Article
Polymer Science
Manisha Pandey, Hira Choudhury, Bapi Gorain, Shao Qin Tiong, Grace Yee Seen Wong, Kai Xin Chan, Xuan They, Wei Shen Chieu
Summary: Skin cancer is a significant public health issue with increasing prevalence and mortality rates, requiring the development of effective and safe treatment options. Research focuses on understanding the biological barriers in skin cancer therapeutics for optimal formulation development. Various vesicular drug delivery systems, such as liposomes and niosomes, show promise in delivering chemotherapeutics for skin cancer treatment, offering targeted drug delivery and minimizing systemic toxicity.
Article
Biochemistry & Molecular Biology
Alessio Vizzoca, Gioia Lucarini, Elisabetta Tognoni, Selene Tognarelli, Leonardo Ricotti, Lisa Gherardini, Gualtiero Pelosi, Mario Pellegrino, Arianna Menciassi, Settimio Grimaldi, Caterina Cinti
Summary: The pulmonary delivery of drugs has gained significant attention due to the high permeability and absorptive surface area of the lungs. Engineered erythrocytes (EMHVs) are used as a novel strategy for efficient lung-targeting drug delivery, utilizing magnetic nanoparticles for effective targeting and hemagglutinin fusion proteins for local release of therapeutic compounds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Junwei Xu, Yunxue Jia, Meili Liu, Xuenan Gu, Ping Li, Yubo Fan
Summary: This study fabricates biomimetic magnetic-luminescent bifunctional drug delivery carriers inspired by the structure of rapeseed pods, which exhibit excellent magnetic and luminescent properties and sequential release of dual drugs. The dual-chamber structure enhances the luminescent intensity and promotes blood and cell compatibilities of the carriers. These rapeseed pod-like drug delivery systems have potential for biomedical applications such as targeted drug delivery, bioimaging, and sustained treatment of diseases.
Article
Biochemistry & Molecular Biology
Deepa U. Warrier, Anantha K. Dhanabalan, Gunasekaran Krishnasamy, Henry Kolge, Vandana Ghormade, Chandan R. Gupta, Premlata K. Ambre, Ujwala A. Shinde
Summary: Targeted-drug administration to liver can reduce side effects and increase therapeutic efficacy. In this study, natural ligands including arabinogalactan, pullulan, and lactobionic acid, were used to target the asialoglycoprotein receptor on hepatocytes. The novel ligands showed high binding affinities and could be successfully incorporated into drug-loaded nanostructured lipid carriers for targeted delivery to hepatocytes. The ligand LAD exhibited low toxicity and high biocompatibility. Overall, the study demonstrates the enhanced targeting efficacy of ASGPR targeting ligands, which could be used for future targeted delivery in treating liver disorders.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Multidisciplinary
Olga Pelikh, Ralph W. Eckert, Shashank Reddy Pinnapireddy, Cornelia M. Keck
Summary: Nanocrystals are a promising formulation for improved drug delivery, targeting the hair follicles and providing long-lasting and efficient dermal drug delivery. Different types of vehicles do not significantly affect the efficacy of nanocrystals' penetration into hair follicles, but they do impact passive dermal penetration. Gels containing humectants can enhance passive penetration effectiveness.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Oncology
Zhi Wei Tay, Prashant Chandrasekharan, Benjamin D. Fellows, Irati Rodrigo Arrizabalaga, Elaine Yu, Malini Olivo, Steven M. Conolly
Summary: Magnetic Particle Imaging (MPI) is an emerging imaging technique that provides direct imaging of superparamagnetic iron oxide nanoparticles, showing great potential in cancer diagnosis and therapy monitoring. Different from MRI, MPI offers ideal image contrast with zero background tissue signal, enabling clear visualization of cancer. MPI enhances therapeutic precision and accuracy through magnetic means, contributing to the advancement of cancer imaging and guided therapy.
Article
Automation & Control Systems
Yunlai Shi, Ning Li, Charles C. Tremblay, Sylvain Martel
Summary: Dipole field navigation (DFN) is a method for navigating microcarriers towards tumor regions by distorting the magnetic field of an MRI scanner, with a piezoelectric system proposed for precise movement. In vitro experiments showed reliable targeting assessments with magnetic distortions for successful navigation of magnetic microparticles, albeit with some decrease in SNR and minor image distortion.
IEEE-ASME TRANSACTIONS ON MECHATRONICS
(2021)
Review
Pharmacology & Pharmacy
R. Majumder, T. Pal, A. Basumallick, Chitrangada Das Mukhopadhyay
Summary: Carbon nano onion-mediated targeted drug delivery system via the nasal pathway bypasses biological barriers, escaping first-pass metabolism and increasing drug bioavailability to the targeted area while reducing the dose of chemotherapeutic reagents with serious side effects.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Zesheng Cheng, Haiying Que, Li Chen, Qiu Sun, Xiawei Wei
Summary: The lymphatic system is crucial for maintaining humoral balance, lipid metabolism, and immune regulation. Lymph nodes, known as primary sites of tumor metastasis, have a significant impact on patient prognosis. Recent advancements in nanotechnology and biomaterials have led to the development of lymph-node-targeted drug-delivery systems, which hold promise for disease diagnosis and tumor therapy.
Review
Nanoscience & Nanotechnology
Wenli Zhang, Enshi Hu, Yajie Wang, Si Miao, Yanyan Liu, Yumin Hu, Ji Liu, Bohui Xu, Daquan Chen, Yan Shen
Summary: Currently, bacteria have developed significant resistance to most antibiotics, highlighting the need to develop targeted antibiotic delivery systems using nanotechnology to increase drug concentration at infection sites and reduce side effects in normal tissues.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Pharmacology & Pharmacy
Olga Furman, Alisa Zaporozhets, Dror Tobi, Andrii Bazylevich, Michael A. Firer, Leonid Patsenker, Gary Gellerman, Bat Chen R. Lubin
Summary: In this study, a new EGFR-specific cyclic peptide was discovered using phage display peptide technology and biopanning. The peptide showed specific and selective binding and internalization into EGFR-positive cells, and demonstrated high specificity for non-small cell lung cancer and glioblastoma cells. When conjugated to camptothecin, the peptide showed increased cytotoxicity to EGFR-positive cells.
Article
Chemistry, Multidisciplinary
Yusheng Yuan, Lei Wang, Andrea Porcheddu, Evelina Colacino, Niclas Solin
Summary: Mechanochemistry was used to prepare fluorescent hydrophobic hydantoins and facilitate their complexation with hydrophilic proteins, leading to the development of protein nanomaterials for drug delivery. The study demonstrated that the conversion of proteins into nanofibrils could modify release properties, making these materials versatile for various applications beyond drug delivery.
Article
Materials Science, Multidisciplinary
Rajakar Selvam, Ashish Gandhi, Shih-Che Hung, Artashes V. Karmenyan, Elena Perevedentseva, Wang-Chi Yeh, Sheng-Yun Wu, Hsin-Hou Chang, Chia-Liang Cheng
Summary: The study utilized magnetic nanodiamond particles as an efficient drug delivery vehicle, conjugated with human serum albumin to improve dispersion in biological medium and facilitate controlled release of drugs. Results showed that when loaded with clinical drug, the particles exhibited significantly improved effectiveness against cancer cells when exposed to a magnetic field.
DIAMOND AND RELATED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Fatemeh Shateran, Mohammad Ali Ghasemzadeh, Seyyed Soheil Aghaei
Summary: In this research, a novel magnetic nanocomposite consisting of NiFe2O4@MIL-101(Fe)/GO was synthesized and used for the delivery of the antibiotic tetracycline. The nanocomposite exhibited good antibacterial activity against both Gram-negative and Gram-positive bacteria, and showed low cytotoxicity on HeLa cells.
Article
Oncology
Nuria Lafuente-Gomez, Paula Milan-Rois, David Garcia-Soriano, Yurena Luengo, Marco Cordani, Hernan Alarcon-Iniesta, Gorka Salas, Alvaro Somoza
Summary: The study introduced a smart gemcitabine delivery system based on magnetic nanoparticles, enabling selective release in pancreatic cancer cells via disulfide bonds. The modified nanoparticles showed promising potential for biomedical applications by reducing drug toxicity in non-cancerous cells, enhancing internalization, and synergistic cytotoxic effects when combined with magnetic hyperthermia.
Article
Oncology
Yangjiong Xiao, Yang Yu, Dan Gao, Wangrui Jin, Pengcheng Jiang, Yuhong Li, Chao Wang, Yuning Song, Peng Zhan, Fei Gu, Cancan Zhang, Bin Wang, Yihua Chen, Bing Du, Rong Zhang
FRONTIERS IN ONCOLOGY
(2019)
Article
Immunology
Ning Wang, Hongjun Huang, Qingqing Xiong, Naiyang Chen, Nanxi Xi, Peilun Wu, Mingyao Liu, Min Qian, Qin Wang, Bing Du
JOURNAL OF IMMUNOLOGY
(2019)
Article
Microbiology
Nannan Wu, Xuan-Nhi Nguyen, Li Wang, Romain Appourchaux, Chengfei Zhang, Baptiste Panthu, Henri Gruffat, Chloe Journo, Sandrine Alais, Juliang Qin, Na Zhang, Kevin Tartour, Frederic Catez, Renaud Mahieux, Theophile Ohlmann, Mingyao Liu, Bing Du, Andrea Cimarelli
Article
Chemistry, Medicinal
Haixiang Pei, Juliang Qin, Fengmian Wang, Binghe Tan, Zeda Zhao, Yangrui Peng, Fangfei Yu, Ennian Li, Mingyao Liu, Rong Zhang, Bo Liu, Bing Du, Yihua Chen
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Letter
Immunology
Juliang Qin, Zhen Zhang, Zhixiang Fu, Hua Ren, Mingyao Liu, Min Qian, Bing Du
CELLULAR & MOLECULAR IMMUNOLOGY
(2020)
Article
Immunology
Chengfei Zhang, Juliang Qin, Su Zhang, Na Zhang, Binhe Tan, Stefan Siwko, Ying Zhang, Qin Wang, Jinlian Chen, Min Qian, Mingyao Liu, Bing Du
MUCOSAL IMMUNOLOGY
(2020)
Article
Oncology
Juliang Qin, Xiaoyu Zhang, Binghe Tan, Su Zhang, Chengcong Yin, Qi Xue, Zhen Zhang, Hua Ren, Jinlian Chen, Mingyao Liu, Min Qian, Bing Du
CANCER IMMUNOLOGY RESEARCH
(2020)
Article
Biochemical Research Methods
Yan Lou, Wenxiang Zhao, Haitao Wei, Min Chu, Ruihua Chao, Hangping Yao, Junwei Su, Yanan Li, Xiulan Li, Yu Cao, Yanyan Feng, Ping Wang, Yongyang Xia, Yushuan Shang, Fengping Li, Pingju Ge, Xinglin Zhang, Wenjing Gao, Gaojie Song, Bing Du, Tingbo Liang, Yunqing Qiu, Mingyao Liu
Summary: The study on neutralizing antibodies derived from COVID-19 recovered patients indicates that some antibodies have stronger inhibitory effects and show potential preventive and therapeutic capabilities against different SARS-CoV-2 mutants.
BIOTECHNOLOGY JOURNAL
(2021)
Article
Biology
Xiaoyu Zhang, Wenxiang Zhao, Yihan Zhao, Zeda Zhao, Zhangsheng Lv, Zhen Zhang, Hua Ren, Qin Wang, Mingyao Liu, Min Qian, Bing Du, Juliang Qin
Summary: The study demonstrates that inflammatory macrophages in the synovium exacerbate joint damage in rheumatoid arthritis (RA) through ADP/P2Y(1) signaling, with extracellular ADP (eADP) triggering neutrophil recruitment. Inhibition of the ADP/P2Y(1) signaling pathway can restore arthritis severity, indicating its dominant role in RA pathology.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Immunology
Chenshen Huang, Na Zhang, Hao Xiong, Ning Wang, Zhizhong Chen, Zhizhan Ni, Xiaohong Liu, Boxu Lin, Bujun Ge, Bing Du, Qi Huang
Summary: This study aims to explore a novel method for transcriptional regulation and proposes a new pipeline for analyzing the role of GPRC5B in COAD. By using RNA-seq, ATAC-seq, and ChIP-seq, researchers found the correlation between GPRC5B and macrophages and identified TF GATA4 as a key upstream factor.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Su Zhang, Fangfei Yu, Anran Che, Binghe Tan, Chenshen Huang, Yuxue Chen, Xiaohong Liu, Qi Huang, Wenying Zhang, Chengbin Ma, Min Qian, Mingyao Liu, Juliang Qin, Bing Du
Summary: Emerging evidence suggests that physiological distress is closely correlated with cancer incidence and mortality. This study demonstrates that acute restraint increases the levels of kisspeptin and the expression of its receptor, Gpr54, in the hypothalamus and T cells within the spleen and tumor microenvironment. The administration of kisspeptin-10 impairs T cell function, while knockout of Gpr54 inhibits lung tumor progression. These findings indicate that kisspeptin/GPR54 signaling plays a nonredundant role in stress-induced tumor immune evasion.
Article
Biochemistry & Molecular Biology
Chenshen Huang, Ning Wang, Na Zhang, Zhizhong Chen, Zhizhan Ni, Xiaohong Liu, Hao Xiong, Huahao Xie, Boxu Lin, Bujun Ge, Qi Huang, Bing Du
Summary: This study identified STAT2 as a direct upstream transcription factor regulating PD-L1 expression. The interaction between STAT2 and PD-L1 might be associated with tumor immune evasion, suggesting potential value for tumor treatment.
Article
Multidisciplinary Sciences
Jiqin Zhang, Yongxian Hu, Jiaxuan Yang, Wei Li, Mingming Zhang, Qingcan Wang, Linjie Zhang, Guoqing Wei, Yue Tian, Kui Zhao, Ang Chen, Binghe Tan, Jiazhen Cui, Deqi Li, Yi Li, Yalei Qi, Dongrui Wang, Yuxuan Wu, Dali Li, Bing Du, Mingyao Liu, He Huang
Summary: A two-in-one approach to generate non-viral, gene-specific targeted CAR-T cells through CRISPR-Cas9 was successfully developed, demonstrating feasibility and efficacy in a preclinical study. An innovative type of anti-CD19 CAR-T cell with PD1 integration showed superior ability to eradicate tumor cells.
Article
Biotechnology & Applied Microbiology
Na Zhang, Xiaohong Liu, Juliang Qin, Yue Sun, Hao Xiong, Boxu Lin, Kexin Liu, Binghe Tan, Chenglin Zhang, Chenshen Huang, Shancheng Ren, Mingyao Liu, Bing Du
Summary: This study found that by expressing LIGHT, the trafficking and cytotoxicity of CAR-T cells can be optimized, expanding and improving the application of CAR-T therapy in solid tumors, with potential clinical significance.
Article
Cell Biology
Chengfei Zhang, Yan Yan, Hongwang He, Li Wang, Na Zhang, Jie Zhang, Hongjun Huang, Nannan Wu, Hua Ren, Min Qian, Mingyao Liu, Bing Du
JOURNAL OF MOLECULAR CELL BIOLOGY
(2019)
