Article
Obstetrics & Gynecology
Jiang-Nan Wu, Ming-Qing Li, Feng Xie, Bin Zhang
Summary: The study found that the second-trimester measured UtA indices had a satisfactory performance at the 9th week in predicting subsequent preeclampsia. The right UtA-RI was the first choice in ruling out preeclampsia, while the left UtA-PI showed the best authenticity of the prediction.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Obstetrics & Gynecology
Manel Mendoza, Erika Bonacina, Berta Serrano, Marta Ricart, Lourdes Martin, Eva Lopez-Quesada, Angels Vives, Anna Maroto, Pablo Garcia-Manau, Clementina De Antonio, Cristina Tusquets, Gabriela Moreano, Mireia Armengol-Alsina, Elena Carreras
Summary: Implementing routine first-trimester screening for preeclampsia in six Catalan maternities significantly reduces the incidence of preterm preeclampsia and maternal ICU admission.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Obstetrics & Gynecology
Suchada Erjongmanee, Vorapong Phupong
Summary: This study aimed to determine the predictive value of first-trimester serum SHARP1 level and second-trimester uterine artery Doppler in singleton pregnancy for the prediction of preeclampsia. The study demonstrated that combining the first-trimester serum SHARP1 level with the second-trimester uterine artery PI had good sensitivity to predict preeclampsia.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Mingxi Liu, Yue Niu, Kongyang Ma, Peter C. K. Leung, Zi-Jiang Chen, Daimin Wei, Yan Li
Summary: Novel first-trimester serum biomarkers were identified and an effective prediction model for preeclampsia (PE) was developed using immune-related factors and placental growth factor (PlGF), which could aid in the development of early diagnostic strategies for PE and provide new insights into its immunological mechanisms.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, General & Internal
Stella Capriglione, Ferdinando Antonio Gulino, Silvia Latella, Giovanna De Felice, Maurizio Filippini, Miriam Farinelli, Francesco Giuseppe Martire, Elsa Viora
Summary: This study aimed to evaluate the efficacy of a screening test conducted in the first trimester in identifying the risk of developing preeclampsia. The results showed that the test performed well in identifying women at high risk and emphasized the importance of medical history evaluation in screening.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Luiza Meelhuysen Sousa Aguiar, Lumena Goncalves Machado Zanotto, Carlos Henrique Mascarenhas Silva, Marianna Amaral Pedroso
Summary: A retrospective study showed that using both transverse and longitudinal Doppler techniques during the first trimester morphological examination can reliably measure the pulsatility index of uterine arteries in pregnant women, without affecting the final outcome of preeclampsia screening.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Keiko Azuma, Atsushi Okubo, Takafumi Suzuki, Nozomi Igarashi, Yoko Nomura, Hirotsugu Soga, Hiroshi Murata, Ryosuke Fujino, Asako Ogawa, Haruka Matsui, Takeshi Nagamatsu, Takayuki Iriyama, Ryo Asaoka, Tatsuya Inoue, Maiko Maruyama-Inoue, Kazuaki Kadonosono, Ryo Obata
Summary: Anatomical differences in choroidal structure between pregnant women in the first trimester and healthy nonpregnant women were investigated using EDI-OCT and choroidal binarization analysis. The study identified a significant correlation between a larger choroidal luminal area and higher systolic blood pressure, particularly in the first trimester of pregnancy.
SCIENTIFIC REPORTS
(2021)
Article
Obstetrics & Gynecology
Wassan Nori, Muna Abdulghani, Ali B. Roomi, Wisam Akram
Summary: The study demonstrates that increased parity and a history of vaginal delivery, along with measured RI, are predictors of successful termination of a first trimester missed abortion. These results can be utilized for counseling patients on the safest and most suitable option to terminate a first trimester missed abortion, based on their demographic criteria and ultrasound scores.
CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY
(2021)
Review
Medicine, General & Internal
Yifan Wu, Yang Liu, Yiling Ding
Summary: PP13 may be an effective serum biomarker for predicting preeclampsia, but further large prospective cohort studies and randomized controlled trials are needed to determine its clinical application. The heterogeneity of the original trials may limit the use of PP13 in clinical practice.
FRONTIERS IN MEDICINE
(2021)
Review
Cell Biology
Manabu Ogoyama, Hironori Takahashi, Hirotada Suzuki, Akihide Ohkuchi, Hiroyuki Fujiwara, Toshihiro Takizawa
Summary: Preeclampsia (PE) is a dangerous condition with challenges in treatment and prevention. Research suggests that identifying maternal circulating non-coding RNAs (ncRNAs) in early pregnancy may help predict the development of PE.
Article
Biochemistry & Molecular Biology
Ekaterina Ilgisonis, Raisa Shalina, Nigyar Kasum-Zade, Kristina G. Burkova, Oxana P. Trifonova, Dmitry L. Maslov, Anna L. Kaysheva, Sergey S. Markin
Summary: This study aimed to identify the characteristic metabolite profile of blood plasma samples from patients with preeclampsia. Direct high-resolution mass spectrometry was used to analyze samples from 79 pregnant women, 34 of whom had preeclampsia. Comparative analysis of the metabolite profiles revealed differences between pregnant women with and without preeclampsia. Lipids and sugars were identified as components likely associated with the development of preeclampsia. Furthermore, specific metabolites for the third trimester were already present in the first trimester, indicating their potential involvement in lipid metabolism disorders and oxidative stress development.
Review
Obstetrics & Gynecology
Piya Chaemsaithong, Daljit Singh Sahota, Liona C. Poon
Summary: Preeclampsia is a significant threat to both mothers and babies, and early-onset disease requiring preterm delivery increases the risk of complications. Low-dose aspirin initiated before 16 weeks reduces the rate of preterm preeclampsia. Identifying pregnant women at risk during the first trimester is crucial, and current screening methods have suboptimal performance compared to the Fetal Medicine Foundation's first trimester prediction model (the triple test). This model has high detection rates and low false-positive rates, outperforming traditional risk factor screening methods.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Berta Serrano, Manel Mendoza, Paula Garcia-Aguilar, Erika Bonacina, Itziar Garcia-Ruiz, Pablo Garcia-Manau, Judit Gil, Mireia Armengol-Alsina, Nuria Fernandez-Hidalgo, Elena Sulleiro, Rosa Maria Lopez-Martinez, Marta Ricart, Lourdes Martin, Eva Lopez-Quesada, Angels Vives, Anna Maroto, Nerea Maiz, Anna Suy, Elena Carreras
Summary: In pregnant women with COVID-19, there is a higher proportion of women at high risk for preeclampsia in the first-trimester screening compared to the general population, mainly due to maternal risk factors rather than placental signs of deficient trophoblastic invasion.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2022)
Article
Cell Biology
Claudia Melina Robellada-Zarate, Janelly Estefania Luna-Palacios, Carlos Agustin Zapata Caballero, Juan Pablo Acuna-Gonzalez, Irlando Lara-Pereyra, Diego Ivan Gonzalez-Azpeitia, Ricardo Josue Acuna-Gonzalez, Elsa Romelia Moreno-Verduzco, Hector Flores-Herrera, Mauricio Osorio-Caballero
Summary: A study found that elevated levels of 60 and 70-KDa extracellular heat shock proteins (eHsp) and decreased levels of eHsp-27 in the first trimester are associated with the development of preeclampsia (PE). These findings suggest that first-trimester eHsp levels may serve as early biomarkers for predicting PE.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Piotr Tousty, Magda Fraszczyk-Tousty, Sylwia Dzidek, Hanna Jasiak-Jozwik, Kaja Michalczyk, Ewa Kwiatkowska, Aneta Cymbaluk-Ploska, Andrzej Torbe, Sebastian Kwiatkowski
Summary: Preeclampsia is a complex disorder of pregnancy with significant fetal and maternal consequences, and aspirin is recommended for high-risk women to reduce the risk. This review compared 14 guidelines and found variations in recommended dose, screening method, and timing for starting aspirin. Many societies now recommend higher doses (>75 mg) of aspirin, with most suggesting initiation before 16 weeks' gestation. The introduction of risk assessment models, such as the one proposed by the Fetal Medicine Foundation, has led to a shift in recommendations towards identifying high-risk populations and implementing aspirin prophylaxis, resulting in reduced morbidity for mothers and infants.
Letter
Acoustics
N. Fratelli, C. Pedretti, V. Gerosa, A. Valcamonico, C. Zanardini, F. Prefumo, A. Fichera
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2018)
Letter
Acoustics
S. Bergamelli, F. Prefumo, N. Fratelli, A. Valcamonico, C. Zanardini, A. Fichera
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2018)
Article
Obstetrics & Gynecology
Annachiara Vitucci, Andrea Lojacono, Enza Gatti, Federico Prefumo, Nicola Fratelli
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2019)
Article
Obstetrics & Gynecology
Anna Fichera, Federico Prefumo, Giorgia Mazzoni, Valentina Molinaris, Cristina Zanardini, Nicola Fratelli, Tiziana Frusca, Enrico Sartori
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2019)
Article
Obstetrics & Gynecology
Federico Prefumo, Anna Fichera, Nicola Fratelli, Enrico Sartori
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2019)
Article
Obstetrics & Gynecology
Claudia Maggi, Giorgia Mazzoni, Vera Gerosa, Nicola Fratelli, Federico Prefumo, Enrico Sartori, Andrea Lojacono
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2019)
Letter
Obstetrics & Gynecology
Roberta Castellani, Nicola Fratelli, Enrico Sartori, Federico Prefumo
FETAL DIAGNOSIS AND THERAPY
(2020)
Letter
Obstetrics & Gynecology
Nicola Fratelli, Valentina Benedetta Brunelli, Vera Gerosa, Enrico Sartori, Andrea Lojacono, Federico Prefumo
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2019)
Article
Obstetrics & Gynecology
Nicola Fratelli, Serena Amighetti, Amar Bhide, Anna Fichera, Asma Khalil, Aris T. Papageorghiou, Federico Prefumo, Basky Thilaganathan
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2020)
Article
Obstetrics & Gynecology
Anna Fichera, Vita Valentina Azzaretto, Nicola Fratelli, Sara Mancino, Daria Marella, Beatrice Negri, Adriana Valcamonico, Cristina Zanardini, Tiziana Frusca, Enrico Sartori, Federico Prefumo
Summary: This study reviewed the experience of fetoscopic laser ablation in treating MCDA twin pregnancies complicated by TTTS in a single center over a ten-year period. The results showed that the survival rate of both twins improved over time and was positively associated with a posterior placenta location and the use of the Solomon technique.
JOURNAL OF PERINATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Nicoletta Rizzini, Nicola Fratelli, Beatrice Negri, Franco E. Odicino, Enrico Sartori, Francesco M. Risso, Federico Prefumo, Anna Fichera
Summary: This study investigated the association between chorionicity, birth weight discordance, and neonatal morbidity in uncomplicated twin pregnancies. The results showed that chorionicity was not associated with neonatal morbidity, while gestational age at birth was the major determinant of neonatal outcome.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2022)
Article
Obstetrics & Gynecology
Marta Papaccio, Anna Fichera, Alessia Nava, Sonia Zatti, Vera Gerosa, Federico Ferrari, Enrico Sartori, Federico Prefumo, Nicola Fratelli
Summary: This study compared delivery outcomes of true-positive, false-positive, and false-negative large-for-gestational-age fetuses. The results showed a significant increase in cesarean section rate for false-positive LGA fetuses, while true-positive LGA fetuses had higher birth weight and neonatal intensive care unit admission rates compared to false-positive and appropriate-for-gestational-age fetuses.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Obstetrics & Gynecology
Cecilia Cavalli, Claudia Maggi, Sebastiana Gambarini, Anna Fichera, Amerigo Santoro, Luigi Grazioli, Federico Prefumo, Franco E. Odicino, Nicola Fratelli
Summary: This study aimed to assess the performance of ultrasound and MRI signs for antenatal detection of placenta accreta spectrum disorders in women with placenta previa. It found that placental lacunae on ultrasound and T2 intraplacental hypointense bands on MRI should raise suspicion of PAS.
JOURNAL OF PERINATAL MEDICINE
(2022)
Article
Acoustics
N. Fratelli, F. Prefumo, C. Maggi, C. Cavalli, A. Sciarrone, A. Garofalo, E. Viora, P. Vergani, S. Ornaghi, M. Betti, I. Vaglio Tessitore, A. F. Cavaliere, S. Buongiorno, A. Vidiri, E. Fabbri, E. Ferrazzi, V Maggi, I Cetin, T. Frusca, T. Ghi, C. Kaihura, E. Di Pasquo, T. Stampalija, C. Belcaro, M. Quadrifoglio, M. Veneziano, F. Mecacci, S. Simeone, A. Locatelli, S. Consonni, N. Chianchiano, F. Labate, A. Cromi, E. Bertucci, F. Facchinetti, A. Fichera, D. Granata, F. D'Antonio, F. Foti, L. Avagliano, G. P. Bulfamante, G. Cali
Summary: This study evaluated the performance of third-trimester ultrasound in diagnosing clinically significant placenta accreta spectrum disorder (PAS) in women with low-lying placenta or placenta previa. The results showed that grayscale ultrasound has good diagnostic performance in identifying low-risk PAS pregnancies and can safely guide management decisions.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Review
Obstetrics & Gynecology
Nicola Fratelli, Anna Fichera, Federico Prefumo
Summary: Ultrasound and MRI are both effective tools for diagnosing PAS in high-risk populations. Ultrasound can guide management decisions and resource allocation in patients with clinically significant PAS, while routine contingent screening based on placental location and previous uterine surgery is effective in identifying PAS disorders in public healthcare settings.
CURRENT OPINION IN OBSTETRICS & GYNECOLOGY
(2022)