Targeting Inhibitors of Apoptosis Proteins (IAPs) For New Breast Cancer Therapeutics

LRIG1 Modulates Cancer Cell Sensitivity to Smac Mimetics by Regulating TNF  Expression and Receptor Tyrosine Kinase Signaling

(2012) L. Bai et al.   CANCER RESEARCH

Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)

(2012) John A. Flygare et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting IAP proteins for therapeutic intervention in cancer

(2012) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Smac Mimetics Activate the E3 Ligase Activity of cIAP1 Protein by Promoting RING Domain Dimerization

(2011) Rebecca Feltham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Potent and Orally Active Antagonist (SM-406/AT-406) of Multiple Inhibitor of Apoptosis Proteins (IAPs) in Clinical Development for Cancer Treatment

(2011) Qian Cai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antagonists Induce a Conformational Change in cIAP1 That Promotes Autoubiquitination

(2011) E. C. Dueber et al.   SCIENCE

Smac mimetics increase cancer cell response to chemotherapeutics in a TNF-α-dependent manner

(2010) B L Probst et al.   CELL DEATH AND DIFFERENTIATION

Prognostic value of the X-linked inhibitor of apoptosis protein for invasive ductal breast cancer with triple-negative phenotype

(2010) Jinjing Wang et al.   HUMAN PATHOLOGY

Down-regulation of c-FLIP Enhances Death of Cancer Cells by Smac Mimetic Compound

(2009) H. H. Cheung et al.   CANCER RESEARCH

Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2-mediated resistance

(2008) M. Fakler et al.   BLOOD

SM-164: A Novel, Bivalent Smac Mimetic That Induces Apoptosis and Tumor Regression by Concurrent Removal of the Blockade of cIAP-1/2 and XIAP

(2008) J. Lu et al.   CANCER RESEARCH

Targeting XIAP Bypasses Bcl-2-Mediated Resistance to TRAIL and Cooperates with TRAIL to Suppress Pancreatic Cancer Growth In vitro and In vivo

(2008) M. Vogler et al.   CANCER RESEARCH