Article
Agriculture, Dairy & Animal Science
Danielle Nicole Coleman, Mario Vailati-Riboni, Russell T. Pate, Ahmad Aboragah, Daniel Luchini, Felipe C. Cardoso, Juan J. Loor
Summary: Enhanced post-ruminal supply of methionine can affect mammary metabolism and immune response. Heat stress and rumen-protected methionine have been found to influence abundance and phosphorylation of signaling proteins in mammary gland. However, rumen-protected methionine supplementation does not attenuate the inflammatory response induced by lipopolysaccharide in vitro.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Endocrinology & Metabolism
Georgia Colleluori, Jessica Perugini, Giorgio Barbatelli, Saverio Cinti
Summary: The mammary gland is an exocrine gland responsible for milk production in female mammals, composed mainly of epithelial cells and adipocytes. It displays highly plastic properties during different stages of the lactation cycle and requires close association with adipocytes for proper development. The role of adipocytes in mammary gland development and diseases like obesity and breast cancer deserves further investigation.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2021)
Article
Nutrition & Dietetics
Min Fu, Yuanpeng Gao, Wenxing Guo, Qi Meng, Qi Jin, Rui Yang, Ying Yang, Yaqi Zhang, Wanqi Zhang
Summary: This research investigates the compensation mechanism of iodine deficiency and excess in the mammary gland during lactation. The study found that milk iodine concentration is positively correlated with iodine intake, and the regulation of glycosylation and degradation of NIS by DPAGT1 and VCP in the mammary gland plays a role in regulating milk iodine level. However, the mammary gland has limited ability to compensate for iodine deficiency and excess.
Article
Pharmacology & Pharmacy
Gregory Gauthier-Coles, Angelika Broer, Malcolm Donald McLeod, Amee J. George, Ross D. Hannan, Stefan Broer
Summary: SNAT2 is an important amino acid transporter involved in amino acid accumulation, cellular osmolarity, and cell growth. A potent inhibitor of SNAT2 has been identified through high-throughput screening, with selectivity against other transporters. Combined with a glucose transport inhibitor, this compound can halt the proliferative growth of cancer cells.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Jinbo Wu, Shiming He, Zhonghua Yu, Daoliang Lan, Xianrong Xiong, Zhu Li
Summary: In this study, RNA-seq was used to analyze the mammary gland transcriptomes of high-yielding and low-yielding yaks during lactation. The results showed that 144 differential genes were identified, which were involved in various biological processes such as carbohydrate metabolism. This study provides new insights into the molecular mechanism of yak mammary gland tissue and potential strategies for improving milk production in yaks.
ANIMAL BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rong Xuan, Jianmin Wang, Qing Li, Yanyan Wang, Shanfeng Du, Qingling Duan, Yanfei Guo, Peipei He, Zhibin Ji, Tianle Chao
Summary: This study conducted transcriptome sequencing of goat-mammary-gland tissue at different developmental stages to reveal the expression characteristics and molecular functions of circRNAs during mammary involution. A total of 11,756 circRNAs were identified, with 2528 circRNAs expressed in all three stages. Gene ontology analysis showed functional diversity of circRNAs' source genes. Furthermore, differentially expressed circRNAs and circRNA-miRNA-mRNA ceRNA regulatory networks were identified, providing insights into the regulatory role of circRNAs in mammary cell involution and remodeling.
Article
Agriculture, Dairy & Animal Science
Wei Xia, Yili Liu, Juan J. Loor, Massimo Bionaz, Mingfeng Jiang
Summary: This study evaluated the transcriptome of mammary tissue in four yaks throughout the lactation cycle. The analysis identified over 6000 differentially expressed genes, with a large number of genes showing differential expression at the onset and end of lactation. The functions affected by transcriptomic adaptation to lactation in yak mammary tissue were similar to those observed in dairy cows, including induction of lipid metabolism, amino acid metabolism, and glycan biosynthesis, as well as suppression of the cell cycle and immune response.
Article
Cell Biology
Ivan Luzardo-Ocampo, Jose L. Dena-Beltran, Xarubet Ruiz-Herrera, Ana Luisa Ocampo-Ruiz, Gonzalo Martinez de la Escalera, Carmen Clapp, Yazmin Macotela
Summary: Obesity is a modern pandemic that negatively impacts women's reproductive health. Women with obesity experience changes in their mammary glands which affect their ability to exclusively breastfeed. The hormone prolactin, which is responsible for lactation, has reduced activity in the mammary glands of obese lactating rodents, contributing to impaired lactation. Treatment with prolactin has shown to improve milk production in women with inadequate lactation. This review focuses on the effects of diet-induced obesity on lactating mammary glands and how obesity impairs the lactogenic action of prolactin. While the impact of obesity on lactation has been studied in both humans and rodents, most of the research has been conducted on rodents.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Cell Biology
Sabrina A. Vallone, Martin Garcia Sola, Carolina Schere-Levy, Roberto P. Meiss, Gladys N. Hermida, Lewis A. Chodosh, Edith C. Kordon, Nancy E. Hynes, Albana Gattelli
Summary: The abnormal expression of RET negatively affects the mammary epithelium during involution, leading to an increased potential for mammary tumor development.
DISEASE MODELS & MECHANISMS
(2022)
Article
Agriculture, Dairy & Animal Science
P. S. Yoder, J. J. Castro, Tatiana Ruiz-Cortes, M. D. Hanigan
Summary: Amino acid uptake in mammary epithelial cells is responsive to varying extracellular supplies to maintain homeostasis, with most amino acids showing no saturation of uptake, indicating that transporter capacity is likely not a limitation for most amino acids except possibly for Arg, Val, and Pro.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Immunology
Dilay Cansever, Ekaterina Petrova, Sinduya Krishnarajah, Caroline Mussak, Christina A. Welsh, Wiebke Mildenberger, Kevin Mulder, Victor Kreiner, Elsa Roussel, Sebastian A. Stifter, Myrto Andreadou, Pascale Zwicky, Nicole Puertas Jurado, Hubert Rehrauer, Ge Tan, Zhaoyuan Liu, Camille Bleriot, Francesca Ronchi, Andrew J. Macpherson, Florent Ginhoux, Giancarlo Natalucci, Burkhard Becher, Melanie Greter
Summary: Macrophages play a role in immune defense, organogenesis, and tissue homeostasis. During lactation, a unique population of macrophages called liMacs emerges in the mammary gland and milk, which is similar to macrophages found in human milk.
Article
Agriculture, Dairy & Animal Science
J. Y. Dourmad, J. J. Matte
Summary: During lactation, the mammary gland in sows adapts its metabolism quickly in response to short-term changes in nutrient availability, demonstrating a rapid ability to adjust nutrient uptake and modify metabolism according to the nutrients in the bloodstream.
Article
Biochemistry & Molecular Biology
Lilia Sanchez, Jessica Epps, Steven Wall, Cole McQueen, Scott J. Pearson, Kelly Scribner, Elizabeth A. Wellberg, Erin D. Giles, Monique Rijnkels, Weston W. Porter
Summary: The functionally differentiated mammary gland adapts to extreme levels of stress by activating specific protective mechanisms. The breast tumor suppressor gene SIM2s is identified as a novel regulator of mitophagy, a key component of this stress response.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Veterinary Sciences
Weihao Chen, Xinyu Gu, Xiaoyang Lv, Xiukai Cao, Zehu Yuan, Shanhe Wang, Wei Sun
Summary: This study used RNA-seq technology to analyze the expression of miRNAs and circRNAs in sheep mammary gland during different lactation periods and identified potential miRNAs and circRNAs related to sheep mammary gland development through bioinformatics analysis.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Genetics & Heredity
Elitsa Ivanova, Sandrine Le Guillou, Cathy Hue-Beauvais, Fabienne Le Provost
Summary: The mammary gland undergoes significant anatomical and physiological changes from embryogenesis through various stages, with epigenetic mechanisms playing a crucial role in these processes. Research has shown the importance of epigenetic marks in milk component biosynthesis and highlights the involvement of DNA methylation, histone modifications, polycomb protein activity, and non-coding RNA functions in regulating gene expression in the mammary gland.