Review
Peripheral Vascular Disease
Kavia Khosla, Sarah Heimberger, Kristin M. Nieman, Avery Tung, Sajid Shahul, Anne Cathrine Staff, Sarosh Rana
Summary: Women with a history of hypertensive disorders of pregnancy have higher rates of long-term cardiovascular events, and the American Heart Association calls for early identification and risk reduction by physicians. This review discusses the epidemiology, pathophysiology, and outcomes of HDP-associated cardiovascular disease.
Review
Peripheral Vascular Disease
Chuyu Yang, Philip N. Baker, Joey P. Granger, Sandra T. Davidge, Chao Tong
Summary: Preeclampsia is associated with an increased risk of cardiovascular disease (CVD) in women and their offspring, and differential methylation of cytosine-phosphate-guanosine islands and alterations in microRNA expression have been observed in individuals with an elevated risk of CVD. Genetic and epigenetic factors play crucial roles in the development of CVD in individuals with a history of preeclampsia, and biomolecules involved in inflammation, oxidative stress, and angiogenesis may link pregnancy vascular disorders to the pathogenesis of future CVD. These findings could provide potential diagnostics and treatment strategies for clinical practice.
Review
Peripheral Vascular Disease
Veronica Giorgione, Gwyneth Jansen, Jamie Kitt, Chahinda Ghossein-Doha, Paul Leeson, Basky Thilaganathan
Summary: There is an increased occurrence of cardiovascular diseases in women within 1 to 2 decades after a preeclamptic pregnancy. Recent evidence suggests that the abnormal biochemical and echocardiographic findings in preeclamptic women do not resolve after giving birth. Many women remain hypertensive in the immediate postnatal period, with some showing signs of cardiac dysfunction. Close monitoring and effective blood pressure control in the immediate postnatal period may lead to persistently lower blood pressures in women years after stopping medication. This review emphasizes the importance of delivering effective medical care in the fourth trimester of pregnancy to improve long-term cardiovascular health after a preeclamptic birth.
Review
Peripheral Vascular Disease
Natalie A. Cameron, Ian K. Everitt, Kristen A. Lee, Lynn M. Yee, Sadiya S. Khan
Summary: Hypertension is a significant risk factor for cardiovascular disease in the US, and its prevalence during pregnancy has almost doubled in the past decade. High blood pressure during pregnancy is concerning due to increased risks of maternal and fetal complications and long-term cardiovascular risks. Identifying chronic hypertension during pregnancy can provide insights into cardiovascular disease risk and offer opportunities for risk reduction. Equitable healthcare interventions during the peripartum period can have a significant impact on preventing chronic hypertension and reducing lifetime cardiovascular disease risk.
Article
Cardiac & Cardiovascular Systems
U. Vivian Ukah, Natalie Dayan, Brian J. Potter, Gilles Paradis, Aimina Ayoub, Nathalie Auger
Summary: Women with severe maternal morbidity have an increased risk of cardiovascular disease after pregnancy, both in the short and long term.
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2022)
Review
Biochemistry & Molecular Biology
Marisa Benagiano, Salvatore Mancuso, Jan J. Brosens, Giuseppe Benagiano
Summary: HDP and PE have lasting consequences for both pregnant women and fetuses, increasing the risk of cardiovascular diseases in the future. The placental vascular lesions characteristic of this pathology may induce long-term adverse effects on the arterial system of pregnant women.
Review
Medicine, General & Internal
Jarawee Sukmanee, Tippawan Liabsuetrakul
Summary: Women with a history of hypertensive disorders of pregnancy (HDP) have an increased risk of cardiovascular diseases (CVDs) in later life, especially within the first 5 years postpartum. Preeclamptic women have a higher risk of CVDs compared to women with normotensive pregnancies.
Review
Endocrinology & Metabolism
Emily A. Rosenberg, Ellen W. Seely
Summary: Cardiovascular disease is the leading cause of death for women, and adverse pregnancy outcomes such as gestational diabetes and preeclampsia are unique risk factors. However, these risk factors are often overlooked by providers. This mini-review focuses on the relationship between gestational diabetes, preeclampsia, and cardiovascular disease, as well as the mechanisms and management strategies for women with a history of adverse pregnancy outcomes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Jennifer J. Stuart, Lauren J. Tanz, Eric B. Rimm, Donna Spiegelman, Stacey A. Missmer, Kenneth J. Mukamal, Kathryn M. Rexrode, Janet W. Rich-Edwards
Summary: This study aimed to evaluate the association between hypertensive disorders of pregnancy (HDP) and long-term cardiovascular disease (CVD) and identify the proportion mediated by established CVD risk factors. The results showed that women with HDP during their first pregnancy had a higher risk of CVD, which was mainly mediated by established CVD risk factors.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Immunology
Erika S. Helgeson, Elise F. Palzer, David M. Vock, Paige Porrett, Deirdre Sawinski, Arthur J. Matas
Summary: This study aimed to investigate the long-term outcomes of women donors who had pregnancy-related complications. The results showed that donors with gestational hypertension and gestational diabetes had an increased risk of developing hypertension and diabetes in the long term, but no association was found between pregnancy complications and reduced renal function.
Article
Medicine, General & Internal
Ismini Mpalatsouka, Myria Zachariou, Maria Kyprianidou, Georgia Fakonti, Konstantinos Giannakou
Summary: This study aims to determine the level of awareness regarding long-term health risks among women who experienced preeclampsia during pregnancy in Cyprus and Greece. The findings revealed that more than half of the women with prior preeclampsia were not aware of hypertensive disorders that can occur during pregnancy before their diagnosis, and a very small percentage of participants were aware of the risk of developing cardiovascular diseases.
FRONTIERS IN MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Kirim Hong, Soo Hyun Kim, Dong Hyun Cha, Hee Jin Park
Summary: Preeclampsia is a complex hypertensive disorder in pregnancy that can be lethal and is considered one of the major risk factors for cardiovascular disease in women. In addition to the higher risk of unfavorable obstetric outcomes, the association between preeclampsia and postpartum cardiovascular health of the mother is crucial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Environmental Sciences
Gyeyoon Yim, Yuting Wang, Caitlin G. Howe, Megan E. Romano
Summary: This scoping review summarizes the literature on the cardiotoxicity of exposure to metal mixtures and identifies the trends and focus areas in the research. The majority of the studies were conducted in the United States and China, with an increase in publications in recent years. The commonly investigated metals included cadmium, lead, arsenic, and cobalt, with a focus on their impact on blood pressure, preeclampsia, dyslipidemia, and cardiovascular disease outcomes.
Article
Obstetrics & Gynecology
Ashley Battarbee, Lisa B. Mele, Mark W. Landon, Michael M. Varner, Brian M. Casey, Uma J. Reddy, Ronald J. Wapner, Dwight M. Rouse, John K. Thorp, Edward Chien, George M. Saade, Alan C. Peaceman, Sean Blackwell
Summary: This study aimed to measure the association between hypertensive disorders of pregnancy (HDP) and long-term maternal metabolic and cardiovascular biomarkers. The results showed no association between HDP and metabolic or cardiovascular biomarkers, but patients with preeclampsia may have lower levels of oxidative stress/cardiac ischemia.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Article
Obstetrics & Gynecology
Kathrin Hassdenteufel, Mitho Muller, Raphael Gutsfeld, Maren Goetz, Armin Bauer, Markus Wallwiener, Sara Y. Brucker, Stefanie Joos, Miriam Giovanna Colombo, Sabine Hawighorst-Knapstein, Ariane Chaudhuri, Gudula Kirtschig, Frauke Saalmann, Stephanie Wallwiener
Summary: Preeclampsia increases the risk of developing chronic hypertension and cardiovascular disease in women, especially those with recurrent preeclampsia. Future medical guidelines should take this potential risk into account.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Shira Bitensky, Gali Pariente, Reut Rotem, Ruslan Sergienko, Adi Yehuda Weintraub
Summary: This study found that women with prior cesarean delivery due to first stage non-progressive labor are more likely to develop hypertensive disorders of pregnancy and have a repeated cesarean delivery in subsequent pregnancies, while those with prior cesarean delivery due to second stage non-progressive labor are more likely to experience preterm birth in subsequent pregnancies.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Ganit Goren, Doron Schwartz, Michael Friger, Hagar Banai, Ruslan Sergienko, Shirley Regev, Heba Abu-Kaf, Dan Greenberg, Anna Nemirovsky, Karny Ilan, Livnat Lerner, Alon Monsonego, Iris Dotan, Henit Yanai, Rami Eliakim, Shomron Ben Horin, Vered Slonim-Nevo, Shmuel Odes, Orly Sarid
Summary: COBMINDEX was effective in improving quality of life and reducing psychological symptoms and fatigue in patients with Crohn disease, especially those with severe baseline symptoms.
INFLAMMATORY BOWEL DISEASES
(2022)
Review
Gastroenterology & Hepatology
Shomron Ben-Horin, Lena Novack, Ren Mao, Jing Guo, Yue Zhao, Ruslan Sergienko, Jian Zhang, Taku Kobayashi, Toshifumi Hibi, Yehuda Chowers, Laurent Peyrin-Biroulet, Jean Frederic Colombel, Gilaad G. Kaplan, Min-hu Chen
Summary: Initiating biologic treatment early in the course of Crohn's disease may yield better treatment outcomes, while disease duration does not significantly impact results in ulcerative colitis.
Meeting Abstract
Gastroenterology & Hepatology
Shomron Ben-Horin, Lena Novack, Ren Mao, Jing Guo, Yue Zhao, Ruslan Sergienko, Jian Zhang, Taku Kobayashi, Toshihumi Hibi, Yehuda Chowers, Laurent Peyrin-Biroulet, Jean-Frederic Colombel, Gilaad Kaplan, Min-Hu Chen
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Pediatrics
Adva Bugaiski-Shaked, Eilon Shany, Oded Mesner, Ruslan Sergienko, Tamar Wainstock
Summary: The study suggests that phototherapy for neonatal jaundice may slightly increase the risk of childhood neoplasms, particularly hematopoietic cancers and leukemia. It is important to adhere to phototherapy treatment guidelines to minimize unnecessary exposure.
JOURNAL OF PEDIATRICS
(2022)
Article
Pediatrics
Judah Freedman, Eugene Leibovitz, Ruslan Sergienko, Amalia Levy
Summary: This study found that Bedouin children from low-income areas had a higher risk of PICU hospitalization after infectious diseases compared to Jewish children. Maternal multiparity, low birth weight, and younger age were identified as significant risk factors for PICU hospitalizations with infectious diseases.
PEDIATRICS AND NEONATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Shirley Regev, Doron Schwartz, Orly Sarid, Ganit Goren, Vered Slonim-Nevo, Michael Friger, Ruslan Sergienko, Dan Greenberg, Alon Monsonego, Anna Nemirovsky, Shmuel Odes
Summary: This study aimed to investigate the effectiveness of a CD-tailored cognitive-behavioral and mindfulness intervention (COBMINDEX) in reducing abdominal pain and fatigue in patients with CD, as well as the mediating role of changes in abdominal pain and fatigue on improvements in work productivity and daily activities. The results showed that the intervention group receiving COBMINDEX had significantly lower levels of abdominal pain, fatigue, and impairments in work and daily activities compared to the control group. Furthermore, changes in abdominal pain and fatigue mediated the beneficial effects of COBMINDEX on work productivity and daily activities.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Obstetrics & Gynecology
Tamar Wainstock, Ruslan Sergienko, Shani Orenshtein, Eyal Sheiner
Summary: This retrospective cohort study aimed to identify maternal background, medical and gynecological characteristics associated with COVID-19 vaccination likelihood among pregnant women. The study found that younger age, lower socioeconomic score, being Bedouin Arab, poor obstetric history, recurrent pregnancy loss, and insufficient prenatal care were associated with lower vaccination rates. The study also observed differences in risk factors between different ethnicities.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Meeting Abstract
Obstetrics & Gynecology
Tamar Wainstock, Ruslan Sergienko, Eyal Sheiner
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
P. Schwarzman, E. Sheiner, R. Sergienko, R. Kessous
Summary: Objective mode of delivery, specifically cesarean section, is associated with an increased future risk for neoplasms, including uterine cancer. This population-based cohort analysis found a significantly higher incidence of benign and malignant neoplasms in patients who underwent cesarean section compared to vaginal delivery. However, no significant association was found with breast and ovarian malignancies.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Meeting Abstract
Economics
R. Sergienko, D. Greenberg
Meeting Abstract
Gastroenterology & Hepatology
Shirley Regev, Doron Schwartz, Ganit Goren, Ruslan Sergienko, Orly Sarid, Vered Slonim-Nevo, Michael Friger, Anna Nemirovsky, Alon Monsonego, Dan Greenberg, Selwyn H. Odes
Meeting Abstract
Gastroenterology & Hepatology
S. Ben-Horin, L. Novack, R. Mao, J. Guo, Y. Zhao, R. Sergienko, J. Zhang, K. Kobayashi, T. Hibi, Y. Chowers, L. Peyrin-Biroulet, J. F. C. Colombel, G. G. K. Kaplan, M. H. Chen
JOURNAL OF CROHNS & COLITIS
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Shomron Ben-Horin, Lena Novack, Ren Mao, Jing Guo, Yue Zhao, Ruslan Sergienko, Jian Zhang, Taku Kobayashi, Toshihumi Hibi, Yehuda Chowers, Laurent Peyrin-Biroulet, Jean-Frederic Colombel, Gilaad Kaplan, Min-Hu Chen
Article
Public, Environmental & Occupational Health
Shirley Regev, Shmuel Odes, Vered Slonim-Nevo, Ganit Goren, Michael Friger, Dan Greenberg, Hillel Vardi, Doron Schwartz, Ruslan Sergienko, Orly Sarid
Summary: This study aimed to provide clinical norms for the Brief Symptom Inventory (BSI) using a cohort of Crohn's disease (CD) patients in Israel. The results showed that CD patients in active disease state had higher levels of mental health symptoms compared to those in remission, and symptomatology did not differ with respect to disease duration. Additionally, younger age and lower economic status were associated with more severe psychological symptoms. The findings suggest the importance of using appropriate BSI norms in assessing psychological symptoms in non-psychiatric patients with chronic illness.
PSYCHOLOGY & HEALTH
(2022)