Article
Materials Science, Ceramics
C. Ruiz-Aguilar, U. Olivares-Pinto, I Alfonso
Summary: In this study, six different compositions of β-TCP scaffolds were produced using sodium chloride as a porogen at varying concentrations. The scaffolds showed promising physical, chemical, mechanical, and in vitro properties, with the formation of new crystalline phases and favorable bioactivity observed.
CERAMICS INTERNATIONAL
(2021)
Article
Polymer Science
Mina Ghafouri Azar, Lucie Wiesnerova, Jana Dvorakova, Petra Chocholata, Omid Moztarzadeh, Jiri Dejmek, Vaclav Babuska
Summary: This research introduces a novel approach of incorporating different types of gelatins into polycaprolactone and poly (lactic-co-glycolic acid) films. The evaluation of these films includes morphology, mechanical properties, thermal stability, biodegradability, hemocompatibility, cell adhesion, proliferation, and cytotoxicity. The results show that the addition of gelatins alters the mechanical properties, biodegradability, and cell behavior of the films. These findings provide valuable insights for future tissue engineering applications involving gelatin incorporation.
Article
Engineering, Biomedical
Gyeongjin Joo, Myeongki Park, Seong-su Park, Garima Tripathi, Byong-Taek Lee
Summary: An alginate-tasted polycaprolactone-gelatin-beta-tricalcium phosphate dual membrane was fabricated to enhance new bone formation under guided bone regeneration (GBR) process. The dual layered membrane exhibited compatibility with cells and suppressed fibrous tissue infiltration while promoting bone growth.
BIOMEDICAL MATERIALS
(2022)
Article
Materials Science, Biomaterials
Qifan Wang, Wenjie Ye, Zhiyong Ma, Wenjia Xie, Linna Zhong, Ying Wang, Qiong Rong
Summary: A scaffold with a cross-scale structure of PCL/beta-TCP was designed to promote cell growth and osteogenic differentiation on 3D printing scaffolds, significantly enhancing osteogenic performance. Cells can pass through the pores of the scaffold, gradually covering them, which accelerates bone defect repair.
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Materials Science, Composites
Zhiyong Ma, Qifan Wang, Wenjia Xie, Wenjie Ye, Linna Zhong, Jile Huge, Ying Wang
Summary: In this study, a PCL/PLGA/HA scaffold with good pore structure was prepared by 3D printing method. The composite scaffold showed good mechanical and cell test performance, indicating potential applications in the field of bone tissue engineering.
POLYMER COMPOSITES
(2021)
Article
Chemistry, Physical
Markus Merk, Orlando Chirikian, Christian Adlhart
Summary: Recent advancements have led to the creation of highly porous three-dimensional nanofiber scaffolds using electrospinning and self-assembly techniques for various tissue engineering applications. These scaffolds, made of biologically relevant materials, exhibit excellent mechanical properties and cell cytocompatibility, showing great potential for future tissue engineering applications.
Article
Nanoscience & Nanotechnology
Abdel H. Mahmoud, Yuanyuan Han, Renan Dal-Fabbro, Arwa Daghrery, Jinping Xu, Darnell Kaigler, Sarit B. Bhaduri, Jos Malda, Marco C. Bottino
Summary: In this study, highly innovative nanoscale beta-tricalcium phosphate (β-TCP)-laden gelatin methacryloyl/polycaprolactone (GelMA/PCL-TCP) photocrosslinkable composite fibrous membranes were fabricated via electrospinning for guided bone regeneration (GBR). The composite microfibers showed a uniform porous network and successful integration of β-TCP particles. The GelMA/PCL-TCP membranes exhibited enhanced cell attachment, proliferation, mineralization, and osteogenic gene expression in alveolar bone-derived mesenchymal stem cells (aBMSCs) compared to pure PCL and GelMA/PCL. Furthermore, the GelMA/PCL-TCP membrane promoted robust bone regeneration in rat calvarial critical-size defects, demonstrating remarkable osteogenesis compared to PCL and GelMA/PCL groups. Overall, the electrospun GelMA/PCL-TCP composite showed great potential as a promising membrane for guided bone regeneration.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Muhammad Umar Aslam Khan, Saiful Izwan Abd Razak, Sarish Rehman, Anwarul Hasan, Saima Qureshi, Goran M. Stojanovic
Summary: Bone tissue engineering is an advanced approach for treating bone fractures and defects. In this study, polymeric nano-composite scaffolds with different characteristics were prepared and characterized. The scaffolds exhibited different pore morphology and mechanical behavior, and promoted bone mineralization and cell proliferation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biotechnology & Applied Microbiology
Xiaoting Zhang, Xinluan Wang, Yuk-wai Lee, Lu Feng, Bin Wang, Qi Pan, Xiangbo Meng, Huijuan Cao, Linlong Li, Haixing Wang, Shanshan Bai, Lingchi Kong, Dick Ho Kiu Chow, Ling Qin, Liao Cui, Sien Lin, Gang Li
Summary: A PLGA/TCP-based scaffold incorporating ICT and HFS was developed, which efficiently facilitates MSCs migration and promotes bone regeneration, showing great potential for clinical application in osteoporosis.
BIOENGINEERING-BASEL
(2022)
Article
Materials Science, Ceramics
Eric Ryan, Shuo Yin
Summary: Bone is responsible for body support and movement as well as cell and nutrient transportation. This study focused on the fabrication and characterization of β-TCP scaffolds using lithography-based ceramic manufacturing. The compressive strengths of the scaffolds were analyzed, showing potential for bone regeneration/tissue engineering applications.
CERAMICS INTERNATIONAL
(2022)
Article
Materials Science, Multidisciplinary
Sneh Gautam, Shiv Dutt Purohit, Hemant Singh, Amit Kumar Dinda, Pravin D. Potdar, Chhavi Sharma, Chia -Fu Chou, Narayan Chandra Mishra
Summary: Bone tissue engineering has received attention for the treatment of bone injury. A tri-polymer scaffold (PCL-gelatin-chitosan) was fabricated through electrospinning and treated with nanohydroxyapatite. The modified scaffold showed a uniform distribution of nanohydroxyapatite particles on the surface of fibers.
MATERIALS TODAY COMMUNICATIONS
(2023)
Article
Polymer Science
Sin Ting Ngo, Wei-Fang Lee, Yi-Fan Wu, Eisner Salamanca, Lwin Moe Aung, Yan-Qiao Chao, Ting-Chia Tsao, Hao-Wen Hseuh, Yi-Huan Lee, Ching-Chiung Wang, Wei-Jen Chang
Summary: Manufacturing 3D objects with polymers/bioceramic composite materials has been explored recently. This study focused on creating and assessing a solvent-free polycaprolactone (PCL) and beta-tricalcium phosphate (b-TCP) composite fiber as a scaffold material for 3D printing. Different ratios of b-TCP mixed with PCL were investigated to determine the optimal feedstock material for 3D printing. The addition of 20% b-TCP significantly improved the mechanical properties, biocompatibility, and osteogenic ability of the PCL/b-TCP mixture. These findings suggest that the solvent-free PCL-20 and PCL-30 fibers are promising materials for 3D printing customized bone scaffolds promptly, sustainably, and cost-effectively.
Article
Polymer Science
Vahid Kheiri Mollaqasem, Azadeh Asefnejad, Mohammad Reza Nourani, Vahabodin Goodarzi, Mohammad Reza Kalaee
Summary: Core-shell nanofibers based on polycaprolactone and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) with different concentrations of graphene oxide and calcium phosphate were prepared for bone scaffolds, exhibiting desired mechanical and bioactivity properties. The scaffolds showed good biocompatibility and promoted osteocyte differentiation and maturation within 21 days.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Engineering, Biomedical
Pengren Huang, Peng Yang, Keming Liu, Wei Tao, Jun Tao, Fanrong Ai
Summary: A solvent method was used to add high concentration bioglass into polycaprolactone to prepare 70% BG/PCL composite scaffolds with high ductility by 3D printing technology. The scaffold showed good mechanical properties, biocompatibility, and osteogenic activity, making it a promising option for personalized repair of bone defects.
BIOMEDICAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Bo Yuan, Zhiwei Wang, Yin Zhao, Yifan Tang, Shengyuan Zhou, Yanqing Sun, Xiongsheng Chen
Summary: This study investigates the enhancement of bone regeneration performance of porous PCL/β-TCP scaffolds by coating with nano-DBM. In vitro and in vivo experiments demonstrate that the nano-DBM coated scaffolds exhibit superior cell activity and better infiltration of new bone tissue.
MACROMOLECULAR BIOSCIENCE
(2021)