Article
Obstetrics & Gynecology
Yaniv Zipori, Roy Lauterbach, Naphtali Justman, Areen Hajaj, Chen Ben David, Yuval Ginsberg, Nizar Khatib, Zeev Weiner, Ron Beloosesky
Summary: In this study, the feasibility of measuring the forebag using transvaginal ultrasound and its correlation with the standard amniotic fluid index (AFI) were assessed. Significant correlations were found between the vaginal pocket measurements and both AFI and maximal vertical pocket measurements. This new ultrasound variable may provide valuable information for future decision making around the time of delivery.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Oncology
Kelechi Njoku, Davide Chiasserini, Bethany Geary, Andrew Pierce, Eleanor R. Jones, Anthony D. Whetton, Emma J. Crosbie
Summary: Endometrial cancer is the most common gynaecological malignancy in high-income countries with a rising incidence. Early detection with sensitive and specific biomarkers can improve outcomes, and SWATH-MS offers a technological advancement for biomarker discovery due to its reproducibility, sensitivity, and potential for data re-interrogation. This study presents a unique spectral library for identifying protein biomarkers in cervico-vaginal fluid for endometrial cancer detection, available via ProteomeXchange.
Article
Oncology
Ariadna Lara Gutierrez, Julia Hedlund Lindberg, Ganna Shevchenko, Inger Gustavsson, Jonas Bergquist, Ulf Gyllensten, Stefan Enroth
Summary: Cervical cancer is the fourth most common cancer among women worldwide, and screening programs increase its detection rate and survivability. Molecular screening for the presence of HPV as an alternative to physical examinations offers cost-efficient solutions, and our study found that protein biomarkers can aid in the detection of cervical cancer pre-stages.
Article
Medicine, General & Internal
Tejaswini Appidi, Murali Vakada, Hima Sree Buddhiraju, Shubham A. Chinchulkar, Akshar Kota, Dokkari Nagalaxmi Yadav, Suseela Kodandapani, Surya Kumar Simhabhatla, Aravind Kumar Rengan
Summary: This paper presents a colorimetric analysis method, C-ColAur, utilizing gold nanoparticles formed with cervico-vaginal fluids collected from healthy and cancer-affected patients. The efficacy of this technique was evaluated against clinical analysis and the sensitivity and specificity were reported. The study also investigated the potential use of the aggregation coefficient and size of the nanoparticles as indicators for malignancy detection. Additionally, a self-sampling device, CerviSelf, was proposed, along with 3D-printed prototypes, to enable rapid and frequent screening in the comfort of the patients' homes.
Article
Ophthalmology
Kexin Li, Xue Feng, Kenji Hikosaka, Kazumi Norose
Summary: A murine model of primary acquired ocular toxoplasmosis was successfully established through peroral infection with Toxoplasma gondii. After infection, various immune mediators in the aqueous humor showed significant increase, providing new insights into the immunopathogenesis of ocular toxoplasmosis.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Ophthalmology
Tina I. L. Chan, Yolanda W. Y. Yip, Tony T. C. Man, Chi Pui Pang, Marten Erik Brelen
Summary: The purpose of this study was to determine if aqueous glucose levels rise in a comparable time frame to interstitial fluid and could therefore be suitable for continuous glucose monitoring (CGM) site. Through experiments on rabbits, it was found that there was no significant difference in the time lag and rate of change in glucose concentrations between blood and interstitial fluids or aqueous humor in either the posterior or anterior chamber. This suggests that aqueous humor can be used as an alternative CGM site.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Article
Obstetrics & Gynecology
Lorrayne Borges Moreira, Camilla Beatriz da Silva, Vinicius Rangel Geraldo-Martins, Frederico Marcio Fonseca Frade, Marcela Santiago Beraldo, Ruchele Dias Nogueira
Summary: This study aimed to evaluate the presence of Streptococcus mutans (SM) in amniotic fluid samples and its relationship with clinical and oral data of healthy pregnancies. The results showed that 69.2% of the amniotic fluid samples had detectable SM, and 65% of the women had the bacteria in both the amniotic fluid and saliva samples.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Giuseppina Campisciano, Nunzia Zanotta, Mariachiara Quadrifoglio, Annalisa Careri, Alessandra Torresani, Carolina Cason, Francesco De Seta, Giuseppe Ricci, Manola Comar, Tamara Stampalija
Summary: In this study, the presence of bacterial DNA in the chorionic villi and amniotic fluids of pregnant women was investigated. The findings suggest a potential connection between the uterine microbiome and oral and vaginal dysbiosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Dilek Duzgun Ergun, Sefik Dursun, Sefa Ergun, Dervis Ozcelik
Summary: The metabolism of trace elements plays a crucial role in the development of diabetes and its complications. This study aimed to investigate zinc, copper, and chromium levels in plasma and aqueous humor fluids of rabbits in a diabetic model. The results showed significant changes in osmolality, zinc, copper, and chromium levels between diabetic and control groups. The findings suggest that comparative studies of diabetic animal models could be valuable for evaluating diabetes and its complications.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Immunology
Bei Jia, Lijun Tang, Huibing Liu, Yan Zhu, Wenqian Chen, Qian Chen, Jing Li, Mei Zhong, Ailan Yin
Summary: Prenatal exposure to intrauterine inflammation (IUI) plays a crucial role in the development of preterm birth. However, the relationship between microflora and preterm birth remains unclear. In this study, a mouse model of intrauterine inflammation was established and the saliva and amniotic fluid were analyzed for microbial composition. The results showed that LPS-induced intrauterine inflammation altered the abundance of microorganisms in both saliva and amniotic fluid, leading to an increase in pathogenic bacterium Escherichia coli and a decrease in immune-associated probiotics, especially in amniotic fluid. The abundance of E. coli in amniotic fluid was positively correlated with the levels of TNF-alpha and IL-1 beta.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Ophthalmology
Javier Murgoitio-Esandi, Benjamin Y. Xu, Brian J. Song, Qifa Zhou, Assad A. Oberai
Summary: This study investigated the relationship between the circumferential extent of angle closure and elevation in intraocular pressure using a novel mechanistic model. The results showed a rapid increase in IOP when the extent of angle closure exceeded 180 degrees, which was associated with a nonlinear increase in AH outflow velocity.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2023)
Article
Obstetrics & Gynecology
K. Kteily, D. Pening, P. Diaz Vidal, M. Devos, J. Dechene, A. Op de Beeck, A. Botteaux, S. Janssens, E. Van den Abbeel, O. Goldrat, A. Delbaere, I Demeestere
Summary: The study found that SARS-CoV-2 mRNA is not detectable in the reproductive tract of asymptomatic patients undergoing ART, regardless of the results from a triage questionnaire and a nasopharyngeal SARS-CoV-2 RNA detection test.
HUMAN REPRODUCTION
(2022)
Article
Medicine, Legal
Daijing Yu, Jun Zhang, Niu Gao, Yumei Huo, Wanting Li, Tian Wang, Xiaomeng Zhang, Halimureti Simayijiang, Jiangwei Yan
Summary: In this study, a new method combining PCR and LFD was developed to simultaneously detect saliva and vaginal fluid for forensic identification. The results show that this method is rapid, simple, reliable, and efficient for identifying body fluids.
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
(2023)
Article
Biology
Nadezhda V. Azbukina, Dmitry V. Chistyakov, Sergei V. Goriainov, Vladislav I. Kotelin, Elena V. Fedoseeva, Sergey Yu. Petrov, Marina G. Sergeeva, Elena N. Iomdina, Evgeni Yu. Zernii
Summary: The analysis of eye liquids from a cohort of primary open-angle glaucoma patients identified signaling lipids that suggest a role of arachidonic acid/platelet-activating factor (PAF)-dependent pathways and oxidative stress in the pathogenesis of the disease, providing novel targets for its diagnostics and treatment.
Article
Obstetrics & Gynecology
Min Jung Lee, Min Kyung Kim, Hyo Jin Lee, Kwang Hee Ahn, Hyeon Ji Kim, Jee Yoon Park
Summary: In this prospective cohort study, we compared the mean interleukin-6 (IL-6) level in the amniotic fluid after rupture of membranes during term pregnancy according to delivery methods. We found that the concentration of IL-6 in the amniotic fluid was significantly higher in the vaginal delivery group than in the caesarean section group. There was also a positive association between the concentration of IL-6 and cervical dilatation.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
K. Csanaky, D. Reglodi, E. Banki, I. Tarcai, L. Mark, Zs Helyes, T. Ertl, J. Gyarmati, K. Horvath, L. Santik, A. Tamas
ACTA PHYSIOLOGICA HUNGARICA
(2013)
Article
Medicine, Legal
Zoltan Patonai, Gabor Maasz, Peter Avar, Janos Schmidt, Tamas Lorand, Istvan Bajnoczky, Laszlo Mark
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
(2013)
Article
Physics, Atomic, Molecular & Chemical
Agnes Revesz, Tibor Andras Rokob, Gabor Maasz, Laszlo Mark, Helga Hever, Laszlo Drahos, Karoly Vekey
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
(2013)
Article
Biochemistry & Molecular Biology
R. Brubel, P. Kiss, A. Vincze, A. Varga, A. Varnagy, J. Bodis, L. Mark, E. Jambor, G. Maasz, H. Hashimoto, Zs. Helyes, G. Toth, A. Tamas, M. Koppan, D. Reglodi
JOURNAL OF MOLECULAR NEUROSCIENCE
(2012)
Article
Biochemistry & Molecular Biology
M. Koppan, A. Varnagy, D. Reglodi, R. Brubel, J. Nemeth, A. Tamas, L. Mark, J. Bodis
JOURNAL OF MOLECULAR NEUROSCIENCE
(2012)
Article
Chemistry, Analytical
Eva Jambor, Agnes Bona, Janos Schmidt, Laszlo Mark, Robert Ohmacht
JOURNAL OF SEPARATION SCIENCE
(2013)
Article
Parasitology
Tamas Hajdu, Erzsebet Fothi, Ivett Kovari, Monika Merczi, Attila Molnar, Gabor Maasz, Peter Avar, Antonia Marcsik, Laszlo Mark
MEMORIAS DO INSTITUTO OSWALDO CRUZ
(2012)
Article
Oncology
Veronika A. Jancsik, Gabor Gelencser, Gabor Maasz, Janos Schmidt, Gergo A. Molnar, Istvan Wittmann, Lajos Olasz, Laszlo Mark
PATHOLOGY & ONCOLOGY RESEARCH
(2014)
Article
Multidisciplinary Sciences
Agnes Bona, Zoltan Papai, Gabor Maasz, Gabor A. Toth, Eva Jambor, Janos Schmidt, Csaba Toth, Csilla Farkas, Laszlo Mark
Article
Biochemistry & Molecular Biology
Erzsebet Mernyak, Judit Huber, Johanna Szabo, Gyula Schneider, Anasztazia Hetenyi, Laszlo Mark, Gabor Maasz, Agnes Berenyi, Ida Kovacs, Renata Minorics, Istvan Zupko, Janos Woelfling
Article
Integrative & Complementary Medicine
Melinda Boros, Agnes Kemeny, Bela Sebok, Terez Bagoly, Aniko Perkecz, Zoltan Petohazi, Gabor Maasz, Janos Schmidt, Laszlo Mark, Terezia Laszlo, Zsuzsanna Helyes, Janos Szolcsanyi, Erika Pinter
EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE
(2013)
Meeting Abstract
Biochemistry & Molecular Biology
R. Brubel, A. Varga, D. Reglodi, A. Tamas, A. Lubics, P. Kiss, A. Varnagy, L. Kornya, J. Bodis, L. Mark, G. Maasz, E. Jambor, M. Koppan
JOURNAL OF MOLECULAR NEUROSCIENCE
(2012)
Meeting Abstract
Biochemistry & Molecular Biology
A. Varnagy, M. Koppan, D. Reglodi, R. Brubel, J. Nemeth, A. Tamas, L. Mark, L. Kornya, J. Bodis
JOURNAL OF MOLECULAR NEUROSCIENCE
(2012)
Meeting Abstract
Biochemistry & Molecular Biology
B. Opper, D. Reglodi, G. Horvath, P. Kiss, A. Tamas, R. Brubel, L. Mark, A. Lubics, E. Laszlo, J. Nemeth, E. Fabian, P. Szakaly
JOURNAL OF MOLECULAR NEUROSCIENCE
(2012)
Meeting Abstract
Medicine, General & Internal
M. Boros, K. Meszaros, J. Grosz, A. Perkecz, T. Bagoly, A. Kemeny, G. Maasz, L. Mark, J. Szolcsanyi, Z. Helyes, E. Pinter
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2012)