing twins conceived by infertility treatments and those conceived spontaneously, a population-based retrospective cohort study found no significant differences in the rate and cumulative incidence of childhood malignancies between the two groups during the study period.
JOURNAL OF CLINICAL MEDICINE
(2023)
Meeting Abstract
Obstetrics & Gynecology
Tamar Wainstock, Ruslan Sergienko, Eyal Sheiner
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
P. Schwarzman, E. Sheiner, R. Sergienko, R. Kessous
Summary: Objective mode of delivery, specifically cesarean section, is associated with an increased future risk for neoplasms, including uterine cancer. This population-based cohort analysis found a significantly higher incidence of benign and malignant neoplasms in patients who underwent cesarean section compared to vaginal delivery. However, no significant association was found with breast and ovarian malignancies.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Shirley Regev, Doron Schwartz, Ganit Goren, Ruslan Sergienko, Orly Sarid, Vered Slonim-Nevo, Michael Friger, Anna Nemirovsky, Alon Monsonego, Dan Greenberg, Selwyn H. Odes
Meeting Abstract
Gastroenterology & Hepatology
S. Ben-Horin, L. Novack, R. Mao, J. Guo, Y. Zhao, R. Sergienko, J. Zhang, K. Kobayashi, T. Hibi, Y. Chowers, L. Peyrin-Biroulet, J. F. C. Colombel, G. G. K. Kaplan, M. H. Chen
JOURNAL OF CROHNS & COLITIS
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Shomron Ben-Horin, Lena Novack, Ren Mao, Jing Guo, Yue Zhao, Ruslan Sergienko, Jian Zhang, Taku Kobayashi, Toshihumi Hibi, Yehuda Chowers, Laurent Peyrin-Biroulet, Jean-Frederic Colombel, Gilaad Kaplan, Min-Hu Chen
Letter
Medicine, General & Internal
Ronen Arbel, Ruslan Sergienko, Ariel Hammerman
NEW ENGLAND JOURNAL OF MEDICINE
(2022)