Article
Chemistry, Physical
Zhaolun Liang, Zhiyong Jiang, Changli Zhang, Zhipeng Liu
Summary: A ratiometric fluorescent MGO probe based on isophorone was designed and synthesized for imaging MGO in living cells. The probe exhibited selective and sensitive response to MGO and showed promising imaging ability for studying the biological roles of MGO in living cells.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Materials Science, Multidisciplinary
Mi Kyung Kim, Jia Chee Leong, Yehhyun Jo, Geon Kook, Hyunjoo J. Lee
Summary: In this study, a multimodal polymer neural probe array based on a dual-side fabrication process is presented, which has the potential for high-density neural recording and electrochemical neurotransmitter detection.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Chemistry, Multidisciplinary
Johannes Gurke, Tobias E. Naegele, Sam Hilton, Roberto Pezone, Vincenzo F. Curto, Damiano G. Barone, Emil J. W. List-Kratochvil, Alejandro Carnicer-Lombarte, George G. Malliaras
Summary: New fabrication approaches for mechanically flexible implants combining thin film microfabrication and additive manufacturing have been demonstrated. These implants with electrode arrays and microfluidic channels can modulate neuronal activity in the hippocampus through localized drug delivery while recording brain activity by its electrodes. The good implant stability and minimal tissue response observed in this study suggest the potential of hybrid fabrication in neurotechnology for the development of multimodal implants.
MATERIALS HORIZONS
(2022)
Review
Chemistry, Multidisciplinary
Yuqi Wang, Yuxuan Hu, Deju Ye
Summary: Multimodal imaging, combining multiple imaging modalities, has become a powerful tool in biomedical research and clinical diagnosis. Activatable multimodal probes, which can generate signal switches in different imaging modalities, have shown great potential for in vivo imaging. This Minireview summarizes recent progress in the design, activation mechanism, and biomedical applications of activatable multimodal probes, and discusses current challenges and future development perspectives.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Yali Wang, Haiyan Jiang, Xueling Liu, Jun Xu, Yan Gao, Nathaniel S. Finney
Summary: This study presents a range of fluorescent corannulene derivatives suitable for cellular imaging, with strong fluorescence, good photostability, and long emission wavelength. Cell staining experiments indicate several of them have excellent cell membrane permeability and targeting ability, while unexpectedly high energy transfer from corannulene to the pendant fluorophore was also discovered.
CHEMICAL COMMUNICATIONS
(2021)
Article
Cell Biology
Min Gao, Young-Tae Chang
Summary: In this study, a novel human-T-cell-selective fluorescent probe was developed, which effectively distinguished T cells from B cells based on the differences in mitochondrial mass and membrane potential. This study enriches the methods for live cell distinction from complex cell communities.
Article
Spectroscopy
Zheng Yang, Tiantian Xu, Xu Zhang, Hui Li, Xiaodan Jia, Shunsheng Zhao, Zaiwen Yang, Xiangrong Liu
Summary: In this study, a water-soluble and highly fluorescent nanosensor based on N-doped carbon quantum dots (CDs) was successfully fabricated for selective sensing of hypochlorite. The nanosensor showed high stability under various interferences and exhibited significant selectivity towards ClO-. It could detect ClO- concentration in the range of 0.1-50 μmol.L-1 with a sensitivity of 0.03 μmol.L-1. Additionally, the nanosensor could be applied for determination of ClO- in environmental water and visualizing ClO- in living cells.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Multidisciplinary
Min Gao, Sun Hyeok Lee, Sang Hyuk Park, Larissa Miasiro Ciaramicoli, Haw-Young Kwon, Heewon Cho, Joseph Jeong, Young-Tae Chang
Summary: This study presented the first fluorescent probe NeutropG for specific distinction and imaging of active neutrophils, with a selective staining mechanism elucidated as metabolism-oriented live-cell distinction (MOLD). NeutropG was successfully applied to accurately quantify neutrophil levels in fresh blood samples, showing a high correlation with the current clinical method.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Chemistry, Inorganic & Nuclear
Wei Quan, Wenhui Song, Qian Zhang, Huawei Huang, Weiying Lin
Summary: The liver, as the metabolic and detoxification center, plays a vital role in various physiological processes. Normal liver function is crucial for maintaining overall health, while abnormal liver function can lead to liver diseases. Early diagnosis of liver diseases is essential for timely treatment. The use of fluorescent probes for detecting biomarkers of liver diseases has provided valuable insights for pathological studies, drug development, and disease diagnosis and treatment in recent years. This review summarizes the progress of fluorescence probes in detecting hepatopathy-related biomarkers and discusses the current challenges and future directions. The development of long wavelength probes, multi-detection probes, quantitative analysis probes, and multi-modal probes is expected to be a popular trend. This review aims to facilitate the development of novel fluorescent probes for disease detection and provide guidance for diagnosis and treatment.
COORDINATION CHEMISTRY REVIEWS
(2023)
Review
Biochemical Research Methods
Liam Adair, Elizabeth J. New
Summary: Small-molecule fluorophores are versatile tools for studying cellular architecture and biological processes. However, their application in vivo faces challenges such as biocompatibility, chemostability, photostability, and light penetration. Recent advances in designing fluorophores with improved properties and functionalization with targeting and sensing groups have allowed the development of in vivo fluorogenic, ratiometric, and reversible sensors.
CURRENT OPINION IN BIOTECHNOLOGY
(2023)
Article
Chemistry, Analytical
Qiaomei Yang, Yizhuang Zhou, Libin Tan, Can Xie, Xiaowen Li, Miao Zeng, Liyi Zhou
Summary: For the early diagnosis and effective evaluation of treatment effects of inflammation, a de novo bioanalytical method is urgently needed to monitor the metabolite nitric oxide (NO) associated with inflammatory diseases. In this work, a de novo host-guest self-assembled nanosensor CTA was reported for the quantitative detection and visualization of NO levels in inflammatory models.
ANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Inorganic & Nuclear
Jingting Zhan, Wenhui Song, Enxiang Ge, Lixuan Dai, Weiying Lin
Summary: Reversible fluorescent probes have been widely used in biological research due to their ability to observe dynamic changes of biomolecules in real-time. This review categorizes reversible fluorescent probes into six groups based on the principles of reversible reactions and focuses on their interactions with physiological compounds and small molecule compounds or microenvironments. Representative examples of reversible processes, including complex reactions, addition reactions, redox reactions, and spiral cyclization, are reviewed to demonstrate the potential of reversible fluorescent probes for visualizing intracellular dynamic changes. Furthermore, the challenges and future directions of utilizing reversible fluorescent probes in biological applications are discussed.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Analytical
Guannan Liu, Guishan Peng, Jianan Dai, Ri Zhou, Chenguang Wang, Xu Yan, Xiaoteng Jia, Xiaomin Liu, Yuan Gao, Lijun Wang, Geyu Lu
Summary: The newly developed Lipi-BDTO molecule fluorescent probe achieves a high resolution of 65 nm in STED imaging with high photostability. This probe not only allows monitoring of LDs dynamics but also visualizes the 3D spatial distribution of LDs through 3D STED imaging.
ANALYTICAL CHEMISTRY
(2021)
Article
Spectroscopy
Lei Hu, Xi Chen, Kun Yu, Na Huang, Hailing Du, Yan Wei, Yunjun Wu, Hui Wang
Summary: Visualizing endogenous histidine in living systems is important and challenging work. Two weak-emission iridium(III) complexes (IrL1 and IrL2) were designed and synthesized, with IrL2 showing better performance for detecting histidine. The recognition mechanism involves histidine substituting solvent ligands, and IrL2 can be used to visualize endogenous histidine in living cells.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Multidisciplinary
Xinzhu Wang, Shasha He, Penghui Cheng, Kanyi Pu
Summary: A dual-locked and tandem activatable probe (DTAP) is developed for real-time NIRF imaging of intratumoral pyroptosis during cancer chemo-immunotherapy in living mice. The activated signal of DTAP correlates well with tumor-infiltrating cytotoxic T lymphocytes and tumor growth inhibition, enabling the prediction of cancer therapeutic efficacy. This study provides a non-invasive technique to study the regulatory mechanism of pyroptosis in cancer therapy and optimize cancer chemo-immunotherapies.
ADVANCED MATERIALS
(2023)
Correction
Instruments & Instrumentation
Melissa Anne Tutty, Gabriele Vella, Antje Vennemann, Martin Wiemann, Adriele Prina-Mello
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Instruments & Instrumentation
Blanka Halamoda-Kenzaoui, Robert Geertsma, Joost Pouw, Adriele Prina-Mello, Moreno Carrer, Matthias Roesslein, Adrienne Sips, Klaus Michael Weltring, Kathleen Spring, Susanne Bremer-Hoffmann
Summary: The identification of regulatory challenges for nanotechnology-enabled health products is crucial, and greater collaboration between regulatory and research communities is needed to support regulatory decision-making with academic data. Through cross-sector workshops, common and sector-specific challenges can be identified and solutions can be discussed.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Instruments & Instrumentation
Melissa Anne Tutty, Gabriele Vella, Adriele Prina-Mello
Summary: Nanobiomaterials (NBMs) have wide applications in medicine and bioimaging, but evaluating their safety, especially their impact on the liver, is a challenge. Current pre-clinical methods cannot accurately predict liver toxicity of NBMs. 3D cell culture models provide a more accurate assessment of NBM-tissue interaction.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Editorial Material
Instruments & Instrumentation
Kathleen Spring, Klaus-M Weltring, Adriele Prina-Mello, Ruth Schmid
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Review
Chemistry, Analytical
Thierry Bastogne, Fanny Caputo, Adriele Prina-Mello, Sven Borgos, Muriel Barberi-Heyob
Summary: Quality-by-Design (QbD) is a risk-based and proactive approach widely used in the pharmaceutical field for drug development. Analytical Quality by Design (AQbD) is the adaptation of QbD for analytical method development, aiming to optimize the accuracy and robustness of analysis results. However, there are challenges in understanding and implementing the AQbD approach in practice.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Chemistry, Physical
Justin Narimbi, Sivakumar Balakrishnan, Tatiana S. Perova, Garret Dee, Gerhard F. Swiegers, Yurii K. Gun'ko
Summary: New composite materials consisting of zeolitic imidazolate framework (ZIF) structures and microchannel glass (MCG) plates were prepared using the hydrothermal method. Their morphological and spectral properties were characterized using XRD, SEM, FTIR, and Raman spectroscopy. The results showed the formation of stable ZIF structures inside the macropores of the MCG substrate, indicating the potential for important applications in sensors and molecular sieving.
Article
Nanoscience & Nanotechnology
Garret Dee, Olivia O'Donoghue, Aran Rafferty, Lee Gannon, Cormac McGuinness, Yurii K. Gun'ko
Summary: Nanofiltration (NF) is a promising technology for water purification, and 2D boron nitride (BN) based nanomaterials have shown great potential as building blocks for NF membranes. In this study, BN nanosheets (BNNS) were functionalized with magnetic nanoparticles (MNPs) to form stable BNNS-MNP nanocomposites. These nanocomposites demonstrated high removal efficiency of methylene blue (MB) dye from water, with the BNNS-magnetite nanocomposites showing higher efficiency than pure BNNS. The BNNS-cobalt ferrite material was successfully regenerated and recycled. Additionally, the BNNS membranes effectively captured magnetite nanoparticles with no MNPs left in the filtrate, indicating strong potential for water remediation.
ACS APPLIED NANO MATERIALS
(2023)
Article
Chemistry, Physical
Aine Coogan, Natalia Garcia Domenech, Donagh Mc Ginley, Tigran Simonian, Aran Rafferty, Quentin Fedix, Amy Donlon, Valeria Nicolosi, Yurii K. Gun'ko
Summary: Increasing urbanisation and industrialisation, biodiversity loss, and climate change are causing widespread shortage of clean water. The development of innovative and sustainable water purification methods is urgently needed. In this study, we report the development of high-performance nanofiltration membranes based on a recyclable CuAl-CO3 LDH/BNOx nanocomposite, which showed exceptional water flux and up to 100% retention of various dyes. Importantly, these membranes also demonstrated the potential to effectively degrade dyes under visible light conditions, offering a low-cost and viable solution to membrane fouling.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Chemistry, Multidisciplinary
Aaron M. King, Teresa Insinna, Connor J. R. Wells, Isabel A. Raby, Yurii K. Gun'ko, Gemma-Louise Davies
Summary: We present a new magnetically-assisted method to fabricate 1-D 'nano-necklace' arrays containing 0-D magnetic nanoparticles, which are coated with an oxide layer to form semi-flexible core@shell structures. These 'nano-necklaces' exhibit excellent MRI relaxation properties despite their coating and permanent alignment, showing low field enhancement due to structural and magnetocrystalline anisotropy.
NANOSCALE ADVANCES
(2023)
Article
Chemistry, Multidisciplinary
Lorenzo Branzi, Aoife Kavanagh, Michele Back, Adolfo Speghini, Yurii K. K. Gun'ko, Alvise Benedetti
Summary: In this study, new chiral luminescent Cs3Cu2Br5 needle-like microcrystals were synthesized and their optical properties were examined. The effect of the ligand structure on the transfer of chirality was also investigated.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Garret Dee, Hend Shayoub, Helen McNeill, Itziar Sanchez Lozano, Aran Rafferty, Yurii K. Gun'ko
Summary: The main objective of this study is to develop new magnetic core-shell nanostructures for the removal of dye pollutants from water using an external magnetic field. The prepared nanoparticles demonstrated excellent adsorption properties for methylene blue dye, which was validated by UV-visible spectroscopy. The particles retained their ability to adsorb the pollutant after multiple cycles and showed no change in morphology. This research highlights the potential of magnetic core-shell nanostructures for water remediation.
Article
Chemistry, Organic
Danielle D. Barnes, Vera Kuznetsova, Anastasia Visheratina, Finn Purcell-Milton, Mikhail A. Baranov, Dylan M. Lynch, Harlei Martin, Yurii K. Gun'ko, Eoin M. Scanlan
Summary: This article describes a method for detecting trehalase using fluorescent nanoprobes based on trehalose-functionalized quantum dots. The aggregates formed by trehalose and quantum dots are released proportionally to the concentration of trehalase, offering a unique and efficient approach for specific sensing of this biologically important enzyme.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Lorenzo Branzi, Oriane Lavet, Yurii K. Gun'ko
Summary: Chirality has been observed in indium sulfide nanoparticles for the first time, with cysteine used as a chiral agent. The successful transfer of chirality to the nanoparticles was confirmed through circular dichroism spectroscopy, and nuclear magnetic resonance analysis revealed a fast chemical exchange between the chiral ligand on the nanoparticle surface and the free ligand in solution. Furthermore, the thiolate group was found to play a critical role in the optimization of chiral transfer.
Article
Chemistry, Multidisciplinary
Natalia Garcia Domenech, Aine Coogan, Finn Purcell-Milton, Maria Luisa Casasin Garcia, Adrian Sanz Arjona, Marc Brunet Cabre, Aran Rafferty, Kim McKelvey, Peter Dunne, Yurii K. Gun'ko
Summary: This study reports the preparation of nanofiltration membranes using partially oxidised boron nitride (BNOx) 2D nanosheets and their excellent performance in water purification and dye removal. The BNOx material was obtained by partially oxidising bulk h-BN powder and exfoliating it in water. The membranes showed outstanding retention values close to 100% and open up new opportunities for further advancements in nanofiltration and separation technologies.
NANOSCALE ADVANCES
(2022)
Article
Chemistry, Multidisciplinary
Lorenzo Branzi, Finn Purcell-Milton, Chiara Cressoni, Michele Back, Elti Cattaruzza, Adolfo Speghini, Yurii K. Gun'ko, Alvise Benedetti
Summary: This study reports the first evidence of ligand-induced chirality in silver indium sulfide quantum dots. By thoroughly investigating the growth and chemico-physical characterization of the nanocrystals, as well as optimizing the surface passivation by chiral ligands, the researchers highlight the dynamic nature of the interaction between the nanocrystal surface and the chiral ligand, clarifying some fundamental aspects for the transfer and optimization of the chiroptical properties.
