Journal
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
Volume 323, Issue 10, Pages 1384-1388Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jmmm.2010.11.051
Keywords
Magnetic separation; Particle fractionation; SPLITT; step-SPLITT
Funding
- NCI NIH HHS [R01 CA062349, R01 CA062349-17] Funding Source: Medline
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The Quadrupole Magnetic Sorter (QMS), employing an annular flow channel concentric with the aperture of a quadrupole magnet, is well established for cell and particle separations. Here we propose a magnetic particle separator comprising a linear array of cylindrical magnets, analogous to the array proposed by Klaus Halbach, mated to a substantially improved form of a parallel plate SPLITT channel, known as the step-SPLITT channel. While the magnetic force and throughput are generally lower than for the QMS, the new separator has advantages in ease of fabrication and the ability to vary the magnetic force to suit the separands. Preliminary experiments yield results consistent with prediction and show promise regarding future separations of cells of biomedical interest. (C) 2010 Elsevier B.V. All rights reserved.
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