Article
Pharmacology & Pharmacy
F. Cau, C. Gerosa, R. Murru, G. Pichiri, P. Coni, M. Piras, A. Scano, G. Orru, G. La Nasa, F. Coghe, M. Castagnola, P. Van Eyken, L. Saba, D. Fanni, G. Faa
Summary: The study found that L1CAM is expressed during fetal human kidney development and is restricted to renal structures derived from the ureteric bud. The expression of L1CAM in the cells of the ureteric bud tips suggests a major role for this adhesion molecule in the induction of metanephric mesenchymal cells to undergo mesenchymal-to-epithelial transition and differentiation into new nephrons.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Fenglin Wang, Jenny Ngo, Yuwen Li, Hongbing Liu, Chao-Hui Chen, Zubaida Saifudeen, Maria Luisa S. Sequeira-Lopez, Samir S. El-Dahr
Summary: Dot1, an epigenetic regulator, plays crucial roles in organismal development and homoeostasis by regulating telomeric silencing, genomic integrity, and homoeotic gene expression. Studies in fruit flies and mice have shown that Dot1 functions differently in various cell lineages, particularly in the development of the kidney. The link between H3K79me and renal developmental pathways highlights the importance of chromatin-based mechanisms in organogenesis.
Article
Oncology
Camille Fedou, Mylene Camus, Ophelie Lescat, Guylene Feuillet, Ilka Mueller, Bryony Ross, Marie Buleon, Eric Neau, Melinda Alves, Dominique Goudouneche, Benjamin Breuil, Franck Boizard, Quentin Bardou, Audrey Casemayou, Ivan Tack, Sophie Dreux, Julie Batut, Patrick Blader, Odile Burlet-Schiltz, Stephane Decramer, Brunhilde Wirth, Julie Klein, Jean Sebastien Saulnier-Blache, Benedicte Buffin-Meyer, Joost P. Schanstra
Summary: Congenital anomalies of the kidney and the urinary tract (CAKUT) are the leading cause of chronic kidney disease in children, with complex genetic and environmental origins. The study identified multiple proteins in the amniotic fluid associated with CAKUT, with some proteins significantly impacting the presence and severity of the condition, particularly PLS3. These findings suggest PLS3 may play a crucial role in maintaining normal kidney function in addition to its potential role in nephrogenesis.
JOURNAL OF PATHOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Monica Piras, Clara Gerosa, Terenzio Congiu, Flaviana Cau, Daniela Fanni, Giuseppina Pichiri, Pierpaolo Coni, Joanna Izabela Lachowicz, Enrico Schirru, Mauro Congia, Rossano Rossino, Sandro Muntoni, Mariusz Jaremko, Marco Piludu
Summary: This study investigates the morphological events of the early stages of the cap mesenchymal-to-epithelial transition and the relationship between cap mesenchymal induction and ureteric bud branching. The results demonstrate a reciprocal induction between the ureteric bud and the metanephric mesenchyme, where the ureteric bud converts mesenchyme to epithelium and stimulates its own growth and branching.
JOURNAL OF PUBLIC HEALTH RESEARCH
(2022)
Article
Cell & Tissue Engineering
Isaac W. Shaw, Eoin D. O'Sullivan, Angela O. Pisco, Gary Borthwick, Kevin M. Gallagher, Bruno Peault, Jeremy Hughes, David A. Ferenbach
Summary: This study characterized the heterogeneity of renal mesenchymal cells in young vs old animals and after injury, demonstrating that age and injury impact the expression patterns and transcriptomes of these cells. The findings reveal distinct subtypes of mesenchymal cells with different expression patterns with aging and following injury, offering new insights into the classification and identification of age-specific pathways and targets in renal mesenchymal cells.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Article
Urology & Nephrology
Meredith P. Schuh, Lyan Alkhudairy, Andrew Potter, S. Steven Potter, Kashish Chetal, Kairavee Thakkar, Nathan Salomonis, Raphael Kopan
Summary: This study used rhesus macaques as a model to investigate the molecular mechanisms of lateral branch nephrogenesis, revealing that the late-gestation rhesus kidney undergoes a process similar to human lateral branch nephrogenesis. Through single-cell and single-nucleus RNA sequencing, transcriptional characteristics of different cell populations were identified, and age-specific molecular markers of rhesus kidney progenitor cells were discovered.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sabrina Leverrier-Penna, Alain Michel, Laetitia L. Lecante, Nathalie Costet, Antonio Suglia, Christele Desdoits-Lethimonier, Hugoline Boulay, Roselyne Viel, Jonathan M. Chemouny, Emmanuelle Becker, Vincent Lavoue, Antoine D. Rolland, Nathalie Dejucq-Rainsford, Cecile Vigneau, Severine Mazaud-Guittot
Summary: This study investigated the effects of analgesics on human fetal kidneys during early pregnancy, revealing a spectrum of abnormalities induced by these drugs, ranging from cell death to a decline in differentiating glomeruli density. Caution is warranted for the use of these medications during the first trimester of pregnancy.
Review
Biochemistry & Molecular Biology
Liang-Ti Huang, Chung-Ming Chen
Summary: Preterm birth and hyperoxia exposure disrupt the development and function of the kidneys, leading to the pathogenesis of chronic kidney disease. Hyperoxia-induced kidney injuries are mediated by various molecular factors, including hypoxia-inducible factor-1 alpha, interleukin-6/Smad2/transforming growth factor-beta, and Wnt/beta-catenin signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Wajima Safi, Andres Marco, Daniel Moya, Patricia Prado, Elena Garreta, Nuria Montserrat
Summary: The differentiation of human pluripotent stem cells towards kidney organoids has advanced regenerative medicine significantly. Understanding the developmental pathways of nephrogenesis has enabled the in vitro recapitulation of kidney development. Genome editing approaches, such as CRISPR/Cas9 technology, have provided insights into specific gene functions during renal differentiation from hPSCs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Diana Karpman, Ashmita Tontanahal
Summary: Extracellular vesicles play a crucial role in cell-to-cell communication and can either protect cells or induce inflammation, contributing to a variety of kidney diseases. Their content of miRNAs and growth factors make them promising candidates for renal regeneration therapy.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Melanie Tepus, Elisa Tonoli, Elisabetta A. M. Verderio
Summary: Chronic kidney disease (CKD) is a global health issue affecting up to 16% of the population worldwide. If left untreated, it can progress to end-stage kidney disease (ESKD), requiring dialysis or transplantation. Kidney fibrosis, the unsuccessful wound-healing of kidney tissue, is the end point of CKD. Urinary extracellular vesicles (uEVs), which carry low-abundant proteins and large molecules, are a potential source of rare CKD biomarkers. This review discusses the diagnostic and prognostic value of uEVs biomarkers and their potential application in experimental antifibrotic therapeutics.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pathology
Daisuke Kiyozawa, Kenichi Kohashi, Dai Takamatsu, Shinya Umekita, Masatoshi Eto, Mitsuru Kinjo, Kenichi Nishiyama, Kenichi Taguchi, Yumi Oshiro, Yusuke Kuboyama, Yoshinao Oda
Summary: The study found differences in the tumor microenvironment and IL-8 expression between CDC and FH-deficient RCC, suggesting IL-8 as a potential therapeutic target for treating CDC.
JOURNAL OF CLINICAL PATHOLOGY
(2022)
Article
Anatomy & Morphology
Sarah N. Lipp, Kathryn R. Jacobson, Andrew L. Schwaderer, David S. Hains, Sarah Calve
Summary: The study found that when the Foxd1 gene was knocked out in the developing kidney of mice, there were differences in the patterning of the extracellular matrix (ECM) proteins, including COL26A1, FBN2, EMILIN1, and TNC. These changes correlated with disrupted patterning of Foxd1(+) cells, but did not occur before branching dysmorphogenesis.
DEVELOPMENTAL DYNAMICS
(2023)
Review
Cell Biology
Chunling Liao, Guangyong Chen, Qian Yang, Yiping Liu, Tianbiao Zhou
Summary: This review summarizes the therapeutic effect of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) on renal fibrosis (RF) and the discovered mechanisms, providing a theoretical basis for further studying the role of MSC-EVs in treating RF diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Physiology
Leticia de Barros Sene, Gabriela Leme Lamana, Andre Schwambach Vieira, Wellerson Rodrigo Scarano, Jose Antonio Rocha Gontijo, Patricia Aline Boer
Summary: The research revealed miRNA and molecular pathway changes in the kidneys affected by protein restriction during fetal development, which may lead to reduced nephron numbers and other related dysfunctions. Further data analysis indicated the involvement of multiple miRNAs in regulating kidney development.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Obstetrics & Gynecology
Daniela Fanni, Michele Peiretti, Valerio Mais, Elena Massa, Clara Gerosa, Francesca Ledda, Maria Luisa Fais, Gavino Faa, Stefano Angioni
Summary: This article reports a case of PAX8-positive primary endometrial squamous cell carcinoma (PESCC), highlighting its Mullerian system origin. Further studies on a large number of cases are needed to better understand the pathologic features and the immunophenotype of PESCC.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
(2022)
Article
Pathology
Simona Stolnicu, Georgia Karpathiou, Esther Guerra, Claudia Mateoiu, Armando Reques, Angel Garcia, Joost Bart, Ana Felix, Daniela Fani, Joao Gama, David Hardisson, Jennifer A. Bennett, Carlos Parra-Herran, Esther Oliva, Nadeem Abu-Rustum, Robert A. Soslow, Kay J. Park
Summary: Cervical clear cell carcinoma (CCC) is a rare human papillomavirus-independent adenocarcinoma. Studies found that the overall survival and recurrence-free survival of CCC showed no significant difference compared to gastric-type adenocarcinoma (GTA), but significant differences compared to human papillomavirus-associated endocervical adenocarcinoma (HPVA ECA). Treatment significantly influences the recurrence-free survival of CCC, but is not an independent prognostic factor.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2022)
Editorial Material
Hematology
Giovanni Caocci, Daniela Fanni, Mariagrazia Porru, Marianna Greco, Sonia Nemolato, Davide Firinu, Gavino Faa, Angelo Scuteri, Giorgio La Nasa
Article
Biochemistry & Molecular Biology
Joanna I. Lachowicz, Giusi Pichiri, Marco Piludu, Sara Fais, Germano Orru, Terenzio Congiu, Monica Piras, Gavino Faa, Daniela Fanni, Gabriele Dalla Torre, Xabier Lopez, Kousik Chandra, Kacper Szczepski, Lukasz Jaremko, Mitra Ghosh, Abdul-Hamid Emwas, Massimo Castagnola, Mariusz Jaremko, Ewald Hannappel, Pierpaolo Coni
Summary: Thymosin beta 4 (T beta 4) is a protein involved in blood clotting, tissue regeneration, angiogenesis, and anti-inflammatory processes. This study reveals the important role of T beta 4 in an iron-dependent form of cell death, and its potential therapeutic implications in cancer and neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Clinical Neurology
Luca Saba, Valentina Nardi, Riccardo Cau, Ajay Gupta, Hooman Kamel, Jasjit S. Suri, Antonella Balestrieri, Terenzio Congiu, Anthony P. H. Butler, Steven Gieseg, Daniela Fanni, Giulia Cerrone, Roberto Sanfilippo, Josep Puig, Qi Yang, Lorenzo Mannelli, Gavino Faa, Giuseppe Lanzino
Summary: This review summarizes the current understanding of carotid plaque calcification and the role of calcium in atherosclerotic carotid disease. The analysis includes laboratory studies, histopathologic studies, and imaging findings, aiming to understand the clinical implications of carotid artery calcifications, such as their association with plaque stability and stroke risk. Further investigations with modern imaging techniques are expected to enhance our understanding of carotid artery calcification and its relationship with stroke risk.
Review
Radiology, Nuclear Medicine & Medical Imaging
Riccardo Cau, Cesare Mantini, Lorenzo Monti, Lorenzo Mannelli, Emanuele Di Dedda, Abdelkader Mahammedi, Refky Nicola, John Roubil, Jasjit S. Suri, Giulia Cerrone, Daniela Fanni, Gavino Faa, Alessandro Carriero, Angelo Scuteri, Marco Francone, Luca Saba
Summary: As of September 18th, 2021, there have been nearly 200 million global casualties due to COVID-19 infections. While several vaccines have been authorized to prevent COVID-19 infection, rare complications following vaccination have been reported to be life-threatening or fatal. This manuscript reviews the role of imaging in identifying and understanding multiorgan complications following SARS-COV-2 vaccination, emphasizing that these complications represent a small fraction among the vaccinated population. The authors of the manuscript are supporters of COVID-19 vaccination and have been vaccinated themselves.
INSIGHTS INTO IMAGING
(2022)
Article
Multidisciplinary Sciences
Pina Ziranu, Andrea Pretta, Marta Pozzari, Antonio Maccioni, Manuela Badiali, Daniela Fanni, Eleonora Lai, Clelia Donisi, Mara Persano, Clara Gerosa, Marco Puzzoni, Fabio Bardanzellu, Rossano Ambu, Valeria Pusceddu, Marco Dubois, Giulia Cerrone, Marco Migliari, Sara Murgia, Dario Spanu, Gianluca Pretta, Valentina Aimola, Francesca Balconi, Stefania Murru, Gavino Faa, Mario Scartozzi
Summary: Immune checkpoint inhibitors have shown efficacy in metastatic colorectal cancer with mismatch-repair deficiency or high microsatellite instability. However, some patients do not benefit from immunotherapy. CDX-2 seems to influence immunotherapy's sensitivity, and positive CDX-2 expression is associated with better outcomes in mCRC patients with MSI-H. Further studies are needed to confirm the predictive role of CDX-2 and explore strategies to overcome primary resistance in CDX-2-negative patients.
SCIENTIFIC REPORTS
(2023)
Review
Oncology
M. Gaillard, P. Van Eyken, G. Verswijvel, K. van der Speeten
Summary: Goblet cell carcinoma (GCC) is a distinct entity in appendiceal neoplasms with mixed glandular and neuro-endocrine features. It can present as acute appendicitis or an incidental finding on surgical pathology. Additional treatment with CRS-HIPEC is recommended for perforation or other risk factors. We report a case of GCC in a 77-year-old male who underwent appendectomy for appendicitis, with incidental finding of GCC. Prophylactic CRS-HIPEC was performed due to possible tumor soiling. A literature review suggests that CRS-HIPEC can be a curative treatment option for GCC.
INDIAN JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Immunology
Roberto Littera, Andrea Perra, Michela Miglianti, Ignazio S. Piras, Stefano Mocci, Sara Lai, Maurizio Melis, Teresa Zolfino, Cinzia Balestrieri, Maria Conti, Giancarlo Serra, Francesco Figorilli, Davide Firinu, Simona Onali, Laura Matta, Carmen Porcu, Francesco Pes, Daniela Fanni, Cristina Manieli, Monica Vacca, Roberto Cusano, Marcello Trucas, Selene Cipri, Stefania Tranquilli, Stefania Rassu, Federica Cannas, Mauro Giovanni Carta, Marta Anna Kowalik, Erika Giuressi, Gavino Faa, Luchino Chessa, Sabrina Giglio
Summary: This study highlights the positive immunomodulatory effect of HLA-G molecules on the clinical course of AIH-1 and how this improvement closely correlates with plasma levels of sHLA-G. However, the ambiguous role of HLA-G molecules expressed by plasma cells, which are pathognomonic features of AIH-1, raises a debate.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
M. Piras, C. Gerosa, D. Fanni, F. Cau, P. Coni, R. Murru, G. Denotti, G. Orru, A. Scano, F. Ledda, P. Van Eyken, F. Coghe, G. Faa, M. Castagnola
Summary: ACBP is expressed in fetal human tissues, with a preferential localization in the epithelium of renal structures such as pelvis and tubules. It may play a crucial role in nephrogenesis by inducing differentiation of metanephric mesenchymal cells into renal structures.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Meeting Abstract
Pathology
J. Caschili, A. Ravarino, L. Nonnis, R. Murru, C. Gerosa, G. Faa, D. Fanni
Article
Pharmacology & Pharmacy
F. Cau, C. Gerosa, R. Murru, G. Pichiri, P. Coni, M. Piras, A. Scano, G. Orru, G. La Nasa, F. Coghe, M. Castagnola, P. Van Eyken, L. Saba, D. Fanni, G. Faa
Summary: The study found that L1CAM is expressed during fetal human kidney development and is restricted to renal structures derived from the ureteric bud. The expression of L1CAM in the cells of the ureteric bud tips suggests a major role for this adhesion molecule in the induction of metanephric mesenchymal cells to undergo mesenchymal-to-epithelial transition and differentiation into new nephrons.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
F. Coghe, D. Fanni, C. Gerosa, A. Ravarino, M. Mureddu, G. Cerrone, P. Coni, G. Pichiri, T. Congiu, M. Piras, F. Cau, V. Aimola, A. Balestrieri, E. Lai, M. Manchia, A. Scano, G. Orru, G. La Nasa, P. Van Eyken, L. Saba, M. Scartozzi, M. Castagnola, G. Faa
Summary: The increasing incidence of cancers has led oncologists to seek new explanations beyond the somatic mutation theory. The exposure of embryos and fetuses to environmental factors during gestation may influence the susceptibility to cancer later in life. Epigenetic factors and gene expression similarities between embryonic development and cancer are important mediators in prenatal human development. Maternal obesity can also impact embryo-fetal development and increase the risk of certain cancers.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
M. Piras, F. Cau, M. Manchia, P. Paribello, L. Saba, J. S. Suri, G. Faa, G. Pichiri, G. Cerrone, A. Scano, G. Orru, G. La Nasa, F. Coghe, M. Castagnola, D. Fanni, C. Gerosa
Summary: This study found a strong expression of ACE2 in the choroid plexuses of the human brain. This new histopathological finding may explain the susceptibility of the human brain to SARS-CoV-2 infection. Our data suggest that the choroid plexus may serve as the entry gate for the virus into the human brain, indicating that the entry of SARS-CoV-2 into the cerebrospinal fluid through the choroid plexuses might be the mechanism by which the virus directly injures brain cells.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
T. Congiu, D. Fanni, M. Piras, C. Gerosa, F. Cau, D. Barcellona, E. D'Aloja, R. Demontis, A. Chighine, M. Nioi, P. Coni, A. Ravarino, G. Cerrone, V Aimola, C. Botta, A. Scano, G. Orru, F. Coghe, P. Van Eyken, G. La Nasa, L. Saba, J. S. Suri, G. Faa, F. Marongiu
Summary: This article reports the lung ultrastructural findings in a male patient with vaccine-induced immune thrombotic thrombocytopenia (VITT). The patient exhibited features such as alveolar dilation, vascular proliferation, and thrombosis during the course of the disease. Similar to COVID-19, both diseases result in severe inflammation and activation of the coagulation system.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
