Review
Chemistry, Multidisciplinary
Zhenguang Li, Yingze Li, Chang Chen, Yu Cheng
Summary: Magnetic-responsive hydrogels, prepared by embedding magnetic nanomaterials into hydrogel networks, have advantages such as rapid magnetic response, precise control, and non-invasively remote operation for biomedical applications. This review summarizes the synthetic methods, roles in different applications, and future perspectives of magnetic hydrogels.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Materials Science, Multidisciplinary
Rinki Singh, Bhaskar Datta
Summary: Hydrogels, with distinctive chemical, physical, and mechanical characteristics, have attracted extensive research attention. Magnetic hydrogels have rapidly responsive and controllable properties, addressing several limitations of conventional hydrogels. They have diverse applications in biomedical and environmental fields.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Agricultural Engineering
Shahenvaz Alam, Tanya Nagpal, Rekha Singhal, Sunil Kumar Khare
Summary: By immobilizing L-asparaginase on magnetic nanoparticles, the study effectively reduced acrylamide formation in food systems. The immobilized enzyme exhibited higher thermal stability and catalytic efficiency, with the ability to be reused for multiple cycles. Additionally, when applied in pretreatment and blanching of potato chips, it led to a significant reduction (over 95%) in acrylamide formation.
BIORESOURCE TECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yunwei Niu, Jiahe Wu, Yanxiang Kang, Pingli Sun, Zuobing Xiao, Di Zhao
Summary: Magnetic chitosan hydrogels are a type of organic-inorganic composite material that combines the characteristics of magnetic materials and natural polysaccharides. These hydrogels, which are made by adding magnetic nanoparticles to chitosan, have improved mechanical strength and exhibit magnetic thermal effects, targeting capabilities, magnetically-sensitive release characteristics, and easy separation and recovery. They have been used in various applications including drug delivery, magnetic resonance imaging, mag-netothermal therapy, and adsorption of heavy metals and dyes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Chemistry, Multidisciplinary
Cezar Tipa, Maria T. Cidade, Joao P. Borges, Luis C. Costa, Jorge C. Silva, Paula I. P. Soares
Summary: In recent decades, there has been a significant interest in the development of new materials, particularly three-dimensional scaffolds, that can meet the diverse needs of the expanding biomedical field. Hydrogels, due to their biocompatibility and ability to mimic the extracellular matrix, have been extensively studied in biomedical applications. However, their poor mechanical integrity and limited cell interaction have limited their broad applicability. To overcome these limitations, researchers have focused on incorporating nanoparticles into polymeric gels to form nanocomposites with tailored functionality and improved properties. This review specifically emphasizes the unique contributions of clay nanoparticles in clay-based nanocomposite hydrogels and their biomedical applications.
Review
Chemistry, Multidisciplinary
Le Xue, Jianfei Sun
Summary: Magnetic hydrogels with ordered structure offer unique anisotropic properties and excellent physical characteristics, making them highly advantageous in biomedical fields. Their morphology and mechanical properties analogous to biological tissues provide better biocompatibility and bioinducibility. Synthetic methods, functionalities, and biomedical applications are key focuses in the research of magnetic ordered hydrogels.
FRONTIERS IN CHEMISTRY
(2022)
Review
Materials Science, Multidisciplinary
Qiu-Yi Duan, Ya-Xuan Zhu, Hao-Ran Jia, Shi-Hao Wang, Fu-Gen Wu
Summary: This review introduces the history, preparation methods, properties, and applications of nanogels. It first discusses the classification and differences of nanogels from macro-sized hydrogels and other nanoparticles. Then, it focuses on the synthetic methods, properties, and applications of nanogels in drug delivery, imaging, detection, and regenerative medicine. It also raises the current problems and challenges in the field of nanogels, aiming to inspire researchers to develop more functional nanogels and promote their practical applications in various fields.
PROGRESS IN MATERIALS SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Armando Ramos-Sebastian, So-Jung Gwak, Sung Hoon Kim
Summary: Magnetic microrobots are highly promising for biomedical applications, but magnetic actuation alone is not enough. This study introduces a multimodal electromagnetic system that enables various modes of locomotion and heating control of magnetic microrobots, as well as the manipulation of magnetic nanoparticles.
Review
Chemistry, Multidisciplinary
Harutyun Gyulasaryan, Astghik Kuzanyan, Aram Manukyan, Alexander S. Mukasyan
Summary: Combustion synthesis is a green and energy-saving method for synthesizing various nanoscale materials. This review focuses on the combustion synthesis of magnetic nanoparticles and their properties relevant to different bio-applications. Challenges are analyzed, and specific research directions are suggested for improving the properties and stability of fabricated materials.
Review
Chemistry, Multidisciplinary
Zhiqiang Luo, Lingyu Sun, Feika Bian, Yu Wang, Yunru Yu, Zhuxiao Gu, Yuanjin Zhao
Summary: Erythrocytes, with their unique morphology and cellular composition, have inspired the development of various artificial biomaterials that have broad prospects in biomedical applications. This comprehensive review covers the fabrication and applications of erythrocyte-inspired functional materials, highlighting the synthesis strategies of particles with erythrocyte-inspired morphologies and discussing their practical biomedical applications. The future possibilities of advanced erythrocyte-inspired biomaterials are also explored, with the aim of inspiring researchers to develop novel biomaterials and accelerate their progress towards clinical biomedical applications.
Article
Chemistry, Physical
Gamze Dik, Ahmet Ulu, Orhan Orcun Inan, Selcuk Atalay, Burhan Ates
Summary: Enzyme immobilization using a novel magnetic carrier improved enzyme stability and activity. The immobilized enzyme displayed enhanced activity under a weak magnetic field and retained significant activity even after multiple cycles of use.
Article
Chemistry, Applied
Elizangela H. Fragal, Vanessa H. Fragal, Elisangela P. Silva, Alexandre T. Paulino, Edson C. da Silva Filho, Marcos R. Mauricio, Rafael Silva, Adley F. Rubira, Edvani C. Muniz
Summary: This review presents recent advances in polysaccharide-based magnetic hydrogels as smart platforms for various biomedical applications, covering their synthesis methods, synergic properties, and contributions in drug delivery, tissue regeneration, and hyperthermia therapy.
CARBOHYDRATE POLYMERS
(2022)
Review
Chemistry, Multidisciplinary
Xue Zhou, Erik Jan Cornel, Shisheng He, Jianzhong Du
Summary: With the increasing global population aging, the incidence of bone-related diseases has significantly increased, making nanomaterials a research hotspot for treating these diseases. This review summarizes the latest advances in bone-targeting nanoparticles, including classification, mechanisms, and applications, providing direction for future research.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Review
Biotechnology & Applied Microbiology
Nour Fatema, Ruben Michael Ceballos, Chenguang Fan
Summary: This review highlights the advances and future prospects of cellulose as a biomaterial. It focuses on the applications of nanofibrillated, nanocrystalline, and bacterial cellulose as biomaterials in the field of biomedicine.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Polymer Science
Yaxin Xie, Qiuyue Guan, Jiusi Guo, Yilin Chen, Yijia Yin, Xianglong Han
Summary: Hydrogels, as hydrophilic polymer networks, have shown significant potential in biomedical applications. Recent studies have focused on embedding exosomes into hydrogels to maintain their biological activity and achieve controlled release.
Article
Chemistry, Physical
Madalina Elena David, Ramona Marina Grigorescu, Lorena Iancu, Elena Ramona Andrei, Raluca Somoghi, Adriana Nicoleta Frone, Irina Atkinson, Luminita Predoana, Adrian-Ionut Nicoara, Rodica-Mariana Ion
Summary: In this paper, multi-walled carbon nanotubes were prepared at low temperatures and pressure through a simple chemical method, with confirmation of their purity and morphology using various analytical techniques. The functionalization of multi-walled carbon nanotubes with hydroxyapatite was successfully achieved, as demonstrated by transmission electron microscopy, Fourier transformed infrared spectroscopy, and X-ray diffraction analysis. This simple approach may be extended to synthesize other composites based on coated multi-walled carbon nanotubes.
FULLERENES NANOTUBES AND CARBON NANOSTRUCTURES
(2021)
Article
Materials Science, Multidisciplinary
Nicoleta Anca Sutan, Irina Fierascu, Claudiu Sutan, Liliana Cristina Soare, Angela Monica Neblea, Raluca Somoghi, Radu Claudiu Fierascu
Summary: This study successfully synthesized silver oxide nanoparticles using hydroalcoholic extracts of Helleborus odorus Waldst. & Kit. Ex Willd. as a reducing agent and confirmed their antitumor effects on onion root-tip cells. The synthesis of Ag2O-NPs was confirmed by X-ray diffraction and transmission electron microscopy.
Article
Chemistry, Physical
Edina Rusen, Alexandra Mocanu, Raluca Somoghi, Daniela C. Culita, Raul Augustin Mitran, Adrian Dinescu, Andreea Matei, Aurel Diacon
Summary: This study synthesized a terpolymer containing styrene, acrylic acid, and N-(isopropyl acrylamide) using a soap-free emulsion process, and investigated the influence of AA/NiPAM ratio on reaction mechanism and kinetics. Different polymerization mechanisms were confirmed for AA-rich and NiPAM-rich substrates through various analyses, with the formation of two distinct types of polymer particles observed at higher NiPAM concentrations. The stability of the latexes and the humidity responsive characteristics of the obtained PCs were also evaluated for potential applications.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Chemistry, Physical
Camelia Ungureanu, Irina Fierascu, Radu Claudiu Fierascu, Teodora Costea, Sorin Marius Avramescu, Mirela Florina Calinescu, Raluca Somoghi, Cristian Pirvu
Summary: This study aimed to develop phytosynthesized silver nanoparticles using Raphanus sativus L. extracts obtained through two extraction methods, and to test their potential application for controlling apple crops pathogens. The results showed that nanoparticles phytosynthesized with Raphanus sativus L. waste extracts (RS1N) exhibited promising antifungal activity against Venturia inaequalis and Podosphaera leucotricha.
Article
Chemistry, Physical
Violeta Purcar, Valentin Raditoiu, Cornelia Nichita, Adriana Balan, Alina Raditoiu, Simona Caprarescu, Florentina Monica Raduly, Raluca Manea, Raluca Somoghi, Cristian-Andi Nicolae, Iuliana Raut, Luiza Jecu
Summary: Silica-gentamicin nanostructured solution was successfully synthesized using microwave-assisted synthesis and showed activity against resistant strains, making it a potential biochemical agent for preventing and treating microbial deposits on various surfaces.
Article
Biochemistry & Molecular Biology
Mihaela Monica Constantin, Catalina Gabriela Corbu, Sorin Mocanu, Elena Irina Popescu, Marin Micutz, Teodora Staicu, Raluca Somoghi, Bogdan Trica, Vlad Tudor Popa, Aurica Precupas, Iulia Matei, Gabriela Ionita
Summary: Riboflavin under UVA radiation generates reactive oxygen species (ROS) that can induce various changes in biological systems. This study provides evidence of the effect of riboflavin on collagen fibril formation, and the importance of adding polysaccharides like hyaluronic acid to reduce the damaging effects of ROS.
Article
Polymer Science
Gabriela Toader, Aurel Diacon, Traian Rotariu, Mioara Alexandru, Edina Rusen, Raluca Elena Ginghina, Florentina Alexe, Ramona Oncioiu, Florina Lucica Zorila, Alice Podaru, Andreea Elena Moldovan, Daniela Pulpea, Ana Mihaela Gavrila, Tanta Verona Iordache, Raluca Somoghi
Summary: This study aimed to develop a new method for biological and chemical decontamination using nano-sized reagent and bentonite as trapping agents. The synthesized nanoparticles of Cu, TiO2, and Ag were dispersed in a polyvinyl alcohol/glycerol solution. Results showed that the proposed solutions were effective in neutralizing and trapping hazardous materials, with high removal efficacy for micro-organisms and chemical contaminants such as HD and DMMP.
Article
Chemistry, Multidisciplinary
Eduard-Marius Lungulescu, Radu Setnescu, Eros A. Patroi, Magdalena V. Lungu, Delia Patroi, Ioana Ion, Radu-Claudiu Fierascu, Raluca Somoghi, Miruna Stan, Nicoleta-Oana Nicula
Summary: The use of nanotechnologies in biomedical sciences offers a new way to treat infections and disinfect contaminated surfaces. Cu-Au nanoparticles obtained through an eco-friendly method exhibit high stability and biocidal efficiency against bacteria, fungi, and viruses.
Article
Materials Science, Multidisciplinary
Violeta Purcar, Valentin Raditoiu, Florentina Monica Raduly, Alina Raditoiu, Mihai Anastasescu, Monica Popa, Simona Caprarescu, Raluca Somoghi, Mariana Constantin, Cristina Firinca, Georgiana Cornelia Ispas
Summary: The main objective of this study was to develop a straightforward and cost-effective method to prepare hybrid coatings by depositing silver-based silica materials on glass substrates under ambient air conditions. The synthesized silica materials containing silver nanoparticles (AgNPs) were found to have AgNPs embedded within the silica matrix. The resulting hybrid coatings exhibited a significant reflectance.
Article
Plant Sciences
Cristina Moale, Marius Ghiurea, Carmen Eugenia Sirbu, Raluca Somoghi, Traian Mihai Cioroianu, Victor Alexandru Faraon, Carmen Lupu, Bogdan Trica, Diana Constantinescu-Aruxandei, Florin Oancea
Summary: Siliceous natural nanomaterials have nanoporous structure that adsorb cations or polarized molecules, with positive effects on physiology and yield of stone-fruit trees as carriers for foliar fertilizers. Their application enhances water use efficiency and yield, while promoting polyphenol accumulation in apricot and peach fruits.
Article
Chemistry, Analytical
Iulia Gabriela David, Nimet Numan, Mihaela Buleandra, Dana-Elena Popa, Simona Carmen Litescu, Sorin Riga, Adela Magdalena Ciobanu
Summary: This study investigated the electrochemical behavior of Hesperidin on a disposable pencil graphite electrode and developed rapid voltammetric methods for its quantification. The main irreversible oxidation signal of HESP was utilized for differential pulse voltammetry analysis, while the adsorption-controlled reduction peak was used for differential pulse adsorptive stripping voltammetry analysis. The linear ranges and detection limits of the methods were determined, and the DPV method was applied for assessing bioflavonoid content in dietary supplements.
Article
Polymer Science
Ionela Alice Podaru, Paul O. Stanescu, Raluca Ginghin, Stefania Stoleriu, Bogdan Tric, Raluca Somoghi, Mircea Teodorescu
Summary: This study investigates the synthesis and properties of nanocomposite hydrogels obtained by the aqueous solution free radical polymerization of N-vinylpyrrolidone (NVP) in the presence of Laponite XLG (XLG) as a crosslinker, and compares them with hydrogels prepared using conventional crosslinking agents. The results show that XLG is a better crosslinking agent than the conventional agent, leading to larger gel fractions and more homogeneous network hydrogels. Adding XLG as a second crosslinker significantly enhances the material properties.
Article
Chemistry, Multidisciplinary
Violeta Purcar, Valentin Raditoiu, Florentina Monica Raduly, Alina Raditoiu, Simona Caprarescu, Adriana Nicoleta Frone, Raluca Somoghi, Mihai Anastasescu, Hermine Stroescu, Cristian-Andi Nicolae
Summary: In recent years, various commercial coatings based on fluorinated materials have been developed using different preparation routes. However, these techniques often require expensive and complex equipment, involve multiple manufacturing steps, or are time- or cost-consuming. This study aimed to develop sustainable hydrophobic and transparent fluorinated hybrid coatings using the sol-gel method, which offers advantages such as lower cost, energy consumption, and easier implementation. The influence of perfluorooctanoic acid in the sol-gel process on the properties of the coatings was evaluated, and different silane precursors were used to synthesize hybrid silica materials. The fluorinated silica coatings showed good transparency and hydrophobicity, making them suitable for potential optical devices.
APPLIED SCIENCES-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Iulia Gabriela David, Simona Carmen Litescu, Raluca Moraru, Camelia Albu, Mihaela Buleandra, Dana Elena Popa, Sorin Riga, Adela Magdalena Ciobanu, Hassan Noor
Summary: A simple and rapid differential pulse voltammetric method using a single-use electroactivated pencil graphite electrode has been proposed for the rapid screening of polyphenolics in citrus fruits with intermediate antioxidant power. The method has been proven to be a cost-effective tool for the estimation of polyphenolics content.
Review
Chemistry, Analytical
Gabriel-Lucian Radu, Simona Carmen Litescu, Alin Enache, Camelia Albu, Sandra A. V. Eremia
Summary: In recent years, new sensor-based technologies have been developed to meet the demand for rapid and accurate analysis of food and environment. Electrochemical sensors, especially those incorporating molecularly imprinted polymers (MIPs) and graphene, have gained considerable attention due to their portability, ease of use, low costs, and enhanced properties such as improved sensitivity and selectivity. This review provides an overview of the recent research on the use of MIPs and graphene in electrochemical sensors for food and environmental analyses, discussing their pros and cons and suggesting potential future developments in the field.
