Article
Biochemistry & Molecular Biology
Jaemin Shim, Jiseon Kang, Seok Il Yun
Summary: The novel chitosan-dipeptide hydrogel prepared exhibited excellent stability and drug release properties, making it a promising candidate for localized and controlled drug delivery in cancer therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Xue Zhang, Xueya Xu, Xiaoying Wang, Yajuan Lin, Yaling Zheng, Wen Xu, Jian Liu, Wei Xu
Summary: A glycyrrhetinic acid-modified carboxymethyl chitosan-thioketal-rhein (GCTR) conjugate was synthesized for the in vivo delivery of celastrol. Celastrol was encapsulated into polymeric micelles formed by GCTR conjugates self-assembly in water, resulting in celastrol/GCTR PMs with high drug loading capacity and small particle size. Celastrol/GCTR PMs exhibited sustained-release in the blood environment and rapid-release in the tumor microenvironment, showing significant proliferation inhibitory effect on HepG2 and BEL-7402 cells and negligible impact on L-02 cells at low concentrations. The reactive oxygen species (ROS)-responsive properties of celastrol/GCTR PMs improved the bioavailability of celastrol and showed remarkable hepatoma-targeting properties. Celastrol/GCTR PMs effectively inhibited tumor growth with no apparent damage to different organs.
CARBOHYDRATE POLYMERS
(2023)
Article
Polymer Science
Jian-Bo Qu, Xue-Fei Zhang, Yi-Bo Zhang, Huan-Jie Che, Gang-Feng Li, Jing Li, Xiaojuan Wang
Summary: Galactosylated core-shell nanoparticles with sub-50 nm diameters were fabricated using reversible addition-fragmentation chain transfer (RAFT) soap-free emulsion polymerization. The galactosylated shells and acidic cores of the nanoparticles provide high targeting and drug loading efficiencies, respectively. Additionally, the physical shrinkage and cleavage of the disulfide cross-linked nanoparticles enable rapid release of loaded doxorubicin under pH 5.0 and reduced glutathione conditions. The combination of these properties results in a lower IC50 for DOX-loaded nanoparticles compared to free DOX, showing promise for targeted therapy of hepatocellular carcinoma.
Article
Chemistry, Medicinal
Quanling Guo, Lu Zhang, Mengmeng He, Xiaohua Jiang, Jingrui Tian, Qiurong Li, Zhiwei Liu, Longgang Wang, Haotian Sun
Summary: A method utilizing amphipathic and natural antibacterial peptide daptomycin to stabilize doxorubicin and form zwitterionic nanodrug showed promising targeting and anti-tumor effects in experiments, with higher cytotoxicity and tumor inhibition rate than free doxorubicin. The biocompatible daptomycin-based drug delivery system selectively accumulated at tumor sites in vivo through EPR effect, reducing toxicity and achieving excellent tumor inhibition.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Applied
Derong Lin, Lijuan Xiao, Wen Qin, Douglas A. Loy, Zhijun Wu, Hong Chen, Qing Zhang
Summary: Chitosan/lignosulfonate composite micelles were successfully prepared and used to encapsulate curcumin. The encapsulation improved the stability, retention efficiency, and antioxidant activity of curcumin. These findings support the potential use of CS-LS as a delivery system for encapsulating hydrophobic biologically active substances.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Multidisciplinary
Wenzhao Han, Fanwei Meng, Hao Gan, Feng Guo, Junfeng Ke, Liping Wang
Summary: ATN-FFPFF-ATN, a new targeted antitumor drug carrier designed in this study, polymerized from phenylalanine dipeptide (FF), ATN-161 peptide, and Pluronic (R) F-127, can smartly unravel in acidic environment to achieve specific drug accumulation, effectively inhibiting cell proliferation.
Article
Nanoscience & Nanotechnology
Jingyi Zhou, Kangkang Li, Xinlong Zang, Yi Xie, Jinxiao Song, Xuehong Chen
Summary: Reactive oxygen species (ROS)-responsive galactosylated nanoparticles (DOX@NPs) were developed as a targeted carrier for doxorubicin (DOX) delivery to inhibit the growth of triple negative breast cancer (TNBC). DOX@NPs showed good ROS responsiveness, effectively triggered tumor cell apoptosis and cycle arrest, efficiently accumulated into tumor sites, and suppressed tumor growth without adverse side effects.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Chemistry, Medicinal
Ahmed M. Fatouh, Ahmed H. Elshafeey, Ahmed Abdelbary
Summary: The study successfully enhanced the delivery of ledipasvir to hepatocytes and prolonged its retention within the liver by synthesizing galactosylated chitosan and coating it on liposomes. The coated liposomes exhibited a small particle size, high entrapment efficiency, and significantly improved uptake of ledipasvir into targeted hepatocytes. Pharmacokinetic analysis revealed increased liver concentration and prolonged half-life and residence time compared to oral dispersal of ledipasvir.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Yin Liu, Jian Zhang, Ying Tu, Lin Zhu
Summary: In this study, two types of fluoroamphiphile analogs were synthesized and self-assembled into core-shell micellar nanocarriers for intracellular delivery and organelle targeting. The core-fluorinated micelles showed favorable physicochemical properties, increased cellular uptake of cargo, efficient endocytosis, and rapid endosomal escape, leading to preferential accumulation in mitochondria and enhanced efficacy of loaded cargo in vitro and in vivo. The charge-neutral fluoroamphiphiles have great potential as a simple and reliable tool for intracellular drug delivery and mitochondrial targeting, with a mechanism involving strong binding affinity with phospholipids, particularly cardiolipin.
Article
Nanoscience & Nanotechnology
Zi Chao Wu, Xin Yu Liu, Jia Yan Liu, Jing Shu Piao, Ming Guan Piao
Summary: This study investigates the use of betulinic acid-loaded galactosylated chitosan nanoparticles (BA-GC-NPs) for liver protection in the treatment of liver fibrosis. The results demonstrate that BA-GC-NPs have a small diameter and a core-shell structure, and can consistently and continuously release betulinic acid. In vitro and in vivo studies show that BA-GC-NPs have good biocompatibility and liver-targeting potential, reducing the degree of liver injury in a mouse model of liver fibrosis.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Chemistry, Physical
Xiudong Liu, Huofei Zhou, Weiting Yu, Xin Xiong, Rumen Krastev, Xiaojun Ma
Summary: The study successfully prepared polymeric micelle-like nanoparticles capable of delivering DOX by modifying chitosan to HT-CS-DCA, and further demonstrated the inhibitory activity of these nanoparticles on MCF-7 cells.
Article
Chemistry, Multidisciplinary
Tarek Baati, Imen Chaabani, Abir Salek, Leila Njim, Mouna Selmi, Ahmed Al-Kattan, Karim Hosni
Summary: This study focuses on the functionalization of SiNPs by modifying their surface with chitosan, in order to improve their therapeutic properties in cancer therapy. In vivo experiments showed that the modified SiNPs-CH exhibited increased accumulation in tumors and prolonged circulation time in the bloodstream, while reducing interaction with the liver and spleen.
NANOSCALE ADVANCES
(2023)
Article
Biochemistry & Molecular Biology
Deevak Ramnandan, Seipati Mokhosi, Aliscia Daniels, Moganavelli Singh
Summary: Cancer-based magnetic theranostics using MgFe2O4 ferrite MNPs functionalized with polymers show promising potential for enhancing drug delivery and effective treatment of cancer. DOX-CHI-MNPs exhibit superior anticancer activity and pH-responsive drug release, indicating their potential in cancer therapy.
Article
Nanoscience & Nanotechnology
Jiaojiao Chen, Yarong Song, Wenqian Yang, Jianhui Guo, Saihui Zhang, Dong Wan, Yonghui Liu, Jie Pan
Summary: In this study, tumor-targeted polymeric micelles were synthesized, and drug release was achieved through extracellular enzyme response and intracellular reduction response, thereby improving the disadvantages of chemotherapy drugs. The experiments demonstrated that this method had good anti-tumor activity in vivo and reduced toxic side effects on normal tissues.
ACS APPLIED NANO MATERIALS
(2023)
Article
Medicine, Research & Experimental
Carolina Henriques Cavalcante, Renata Salgado Fernandes, Juliana de Oliveira Silva, Caroline Mari Ramos Oda, Elaine Amaral Leite, Geovanni Dantas Cassali, Ives Charlie-Silva, Bianca Helena Ventura Fernandes, Lucas Antonio Miranda Ferreira, Andre Luis Branco de Barros
Summary: The developed pH-sensitive micelles encapsulating DOX showed promising results with small diameter, high stability, low toxicity, and significantly better inhibition of tumor growth compared to other forms of DOX.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Engineering, Industrial
Huimin Li, Limin Su, Jian Zuo, Xiaowei An, Guanghua Dong, Lunyan Wang, Chengyi Zhang
Summary: This study aims to develop an identification method of unbalanced bidding in the construction industry. The proposed model uses a data-driven unit price database to identify unbalanced bidding through an extended TOPSIS method, supporting owners in efficiently identifying unbalanced bidding in the bid evaluation stage.
ENGINEERING CONSTRUCTION AND ARCHITECTURAL MANAGEMENT
(2023)
Article
Chemistry, Multidisciplinary
Yue Li, Bo Yu, Huimin Li, Bo Liu, Xiang Yu, Kewei Zhang, Gang Qin, Jiahao Lu, Lihui Zhang, Longlu Wang
Summary: This study investigates the catalytic mechanism of molybdenum disulfide (MoS2) in hydrogen peroxide (H2O2) activation and finds that the 1T-MoS2 phase exhibits higher degradation rate of organic pollutants under light irradiation compared to the 2H-MoS2 phase. Introduction of light irradiation accelerates the desorption of 'OHads on the surface, leading to further degradation of organic pollutants. The 1T-MoS2 catalysts show excellent stability and ability to degrade various organics in the two systems.
CHINESE CHEMICAL LETTERS
(2023)
Article
Plant Sciences
Qian You, Huimin Li, Jun Wu, Tao Li, Yikui Wang, Guangwen Sun, Zhiliang Li, Baojuan Sun
Summary: This study identified three major genes (D, P, and Y) that control the anthocyanin coloration in eggplant fruits through genetic mapping and gene expression analysis. The candidate genes for D and P, SmMYB1 on chromosome 10 and SmANS on chromosome 8, were identified. Additionally, three gene variations related to phenotypic differences in two white-fruit accessions were discovered. These findings have significant implications for breeding eggplant fruit peel color.
HORTICULTURE RESEARCH
(2023)
Review
Pharmacology & Pharmacy
He Diao, Yunhua Lu, Yun Ling, Yingjie Shen, Jingmou Yu, Kun Ma
Summary: The self-assembly of peptides is widely used in biomedical fields. By changing the molecular structure and self-assembly conditions, the morphology and structure of peptide self-assembly can be altered. Engineering peptide assemblies have great potential in medical applications. This review describes the structure and function of peptide self-assembly and highlights the advances in peptide-based self-assembly in biomedical applications such as drug packaging and delivery, tissue engineering, antibacterial agents, siRNA-targeted delivery, and vaccines. Additionally, the challenges and future perspectives of polypeptide self-assembly are discussed.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Article
Engineering, Mechanical
Chengyu Guan, Zi-Jia Tang, Fei Zhao, Zhiyong Yang, Huimin Li
Summary: A homogenization method is proposed for the vibration analysis of periodic sandwich panels. Periodic boundary conditions are applied to a representative volume element (RVE) and the complex stiffness matrix of the sandwich panels is obtained through direct-solution steady-state dynamic analysis (DSDA) using the finite element method (FEM) in the frequency domain. The natural frequencies, mode shapes, and loss factors of the structures are obtained using shell models based on equivalent single-layer (ESL) theory and finite element-modal strain energy (FE-MSE) method. Pyramidal lattice truss sandwich panels made of carbon fiber reinforced plastics (CFRP) are used to validate the effectiveness of the homogenization method, and the results are compared with experiments and solid models. The effects of the number of cells and damping layers are discussed.
JOURNAL OF SANDWICH STRUCTURES & MATERIALS
(2023)
Article
Materials Science, Composites
Ruishen Lou, Huimin Li, Baosheng Liu, Xianglin Chen, Yulin Wang
Summary: A two-scale method combining micro-CT is proposed to predict 3D printed continuous fiber reinforced thermoplastic composites. The method is verified by tensile experiments and uses micro-CT scans to reconstruct and quantify the distribution of voids and fibers. Two-scale models are established based on the scanned data. Effective properties of the fiber-rich region are predicted through micro-scale analysis and transferred to meso-scale analysis. Maintaining the overall fiber volume fraction, the accuracy of prediction relies heavily on the fiber volume fraction in the fiber-rich region.
POLYMER COMPOSITES
(2023)
Article
Materials Science, Composites
Chengyu Guan, Zi-Jia Tang, Fei Zhao, Zhiyong Yang, Huimin Li
Summary: A novel method for obtaining anisotropic complex moduli of fibers based on complex moduli of matrix and composites was presented. The complex moduli of unidirectional T700 carbon fiber reinforced epoxy resin composite and its matrix were measured using dynamic mechanical analysis. The predicted properties of the composite were calculated using the generalized method of cells (GMC). The complex moduli of the carbon fibers were obtained by minimizing the difference between test and predicted properties. The results were compared with experiment and finite element analysis, showing accurate evaluation of axial and transverse moduli but difficulties in determining axial shear modulus.
POLYMER COMPOSITES
(2023)
Article
Engineering, Environmental
Lei Zhang, Minglu Hao, Liang Yao, Cheng Xing, Qingmei Wen, Zhining Zhang, Jingmou Yu, Jun Wang, Dongming Xing, Tao Zheng, P. Chen
Summary: This study used silk sericin to encapsulate anthocyanins, improving their stability and bioactivity, and investigated the interaction between silk sericin and anthocyanins through experimental and computational methods. The hydrogel formulation of silk sericin showed higher encapsulation efficiency and stability under different conditions. The encapsulated anthocyanins exhibited enhanced bioactivity, particularly in scavenging reactive oxygen species. This study highlights the potential of using two bioactive components from the same source to enhance stability and regulate bioactivity in tissue engineering applications.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biophysics
Jingmou Yu, Liangliang Wang, Yun Ling, Xin Xiao, Juntao Gong, Hongguang Jin, Jing Xu, Pu Chen, Xin Xie, Lei Zhang
Summary: In this study, novel polymeric nanoparticles targeting dual receptors and responding to reducing conditions for drug release were developed for the treatment of triple-negative breast cancer. The bioresponsive drug release of the nanoparticles was demonstrated, and it was found that they effectively targeted specific receptors both in vitro and in vivo. The nanoparticles showed higher cytotoxicity and cellular uptake compared to unmodified drug-containing micelles, and they exhibited the strongest suppression of tumor growth in a mouse model. These findings suggest that amphiphilic nanoparticles can serve as a targeted and intelligent delivery vehicle for triple-negative breast cancer therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Mechanics
Yulin Wang, Huimin Li, Zi-Jia Tang, Fei Zhao, Dainnig Fang
Summary: With high specific strength and stiffness, composite orthogrid stiffened cylinders (COSC) have great potential in the aerospace industry. However, the traditional silicone mold preparation methods have limitations in manufacturing accuracy and mold reuse rate. This paper presents an improved COSC manufacturing method using a combined metal mold and prepreg laying process. The improved method enables the production of high-precision COSCs with intersection fillets.
COMPOSITE STRUCTURES
(2023)
Article
Mechanics
Huimin Li, Ruishen Lou, Baosheng Liu, Yi Chen, Yulin Wang
Summary: This study reveals the influence mechanism of continuous fiber on the fusion process and investigates the effects of fiber volume fraction, fiber shape, and fiber eccentricity on fusion process through numerical simulations. The concepts of normalized distance and effective volume fraction are proposed to quantify the influence of the fibers.
INTERNATIONAL JOURNAL OF SOLIDS AND STRUCTURES
(2023)
Article
Mechanics
Yuyang Zhang, Huimin Li, Xin Liu, Yihang Gao, Chengyu Guan
Summary: This paper establishes an elastic-plastic damage constitutive model for 3D tubular braided composites with defects, considering plastic effects and damage accumulation. The sequential trans-scale analysis method is used to establish 3D tubular braided composite models with defects. The elastic and elastic-plastic damage models of the fiber and the matrix are established based on the brittleness of the fiber or yarn and the plasticity of the matrix. An interface element is also established to characterize the mechanical properties of the interface with the tractor-separation constitutive model. The finite element results of the axial compression properties of 3D tubular braided composites are in good agreement with the experimental results, considering porosity and plasticity of the matrix, longitudinal shear nonlinearity of the yarn, and bilinear constitutive relationship of the interface.
INTERNATIONAL JOURNAL OF SOLIDS AND STRUCTURES
(2023)
Article
Materials Science, Composites
Baosheng Liu, Ruishen Lou, Xin Liu, Yunxiang Yao, Huimin Li
Summary: In this study, continuous fiber reinforced thermoplastic negative Poisson's ratio structures (CFNPRSs) with rotating squares were fabricated using 3D printing. The effects of the printing path on the Poisson's ratio, elastic modulus, and energy absorption of the structures under compression were systematically investigated. The distribution of continuous fiber at the hinge had a significant influence on the compression behavior of the structures.
POLYMER COMPOSITES
(2023)
Article
Materials Science, Composites
Chengyu Guan, Yanhong Chen, Chengwei Qin, Zhiyuan Shi, Huimin Li
Summary: Global sensitivity analysis is performed on the complex moduli of carbon fiber reinforced polymer (CFRP) using variance-based sensitivity analysis. Twelve material properties are selected as input arguments, and ten thousand samples are generated. Various complex moduli of unidirectional CFRP and laminates with different fiber angles are predicted. The results indicate that the loss factors of CFRP are mainly influenced by the matrix and fiber properties.
POLYMER COMPOSITES
(2023)
Article
Social Sciences, Interdisciplinary
Huimin Li, Yu Zhang, Mengxuan Liang, Yongchao Cao, Wenjuan Zhang, Limin Su
Summary: This paper establishes a trust evolutionary game model to analyze the impact of the evolution of trust in the PPP supply chain on investment companies and suppliers' strategic choices, and promote the healthy and sustainable development of PPP supply chain projects. The findings indicate that trust asymmetry or an increase in trust can facilitate investment companies and suppliers to opt for positive cooperation strategies, and both parties' strategies are less influenced by their initial willingness and more by trust degree.
