Journal
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
Volume 25, Issue 4, Pages 1055-1064Publisher
SPRINGER
DOI: 10.1007/s10856-013-5134-8
Keywords
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Funding
- Natural Science Foundation of Chongqing Municipal Government (CSTC) [2011JJJQ10004]
- Natural Science Foundation of China [51173216, 11032012, 31170923]
- Chongqing University Innovative Talent Training Project of the Third Stage of 211 Project [S-09104]
- Fundamental Research Funds for the Central Universities [CDJXS10 23 22 11]
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A new fabrication protocol is described to obtain heparin and chitosan conjugated magnetic nanocomposite as a blood purification material for removal of low-density lipoprotein (LDL) from blood plasma. The adsorbent could be easily separated with an external magnet for recyclable use since it had a magnetic core. The LDL level of plasma decreased by 67.3 % after hemoperfusion for 2 h. Moreover, the adsorbent could be recycled simply washing with NaCl solution. After eight cycles, the removal efficiency of the adsorbent was still above 50 %. The recyclable magnetic adsorbent had good blood compatibility due to the conjugation of heparin to the chitosan-coated magnetic nanocomposites. The fabricated magnetic adsorbent could be applied for LDL apheresis without side effects.
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