Article
Neurosciences
Jung E. Park, Mark Hallett, Hyung-Ryeol Jang, Lee-Uhn Kim, Keun-Jin Park, Seo-Kyung Kim, Jeong-Eun Bae, Ji-yi Hong, Jeong-Ho Park
Summary: Anodal transcranial direct current stimulation of the left posterior parietal cortex followed by motor practice appears to be effective in improving limb-kinetic apraxia in patients with Parkinson's disease, with immediate and sustained effects.
EXPERIMENTAL BRAIN RESEARCH
(2022)
Review
Neurosciences
Esma Nur Kolbasi, Burcu Ersoz Huseyinsinoglu, Zubeyir Bayraktaroglu
Summary: This systematic review investigates the effects of upper extremity focal muscle vibration (FMV) on cortical activity and finds contradictory effects on cortical areas.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Jennifer K. Ferris, Jason L. Neva, Irene M. Vavasour, Kaitlin J. Attard, Brian Greeley, Kathryn S. Hayward, Katie P. Wadden, Alex L. MacKay, Lara A. Boyd
Summary: The study found that NAA concentrations were generally reduced in stroke patients with right hemisphere lesions, and NAA and GLX were also lower in the ipsilesional sensorimotor cortex. Lower NAA concentrations were related to the extent of corticospinal tract injury, but cortical MRS metabolites did not significantly correlate with the severity of chronic upper-extremity impairment in stroke patients.
HUMAN BRAIN MAPPING
(2021)
Article
Biochemistry & Molecular Biology
Tomohiko Takei, Stephen G. Lomber, Douglas J. Cook, Stephen H. Scott
Summary: The research revealed that temporary cooling of PMd and A5 impaired the accuracy and speed of corrective responses, with simulations based on OFC models demonstrating the underlying mechanisms. Additionally, simultaneous deactivation of two cortical regions led to additive impairments, while reducing the amount of cooling to PMd resulted in decreased response speed.
Article
Medicine, General & Internal
Sung Ho Jang, Dong Hyun Byun
Summary: This paper reports on a case of delayed gait recovery in a chronic hemiparetic stroke patient due to resolution of limb-kinetic apraxia (LKA). The patient showed significant improvement in gait after receiving adequate doses of dopaminergic drugs to resolve the LKA. These results highlight the importance of identifying the neurological potential for gait ability and the underlying causes of gait inability in stroke patients.
Article
Rehabilitation
Fatih Soke, Elvan Ozcan Gulsen, Nigar Esra Erkoc Ataoglu, Bilge Kocer, Cagri Gulsen, Duygu Turker, Selim Selcuk Comoglu, Ayse Bora Tokcaer
Summary: This study aimed to investigate the reliability and validity of the coin rotation test (CRT) in people with Parkinson's Disease (PwPD). The results showed that the CRT had excellent reliability and correlated with other outcome measures. It was also able to discriminate PwPD from healthy people and functionally dependent PwPD from functionally independent PwPD.
DISABILITY AND REHABILITATION
(2023)
Article
Neurosciences
Martina Gandola, Laura Zapparoli, Gianluca Saetta, Carlo Reverberi, Gerardo Salvato, Silvia Amaryllis Claudia Squarza, Paola Invernizzi, Maurizio Sberna, Peter Brugger, Gabriella Bottini, Eraldo Paulesu
Summary: This study found that Body Integrity Dysphoria is associated with altered integration of somatosensory and motor signals, involving limb-specific cortical maps and brain regions where the first integration of body-related signals is achieved through convergence.
Article
Rehabilitation
Hakan Carlsson, Birgitta Rosen, Anders Bjorkman, Helene Pessah-Rasmussen, Christina Brogardh
Summary: This pilot randomized controlled trial evaluated the efficacy of sensory relearning and task-specific training compared to task-specific training only for improving upper limb functioning in chronic stroke patients. The results showed that combined sensory relearning and task-specific training led to significant improvements in touch thresholds, use of the hand in daily activities, and movement quality compared to task-specific training alone. The training was well tolerated and feasible in this population.
Article
Clinical Neurology
Joseph W. Olson, Arie Nakhmani, Zachary T. Irwin, Lloyd J. Edwards, Christopher L. Gonzalez, Melissa H. Wade, Sarah D. Black, Mohammad Z. Awad, Daniel J. Kuhman, Christopher P. Hurt, Bart L. Guthrie, Harrison C. Walker
Summary: This study investigates the characteristics of dystonia in patients with Parkinson's disease (PD) and its relationship with brain electrophysiology. The results show significant differences in spectral power in the motor cortex and subcortical areas during repetitive limb movements, especially in PD patients with dystonia.
MOVEMENT DISORDERS
(2022)
Article
Neurosciences
Julia P. Slopsema, Antonietta Canna, Michelle Uchenik, Lauri J. Lehto, Jordan Krieg, Lucius Wilmerding, Dee M. Koski, Naoharu Kobayashi, Joan Dao, Madeline Blumenfeld, Pavel Filip, Hoon-Ki Min, Silvia Mangia, Matthew D. Johnson, Shalom Michaeli
Summary: This study investigated the effects of direction and orientation of the electric field induced by VL-thalamus DBS on activity in the sensorimotor cortex using a swine animal model. Results showed that directional and orientation-selective stimulation could tune network-level modulation patterns in the sensorimotor cortex.
Article
Neurosciences
Heng Zhang, Xing-yue Cao, Li-na Wang, Qing Tong, Hui-min Sun, Cai-ting Gan, Ai-di Shan, Yong-sheng Yuan, Ke-zhong Zhang
Summary: In this study, the effect of 20 Hz transcutaneous auricular vagus nerve stimulation (taVNS) on gait impairments in Parkinson's disease (PD) patients was investigated. The results showed that taVNS can improve gait characteristics in PD patients and remodel sensorimotor integration.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Likai Wang, Fei Gao, Yongli Dai, Zhan Wang, Feng Liang, Jingyi Wu, Mengchun Wang, Litong Wang
Summary: This study aims to investigate the influence of taVNS on cortical responses in stroke patients with left or right hemiparesis and its potential impact on upper limb rehabilitation. They used fNIRS to examine patterns of cerebral activation in stroke patients during a block transfer task. The results showed that taVNS significantly increased cerebral activation, particularly in the left motor cortical network, without affecting cerebral lateralization.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Hong Li, Xiaoyun Li, Jiyuan Wang, Fei Gao, Katja Wiech, Li Hu, Yazhuo Kong
Summary: Studies have found that functional and structural changes in the primary somatosensory cortex (S1) are associated with postherpetic neuralgia (PHN). Patients with PHN show increased activation in S1 and decreased functional connectivity. These findings suggest the importance of S1 reorganization in chronic pain related to PHN and highlight its potential as a treatment target.
HUMAN BRAIN MAPPING
(2022)
Article
Clinical Neurology
Giovanna Gracioli Genoves, Caio Ferraz Cruz, Flavia Dona, Tatiane Alessandra Miranda Andrade, Henrique Ballalai Ferraz, Jose Angelo Barela
Summary: Individuals with early-stage Parkinson's disease demonstrated reduced sensitivity and required larger angular displacement in both reaction time tests and passive motion detection, suggesting impaired joint proprioception.
NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Isabelle Buard, Natalie Lopez-Esquibel, Finnuella J. Carey, Mark S. Brown, Luis D. Medina, Eugene Kronberg, Christine S. Martin, Sarah Rogers, Samantha K. Holden, Michael R. Greher, Benzi M. Kluger
Summary: Cognitive impairment in Parkinson's disease (PD) could be related to fluctuations in prefrontal glutamate metabolism. These preliminary findings suggest that prefrontal glutamate may serve as a biomarker for the progression of cognitive impairments in PD.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Psychology, Biological
Silvia Erika Kober, Manuel Ninaus, Matthias Witte, Finn Buchrieser, Doris Groessinger, Florian Ph S. Fischmeister, Christa Neuper, Guilherme Wood
Summary: Regular exercise improves cognitive control abilities and successful self-regulation of physical activity. This study investigated whether exercise also improves the ability to self-regulate brain activity. The results showed that triathletes were able to self-regulate their own brain activity over a longer period of time, and they exhibited differences in brain structure compared to the control group.
BIOLOGICAL PSYCHOLOGY
(2022)
Article
Clinical Neurology
Martin Krenn, Merve Sener, Jakob Rath, Gudrun Zulehner, Omar Keritam, Matias Wagner, Franco Laccone, Stephan Iglseder, Sonja Marte, Manuela Baumgartner, Astrid Eisenkolbl, Christian Liechtenstein, Sabine Rudnik, Stefan Quasthoff, Susanne Grinzinger, Johannes Spenger, Saskia B. Wortmann, Wolfgang N. Loscher, Fritz Zimprich, Anna Kellersmann, Mika Rappold, Gunther Bernert, Michael Freilinger, Hakan Cetin
Summary: By studying the clinical and molecular characteristics of CMS patients in Austria, this research provides prevalence estimates and genotype-phenotype correlations, which can contribute to improved diagnostic approaches and patient management.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Philip Pruckner, Karl-Heinz Nenning, Florian Ph S. Fischmeister, Mehmet-Salih Yildirim, Michelle Schwarz, Andreas Reitner, Susanne Aull-Watschinger, Johannes Koren, Christoph Baumgartner, Daniela Prayer, Karl Roessler, Christian Dorfer, Thomas Czech, Ekaterina Pataraia, Gregor Kasprian, Silvia Bonelli
Summary: In this study, a multimodal imaging approach was used to assess visual outcomes after epilepsy surgery. The study found that visual field deficits (VFDs) were more severe after anterior temporal lobectomy (ATL) compared to transsylvian selective amygdalohippocampectomy (tsSAHE). Volumetric optic radiation tractography damage could reliably predict the occurrence and extent of VFDs. Fixel-based analysis revealed a widespread decline in fiber cross-section within the ATL group.
Article
Geriatrics & Gerontology
Paula Knechtl, Johann Lehrner
Summary: Via the Vienna Visuoconstructional Test 3.0 (VVT 3.0) delayed recall, the study combined the assessment of visuoconstructive abilities and memory to support diagnostic processes, including staging and the elaboration of a cognitive profile. The results showed that the VVT 3.0 delayed recall scores were able to differentiate between different diagnostic groups, except for the healthy controls (HC) and subjective cognitive decline (SCD) groups. The ROC analysis determined an AUC of 0.890, 95% CI [0.855; 0.925], P < .001, with the ideal cut-off at 29.5 points maximizing sensitivity at 0.896 and specificity at 0.81.
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
(2023)
Article
Neurosciences
Daniel B. Free, Ian Syndergaard, Adam C. Pigg, Silvia Muceli, Johanna Thompson-Westra, Karin Mente, Carine W. Maurer, Dietrich Haubenberger, Mark Hallett, Dario Farina, Steven K. Charles
Summary: Although there are limited treatment options for essential tremor (ET), peripheral tremor suppression methods have shown potential. This study aimed to quantify the relationships between tremor activity in muscles throughout the upper limb. Muscle activity was recorded from 15 major upper limb muscles in subjects with ET, and coherence and phase difference between muscle pairs were calculated. The results showed that patients had significantly more coherence than control subjects, particularly among agonists.
JOURNAL OF NEUROPHYSIOLOGY
(2023)
Article
Biology
Lisa Bartha-Doering, Kathrin Kollndorfer, Ernst Schwartz, Florian Ph. S. Fischmeister, Georg Langs, Michael Weber, Sonja Lackner-Schmelz, Patric Kienast, Marlene Stuempflen, Athena Taymourtash, Sophie Mandl, Johanna Alexopoulos, Daniela Prayer, Rainer Seidl, Gregor Kasprian
Summary: The depth asymmetry of the superior temporal sulcus (STS) may serve as a potential biomarker for the maturity and integrity of neural correlates of language. This study explored the prognostic value of STS depth asymmetry in healthy fetuses for later language abilities. The findings suggest that less right fetal STS depth asymmetry is associated with better verbal abilities and increased left language localization during childhood.
COMMUNICATIONS BIOLOGY
(2023)
Article
Clinical Neurology
Felipe Vial, Patrick McGurrin, Thomas Osterholt, Debra J. Ehrlich, Susan T. Iannacone, Sandra Donkervoort, Sarah B. Neuhaus, Katherine C. Chao, Carsten G. Bonnemann, Dietrich Haubenberger, Mark Hallett
Summary: This study reports the first case of an individual with tremor found to have a de-novo likely pathogenic variant in Myosin Heavy Chain 7 (MYH7) gene. Through a detailed electrophysiological characterization of the tremor syndrome in this individual with a myopathy and MYH7 variant, the phenotypic spectrum and pathomechanism of myogenic tremors in skeletal sarcomeric myopathies are further elucidated. The results suggest that the tremor may originate at the sarcomere level within muscles and is picked up by muscle spindles, leading to activating input to the neuraxis segment. Additionally, the stability of the tremor frequency indicates the presence of central oscillators at the segmental level.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Letter
Clinical Neurology
Nahid Olfati, Dennis W. Dickson, Ali Shoeibi, Dietrich Haubenberger, Irene Litvan
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Psychology, Clinical
Anselm B. M. Fuermaier, Brechje Dandachi-Fitzgerald, Johann Lehrner
Summary: The present study explores the potential value of a computerized attention test, the Cognitrone, as an embedded validity indicator in the neuropsychological assessment of early retirement claimants. The study found that the Cognitrone was sensitive in revealing attention deficits in early retirement claimants and could serve as an embedded validity indicator.
PSYCHOLOGICAL INJURY & LAW
(2023)
Article
Psychiatry
Amelie Tokaj, Johann Lehrner
Summary: This study examines the role of the Vienna Visuo-constructional Test 3.0 Screening (VVT 3.0 Screening) in diagnosing Alzheimer's disease (AD) and predicting disease progression. The results show that the VVT 3.0 Screening is able to discriminate between AD patients and other participants, and can be considered as an alternative to the MMSE test in certain situations.
Article
Multidisciplinary Sciences
Cinzia Cecchetto, Elisa Dal Bo, Marilena Aiello, Florian Ph. S. Fischmeister, Claudio Gentili, Sofia Adelaide Osimo
Summary: Although emotion and olfaction are closely linked, only a few studies have investigated olfactory processing in alexithymia, a condition characterized by altered emotional processing. The results of these studies suggest that individuals with high alexithymia levels do not have lower olfactory abilities or different perceptions of odors, but they do exhibit lower levels of awareness and indifference towards odors. The cognitive and affective components of alexithymia have different effects on olfactory perception.
Article
Multidisciplinary Sciences
Matthias Tomschik, Eva Renaud, Fiona Jaeger, Chiara Paternostro, Jakob Rath, Walter Rinner, Gudrun Zulehner, Fritz Zimprich, Hakan Cetin
Summary: This study aimed to determine the diagnostic and prognostic utility of repetitive nerve stimulation (RNS) in myasthenia gravis (MG) patients. The results showed that RNS was more sensitive in patients with generalized disease, but it is not supported as a long-term outcome prediction tool.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Anselm B. M. Fuermaier, Brechje Dandachi-Fitzgerald, Johann Lehrner
Summary: The primary objective of this research was to investigate the use of the BDI-II as a tool for identifying possible invalid symptom report in forensic neuropsychological evaluations. The study found that individuals with invalid symptom report had significantly higher BDI-II scores compared to those passing symptom validity assessment, indicating that the BDI-II can differentiate valid from invalid symptom report. Additionally, the recommended cut score may vary depending on the educational level of the individual.
APPLIED NEUROPSYCHOLOGY-ADULT
(2023)
Article
Medicine, General & Internal
Gisela Pusswald, Blaz Dapic, Carina Bum, Eva Schernhammer, Elisabeth Stoegmann, Johann Lehrner
Summary: This retrospective study aimed to assess the impact of odor impairment on mortality in patients with Alzheimer's disease (AD), subjective cognitive decline (SCD), and mild cognitive impairment (MCI). The results showed no association between olfactory test performance and mortality among patients with cognitive impairment, but decreased attention function was identified as an influential predictor for mortality.
WIENER MEDIZINISCHE WOCHENSCHRIFT
(2023)
Article
Clinical Neurology
Erin Furr Stimming, Daniel Claassen, Elise Kayson, Jody Goldstein, Raja Mehanna, Hui Zhang, Grace S. Liang, Dietrich Haubenberger
Summary: Valbenazine was evaluated as a treatment for chorea associated with Huntington's disease, and it was found to be more effective than placebo in improving chorea symptoms and well tolerated.
Article
Clinical Neurology
Jun-Pyo Hong, Hanim Kwon, Euyhyun Park, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Summary: In patients with mild-to-moderate PD, vestibular function assessed by video head-impulse tests appears relatively preserved and has minimal impact on the risk of falls. Risk of postural instability is associated with the severity of clinical symptoms in PD.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yaqin Xiang, XiuRong Huang, Qian Xu, Zhenhua Liu, Yase Chen, Qiying Sun, Junling Wang, Hong Jiang, Lu Shen, Xinxiang Yan, Beisha Tang, Jifeng Guo
Summary: Using the novel data-driven method DEBM, this study determined the sequence of several common biomarker changes in Parkinson's disease (PD). The left putamen was found to be the earliest biomarker to become abnormal, followed by the right putamen, CSF alpha-synuclein, right caudate, left caudate, and serum NfL. The estimated disease stages showed significant differences between PD and healthy controls, and achieved a high accuracy for distinguishing PD from HC.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)